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THAT EACH INDIVIDUAL IS BIOLOGICALLY UNIQUE HAS BECOME INCREASINGLY RECOGNIZED WITHIN THE DEVELOPING FIELD OF BEHAVIOR GENETICS AS A SCIENTIFIC FACT OF THE FIRST MAGNITUDE. THE ESTABLISHMENT OF HUMAN GENETIC VARIABILITY IMPLIES 2 MAJOR PARADIGMATIC SHIFTS FOR THE SOCIAL SCIENCES: (1) THE RECOGNITION OF THE INTERACTION OF BOTH BIOLOGICAL & ENVIRONMENTAL FACTORS IN DETERMINING HB, & (2) THE ACKNOWLEDGEMENT OF THE SIGNIFICANCE OF BOTH GENETIC & ENVIRONMENTAL DIVERSITY IN SOCIAL & POLITICAL LIFE. VARIOUS APPROACHES IN SOCIAL SCIENCE, INCLUDING BEHAVIORISM & ENVIRONMENTALISM ARE EXAMINED, AS WELL AS THE WORKS OF E. BANFIELD (SEE SA 20:4/72F6394) & P. BACHRACH & M. BARATZ (POWER AND POVERTY, NEW YORK, NY: OXFORD U PRESS, 1970). FOR THE POLICY-MAKER IN PARTICULAR, THE IMPORTANCE OF INDIVIDUAL DIFFERENCES DEMANDS FULL RECOGNITION. 3 FIGURES, 1 TABLE. AA.

A dichotomy of biological vs soc factors in human aggressiveness is rejected, since both interact. Recent res on hormonal influences upon brain org in animals early in life as affecting later aggressive & sexual behavior is summarized. Res on the role of testosterone in the development of aggressive behavior has now been extended to primates. F monkeys exposed to testosterone during uterine development have been shown to exhibit aggressive & masculinized behavior in later life. Clinical observations suggest that certain reproductive as well as non-reproductive hormones may affect the probability of aggressive behavior in humans. But little is yet known of the endocrine concomitants of anger, threat & attack in man, although there are intriguing clues involving steroid hormones & biogenic amines. Work done on rodents in recent yrs has been concerned with the relations between pop density, endocrine function & behavior. Results have suggested that as pop density reaches a high level, adrenal function tends to increase considerably, while gonadal function tends to diminish & aggressive behavior tends to increase. Res leads beyond strictly hormonal studies to hormone-related biochemistry of informationprocessing in the nervous system, & into the broader field of human biochemical genetics. Of particular interest is res begun a few yrs ago- into the 'Lesch-Nyhan syndrome.' This is a disorder of purine metabolism in which overproduction of aric acid is accompanied by severe behavior disturbance including unusual aggressive manifestations. The disease is transmitted as an X-linked recessive trait, & a specific enzyme deficiency has been delineated. The presence of abnormal enzyme can now be identified by tests. A range of res possibilities exists re the effects of various brain-stimulating purines on parame - ters of aggressive behavior. It is concluded that the biological set's must ultimately work in conjunction with the soc set's toward a better understanding of endocrine, biochemical, genetic evolutionary & neuropbysiological factors involved in human behavior. M. Maxfield.

I. Introduction -- II. Basic Biomedicine -- Speed of application -- Reproductive physiology -- Regulatory mechanisms -- The lungs -- The hormones, insulin and diabetes -- Hormones and ulcers -- Neurophysiology and mental diseases -- Cardiovascular diseases -- Comparative physiology -- Macromolecules and DNA -- The proteins -- Enzymes -- Biosynthesis -- Metabolic events -- Energy -- The molecular basis of disease -- Rational design of drugs -- Application of basic knowledge -- Selected additional reading -- III. Clinical Medicine -- Infectious diseases -- Parasitic diseases -- Community health and epidemiology -- Military research contributions -- Drugs -- Immunology -- Transplantation -- Anesthesiology -- Surgery -- Cardiovascular surgery -- Cardiovascular disease -- Renal disease -- Pulmonary disease -- Hematology -- Endocrinology -- Medical genetics -- Pediatrics -- Obstetrics and gynecology -- Geriatrics -- Nutrition -- Neurology -- Psychiatry -- Ophthalmology -- Otorhinolaryngology -- Radiology -- Nuclear medicine -- Bioengineering -- Automation -- Rehabilitation -- Conclusion -- Selected additional reading -- IV. Dental Science -- Dental decay -- Periodontal disease -- Other clinical considerations -- Delivery of dental services -- Dental materials -- Orthodontics -- Surgical orthodontics -- Maxillofacial prosthesis -- Selected additional reading -- V. Food -- Food from plants -- Harvest to table -- Food from animals -- Animal disease control -- Preserving and distributing food from animals -- Processing and preserving foods -- Conclusion -- Selected additional reading -- VI. Population Biology -- Population potential and carrying capacity -- Populations in ecosystems -- Controlling pest populations -- Selected additional reading -- VII. Environmental Hazards -- Biological hazards to man -- Chemical hazards to man -- Physical hazards to man -- Selected additional reading -- VIII. Marine Sciences -- Feeding man -- Resource assessment -- Behavior studies -- Value of prediction of fishing success -- Preservation of fishery products -- Fish protein concentrate -- Management of renewable resources -- Diseases and parasites -- Man and his environment -- Health and medical research -- Selected additional reading -- IX. Natural Resources -- Man and his resources -- Land: the greatest resource -- Forest and timber resources -- Game management -- Technology in resource management -- Microbes—the unseen resource -- Conversion of waste to resource -- Preserving for the future -- Conservation of man's abundance -- Selected additional reading.