Open Access BASE2014

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium

Koivula, Robert; Heggie, Alison; Barnett, Anna; Cederberg, Henna; Hansen, Tue H; Koopman, Anitra D; Ridderstråle, Martin; Rutters, Femke; Vestergaard, Henrik; Gupta, Ramneek; Herrgård, Sanna; Heymans, Martijn W; Perry, Mandy H; Rauh, Simone; Siloaho, Maritta; Teare, Harriet J A; Thorand, Barbara; Bell, Jimmy; Brunak, Søren; Frost, Gary; Jablonka, Bernd; Mari, Andrea; McDonald, Tim J; Dekker, Jacqueline M; Hansen, Torben; Hattersley, Andrew; Laakso, Markku; Pedersen, Oluf; Koivisto, Veikko; Ruetten, Hartmut; Walker, Mark; Pearson, Ewan; Franks, Paul

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Abstract

The DIRECT (Diabetes Research on Patient Stratification) Study is part of a European Union Framework 7 Innovative Medicines Initiative project, a joint undertaking between four industry and 21 academic partners throughout Europe. The Consortium aims to discover and validate biomarkers that: (1) predict the rate of glycaemic deterioration before and after type 2 diabetes onset; (2) predict the response to diabetes therapies; and (3) help stratify type 2 diabetes into clearly definable disease subclasses that can be treated more effectively than without stratification. This paper describes two new prospective cohort studies conducted as part of DIRECT.

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