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APPROVED ; The work which follows examines the process by which private actors in the digital market are redefining fundamental rights through their contractual terms and practical operation. The argument is allied to works which consider ?digital constitutionalism,? the idea that private actors in the digital market are increasingly displaying constitutional features through their contractual terms and documents. Unlike a majority of work in the area of digital constitutionalism the work does not argue that private actors setting rights based standards represents a positive development. Rather, the work argues that private actors, through their re-definition of public, normative standards are generating a body of rules and practices which have displaced democratically decided rights standards with negative consequences for individual autonomy and the Rule of Law. The work argues that this process has been enabled by three features of EU law and policy. The first is an approach of functional equivalence to laws governing the digital market. In accordance with this approach the digital market has been treated as equivalent to traditional markets and its participants are viewed as requiring no additional or supplementary protections or regulations. Of particular significance in functionally equivalent attitudes to the digital market is the Union?s deference to freedom of contract as part of an ordoliberal attitude to market regulation. While this attitude is now beginning to erode (to some extent) in the context of data protection it remains the dominant regulatory approach of the European Union in the digital market. The second feature, not unrelated to the first, is the Union?s preference for economic rather than socially orientated standards and protections in it policies as well as its secondary laws. As part of this preference, when fundamental rights cross the Rubicon from vertically enforced constitutional protections to horizontally enforceable legislative ones their content is transmuted in a manner which favours their economic over socially oriented aspects. The third feature, is what is referred to within the work as the Union?s brittle constitutionalism ? that is the Union?s hesitant and incomplete articulation of and commitment to rights enforcement. This feature is the result in part of the Union?s ambiguous and at times hostile attitude to the development of fundamental rights policy. The work examines the impact of these trends and the rise of private policy they have generated on the rights to privacy and property under the Charter of Fundamental Rights.

[112] p. ; In verse. ; Signatures: [par.]-2[par.]⁴ A-M⁴. ; Reproduction of the original in the Henry E. Huntington Library and Art Gallery.

Discrimination against minority groups still occurs in Indonesia, both in the form of verbal and non-verbal violence. The last discrimination that occurred was the closure of the Ahmadiyah Mosque in Garut, West Java in 2021. According to Foucault, discrimination occurs due to the existence of a power system to regulate knowledge and hegemony in society through the normalization of knowledge which is a tool of power so that discrimination and even intolerance can be justified in society. The Wawuh boardgame is a medium for spreading tolerance and peace through 9 basic human rights, namely; the right to life, the right to receive, the right to work, the right to health, the right to education, the right to facilities, the right to protection, the right to voice, and the right to administration. This study aims to determine the extent of changes in perspective and behavior of tolerance after playing the Wawuh Boardgame. This game is played to members of the Scouts of UIN Sunan Gunung Djati Bandung Batch 39 who have not been exposed to the issue of peace and violence based on minority group discrimination. This research method uses a combined qualitative and quantitative approach because the data collection uses a questionnaire whose results will be described in written form and the researcher can describe with a clear purpose. The results and discussion of this study prove that there is an attitude of tolerance and a change in perspective by 86% as well as increasing information about minority groups against members of the Scouts of UIN Sunan Gunung Djati Bandung Batch 39. The conclusion of this study is that the Wawuh Boardgame is effective in campaigning for peace and can introduce minority groups as well as being able to prevent discrimination at all levels.

[88] p. ; Signatures: A-L⁴. ; "A kalender containing the square roote of any number from 100. to 10000" has divisional title page; register is continuous. ; Reproduction of the original in the Henry E. Huntington Library and Art Gallery.

[128] p. ; In verse. ; Printer's name and place of publication from colophon. ; Dedication dated 1574; printer's device at foot of colophon dated 1573. ; Signatures: A-Q⁴. ; Identified as STC 21120 on UMI microfilm reel 351. ; Reproductions of the originals in the Henry E. Huntington Library and Art Gallery and the British Library. ; Appears at reel 351 (Henry E. Huntington Library and Art Gallery copy) and at reel 1840 (British Library copy).

