Suchergebnisse

Het samengaan van een grondige studie van de basisprincipes van het Belgisch administratief recht en een gedetailleerde en geactualiseerde bespreking van de grote domeinen van het materieel administratief recht maakt het boek uniek in de Vlaamse rechtswereld. 0'Overzicht van het Belgisch administratief recht 2017' bevat een diepgaande bespreking van alle belangrijke bestuursrechtelijke leerstukken, zoals onder meer die betreffende de beginselen van behoorlijk bestuur en de werking van de openbare dienst. Daarnaast biedt het boek een geactualiseerde en grondige bespreking de grote onderwerpen uit het materieel administratief recht zoals het omgevingsrecht, het overheidsopdrachten- en het onteigeningsrecht, het openbaar ambt en de organisatie en de werking van de uiteenlopende vormen van lokaal en interlokaal bestuur. Bijzondere aandacht gaat uit naar de rechtsbescherming van de burger tegenover het bestuur waarbij niet enkel de diverse vormen van repressieve rechtsbescherming en de almaar aan belang winnende alternatieve geschillenbeslechting. Het geheel wordt onderbouwd met een massa verwijzingen naar de rechtsleer

This book offers insights into facilitating sustainable careers through the study of a wide interdisciplinary range of policy investigations and assessment of ongoing practices in the field. By assessing and comparing the transferability of policies and good practices between firms in ten countries and regions of the European Union this book considers the development of sustainable careers across the lifespan at the levels of individuals, organizations and systems. This book is the culmination of a research project from the international European Social Fund network on 'Career and Age, Generation, Experience(AGE)'. It discusses and offers observations on key concerns at the European level: How to make people work longer, remain employable, develop sustainable competencies ? How to adapt the work environment and human resource management policies at employer's level ? And finally, how can public authorities take measures and incentives to support sustainable careers for individuals?

International audience ; To estimate the seismic hazard, the geometry (dip, length and orientation) and the dynamics (type of displacements and amplitude) of the faults in the area of interest need to be understood. In this paper, in addition to geomorphologic observations, we present the results of two ground penetrating radar (GPR) campaigns conducted in 2010 and 2011 along the Emeelt fault in the vicinity of Ulaanbaatar, capital of Mongolia, located in an intracontinental region with low deformation rate that induces long recurrence time between large earthquakes. As the geomorphology induced by the fault activity has been highly smoothed by erosion processes since the last event, the fault location and geometry is difficult to determine precisely. However, by using GPR first, a non-destructive and fast investigation, the fault and the sedimentary deposits near the surface can be characterized and the results can be used for the choice of trench location. GPR was performed with a 50 MHz antenna over 2-D lines and with a 500 MHz antenna for pseudo-3-D surveys. The 500 MHz GPR profiles show a good consistency with the trench observations, dug next to the pseudo-3-D surveys. The 3-D 500 MHz GPR imaging of a palaeochannel crossed by the fault allowed us to estimate its lateral displacement to be about 2 m. This is consistent with a right lateral strike-slip displacement induced by an earthquake around magnitude 7 or several around magnitude 6. The 2-D 50 MHz profiles, recorded perpendicular to the fault, show a strong reflection dipping to the NE, which corresponds to the fault plane. Those profiles provided complementary information on the fault such as its location at shallow depth, its dip angle (from 23 • to 35 •) and define its lateral extension. Central Asia is known for its high level of seismic hazards, especially Mongolia, which has been one of the most seismically active intracontinental regions in the world with four large earthquakes (magnitude around 8) along its active faults in the western part of the country during the last century (Khilko et al. 1985). The deformation in Mongolia is located between compressive structures related to the collision and penetration of the Indian plate into the Eurasian plate and extensive structures in the north of the country related with the Baykal rift (Tapponnier & Molnar 1979; Baljinnyam et al. 1993; Schlupp 1996; Bayasgalan & Jackson 1999). The seismic activity observed in the vicinity of Ulaanbaatar (UB), capital of Mongolia, is relatively low compared to the activity observed in western Mongolia. Nevertheless, since 2005, the seismic activity around UB not only has increased, but is also organized (see Fig. 1) at the west of UB along two perpendicular directions, which determine two active faults: Emeelt fault, discovered in 2008 (NNW-SSE direction, 25-km-long minimum and situated about 10 km W of UB) and Hustai fault (WSW–ENE direction, 80 km long, with its NE tip at less than 20 km west of UB); their length and morphology indicate that they can produce earthquakes of magnitude 6.5–7.5 (Schlupp et al. 2012). Most of the Mongolian population (1.2 million over 3 million) is concentrated at UB, which is the main political and economical centre of the country. Hence, the study of seismic hazard and the estimation of the probability of future destructive earthquakes are of primary importance for the country (Dugarmaa et al. 2006). Since the last large earthquake, the faults geomorphology has been highly smoothed by erosional processes and the exact location of the fault plane surface rupture is thus hidden within a several metre wide strip. The GPR method has been proven to give good and useful results to characterize faults by identifying offsets of radar reflections (Malik et al. 2007; Christie et al. 2009; Yalçiner et al. 2013) and

