Open Access BASE2019

Next-generation ARIA care pathways for rhinitis and asthma : a model for multimorbid chronic diseases

Bousquet, J. Jean; Schunemann, Holger J; Togias, Alkis; Erhola, Marina; Hellings, Peter W; Zuberbier, Torsten; Agache, Ioana; Ansotegui, Ignacio J; Anto, Josep M; Bachert, Claus; Becker, Sven; Bedolla-Barajas, Martin; Bewick, Michael; Bosnic-Anticevich, Sinthia; Bosse, Isabelle; Boulet, Louis P; Bourrez, Jean Marc; Brusselle, Guy; Chavannes, Niels; Costa, Elisio; Cruz, Alvaro A; Czarlewski, Wienczyslawa; Fokkens, Wytske J; Fonseca, Joao A; Gaga, Mina; Haahtela, Tari; Illario, Maddalena; Klimek, Ludger; Kuna, Piotr; Kvedariene, Violeta; Le, L. T. T; Larenas-Linnemann, Desiree; Laune, Daniel; Lourenco, Olga M; Menditto, Enrica; Mullo, Joaquin; Okamoto, Yashitaka; Papadopoulos, Nikos; Pham-Thi, Nhan; Picard, Robert; Pinnock, Hilary; Roche, Nicolas; Roller-Wirnsberger, Regina E; Rolland, Christine; Samolinski, Boleslaw; Sheikh, Aziz; Toppila-Salmi, Sanna; Tsiligianni, Ioanna; Valiulis, Arunas; Valovirta, Erkka; Vasankari, Tuula; Ventura, Maria-Teresa; Walker, Samantha; Williams, Sian; Akdis, Cezmi A; Annesi-Maesano, Isabella; Arnavielhe, Sylvie; Basagana, Xavier; Bateman, Eric; Bedbrook, Anna; Bennoor, K. S; Benveniste, Samuel; Bergmann, Karl C; Bia, Slawomir; Billo, Nils; Bindslev-Jensen, Carsten; Bjermer, Leif; Blain, Hubert; Bonini, Mateo; Bonniaud, Philippe; Bouchard, Jacques; Briedis, Vitalis; Brightling, Christofer E; Brozek, Jan; Buhl, Roland; Buonaiuto, Roland; Canonica, Giorgo W; Cardona, Victoria; Carriazo, Ana M; Carr, Warner; Cartier, Christine; Casale, Thomas; Cecchi, Lorenzo; Cepeda Sarabia, Alfonso M; Chkhartishvili, Eka; Chu, Derek K; Cingi, Cemal; Colgan, Elaine; de Sousa, Jaime Correia; Courbis, Anne Lise; Custovic, Adnan; Cvetkosvki, Biljana; D'Amato, Gennaro; da Silva, Jane; Dantas, Carina; Dokic, Dejand; Dauvilliers, Yves; Dedeu, Antoni; De Feo, Giulia; Devillier, Philippe; Di Capua, Stefania; Dykewickz, Marc; Dubakiene, Ruta; Ebisawa, Motohiro; El-Gamal, Yaya; Eller, Esben; Emuzyte, Regina; Farrell, John; Fink-Wagner, Antjie; Fiocchi, Alessandro; Fontaine, Jean F; Gemicioglu, Bilun; Schmid-Grendelmeir, Peter; Gamkrelidze, Amiran; Garcia-Aymerich, Judith; Gomez, Maximiliano; Gonzalez Diaz, Sandra; Gotua, Maia; Guldemond, Nick