Suchergebnisse

Digital Life Norway (DLN) Initiative to foster and boost transdisciplinary biotechnology research and innovation
Meeting the rapid developments in biotechnology by fostering transdisciplinarity, including digitalisation and big data, to create convergence for innovation in a virtual centre. The Centre for Digital Life Norway (DLN) is a strategic national initiative originally conceived in 2014 by the BIOTEK2021 programme of the Research Council of Norway (RCN). It is an ambitious and large-scale initiative to foster and boost transdisciplinary biotechnology research and innovation activities, combined with a novel framework of responsible research and innovation, to solve challenges of societal importance and create value. DLN departs from the traditional organisation of research and development among Norwegian research institutions. The centre aims to untangle and resolve some of the fundamental societal challenges facing new and emerging biotechnology by emphasising technological convergence and transdisciplinarity.

The outbreak of coronavirus disease (COVID-19) has forced major countries to apply strict policy toward society. People must wear a facemask and always keep their distance from each other's to avoid virus contamination. Government employ officers to monitor citizen and warn them if not wearing a face mask. The warning message also spread through SMS and social media to ensure people about safety and awareness. This paper aims to provide face mask detection using the Deep Learning Network(DLN) and warning system through video stream input from CCTV or images then analyzed. If people not wearing a mask are detected, they will alert them through the speaker and remind them about a penalty. AR distancing very useful to give position toward violator location based on the detected person in a certain area. The system is designed to work intelligently and automatically without human intervention. With the accuracy of 99% recognition, it's expected that the system can help the government to increase people awareness toward the safety of themselves and people around them.

Minimum Wage (MW) is a policy set by the government as a basis reference at labor market for every company to pay their workers wages. Since workers always have a low bargaining position when dealing with employers in the determination of their wage rates, therefore the MW could becomes the safety net for workers to have "decent living" when he began to enter the world of work. In the case of Indonesia, the formulation of WM is referring to the parameters of Decent Living Needs (DLN) according to the Ministry of Manpower Decree No. 13, the year 2012. There are at least seven components in order to formulate MW within the DLN Framework, namely: (1) food and beverages, (2) clothing/apparel (3) housing, (4) education, (5) health, (6) transportation and (7) recreation and savings. Meanwhile, in Islam, every transaction made must be ensured preserve and achieve maqashid al sharia (sharia objectives): (1) religion/faith, (2) life, (3) intellect, (4) posterity, and (5) property. Using content analysis, the paper indicates that the regulation above is relevant to the conditions and objectives of sharia-based wage system (maqashid sharia). The Decent Living Needs (DLN)-based minimum wage setting which operated in the 60 components meet the basic needs components of the workers for their daily life which includes the needs of education, health, recreation, and saving. Hence, another challenge in relation to the DLN is how to ensure that the purchasing power of labor for their shelter within the existing MW formulation. What kind of shelter that considered as al dharuriyah within the existing MW setting. Therefore, there is a call for synergy between the government and the housing industry that can offer shelter in accordance with the purchasing power of labor with the existing level of MW and feasible within the framework of DLN so that might be considered as social policy elements. =========================================== Formulasi Upah Minimum dalam Perspektif Maqashid Syariah di ...

Sufism is often regarded as standing mystically aloof from its wider cultural settings. By turning this perspective on its head, Indian Sufism since the Seventeenth Century reveals the politics and poetry of Indian Sufism through the study of Islamic sainthood in the midst of a cosmopolitan Indian society comprising migrants, soldiers, litterateurs and princes. Placing the mystical traditions of Indian Islam within their cultural contexts, this interesting study focuses on the shrines of four Sufi saints in the neglected Deccan region and their changing roles under the rule of the Mughals, the Nizams of Haydarabad and, after 1948, the Indian nation. In particular Green studies the city of Awrangabad, examining the vibrant intellectual and cultural history of this city as part of the independent state of Haydarabad. He employs a combination of historical texts and anthropological fieldwork, which provide a fresh perspective on developments of devotional Islam in South Asia over the past three centuries, giving a fuller understanding of Sufism and Muslim saints in South Asia.

