QCloud2: an improved cloud-based quality-control system for mass-spectrometry-based proteomics laboratories

Abstract

QCloud is a cloud-based system to support proteomics laboratories in daily quality assessment using a user-friendly interface, easy setup, and automated data processing. Since its release, QCloud has facilitated automated quality control for proteomics experiments in many laboratories. QCloud provides a quick and effortless evaluation of instrument performance that helps to overcome many analytical challenges derived from clinical and translational research. Here we present an improved version of the system, QCloud2. This new version includes enhancements in the scalability and reproducibility of the quality-control pipelines, and it features an improved front end for data visualization, user management, and chart annotation. The QCloud2 system also includes programmatic access and a standalone local version. ; The CRG/UPF Proteomics Unit is part of the Spanish Infrastructure for Omics Technologies (ICTS OmicsTech), and it is a member of the ProteoRed PRB3 consortium, which is supported by grant PT17/0019 of the PE I+D+i 2013−2016 from the Instituto de Salud Carlos III (ISCIII), ERDF, and "Secretaria d'Universitats i Recerca del Departament d'Econòmia i Coneixement de la Generalitat de Catalunya" (2017SGR595). This project was supported by EPIC-XS, project number 823839, funded by the Horizon 2020 Programme of the European Union. We also acknowledge support of the Spanish Ministry of Science and Innovation to the EMBL partnership, the Centro de Excelencia Severo Ochoa and the CERCA Programme from Generalitat de Catalunya