A; Guzman, Maria-Antonieta; Hajjam, Jawad; Hourihane, John O'B; Humbert, Marc; Iaccarino, Guido; Ierodiakonou, Despo; Ivancevich, Juan C; Joos, Guy; Jung, Ki-Suck; Jutel, Marek; Kaidashev, Igor; Kalayci, Omer; Kardas, Przemyslaw; Keil, Thomas; Khaitov, Mussa; Khaltaev, Nikolai; Kleine-Tebbe, Jorg; Kowalski, Marek L; Kritikos, Vicky; Kull, Inger; Leonardini, Lisa; Lieberman, Philip; Lipworth, Brian; Carlsen, Karin C. Lodrup; Loureiro, Claudia C; Louis, Renaud; Mair, Alpana; Marien, Gert; Mahboub, Bassam; Malva, Joao; Manning, Patrick; Keenoy, Esteban De Manuel; Marshall, Gallen D; Masjedi, Mohamed R; Maspero, Jorge F; Mathieu-Dupas, Eve; Matricardi, Poalo M; Melen, Eric; Melo-Gomes, Elisabete; Meltzer, Eli O; Mercier, Jacques; Miculinic, Neven; Mihaltan, Florin; Milenkovic, Branislava; Moda, Giuliana; Mogica-Martinezl, Maria-Dolores; Mohammad, Yousser; Montefort, Steve; Monti, Ricardo; Morais-Almeida, Mario; Moesges, Raft; Munter, Lars; Muraro, Antonella; Murray, Ruth; Naclerio, Robert; Napoli, Luigi; Namazova-Baranova, Leila; Neffen, Hugo; Nekam, Kristoff; Neou, Angelo; Novellino, Enrico; Nyembue, Dieudonne; O'Hehir, Robin; Ohta, Ken; Okubo, Kimi; Onorato, Gabrielle; Ouedraogo, Solange; Pali-Schoell, Isabella; Palkonen, Susanna; Panzner, Peter; Park, Hae-Sim; Pepin, Jean-Louis; Pereira, Ana-Maria; Pfaar, Oliver; Paulino, Ema; Phillips, Jim; Plavec, Davor; Popov, Ted A; Portejoie, Fabienne; Price, David; Prokopakis, Emmanuel P; Pugin, Benoit; Raciborski, Filip; Rajabian-Soderlund, Rojin; Reitsma, Sietze; Rodo, Xavier; Romano, Antonino; Rosario, Nelson; Rottem, Menahenm; Ryan, Dermot; Salimaki, Johanna; Sanchez-Borges, Mario M; Sisul, Juan-Carlos; Sole, Dirceu; Somekh, David; Sooronbaev, Talant; Sova, Milan; Spranger, Otto; Stellato, Cristina; Stelmach, Rafael; Ulrik, Charlotte Suppli; Thibaudon, Michel; To, Teresa; Todo-Bom, Ana; Tomazic, Peter, V; Valero, Antonio A; Valenta, Rudolph; Valentin-Rostan, Marylin; van der Kleij, Rianne; Vandenplas, Olivier; Vezzani, Giorgio; Viart, Frederic; Vieg, Giovanni; Wallace, Dana; Wagenmann, Martin; Wang, De Y; Waserman, Susan; Wickman, Magnus; Williams, Dennis M; Wong, Gary; Wroczynski, Piotr; Yiallouros, Panayiotis K; Yorgancioglu, Arzu; Yusuf, Osman M; Zar, Heahter J; Zeng, Stephane; Zernotti, Mario; Zhang, Luo; Zhong, Nan S; Zidarn, Mihaela