1+ leaves. ; Last complete line of text in right column ends "to". ; Imperfect: torn, leaf 2 only; best copy available for photographing. ; Reproduction of original in: Society of Antiquaries.

Dam Safety and dam incidents are treated here looked at from the "Human Factors" perspective. An attempt is made to explore these factors as an important drive in impairing dams' safety and increases their risks. Distinction is drawn between the "Normal Human Caused Incidents" and the "Extraordinary Human Caused Incidents" together with the description of their root origins and subsequent consequences. The first type includes unintentional mistakes, errors and flaws committed by the operators of dams inadvertently, in addition to negligence, lack of experience or overconfidence. Such failings can happen in manual operation of dams, or through the use of their Supervision, Control and Data Acquisition (SCADA) systems as in industrial control system (ICS). They can occur also due to flaws in software or even in the application of information and communication technology (ICT) in remote control operations. As for the second group; the extraordinary human factors, they are defined here as those committed by man with the full understanding of their possible damage. They are done purposely for destabilizing dams after thoughtful and carefully meditated decision making process and they are manifested in acts of war, sabotage and terrorists actions. In this modern age, these acts are characteristics of hackers' attacks on dam(s) operating systems. This is done through the use of cyberspace by the widespread interconnected digital technology with the accompanying advances in the communication technologies. As such, these technologies have made remote control of such systems possible. Not limited to this, dams remain now, as they were always in the past, the obvious targets in wars and conflicts to inflict losses on the enemy and to use them as weapons, and for terrorism actions for challenging governments. Examples of the aforementioned threats are described with examples given from real cases to elucidate the dangers involved. Lessons to be learned from these incidents are derived and recommendations are presented to be followed to avoid risky situations. ; Validerad;2020;Nivå 1;2020-09-29 (johcin)

[4], 23, 23-54, [1] p. ; A translation by Claudis Hollyband of the French version of: Explanatio veri ac legitimi juris, quo serenissimus Lusitaniae Rex Antonius eius nominis primis nititur. ; The imprint is false; probably printed in London by Thomas Purfoot (STC), who appropriated the imprint of the edition in French. ; The second leaf is a folded genealogical chart. ; Text continuous despite pagination. ; Reproduction of the original in the Henry E. Huntington Library and Art Gallery.

Endocrine disrupting chemicals (EDCs) are ubiquitous in the environment and involve diverse chemical-receptor interactions that can perturb hormone signaling. The Organization for Economic Co-operation and Development has validated several EDC-receptor bioassays to detect endocrine active chemicals and has established guidelines for regulatory testing of EDCs. Focus on testing over the past decade has been initially directed to EATS modalities (estrogen, androgen, thyroid, and steroidogenesis) and validated tests for chemicals that exert effects through non-EATS modalities are less established. Due to recognition that EDCs are vast in their mechanisms of action, novel bioassays are needed to capture the full scope of activity. Here, we highlight the need for validated assays that detect non-EATS modalities and discuss major international efforts underway to develop such tools for regulatory purposes, focusing on non-EATS modalities of high concern (i.e., retinoic acid, aryl hydrocarbon receptor, peroxisome proliferator-activated receptor, and glucocorticoid signaling). Two case studies are presented with strong evidence amongst animals and human studies for non-EATS disruption and associations with wildlife and human disease. This includes metabolic syndrome and insulin signaling (case study 1) and chemicals that impact the cardiovascular system (case study 2). This is relevant as obesity and cardiovascular disease represent two of the most significant health-related crises of our time. Lastly, emerging topics related to EDCs are discussed, including recognition of crosstalk between the EATS and non-EATS axis, complex mixtures containing a variety of EDCs, adverse outcome pathways for chemicals acting through non-EATS mechanisms, and novel models for testing chemicals. Recommendations and considerations for evaluating non-EATS modalities are proposed. Moving forward, improved understanding of the non-EATS modalities will lead to integrated testing strategies that can be used in regulatory bodies to protect environmental, animal, and human health from harmful environmental chemicals. ; LNM was supported by a H2020-Marie Skłodowska-Curie Action MSCA-IF-RI- 2017 awarded by the European Commission (ref. 797725-EpiSTOX). JK was funded by the European Union's Horizon 2020 research and innovation program under grant agreement GOLIATH No. 825489. AS and LEC were supported by a Grant-in-Aid from the Heart and Stroke Foundation of Canada. ; Peer reviewed