The importance of physical place for interdisciplinary research collaborations is often taken for granted by scientists and policy makers. One result of this is a trend of funding interdisciplinary research centers where scientists are colocated in the same building. Previous research findings on the matter are, however, ambiguous and show that though geographical proximity clearly matters, proximity is insufficient to foster interdisciplinary collaboration. This paper is based on an ethnographic study of a multi-sited Norwegian biotechnology research center—the Centre for Digital Life Norway (DLN), funded in 2015 to stimulate a transition in biotechnology research toward inter- and transdisciplinarity and digitalization. The multi-sited character makes DLN different from the much-studied trend of colocation of research groups in research centers. The paper asks: how are scientists socialized into an interdisciplinary mentality in a multi-sited research center? The analysis focus on three aspects: place, socialization, and the role of affective features and experiences. The paper's main contribution is to demonstrate the role of placemaking in motivating for inter- and transdisciplinary collaboration, in particular by allowing for development of affective relations among the participating scientists.

Sphingosine 1-phosphate (S1P) and S1P receptors (S1PRs) regulate migration of lymphocytes out of thymus to blood and lymph nodes (LNs) to efferent lymph, whereas their role in other tissue sites is not known. Here, we investigated the question of how these molecules regulate leukocyte migration from tissues through afferent lymphatics to draining LNs (dLNs). S1P, but not other chemokines, selectively enhanced human and murine CD4 T cell migration across lymphatic endothelial cells (LECs). T cell S1PR1 and S1PR4, and LEC S1PR2, were required for migration across LECs and into lymphatic vessels and dLNs. S1PR1 and S1PR4 differentially regulated T cell motility and vascular cell adhesion molecule-1 (VCAM-1) binding. S1PR2 regulated LEC layer structure, permeability, and expression of the junction molecules VE-cadherin, occludin, and zonulin-1 through the ERK pathway. S1PR2 facilitated T cell transcellular migration through VCAM-1 expression and recruitment of T cells to LEC migration sites. These results demonstrated distinct roles for S1PRs in comodulating T cell and LEC functions in migration and suggest previously unknown levels of regulation of leukocytes and endothelial cells during homeostasis and immunity. Copyright 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. ; https://dx.doi.org/10.1126/sciimmunol.aav1263

DIN-TAB-409_E-Book.pdf -- Für das Fachgebiet Bauwesen bestehen folgende DlN-Taschenbücher: -- Copyright / Impresseum -- Vorwort -- Inhalt -- Hinweise zur Nutzung von DIN-Taschenbüchern und Normen-Handbüchern -- DIN-Nummernverzeichnis -- Verzeichnis abgedruckter Normen (nach steigenden DIN-Nummern geordnet) -- Service-Angebote des Beuth Verlags -- Stichwortverzeichnis -- Anzeigen -- Institut für Schädlingsanalyse Dr. Martin Strohmeyer -- DIN EN 15757:2010-12 -- DIN EN 15757:2010-12 -- Nationales Vorwort -- Inhalt -- Vorwort -- Einleitung -- 1 Anwendungsbereich -- 2 Normative Verweisungen -- 3 Begriffe -- 4 Allgemeine Empfehlungen für organische hygroskopische Materialien -- 5 Festlegung der Lufttemperatur und der relativen Luftfeuchte für organische hygroskopische Materialien -- 5.1 Bestimmung der Prioritäten -- 5.2 Aufrechterhaltung stabiler Umgebungsbedingungen -- 5.3 Priorität des historischen Klimas -- 5.4 Weitere Festlegungen -- Anhang A (informativ)Bestimmung der Zielbereiche der relativen Luftfeuchte -- A.1 Begründung -- A.2 Überwachung der Umgebung - Datensatz -- A.3 Berechnung der Zielgrößen -- A.3.1 Mittelwert -- A.3.2 Jahreszeitlicher Zyklus -- A.3.3 Kurzzeit-Schwankungen -- A.4 Bestimmung des Zielbereiches -- A.5 Beispiel -- Literaturhinweise -- DIN EN 15758:2010-12 -- DIN EN 15758:2010-12 -- Nationales Vorwort -- Inhalt -- Vorwort -- Einleitung -- 1 Anwendungsbereich -- 2 Normative Verweisungen -- 3 Begriffe -- 4 Empfehlungen im Zusammenhang mit den Messverfahren -- 4.1 Messung der Lufttemperatur -- 4.2 Messung der wirksamen Temperatur einschließlich der Strahlungsabgabe -- 4.2.1 Schwarzkugelthermometer -- 4.2.2 Temperaturmessung mit einem streifenförmigen Schwarzkörperziel -- 5 Messung der Oberflächentemperatur -- 5.1 Allgemeines -- 5.2 Thermometer mit Kontaktsensoren -- 5.3 Infrarotthermometer (Ferntemperatursensoren).

