The Senate and the House each passed spending reduction reconciliation bills. A conference agreement of approximately $40 billion in reductions was reached on December 19, but has yet to clear Congress. The Senate passed a five-year revenue reduction reconciliation bill on December 8. The net effect of the legislation on the budget would be to raise the deficit in fiscal year 2006 and over the five-year period covered in the legislation.
Is the New Year really new or old? Happy or sad? Is it only part of the process and the cycle of seasons making one look back and think of death? Is it a time to wish to stay where one is or hope for opportunities and possibilities? Like a point in a circle, is every day a New Year's day? Is it a time for nostalgia and reminiscence or promises and resolutions for the future? With the (Gregorian and the British Government) changes in the Western calendar at different times in history and with different countries/cultures celebrating the New Year at different times of the year and with the fiscal year, political (election) year, and academic year being different from the traditional New Year of January 1st, does the New Year mark the beginning and the ending in just an arbitrary way? Centuries ago Britain's earliest Poets Laureate introduced the tradition of writing a New Year poem. Since then there have been many authors writing New Year essays and poems. They include Robert Herrick, Charles Cotton, Johann Von Goethe, S. T. Coleridge, Charles Lamb, Lord Alfred Tennyson, William Cullen Bryant, Helen Hunt Jackson, Emily Dickinson, George Curtis, Thomas Hardy, Fiona Macleod (William Sharp), D. H. Lawrence, Rabindranath Tagore, and Sylvia Plath, among others.
Hongliang Li,1,* Xiaopeng Guo,1,* Qiutian Li,2,* Pengzhan Ran,1 Xudong Xiang,3 Yuncang Yuan,1 Tianqi Dong,1 Bei Zhu,1 Lei Wang,1 Fangfang Li,1 Chunyan Yang,1 Dengcai Mu,1 Dan Wang,4 Chunjie Xiao,1 Shangyong Zheng1 1School of Medicine, Yunnan University, Kunming, China; 2Department of Oncology, Kunming General Hospital of Chengdu Military Command, Teaching Hospital of Kunming Medical University, Kunming, China; 3Department of Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University, Kunming, China; 4Department of Pharmacy, Kunming General Hospital of Chengdu Military Command, Teaching Hospital of Kunming Medical University, Kunming, China *These authors contributed equally to this work Purpose: Emerging evidence suggests that many differentially expressed long non-coding RNAs (lncRNAs) are involved in tumorigenesis. However, the functional roles of these transcripts and the mechanisms responsible for their deregulation in non-small-cell lung cancer (NSCLC) remain elusive. Here, we identified a novel lncRNA (lncRNA 1308), which was significantly upregulated in NSCLC tissues and investigated its biological function and potential molecular mechanism.Methods: Differences in the lncRNA expression profiles between NSCLC and tumor-adjacent normal tissues were assessed by lncRNA expression microarray analysis. The microRNA in vivo precipitation (miRIP) method was used to identify the targeting microRNAs (miRNAs) on lncRNA 1308, and luciferase reporter assays were performed. Loss-of-function studies were used to explore the effect of lncRNA 1308 on lung carcinogenesis in NSCLC cells.Results: The novel lncRNA 1308 was upregulated in NSCLC tissues and cell lines. By using biotin-labeled lncRNA 1308 for miRIP in NSCLC cells and dual-luciferase reporter assays, the results suggested that miRNA-124 was associated with lncRNA 1308. Furthermore, the expression of a disintegrin and a metalloproteinase 15 (ADAM 15) was downregulated in NSCLC cells when silencing of lncRNA 1308, the target of oncogenic miR-124, inhibits NSCLC cell proliferation and invasion. Conversely, the expression of ADAM 15 was significantly increased, when inhibiting the expression of miR-124, and alleviated cell invasion inhibition.Conclusion: The results suggested that lncRNA 1308 may function as a competing endogenous RNA (ceRNA) for miR-124 to regulate cell invasion through the miR-124/ADAM 15 signaling pathway, indicating that lncRNA 1308 plays an important role in the disease progression of NSCLC. Keywords: lung cancer, lncRNA 1308, miR-124, ADAM 15, competing endogenous RNA
Editor: H.G.W. Woodhead (with H.T.M. Bell, 1912-1922). ; Yearbook bearing the date 1938- contains data for the calendar year 1937- ; preceding yearbooks -1936 contained data for calendar year -1936. ; None published, 1915, 1917-1918, 1920, 1927, 1937.` ; Mode of access: Internet.
