New Oleic Acid-Capped Mesoporous Silica Particles as Surfactant-Responsive Delivery Systems

Abstract

[EN] A new delivery microdevice, based on hydrophobic oleic acid¿capped mesoporous silica particles and able to payload release in the presence of surfactants, has been developed. The oleic acid functionalization confers to the system a high hydrophobic character, which avoids cargo release unless surfactant molecules are present. The performance of this oleic¿acid capped microdevice in the presence of different surfactants is presented and its zero¿release operation in the absence of surfactants is demonstrated. ; The authors want to thank the Spanish Government (projects MAT2015-64139-C4-1-R, AGL2015-70235-C2-1-R and AGL2015-70235-C2-2-R (MINECO/FEDER)) and RTI2018-100910-B-C41, RTI2018-101599-B-C22 and RTI2018-101599-B-C21 (MCUI/AEI/FEDER, UE)) and Generalitat Valenciana (project PROMETEO/2018/024) for support. E.P.-R. thanks the Generalitat Valenciana for her predoctoral fellowship. A.B. wants to acknowledge the Spanish Government for the financial support Juan de la Cierva Incorporación IJCI-2014-21534. The authors also thank the Electron Microscopy Service at the UPV for support. ; Poyatos-Racionero, E.; Pérez-Esteve, É.; Marcos Martínez, MD.; Barat Baviera, JM.; Martínez-Máñez, R.; Aznar, E.; Bernardos Bau, A. (2019). New Oleic Acid-Capped Mesoporous Silica Particles as Surfactant-Responsive Delivery Systems. ChemistryOpen. 8(8):1052-1056. https://doi.org/10.1002/open.201900092 ; S ; 1052 ; 1056 ; 8 ; 8 ; HARRISON, K. (2007). Introduction to polymeric drug delivery systems. Biomedical Polymers, 33-56. doi:10.1533/9781845693640.33 ; Bourganis, V., Karamanidou, T., Kammona, O., & Kiparissides, C. (2017). Polyelectrolyte complexes as prospective carriers for the oral delivery of protein therapeutics. European Journal of Pharmaceutics and Biopharmaceutics, 111, 44-60. doi:10.1016/j.ejpb.2016.11.005 ; El-Safty, S. A., Shenashen, M. A., & Ismail, A. A. (2012). A multi-pH-dependent, single optical mesosensor/captor design for toxic metals. Chemical Communications, 48(77), 9652. doi:10.1039/c2cc34788a ...