Suchergebnisse

Abstract. Storm surge is one of the most destructive marine disasters to life and property for Chinese coastal regions, especially for Guangdong Province. In Huizhou city, Guangdong Province, due to the high concentrations of chemical and petroleum industries and the high population density, the low-lying coastal area is susceptible to the storm surge. Therefore, a comprehensive risk assessment of storm surge over the coastal area of Huizhou can delimit zones that could be affected to reduce disaster losses. In this paper, typhoon intensity for the minimum central pressure of 880, 910, 920, 930, and 940 hPa (corresponding to a 1000-, 100-, 50-, 20-, and 10-year return period) scenarios was designed to cover possible situations. The Jelesnianski method and the Advanced Circulation (ADCIRC) model coupled with the Simulating Waves Nearshore (SWAN) model were utilized to simulate inundation extents and depths of storm surge over the computational domain under these representative scenarios. Subsequently, the output data from the coupled simulation model (ADCIRC–SWAN) were imported to the geographic information system (GIS) software to conduct the hazard assessment for each of the designed scenarios. Then, the vulnerability assessment was made based on the dataset of land cover types in the coastal region. Consequently, the potential storm surge risk maps for the designed scenarios were produced by combining hazard assessment and vulnerability assessment with the risk matrix approach. The risk maps indicate that due to the protection given by storm surge barriers, only a small proportion of the petrochemical industrial zone and the densely populated communities in the coastal areas were at risk of storm surge for the scenarios of 10- and 20-year return period typhoon intensity. Moreover, some parts of the exposed zone and densely populated communities were subject to high and very high risk when typhoon intensities were set to a 50- or a 100-year return period. Besides, the scenario with the most intense typhoon (1000-year return period) induced a very high risk to the coastal area of Huizhou. Accordingly, the risk maps can help decision-makers to develop risk response plans and evacuation strategies in coastal communities with a high population density to minimize civilian casualties. The risk analysis can also be utilized to identify the risk zones with the high concentration of chemical and petroleum industries to reduce economic losses and prevent environmental damage caused by the chemical pollutants and oil spills from petroleum facilities and infrastructures that could be affected by storm surge.

BACKGROUND: In drug-resistant epilepsy, surgical resection of the epileptic focus can end seizures. However, success is dependent on the ability to identify foci locations and, unfortunately, current methods like electrophysiology and positron emission tomography can give contradictory results. During seizures, glucose is metabolized at epileptic foci through aerobic glycolysis, which can be imaged through the oxygen-glucose index (OGI) biomarker. However, inter-ictal (between seizures) OGI changes have not been studied, which has limited its application. METHODS: 18 healthy controls and 24 inter-ictal, temporal lobe epilepsy patients underwent simultaneous positron emission tomography (PET) and magnetic resonance imaging (MRI) scans. We used [(18)F]fluorodeoxyglucose-PET (FDG-PET) to detect cerebral glucose metabolism, and calibrated functional MRI to acquire relative oxygen consumption. With these data, we calculated relative OGI maps. FINDINGS: While bilaterally symmetrical in healthy controls, we observed, in patients during the inter-ictal period, higher OGI ipsilateral to the epileptic focus than contralateral. While traditional FDG-PET results and temporal lobe OGI results usually both agreed with invasive electrophysiology, in cases where FDG-PET disagreed with electrophysiology, temporal lobe OGI agreed with electrophysiology, and vice-versa. INTERPRETATION: As either our novel epilepsy biomarker or traditional approaches located foci in every case, our work provides promising insights into metabolic changes in epilepsy. Our method allows single-session OGI measurement which can be useful in other diseases. FUNDING: This work was supported by ShanghaiTech University, the Shanghai Municipal Government, the National Natural Science Foundation of China Grant (No. 81950410637) and Shanghai Municipal Key Clinical Specialty (No. shslczdzk03403). F. H. and P. H. were supported by USA National Institute of Health grants (R01 NS-100106, R01 MH-067528).Z. W. was supported by the Key-Area Research and Development ...