Suchergebnisse

Semaphorin 3A (Sema3A) is a cell-secreted protein that participates in the axonal guidance pathways. Sema3A acts as a canonical repulsive axon guidance molecule, inhibiting CNS regenerative axonal growth and propagation. Therefore, interfering with Sema3A signaling is proposed as a therapeutic target for achieving functional recovery after CNS injuries. It has been shown that Sema3A adheres to the proteoglycan component of the extracellular matrix (ECM) and selectively binds to heparin and chondroitin sulfate-E (CS-E) glycosaminoglycans (GAGs). We hypothesize that the biologically relevant interaction between Sema3A and GAGs takes place at Sema3A C-terminal polybasic region (SCT). The aims of this study were to characterize the interaction of the whole Sema3A C-terminal polybasic region (Sema3A 725–771) with GAGs and to investigate the disruption of this interaction by small molecules. Recombinant Sema3A basic domain was produced and we used a combination of biophysical techniques (NMR, SPR, and heparin affinity chromatography) to gain insight into the interaction of the Sema3A C-terminal domain with GAGs. The results demonstrate that SCT is an intrinsically disordered region, which confirms that SCT binds to GAGs and helps to identify the specific residues involved in the interaction. NMR studies, supported by molecular dynamics simulations, show that a new peptoid molecule (CSIC02) may disrupt the interaction between SCT and heparin. Our structural study paves the way toward the design of new molecules targeting these protein–GAG interactions with potential therapeutic applications. ; This work was funded by the European Union Seventh Framework Programme (FP7/2007–2013) under Project VISION, grant No. 304884, the Spanish Ministry of Science and Innovation/Spanish Research Agency (MCI/AEI/FEDER, RTI2018–096182-B-I00) and AGAUR (2017 SGR 208). ; Peer reviewed

Volume III of National Accounts of OECD Countries comprises Volume IIIa - Financial Accounts - Flows and Volume IIIb - Financial Balance Sheets - Stocks . In both volumes, data, based on the System of National Accounts (SNA 1993), are expressed in national currency (in euros for euro area countries). Volume IIIa covers financial accounts of OECD countries and includes financial transactions (both net acquisition of financial assets and net incurrence of liabilities), by institutional sector (non-financial corporations, financial corporations, general government, households and non-profit insti

"11 December 1978." ; Shipping list no.: 89-483-P. ; "Reprint which includes current pages from changes 1 and 2." ; Cover title. ; Includes bibliographical references. ; Mode of access: Internet. ; 14

The Tweed Family Papers consists primarily of correspondence between Mrs. Richard Tweed and her children, relatives, and friends. Diaries, essays and poetry written by family members, newspaper clippings (photocopies), and financial and legal material are also included, as are a handful of photographs. All related primarily to the life of Mrs. Richard Tweed and her descendants. ; Mrs. Richard Tweed, upon whom the majority of the materials focus, was the sister-in-law of William Marcy ("Boss") Tweed, who controlled the Democratic political machine at New York City's Tammany Hall during the mid-19th century. He and his associates misappropriated public funds on a large scale, leading to his arrest and imprisonment in 1871. ; The Tweed Family Papers are organized by the following categories: Correspondence, Newspapers, Literary Production, Photographs, Financial Material, Printed Material, Scrapbook Material, Legal Material, and Artifacts. ; Tweed Family Papers, 1836-1932 and undated, Southwest Collection/Special Collections Library, Texas Tech University, Lubbock, Texas ; Box 1, File 14

This biography examines the life of Helen Keller using easy-to-read, compelling text. Through striking historical and contemporary images and photographs and informative sidebars, readers will learn about Keller's family background, childhood, education, and time as a world-renowned activist and speaker. Informative sidebars enhance and support the text. Features include a table of contents, timeline, facts page, glossary, bibliography, and an index. Aligned to Common Core Standards and correlated to state standards. Essential Library is an imprint of Abdo Publishing, a division of ABDO