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Abstract

Background: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy. Main body: As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted "patient activation", (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Sante as a Good Practice in the field of digitally-enabled, integrated, person-centred care. Conclusion: In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.

Themen

Health care transformationCare pathwaysRhinitisARIAMASKPOLLARRespiratory Medicine and AllergyLungmedicin och allergi

Sprachen

Englisch

Verlag

Uppsala universitet, Centrum för klinisk forskning i Sörmland (CKFD); CHU, Fondat Partenariale FMC VIA LR, MACVIA France, F-34295 Montpellier 5, France;Villejuif Univ Versailles St Quentin En Yvelines, VIMA Ageing & Chron Dis Epidemiol & Publ Hlth App, INSERM U 1168, UMR S 1168, Montigny Le Bretonneux, France;European Forum Res & Educ Allergy & Airway Dis EU, Brussels, Belgium;Charite Univ Med Berlin, Berlin, Germany;Free Univ Berlin, Berlin, Germany;Humboldt Uniersitat Berlin, Berlin, Germany; McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON, Canada; NIAID, DAIT, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA; Natl Inst Hlth & Welf, Helsinki, Finland; European Forum Res & Educ Allergy & Airway Dis EU, Brussels, Belgium;Univ Hosp Leuven, Dept Otorhinolaryngol, Louvain, Belgium;Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands; Charite Univ Med Berlin, Berlin, Germany;Free Univ Berlin, Berlin, Germany;Humboldt Uniersitat Berlin, Berlin, Germany;Berlin Inst Hlth, Comprehens Allergy Ctr, GA2LEN, Dept Dermatol & Allergy, Berlin, Germany; Transylvania Univ, Fac Med, Brasov, Romania; Hosp Quironsalud Bizkaia, Dept Allergy & Immunol, Erandio, Spain; Ctr Res Environm Epidemiol CREAL, ISGlobAL, Barcelona, Spain;Hosp del Mar, Res Inst, IMIM, Barcelona, Spain;CIBERESP, Barcelona, Spain;UPF, Barcelona, Spain; Ghent Univ Hosp, ENT Dept, Upper Airways Res Lab, Ghent, Belgium; Johannes Gutenberg Univ Mainz, Dept Otolaryngol Head & Neck Surg, Mainz, Germany; Hosp Civil Guadalajara Dr Juan I Menchaca, Guadalarara, Mexico; iQ4U Consultants Ltd, London, England; Univ Sydney, Woolcock Inst Med Res, Sydney, NSW, Australia;Woolcock Emphysema Ctr, Sydney, NSW, Australia;Sydney Local Hlth Dist, Glebe, NSW, Australia; Laval Univ, Quebec Heart & Lung Inst, Quebec City, PQ, Canada; EFT Hlth France, Paris, France; Ghent Univ Hosp, Dept Resp Med, Ghent, Belgium; Leiden Univ, Dept Publ Hlth & Primary Care, Med Ctr, Leiden, Netherlands; Univ Porto, Porto4Ageing, Fac Pharm, UCIBIO,REQUINTE, Porto, Portugal;Univ Porto, Porto4Ageing, Competence Ctr Act & Hlth Ageing, Porto, Portugal; Univ Fed Bahia, ProAR Nucleo Excelencia Asma, Salvador, BA, Brazil;WHO GARD Planning Grp, Salvador, BA, Brazil; Med Consulting Czarlewski, Levallois Perret, France; European Forum Res & Educ Allergy & Airway Dis EU, Brussels, Belgium;Amsterdam Univ Med Ctr, Dept Otorhinolaryngol, AMC, Amsterdam, Netherlands; Univ Porto, Fac Med, Ctr Res Hlth Technol & Informat Syst, CINITESIS, Porto, Portugal;Medida Lda, Porto, Portugal; Athens Chest Hosp, Resp Med Dept 7, Athens, Greece;Athens Chest Hosp, Asthma Ctr, Athens, Greece; Helsinki Univ Hosp, Skin & Allergy Hosp, Helsinki, Finland;Univ Helsinki, Helsinki, Finland; Medida Lda, Porto, Portugal;Campania Reg, Div Hlth Innovat, Naples, Italy;Federico II Univ Hosp Naples, R&D, Naples, Italy;Federico II Univ Hosp Naples, DISMET, Naples, Italy; Ctr Rhinol & Allergol, Wiesbaden, Germany; Med Univ Lodz, Barlicki Univ Hosp, Div Internal Med Asthma & Allergy, Lodz, Poland; Vilnius Univ, Fac Med, Vilnius, Lithuania; Univ Med & Pharm, Hochiminh City, Vietnam; Med Sur Clin Fdn & Hosp, Ctr Excellence Asthma & Allergy, Mexico City, DF, Mexico; KYomed INNOV, Montpellier, France; Univ Beira Interior, Fac Hlth Sci, Covilha, Portugal;Univ Beira Interior, Hlth Sci Res Ctr, CICS UBI, Covilha, Portugal; Univ Naples Federico II, CIRFF, Naples, Italy; Hosp Clin Barcelona, ENT Dept, Rhinol Unit, Barcelona, Spain;Hosp Clin Barcelona, ENT Dept, Smell Clin, Barcelona, Spain;Univ Barcelona, CIBERES, IDIBAPS, Clin & Expt Resp Immunoallergy, Barcelona, Spain; Chiba Univ Hosp, Dept Otorhinolaryngol, Chiba, Japan; Univ Manchester, Royal Manchester Childrens Hosp, Div Infect Immun & Resp Med, Manchester, Lancs, England;Univ Athens, Athens Gen Childrens Hosp P&A Kyriakou, Pediat Clin 2, Allergy Dept, Athens, Greece; Minist Econ Ind & Numer, Conseil Gen Econ, Paris, France; Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland; Hop Univ Paris, Ctr Hop Cochin, Pneumol & Soins Intensifs Resp, Paris, France; Med Univ Graz, Dept Internal Med, Graz, Austria; 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Ecole Mines, Ales, France; Univ Manchester, Ctr Resp Med & Allergy, Inst Inflammat & Repair, Manchester, Lancs, England;Univ Hosp South Manchester, Manchester, Lancs, England; High Specialty Hosp A Cardarelli, Dept Resp Dis, Div Resp & Allerg Dis, Naples, Italy; Univ Hosp Fed Univ Santa Catarina HU UFSQ, Allergy Serv, Florianopolis, SC, Brazil; Caritas Diocesana Coimbra, Coimbra, Portugal;Ageing Coimbra EIP AHA Reference Site, Coimbra, Portugal; Univ Clin Pulmonol & Allergy, Med Fac Skopje, Skopje, Macedonia; Hop Gui de Chauliac Montpellier, Sleep Unit, Dept Neurol, Inserm U1061, Montpellier, France; AQuAS, Barcelna, Spain;European Reg & Local Hlth Assoc, EUREGHA, Brussels, Belgium; Univ Salerno, Scuola Med Salernitana, Dept Med Surg & Dent, Salerno, Italy; Univ Paris Saclay, Hop Foch, Pole Malad Voies Resp, UPRES EA220, Suresnes, France; Farmacie Golfi Grp, Massa Lubrense, Italy; St Louis Univ, Sch Med, Sect Allergy & Immunol, St Louis, MO USA; Vilnius Univ, Clin Infect Chest Dis Dermatol & Allergol, Vilnius, Lithuania; Sagamihara Natl Hosp, Clin Res Ctr Allergy & Rheumatol, Sagamihara, Kanagawa, Japan; Ain Shams Univ, Childrens Hosp, Pediat Allergy & Immunol Unit, Cairo, Egypt; Vilnius Univ, Fac Med, Clin Childrens Dis, Vilnius, Lithuania; ICVS 3Bs, PT Govt Associate Lab, Braga, Portugal; Global Allergy & Asthma Platform GAAPP, Vienna, Austria; Bambino Gesu Childrens Res Hosp Holy See, Dept Pediat Med, Div Allergy, Rome, Italy; Istanbul Univ Cerrahpasa, Cerrahpasa Fac Med, Dept Pulm Dis, Istanbul, Turkey; Univ Hosp Zurich, Dept Dermatol, Allergy Unit, Zurich, Switzerland; Natl Ctr Dis Control & Publ Hlth Georgia, Tbilisi, Georgia; Ctr Res Environm Epidemiol CREAL, ISGlobAL, Barcelona, Spain; Hosp San Bernardo Salta, Allergy & Asthma Unit, Salta, Argentina; Univ Autonoma Nuevo Leon, San Nicolas De Los Garza, Mexico; Georgian Assoc Allergol & Clin Immunol, Ctr Allergy & Immunol, Tbilisi, Georgia; Erasmus Univ, Inst Hlth Policy & Management iBMG, Rotterdam, Netherlands; Univ Chile, Clin Hosp, Immunol & Allergy Div, Santiago, Chile; Conseil Reg Pays Loire, Ctr Expertise Partenariat Europeen Innovat Vieill, Gerontopole Auton Longevite Pays Loire, Centich Ctr Expertise Natl Technol Informat & Com, Nantes, France; Univ Coll Cork, Dept Paediat & Child Hlth, Cork, Ireland; Univ Paris Sud, Le Kremlin Bicetre, France;Hop Bicetre, Serv Pneumol, Inserm UMR 5999, Le Kremlin Bicetre, France; Univ Salerno, Dept Med & Surg, Baronissi, Italy; Univ Crete, Fac Med, Dept Social Med, Hlth Planning Unit, Iraklion, Greece;Univ Turku, Dept Lung Dis & Clin Immunol, Turku, Finland;Terveystalo Allergy Clin, Turku, Finland; Clin Santa Isabel, Serv Alergia & Immunol, Buenos