International audience ; To estimate the seismic hazard, the geometry (dip, length and orientation) and the dynamics (type of displacements and amplitude) of the faults in the area of interest need to be understood. In this paper, in addition to geomorphologic observations, we present the results of two ground penetrating radar (GPR) campaigns conducted in 2010 and 2011 along the Emeelt fault in the vicinity of Ulaanbaatar, capital of Mongolia, located in an intracontinental region with low deformation rate that induces long recurrence time between large earthquakes. As the geomorphology induced by the fault activity has been highly smoothed by erosion processes since the last event, the fault location and geometry is difficult to determine precisely. However, by using GPR first, a non-destructive and fast investigation, the fault and the sedimentary deposits near the surface can be characterized and the results can be used for the choice of trench location. GPR was performed with a 50 MHz antenna over 2-D lines and with a 500 MHz antenna for pseudo-3-D surveys. The 500 MHz GPR profiles show a good consistency with the trench observations, dug next to the pseudo-3-D surveys. The 3-D 500 MHz GPR imaging of a palaeochannel crossed by the fault allowed us to estimate its lateral displacement to be about 2 m. This is consistent with a right lateral strike-slip displacement induced by an earthquake around magnitude 7 or several around magnitude 6. The 2-D 50 MHz profiles, recorded perpendicular to the fault, show a strong reflection dipping to the NE, which corresponds to the fault plane. Those profiles provided complementary information on the fault such as its location at shallow depth, its dip angle (from 23 • to 35 •) and define its lateral extension. Central Asia is known for its high level of seismic hazards, especially Mongolia, which has been one of the most seismically active intracontinental regions in the world with four large earthquakes (magnitude around 8) along its active faults in the western part of the country during the last century (Khilko et al. 1985). The deformation in Mongolia is located between compressive structures related to the collision and penetration of the Indian plate into the Eurasian plate and extensive structures in the north of the country related with the Baykal rift (Tapponnier & Molnar 1979; Baljinnyam et al. 1993; Schlupp 1996; Bayasgalan & Jackson 1999). The seismic activity observed in the vicinity of Ulaanbaatar (UB), capital of Mongolia, is relatively low compared to the activity observed in western Mongolia. Nevertheless, since 2005, the seismic activity around UB not only has increased, but is also organized (see Fig. 1) at the west of UB along two perpendicular directions, which determine two active faults: Emeelt fault, discovered in 2008 (NNW-SSE direction, 25-km-long minimum and situated about 10 km W of UB) and Hustai fault (WSW–ENE direction, 80 km long, with its NE tip at less than 20 km west of UB); their length and morphology indicate that they can produce earthquakes of magnitude 6.5–7.5 (Schlupp et al. 2012). Most of the Mongolian population (1.2 million over 3 million) is concentrated at UB, which is the main political and economical centre of the country. Hence, the study of seismic hazard and the estimation of the probability of future destructive earthquakes are of primary importance for the country (Dugarmaa et al. 2006). Since the last large earthquake, the faults geomorphology has been highly smoothed by erosional processes and the exact location of the fault plane surface rupture is thus hidden within a several metre wide strip. The GPR method has been proven to give good and useful results to characterize faults by identifying offsets of radar reflections (Malik et al. 2007; Christie et al. 2009; Yalçiner et al. 2013) and

In a recent paper, Nagpal et al. voiced concerns about the limited or biased use of scientific evidence to support public health interventions to control neglected tropical diseases (NTDs). Visceral leishmaniasis (VL), also known as kala-azar, is one of the major NTDs and does not escape this problem. Transmission is vector-borne and the Indian subcontinent is the region reporting most of the VL cases worldwide. In this region, the main causative species is Leishmania donovani and Phlebotomus argentipes is the vector. Transmission is considered anthroponotic and peridomestic—occurring at night when female sand flies bite people sleeping inside their house. The World Health Organization and the governments of India, Nepal, and Bangladesh set out in 2005 to eliminate VL from the region by 2015 through a combination of early treatment of cases and vector control. However, while recent advances in diagnostic tools and drugs have significantly improved case management strategies, the available vector control tools against P. argentipes remain limited. The elimination initiative promotes the use of indoor residual spraying (IRS) of households and cattle sheds to reduce vector density, but the evidence underpinning the effectiveness of IRS in this region is scanty. Historical observations show that L. donovani transmission declined concomitantly with dichlorodiphenyltrichloroethane (DDT) spraying during the 1950s–60s to eradicate malaria. In the aftermath of this malaria eradication campaign, very few VL cases were observed in endemic regions until the mid-seventies, when there was resurgence of a VL epidemic in India. To date, there are no randomized trials showing the effect of IRS on the incidence of clinical VL, though some studies showed a reduction in vector density. When the VL elimination initiative was launched in 2005, there were no clear alternatives for IRS as a vector control strategy. Insecticide treated nets (ITNs) were proposed as an alternative or complement to IRS on the basis of analogy arguments regarding their given efficacy against malaria or on data from observational studies suggesting ITNs reduce the risk of VL; but as for IRS, there were no randomized trials evaluating the effect of ITNs on L. donovani transmission. In this context, a number of field studies were conducted in the Indian subcontinent in the past decade to evaluate the effectiveness and impact of ITNs and other vector control tools on VL. Most of these studies have been reviewed in detail in two recent papers. The only two studies evaluating the impact of vector control interventions on clinical outcomes found conflicting results. First, the KALANET project, a cluster randomised controlled trial (CRT) in India and Nepal, showed that mass-distribution of ITNs did not reduce the risk of L. donovani infection or clinical VL. Then, an intervention trial in Bangladesh suggested that widespread bed net impregnation with slow-release insecticide may reduce the frequency of VL. Technical (e.g., type of nets and insecticides, lack of replicas and randomisation in Bangladesh) and biological factors (e.g., insecticide susceptibility and sand fly behaviour) may explain the different results observed. This apparent contradiction raises the question about the role that ITN may play in controlling VL in the Indian subcontinent but has also triggered a lot of discussion on methodology and evidence levels required when evaluating vector control tools for VL. In this paper, we would like to summarise the lessons learned from the KALANET CRT in terms of methodology to inform the generation of future evidence and discuss interpretation of findings against this background.