Multipotent mesenchymal stromal cells (MSCs) have emerged as a promising therapy for autoimmune diseases, including multiple sclerosis (MS). Administration of MSCs to MS patients has proven safe with signs of immunomodulation but their therapeutic efficacy remains low. The aim of the current study has been to further characterize the immunomodulatory mechanisms of adipose tissue-derived MSCs (ASCs) in vitro and in vivo using the EAE model of chronic brain inflammation in mice. We found that murine ASCs (mASCs) suppress T cell proliferation in vitro via inducible nitric oxide synthase (iNOS) and cyclooxygenase- (COX-) 1/2 activities. mASCs also prevented the lipopolysaccharide- (LPS-) induced maturation of dendritic cells (DCs) in vitro. The addition of the COX-1/2 inhibitor indomethacin, but not the iNOS inhibitor L-NAME, reversed the block in DC maturation implicating prostaglandin (PG) E2 in this process. In vivo, early administration of murine and human ASCs (hASCs) ameliorated myelin oligodendrocyte protein- (MOG35-55-) induced EAE in C57Bl/6 mice. Mechanistic studies showed that mASCs suppressed the function of autoantigen-specific T cells and also decreased the frequency of activated (CD11c+CD40 and CD11c+TNF-α+) DCs in draining lymph nodes (DLNs). In summary, these data suggest that mASCs reduce EAE severity, in part, through the impairment of DC and T cell function. ; This work has been financed by the Instituto de Salud Carlos III, Spain (http://www.isciii.es) and Fondo Europeo de Desarrollo Regional (FEDER, http://ec.europa.eu/regional_policy/es/funding/erdf/) from the European Union, through the Research Grants PI15/00794, CP09/00228, and CPII15/00032 (Per Anderson); PI12/01097, PI15/02015, and ISCIII Red de Terapia Celular (RD12/0019/0006, http://www.red-tercel.com/) (Francisco Martin); and PS09-00928 (Mario Delgado). Mario Delgado was supported by a grant (PSE-010000-2009-3) from the Ministerio de Ciencia e Innovación, Spain (http://www.idi.mineco.gob.es/), and P09-CTS-4723 from the Junta de Andalucia (Proyecto de Excelencia). Francisco Martin is funded by the Fundación Progreso y Salud (Consejería de Salud, Junta de Andalucía, http://www.juntadeandalucia.es/fundacionprogresoysalud/). ; Peer reviewed

