Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1

Abstract

We thank all participating subjects with AS and healthy individuals who provided the DNA and clinical information necessary for this study. This work was in part funded by grants from Arthritis Research UK (19536 and 18797), the NIHR Oxford comprehensive Biomedical Research Centre (immunity and inflammation theme A93081) and NIHR Thames Valley collaborative research network and National Ankylosing Spondylitis Society (UK). SPARCC was established through the support of the Arthritis Society of Canada. Support was received from National Institutes of Health/National Institute of Allergy and Infectious Diseases grant 1U01AI09090-01. This work was supported in part by grant PI12/02587 (Inst. Carlos III, Spain) and by European Union 'Fondos FEDER'. Support was received from Agence Nationale de la Recherche (grant ANR 2010 GEMISA and Investissements d'Avenir programme ANR-11-IDEX-0005-02), the Socie´te´ Franc¸aise de Rhumatologie (SFR) and the Arthritis Foundation. M.W. is funded by the Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health. M.A.B. is funded by a National Health and Medical Research Council (Australia) Senior Principal Research Fellowship. D.M.E. is funded by an Australian Research Council Future Fellowship (FT130101709). P.I.W.d.B. is funded in part by the Netherlands Organization for Scientific Research (VIDI Vernieuwingsimpuls project 016.126.354) and by the National Institutes of Health (1R01AR062886-1) ; Cortes, A., Pulit, S.L., Leo, P.J., Pointon, J.J., Robinson, P.C., Weisman, M.H., Ward, M., Gensler, L.S., Zhou, X., Garchon, H.-J., Chiocchia, G., Nossent, J., Lie, B.A., Førre, Ø., Tuomilehto, J., Laiho, K., Bradbury, L.A., Elewaut, D., Burgos-Vargas, R., Stebbings, S., Appleton, L., Farrah, C., Lau, J., Haroon, N., Mulero, J., Blanco, F.J., Gonzalez-Gay, M.A., Lopez-Larrea, C., Bowness, P., Gaffney, K., Gaston, H., Gladman, D.D., Rahman, P., Maksymowych, W.P., Crusius, J.B.A., Van Der Horst-Bruinsma, I.E., Valle-Oñate, ...