The Confederate Graves Survey Archive of the Texas Division, Sons of Confederate Veterans consists of surveys of cemeteries throughout Texas, and portions of Oklahoma and New Mexico. The surveys document the interment of Confederate States of America military veterans. United States of America (Union) veterans, as well as able-bodied men at the time of the Civil War, are also documented. 13 boxes entitled "Grave Surveys" contain grave surveys listed county-by-county, 3 boxes of "Unit Files" list surveyed individuals by their military unit. Finally, 17 boxes contain "Veteran Files" that document each veteran by name in "last name, first name, middle initial" format. An index that cross-references each of the collection series (Grave Surveys, Unit Files, and Veteran Files) is included, as are institutions to surveyors on how and what to document while conducting surveys. ; Pendleton Cemetery #678, Pendleton, Bell County, Texas | Veterans Interred: Brown, E. A. ; Abilene Cemetery #138, Abilene, Taylor County, Texas | Veterans Interred: Thomas, J. W. ; Abilene Cemetery #138, Abilene, Taylor County, Texas | Veterans Interred: Thomas, J. H. ; Weiland Cemetery #578, Weiland, Hunt County, Texas | Veterans Interred: Phillips, Robt Jackson. ; King Cemetery #685, Coryell County, Texas | Veterans Interred: Moseley, Elisha Alfred. ; Norton Cemetery #915, Runnels County, Texas | Veterans Interred: McDaniel, James M. ; Dickens Cemetery #340, Dickens, Dickens County, Texas | Veterans Interred: Sheilds, Thos. Jefferson. ; Shady Grove Cemetery #634, Wood County, Texas | Veterans Interred: Crone, Franklin M. ; Shady Grove Cemetery #634, Wood County, Texas | Veterans Interred: Jarred, James. ; Shady Grove Cemetery #634, Wood County, Texas | Veterans Interred: Brawning, Thomas. ; Moody Cemetery #28, Moody, McLennon County, Texas | Veterans Interred: Phillips, A. J. ; Weiland Cemetery #578, Weiland, Hunt County, Texas | Veterans Interred: Cummings, Henry. ; Weiland Cemetery #578, Weiland, Hunt County, Texas | Veterans Interred: Elledge, W. W. ; Forrest Park Cemetery #582, Hunt County, Texas | Veterans Interred: McMillan, Lee G. ; Abilene Cemetery #138, Abilene, Taylor County, Texas | Veterans Interred: Thomas, J. W. ; East Mt. Cemetery #572, Hunt County, Texas | Veterans Interred: Fountain E. P.

"This material appeared originally in Public documents . It was privately reprinted without change in 1935, was revised and published by the Library of Congress in 1939 and is here reissued with slight revision of the introductory section."--p. [2] ; At head of title: Library of Congress. Division of documents. ; Mode of access: Internet.

The Confederate Graves Survey Archive of the Texas Division, Sons of Confederate Veterans consists of surveys of cemeteries throughout Texas, and portions of Oklahoma and New Mexico. The surveys document the interment of Confederate States of America military veterans. United States of America (Union) veterans, as well as able-bodied men at the time of the Civil War, are also documented. 13 boxes entitled "Grave Surveys" contain grave surveys listed county-by-county, 3 boxes of "Unit Files" list surveyed individuals by their military unit. Finally, 17 boxes contain "Veteran Files" that document each veteran by name in "last name, first name, middle initial" format. An index that cross-references each of the collection series (Grave Surveys, Unit Files, and Veteran Files) is included, as are institutions to surveyors on how and what to document while conducting surveys. ; Hogeye Cemetery #759, Hunt County, Texas | Veterans Interred: Tatom, Felix G. ; Wesley Chpl. Cemetery #773, Hunt County, Texas | Veterans Interred: Byars, Daniel W. ; Panhandle Cemetery #193, Panhandle, Carson County, Texas | Veterans Interred: Jameson, Wm. Savage. ; Miami Cemetery #202, Miami, Roberts County, Texas | Veterans Interred: Whatley, John Williams. ; Highland Cemetery #154, Stanford, Haskell County, Texas | Veterans Interred: Self, John M. ; Highland Cemetery #154, Stanford, Haskell County, Texas | Veterans Interred: Buie, Archibald. ; Terrace Cemetery #377, Post, Garza County, Texas | Veterans Interred: Smith, Isaac. ; McWright Cemetery #573, Greenville, Hunt County, Texas | Veterans Interred: VanCleave, George W. ; Forrest Prk Cemetery #582, Hunt County, Texas | Veterans Interred: Ende, Fred Von. ; East Mount Cemetery #572, Hunt County, Texas | Veterans Interred: Robey, James Garrison. ; East Mount Cemetery #572, Hunt County, Texas | Veterans Interred: Lamar, J. H. ; East Mount Cemetery #572, Hunt County, Texas | Veterans Interred: Latimer, Isham Pruitt. ; East Mount Cemetery #572, Hunt County, Texas | Veterans Interred: Gee, Robert B. ; Quay Cemetery #722, Quay County, New Mexico. ; Graham Point Cemetery #756, Hunt County, Texas | Veterans Interred: VanCleave, Wm. Grenade. ; Hooker Ridge Cemetery #760, Hunt County, Texas | Veterans Interred: Fortenberry, Oliver A. ; Plainview Cemetery #317, Plainview, Hale County, Texas | Veterans Interred: Howell, Alfred T. ; Kress Cemetery #186, Kress, Swisher County, Texas | Veterans Interred: Askey, James Harrison. ; West Park Cemetery #184, Hereford, Deaf Smith County, Texas | Veterans Interred: Rector, Thos. K. ; Dreamland Cemetery #192, Canyon, Randall County, Texas | Veterans Interred: Slack, Oliver Perry. ; Rosston Cemetery #1048, Rosston, Cooke County, Texas | Veterans Interred: Glover, Isaac. ; East Mount Cemetery #572, Hunt County, Texas | Veterans Interred: Arnold, Marcellus M. ; Kelly Cemetery #763, Hunt County, Texas | Veterans Interred: Walker, Wesley Clark. ; Shiloh Cemetery #591, Campbell, Hunt County, Texas | Veterans Interred: Voyles, Rudolphus. ; Abilene Cemetery #1138, Abilene, Taylor County, Texas | Veterans Interred: Sorelle, Wiley H.