[48] p. ; Martin Marprelate has been identified with John Penry and, more probably, with Job Throckmorton. ; A reply to: Bridges, John. A defence of the government established in the Church of Englande for ecclesiasticall matters. ; The epitome only; the epistle was published earlier the same year. ; The imprint is false; actual imprint from STC. ; Signatures: [A]² B-F⁴ G² . ; The last leaf is blank. ; Reproduction of the original in the Henry E. Huntington Library and Art Gallery.

[168] p. ; Place of publication conjectured by STC. ; Dated at end: MDCXI. ; Signatures: A-K L⁴. ; Reproduction of the original in the British Library.

ABSTRACT Human life is increasingly developing, making demands for fulfilment of needs are also growing. Likewise with the clothing needs used. Nowadays the use of one's clothing shifts into a lifestyle that cannot be separated from it. This condition can benefit the market to make it an opportunity. This happens in Indonesia, where the country whose population is the largest Moslem religion up to 85% of the total population has a fashion style that is influenced by the beliefs adopted by Islam. This fashion industry has an important role as a contributor to improving the economy. The development of the domestic Muslim fashion industry will be able to answer domestic to international market demand if it can formulate strategies in answering the challenges that exist. In this case the actors who play a role in the Muslim Fashion Industry must have a reliable strategy that can improve the development of the Muslim Fashion Industry. This development has also become the main focus of the Indonesian government where it has a target that makes Indonesia the World Muslim Fashion Qibla in 2020. By utilizing the wealth of Indonesian Human Resources, Nature and Culture, Indonesia will be able to reach its dreams. The impact that will be felt in achieving this target is very large, such as increasing economic productivity, increasing employment opportunities, national income and the role of Indonesia in the development of world Muslim fashion.

Glyphosate is the active ingredient of some of the most highly produced and used herbicides worldwide. The intensive applications of glyphosate-based herbicides and its half-life in water lead to its presence in many aquatic ecosystems. Whereas recent studies have reported neurotoxic effects of glyphosate including autism-related effects, most of them used extremely high (mg/L to g/L) concentrations, so it is still unclear if chronic, low environmentally relevant concentrations of this compound (ng/L to μg/L) can induce neurotoxicity. In this study we analyzed the neurotoxicity of glyphosate in adult zebrafish after waterborne exposure to environmentally relevant concentrations (0.3 and 3 μg/L) for two weeks. Our data showed that exposed fish presented a significant impairment of exploratory and social behaviors consistent with increased anxiety. The anterior brain of the exposed fish presented a significant increase in dopamine and serotonin levels, as well as in the DOPAC/dopamine and homovanillic acid/dopamine turnover ratios. Moreover, the expression of genes involved in the dopaminergic system, as th1, th2, comtb, and scl6a3 was downregulated. Finally, the brain of exposed fish presented a significant increase in the catalase and superoxide dismutase activities, with a concomitant decrease of glutathione stores. These changes in the antioxidant defense system are consistent with the observed increase in oxidative stress, reflected by the increase in the levels of lipid peroxidation in the brain. The presented results show that current glyphosate concentrations commonly found in many aquatic ecosystems may have detrimental consequences on fish survival by decreasing exploration of the environment or altering social interactions. Furthermore, as zebrafish is also a vertebrate model widely used in human neurobehavioral studies, these results are relevant not only for environmental risk assessment, but also for understanding the risk of chronic low-dose exposures on human health. ; This work was supported by the Spanish Government with FEDER Funds (CTM2017-83242-R; D.R.) and the network of recognized research groups by the Catalan Government (2017 SGR_902). J.B. was supported by a Spanish fellowship PRE2018-083513. Mention of specific products or trade names does not indicate endorsement by the US federal government. ; Peer reviewed