Description based on: 1873/74. ; Published by: Hoyt, Fogg & Donham, 1875-1887. ; Vols. for 1881/1882-1886/1887 lack subtitle. ; "Contains the usual calendar matter; diary pages; historical summary of the state; vote for president 1868; for governor for 1870 and 1871; list of past officers of the state; rights and qualifications of voters; conditions of eligibility to office; ratable polls; population and valuation of towns; list of courts, banks, newspapers, postmasters, selectmen, town-clerks, clergymen, physicians, dentists, lawyers, notaries, sheriffs, justices, merchants, manufacturers, etc.; stamp duties; postage rates, revenue officers; U.S. statistics; schools; colleges; orders of Good Templars, Odd Fellows, and Masons, &c." ; Mode of access: Internet.
This article addresses firstly the terminological problems modern historians encounter when discussing the law of property in the Middle Ages, and how its decontextualization has led to numerous inaccurate studies in the field of legal history, and secondly it is dedicated to Rudolph Sohm and his interpretation of the law of property and how his idea of institutional law can be applied to the medieval institutions of Transylvania in the early 14th century. Rudolph Sohm considers in his work Outlines of Church History that in the Middle Ages, society was composed of only two classes, the nobility and the clergy. They alone possessed property and they alone ruled. He describes landed property as the only kind of property recognized in that period. It is interesting to investigate in light of recent studies how political authority went hand in hand with the possession of land, and how were the classes defined by Sohm identified with and within the nation or the realm. His classification is still used by many Hungarian and Romanian historians, and we argue against the use of the modern concept of property and offer a new definition for the numerous and various types of possession we encounter. Was the history of the nation their history? What defines the society in the Middle Ages? Is Sohm's definition of medieval property still functional correlated with the new developments in legal history? These are several questions that this research aims to answer by investigating the roman and medieval terminology used to define possession and nobility in 13th and 14th century Transylvania. ; Questo articolo riguarda, in primo luogo, i problemi terminologici per gli storici moderni quando si discute la legge della proprietà nel Medioevo, e come la decontestualizzazione ha creato numerosi studi erronati nel campo della storia del diritto, e in secondo luogo è dedicata a Rudolph Sohm e la sua interpretazione di la legge della proprietà e di come la sua idea di legge può essere applicata alle istituzioni medievali della Transilvania nei primi anni del 14° secolo. Rudolph Sohm considera, nella sua opera Outlines of Church History, che nel Medioevo, la società era composta da solo due classi, la nobiltà e il clero. Solo loro possedevano proprietà e solo loro governati. Egli descrive la proprietà fondiaria come l'unico tipo di proprietà riconosciuto in quel periodo. E 'interessante indagare alla luce di recenti studi come l'autorità politica è andato di pari passo con il possesso della terra, e di come sono state le classi definite da Sohm identificato con e all'interno della nazione o il regno. La sua classificazione è ancora utilizzato da molti storici ungheresi e rumene, e ci sostengono contro l'uso del moderno concetto di proprietà e offrire una nuova definizione per i numerosi e vari tipi di possesso che incontriamo. Era la storia della nazione loro storia? Ciò che definisce la società nel Medioevo? È la definizione di Sohm di struttura medievale ancora funzionali correlati con i nuovi sviluppi nella storia del diritto? Queste sono alcune domande che questa ricerca si propone di rispondere indagando la terminologia romana e medievale utilizzato per definire il possesso e nobiltà nel 13 ° e 14 ° secolo la Transilvania. ; Ciencias Religiosas ; Derecho
International audience ; In 1307-1308, pope Clement V had an inquiry made into a series of crimes attributed to bishop of Albi Bernard de Castanet by two canons of the cathedral, who had presented at the roman Curia a list of accusations against their spiritual ruler. The bishop was accused of pastoral negligence, of simony, of dilapidation, of irregularities and systematic cruelty in the practice of justice, of murders and of incontinence. Soon after the hearing by pontifical commissioners of a hundred and fourteen witnesses presented by the denouncers, the pope called off the procedure. But three days later, he implicitly penalized the bishop, removing him from the see of Albi to that of Le Puy, which was much less prestigious. The study of this case develops from the critical edition of the records of the inquiry at Albi, which are held at the Vatican Archives (register 404 of the Collectoriae). The initiative of the denouncers is examined in the perspective of the conflictual history of Bernard de Castanet's episcopate (1276-1308). A continuity is shown between the witnesses' will to have the bishop's guilt admitted, on the one hand, and, on the other hand, the struggle of the urban élite against the bishop's lordly jurisdiction, but also the anti-inquisitorial movement lead by brother Bernard Délicieux in 1299-1306. The heresy of the good men, which was vigorously fought by the bishop, proves to be at the heart of the matter, though the denouncer didn't mention it at all. The analysis show the informal consistency and the social and theologico-political grounds of religious dissent. Besides, by replacing the procedure in the series of processus inquisitionis dealing with " enormous crimes " (enormia) launched by popes against prelates since the beginning of the XIIIth century and by examining it from a juridical point of view, the study of this casus shows the role played by inquiry, as a tool of State government, in the construction of a public opinion (fama), and in the differentiation of an ...