This article provides a biographical look at the American author James Fenimore Cooper. It traces his roots from his youth in Cooperstown—named after his father William—to his ill-timed naval career, and on to his time as a self-conscious novelist.

The writings of the Indian Diaspora have received a great deal of attention and critical acclaim throughout the world. Rohinton Mistry is a well renowned author in the contemporary commonwealth literature and occupies a significant place among the writers of Indian Diaspora. Even though he is settled in Canada; it is his upbringing in Mumbai that reflects in all his writings. The distinct Mumbai culture, particularly the Parsee way of life, the people of the city and even the politics of India are major themes in his novels. Rohinton Mistry as a writer of Diaspora has carved a niche for himself. His works such as: "Tales from Firozsha Baag", "Such A Long Journey", "A Fine Balance" and "Family Matters"; mark a new kind of writing, resulting from a fragmented, splintered world. As a Diasporic Parsi writer, very sensitively he has recalled his community's journey through time and history with a sense of loss and nostalgia. His books portray diverse facets of Indian socioeconomic life; as well as Parsi Zoroastrian life, customs, and religion. Many of his writings are markedly "Indo-nostalgic". Rohinton Mistry through his Diasporic discourse has well depicted his ancestral background, his community's engaged situation in a metropolis like Bombay and his deep attachment with and nostalgia for a world gone by. In this paper an attempt has been made to delineate diasporic discourse in the works of Rohinton Mistry. Although he is obsessed with the colonial and postcolonial experiences in India, we can find some traces of Canada in his literature. His characters dream of being integrated into, and accepted by, Canadian society on the one hand and on the other hand, these same characters are torn by an insatiable desire to be true to their native culture; to honor and cherish their own, distinct cultural identity.Keywords: Diaspora, Cultural identity, Contemporary Canadian literature, Parsi.

Charles Underwood was in the United States Army for more than 31 years from 1941 to 1972. His active military service included command of infantry, armored infantry and armored units from platoon through brigade. Most staff assignments were in information and public affairs. He was a Prisoner of War for the Japanese Imperial Army from 1942-1945 and survived the Bataan Death March. ; The collection consists of slides, photographs, letters, military documents, and other personal documents of Charles Underwood. It includes information on the Bataan Death March as well as the different bases around the world he was stationed at during his time in the Army. ; The collection is organized by the following series: Bataan, Birth Records, Certificates, Correspondence, Drawings, Financial Records, Genealogy, Legal Document, Literary Productions, Medical Records, Memorial, Military Documents, Newspaper, Periodical, Personal Documents, Photographs, Printed Material, Retirement Records, School Records, Scrapbook, and Slides. ; Box 1, Folder 22

Since the industrialization in the 19th century, Switzerland has been an attractive destination for immigrants. In 2009, foreign residents constituted 22.9 percent of the total population. Switzerland was thus host to more foreigners than many other European countries. Despite these facts, Switzerland has - for a long time - denied to be a country of immigration. Coherent integration policies have therefore been designed only in recent years. While conditions for immigration have been eased for EU citizens since the 1990s, immigration of third country citizens is currently limited to the highly qualified and family reunification.

Cover -- Title Page -- Copyright -- Contents -- America's Unsung Hero -- Growing Up with Inequality -- Hardships as a Young Adult -- Early Political Publishing -- A Fateful Meeting with Benjamin Franklin -- Paine Finds His Voice -- A Call for Independence -- Times That Try Men's Souls -- Serving a New Nation -- Rights of Man -- From French Hero to Enemy -- The Age of Reason -- A Mind for Invention -- Coming Back to America -- Inspiration for Workers and Women -- Paine's Legacy for the Nation -- GLOSSARY -- FOR MORE INFORMATION -- FOR FURTHER READING -- BIBLIOGRAPHY -- INDEX -- Back Cover