Multipotent mesenchymal stromal cells (MSCs) have emerged as a promising therapy for autoimmune diseases, including multiple sclerosis (MS). Administration of MSCs to MS patients has proven safe with signs of immunomodulation but their therapeutic efficacy remains low. The aim of the current study has been to further characterize the immunomodulatory mechanisms of adipose tissue-derived MSCs (ASCs) in vitro and in vivo using the EAE model of chronic brain inflammation in mice. We found that murine ASCs (mASCs) suppress T cell proliferation in vitro via inducible nitric oxide synthase (iNOS) and cyclooxygenase- (COX-) 1/2 activities. mASCs also prevented the lipopolysaccharide- (LPS-) induced maturation of dendritic cells (DCs) in vitro. The addition of the COX-1/2 inhibitor indomethacin, but not the iNOS inhibitor L-NAME, reversed the block in DC maturation implicating prostaglandin (PG) E2 in this process. In vivo, early administration of murine and human ASCs (hASCs) ameliorated myelin oligodendrocyte protein- (MOG35-55-) induced EAE in C57Bl/6 mice. Mechanistic studies showed that mASCs suppressed the function of autoantigen-specific T cells and also decreased the frequency of activated (CD11c+CD40high and CD11c+TNF-α+) DCs in draining lymph nodes (DLNs). In summary, these data suggest that mASCs reduce EAE severity, in part, through the impairment of DC and T cell function. ; This work has been financed by the Instituto de Salud Carlos III, Spain (http://www.isciii.es) and Fondo Europeo de Desarrollo Regional (FEDER, http://ec.europa.eu/regional_policy/es/funding/erdf/) from the European Union, through the Research Grants PI15/00794, CP09/00228, and CPII15/00032 (Per Anderson); PI12/01097, PI15/02015, and ISCIII Red de Terapia Celular (RD12/0019/0006, http://www.red-tercel.com/) (Francisco Martin); and PS09-00928 (Mario Delgado). Mario Delgado was supported by a grant (PSE-010000-2009-3) from the Ministerio de Ciencia e Innovación, Spain (http://www.idi.mineco.gob.es/), and P09-CTS-4723 from the Junta de Andalucia (Proyecto de Excelencia). Francisco Martin is funded by the Fundación Progreso y Salud (Consejería de Salud, Junta de Andalucía, http://www.juntadeandalucia.es/fundacionprogresoysalud/). ; Peer reviewed

Multipotent mesenchymal stromal cells (MSCs) have emerged as a promising therapy for autoimmune diseases, including multiple sclerosis (MS). Administration of MSCs to MS patients has proven safe with signs of immunomodulation but their therapeutic efficacy remains low. The aim of the current study has been to further characterize the immunomodulatory mechanisms of adipose tissue-derived MSCs (ASCs) in vitro and in vivo using the EAE model of chronic brain inflammation in mice. We found that murine ASCs (mASCs) suppress T cell proliferation in vitro via inducible nitric oxide synthase (iNOS) and cyclooxygenase- (COX-) 1/2 activities. mASCs also prevented the lipopolysaccharide- (LPS-) induced maturation of dendritic cells (DCs) in vitro. The addition of the COX-1/2 inhibitor indomethacin, but not the iNOS inhibitor L-NAME, reversed the block in DC maturation implicating prostaglandin (PG) E2 in this process. In vivo, early administration of murine and human ASCs (hASCs) ameliorated myelin oligodendrocyte protein- (MOG35-55-) induced EAE in C57Bl/6 mice. Mechanistic studies showed that mASCs suppressed the function of autoantigen-specific T cells and also decreased the frequency of activated (CD11c+ and CD11c+TNF-α+) DCs in draining lymph nodes (DLNs). In summary, these data suggest that mASCs reduce EAE severity, in part, through the impairment of DC and T cell function. ; This work has been financed by the Instituto de Salud Carlos III, Spain (http://www.isciii.es) and Fondo Europeo de Desarrollo Regional (FEDER, http://ec.europa.eu/regional_policy/es/funding/erdf/) from the European Union, through the Research Grants PI15/00794, CP09/00228, and CPII15/00032 (Per Anderson); PI12/01097, PI15/02015, and ISCIII Red de Terapia Celular (RD12/0019/0006, http://www.red-tercel.com/) (Francisco Martin); and PS09-00928 (Mario Delgado). Mario Delgado was supported by a grant (PSE-010000-2009-3) from the Ministerio de Ciencia e Innovación, Spain (http://www.idi.mineco.gob.es/), and P09-CTS-4723 from the Junta de Andalucia (Proyecto de Excelencia). Francisco Martin is funded by the Fundación Progreso y Salud (Consejería de Salud, Junta de Andalucía, http://www.juntadeandalucia.es/fundacionprogresoysalud/).