Protozoan parasites of the genus Leishmania adapt to environmental change through chromosome and gene copy number variations. Only little is known about external or intrinsic factors that govern Leishmania genomic adaptation. Here, by conducting longitudinal genome analyses of 10 new Leishmania clinical isolates, we uncovered important differences in gene copy number among genetically highly related strains and revealed gain and loss of gene copies as potential drivers of long-term environmental adaptation in the field. In contrast, chromosome rather than gene amplification was associated with short-term environmental adaptation to in vitro culture. Karyotypic solutions were highly reproducible but unique for a given strain, suggesting that chromosome amplification is under positive selection and dependent on species- and strain-specific intrinsic factors. We revealed a progressive increase in read depth towards the chromosome ends for various Leishmania isolates, which may represent a nonclassical mechanism of telomere maintenance that can preserve integrity of chromosome ends during selection for fast in vitro growth. Together our data draw a complex picture of Leishmania genomic adaptation in the field and in culture, which is driven by a combination of intrinsic genetic factors that generate strain-specific phenotypic variations, which are under environmental selection and allow for fitness gain.IMPORTANCE Protozoan parasites of the genus Leishmania cause severe human and veterinary diseases worldwide, termed leishmaniases. A hallmark of Leishmania biology is its capacity to adapt to a variety of unpredictable fluctuations inside its human host, notably pharmacological interventions, thus, causing drug resistance. Here we investigated mechanisms of environmental adaptation using a comparative genomics approach by sequencing 10 new clinical isolates of the L. donovani, L. major, and L. tropica complexes that were sampled across eight distinct geographical regions. Our data provide new evidence that parasites adapt to environmental change in the field and in culture through a combination of chromosome and gene amplification that likely causes phenotypic variation and drives parasite fitness gains in response to environmental constraints. This novel form of gene expression regulation through genomic change compensates for the absence of classical transcriptional control in these early-branching eukaryotes and opens new venues for biomarker discovery. ; This study was supported by a seeding grant from the Institut Pasteur International Department to the LeiSHield Consortium, the EU FP7 (Kaladrug-R, contract 222895), the Belgian Science Policy Office (TRIT, P7/41), the Department of Economy, Science and Innovation in Flanders (ITM-SOFIB), and the Flemish Fund for Scientific Research (G.0.B81.12 to J.C.D. and F.D.). ; Sí

Global priorities for research in neglected infectious diseases (NIDs) can be assessed in different ways, but it is important to realize that regional priorities may significantly differ one from another. The region of Latin America and the Caribbean (LAC) is—along with Africa and Asia—more affected by NIDs than other regions of the world. Some of the Latin American NIDs are common to other continents, while others are very specific or disproportionately affect the Latin American region [1– 3] (Table 1). Because of its huge ecological diversity, ongoing environmental changes, and massive migrations, LAC is also a catalyst for the (re-)emergence and spreading of NIDs, both inside and outside the subcontinent. Following a colloquium on NIDs in LAC held in Lima, Peru, between 12 and 14 November 2009, a thematic workshop was organized with the support of the European Commission (EC). It involved 29 scientists (16 from the Americas, two from the Democratic Republic of Congo and India, respectively, and nine from Europe) working on different NIDs and representing several research areas from basic to applied. This report summarizes the consensus comments of the expert group after oral and written consultation. It is envisaged that this document should stimulate a debate within the scientific community and serve as a recommendation for future actions by international or regional funding agencies in the area of NIDs in LAC. (Párrafo extraído del texto a modo de resumen) ; Facultad de Ciencias Médicas