miR-124, a potential therapeutic target in colorectal cancer

In: info:eu-repo/semantics/altIdentifier/doi/10.2147/OTT.S179501

Abstract

Zhen Qin,1,2 Xia Liu1,2 1Department of Clinical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China; 2Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China Abstract: Recently, miR-124 has been regarded as a critical modulator of colorectal cancer. We here summarize the studies on the role and mechanism of miR-124 in colorectal cancer. They indicate that miR-124 is methylated during carcinogenesis and functions as a tumor-suppressor in colorectal cancer. miR-124 might serve as a potential diagnostic biomarker and therapeutic target in colorectal cancer in the foreseeable future. Keywords: miR-124, colorectal cancer, biomarker, methylation, therapeutic target