Vol. 2: 7, [1] text leaves (the last blank), [61] double-page leaves of plates; for collation of v. 1, see Fowler. The etched plans, elevations and views have legends in Middle French and Latin. T.p. purely typographic, but the text with head and tail pieces, initials. ; Fowler ; Cicognara, ; Mode of access: Internet. ; In Getty c. 1 the plate leaves are numbered 1-110 in brown ink, and the "Table des bastimens" on t.p. verso has been numbered accordingly. The plates also have later numbering from 1 to 57 in pencil at the upper right-hand corners. On leaf 7r the description of "Beauregard" has been annotated in the margin with an excerpt from abbé Jean Joseph d'Expilly's Dictionnaire géographique, historique et politique des Gaules et de la France (1762-1770). ; Binding, c. 1: old vellum. Title written at head of spine: Chateaux / de / Ducerceau. Holes for two pairs of ties at foredge. Centered on front pastedown is Giovanni Muzio's etched bookplate by Giacomo Manzù. Binding, c. 2: old sheepskin, rebacked and repaired. Spine now gold tooled, with author and title on red label. ; Library's copies incomplete: both lack v. 1. In addition c. 1 lacks one of the plates for Dampierre ("Estuues") and the three plates for Bury.

La educación como cualquier otro servicio de carácter público, es un derecho que el Estado otorga a través de sus instituciones, regulado por un Marco Jurídico, constituido por normas de observancia obligatoria, para gobernantes como para gobernados, por lo que, su cumplimiento se traduce a partir de las disposiciones emitidas por la autoridad competente, en cuyo discurso se encuentran dos premisas indisolubles: el filosófico y el político, en el primero de éstos, se plasma el deber-ser construido a partir de las aspiraciones del sentido humano por alcanzar una vida digna, donde el respeto, la tolerancia, la bondad y la honestidad, figuran como el estandarte ético, con el que ha de educarse a la ciudadanía y con el que habrá de formarse cada uno de los individuos, mientras que el aspecto político suscribe al consenso de las mayorías, como el fundamento de la legitimidad para instituir los principios legales, que habrán de traducirse en ordenamientos para mantener el orden y los procedimientos, para el cabal cumplimiento de las necesidades públicas. En este sentido, corresponde al Artículo 3° Constitucional, ser la norma suprema a través de la cual, se ha de normar para operar los servicios educativos en todos sus tipos y modalidades, en cuya conformación histórica, nos revela la inseparable presencia filosófica y política en su discurso, como un prototipo ideológico del Estado de Derecho, sin embargo, no es la norma su cuestión absoluta, sino su grado de cumplimiento, dado los alcances de su operación, por ello, en este artículo se presenta de manera general, el proceso de evolución y cambio que ha sufrido, durante su desarrollo. Después de su revisión Bibliográfica y Hemerográfica, se describe la trayectoria del Artículo 3° Constitucional, así como su despliegue operativo a partir de lo que regula la Secretaría de Educación Pública, como órgano de la Administración Pública Federal. Palabras-clave: Artículo Tercero Constitucional, Ley Orgánica de la Administración Pública Federal, Ley de Planeación. ; : Education, like any other public service, is a right that the State grants through its institutions, regulated by a Legal Framework, made up of mandatory rules, for governors as well as for the governed, therefore, its compliance translates into based on the provisions issued by the competent authority, in whose discourse there are two indissoluble premises: the philosophical and the political, in the first of these, the must-be constructed from the aspirations of the human sense to achieve a A dignified life, where respect, tolerance, goodness and honesty appear as the ethical standard, with which citizens must be educated and with which each individual must be formed, while the political aspect subscribes to the consensus of the majorities, as the basis of the legitimacy to institute legal principles, which will have to be translated into regulations to maintain order and procedures. measures, for the full fulfillment of public needs. In this sense, it corresponds to Article 3 of the Constitution, to be the supreme norm through which, it is necessary to regulate to operate educational services in all its types and modalities, in whose historical conformation, reveals the inseparable philosophical and political presence In his discourse, as an ideological prototype of the Rule of Law, however, its absolute question is not the norm, but its degree of compliance, given the scope of its operation, therefore, this article presents in a general way, the process of evolution and change that it has undergone during its development. Key-Word: Third Constitutional Article, Organic Law of the Federal Public Administration, Planning Law.