Aires, DF, Argentina; Hallym Univ, Coll Med, Sacred Heart Hosp, Anyang, Gyeonggi Do, South Korea; Wroclaw Med Univ, Dept Clin Immunol, Wroclaw, Poland; Ukrainian Med Stomatol Acad, Poltava, Ukraine; Hacettepe Univ, Pediat Allergy & Asthma Unit, Sch Med, Ankara, Turkey; Med Univ Lodz, Dept Family Med 1, Lodz, Poland; Charite Univ Med Berlin, Inst Social Med Epidemiol & Hlth Econ, Berlin, Germany;Univ Wurzburg, Inst Clin Epidemiol & Biometry, Wurzburg, Germany; Fed Med Biol Agcy, Natl Res Ctr, Inst Immunol, Lab Mol Immunol, Moscow, Russia; GARD Chairman, Geneva, Switzerland; Allergy & Asthma Ctr Westend, Berlin, Germany; Med Univ Lodz, Hlth Ageing Res Ctr, Dept Immunol & Allergy, Lodz, Poland; Karolinska Inst, Soder Sjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden;Soder Sjukhuset, Sachs Children & Youth Hosp, Stockholm, Sweden; Mattone Int Program, Bologna, Veneto Region, Italy; Univ Tennessee, Coll Med, Dept Internal Med, Div Allergy, Germantown, TN USA;Univ Tennessee, Coll Med, Dept Internal Med, Div Immunol, Germantown, TN USA;Univ Tennessee, Coll Med, Dept Pediat, Div Allergy, Germantown, TN USA;Univ Tennessee, Coll Med, Dept Pediat, Div Immunol, Germantown, TN USA; Univ Dundee, Ninewells Hosp, Med Res Inst, Scottish Ctr Resp Res Cardiovasc & Diabet Med, Dundee, Scotland; Oslo Univ Hosp, Dept Paediat, Oslo, Norway;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway; Ctr Hosp Univ Coimbra, Imunoalergol, Coimbra, Portugal;Univ Coimbra, Fac Med, Coimbra, Portugal; CHU Sart Tilman, Dept Pulm Med, Liege, Belgium;GIGA I3 Res Grp, Liege, Belgium; Scottish Govt, DG Hlth & Social Care, Edinburgh, Midlothian, Scotland; Rashid Hosp, Dept Pulm Med, Dubai, U Arab Emirates; Ageing Coimbra EIP AHA Reference Site, Coimbra, Portugal;Univ Coimbra, Fac Med, Coimbra Inst Clin & Biomed Res iCBR, Coimbra, Portugal; Bon Secours Hosp, Dept Med RCSI, Dublin, Ireland; Int Ctr Excellence Chronic Res Barakaldo, Kronikgune, Baracaldo, Bizkaia, Spain; Univ Mississippi, Med Ctr, Div Clin Immunol & Allergy, Lab Behav Immunol Res, Jackson, MS 39216 USA; Iranian Anti Tobacco Assoc, Tobacco Control Res Ctr, Tehran, Iran; Argentine Assoc Allergy & Clin Immunol, Buenos Aires, DF, Argentina; Charite Med Univ, Dept Pediat Pneumol & Immunol, AG Mol Allergol & Immunomodulat, Berlin, Germany; Soder Sjukhuset, Sachs Children & Youth Hosp, Stockholm, Sweden;Karolinska Inst, Inst Environm Med, Stockholm, Sweden; Fac Med Lisbon, PNDR, Portuguese Natl Programme Resp Dis, Lisbon, Portugal; Allergy & Asthma Med Grp & Res Ctr, San Diego, CA USA; Univ Montpellier, CHRU, Dept Physiol, Res,PhyMedExp,INSERM U1046,CNRS,UMR 9214, Montpellier, France; Croatian Pulm Soc, Zagreb, Croatia; Natl Inst Pneumol M Nasta, Bucharest, Romania; Univ Belgrade, Fac Med, Clin Ctr Serbia, Serbian Assoc Asthma & COPD,Clin Pulm Dis, Belgrade, Serbia; Reg Piemonte, Turin, Italy; Tishreen Univ, Natl Ctr Res Chron Resp Dis, Sch Med, Latakia, Syria;Syrian Private Univ, Damascus, Syria; Univ Med, Fac Med & Surg, La Valette, Malta; Univ Torino, Dept Med Sci, Allergy & Clin Immunol Unit, Turin, Italy;Mauriziano Hosp, Turin, Italy; CUF Descobertas Hosp, Allergy Ctr, Lisbon, Portugal; Univ Cologne, Med Fac, Inst Med Stat & Computat Biol, Cologne, Germany;CRI Clin Res Int Ltd, Hamburg, Germany; Danish Commitee Hlth Educ, Copenhagen East, Denmark; Padua Gen Univ Hosp, Food Allergy Referral Ctr Veneto Reg, Dept Women & Child Hlth, Padua, Italy; MedScript Ltd, Paraparomu, New Zealand;OPC, Cambridge, England; Johns Hopkins Sch Med, Baltimore, MD USA; Consortium Pharm & Serv COSAFER, Salerno, Italy; Russian Acad Med Sci, Sci Ctr Childrens Hlth, Moscow, Russia; Ctr Allergy Immunol & Resp Dis, Santa Fe, Argentina; Hosp Hosp Ler Bros Buda, Budapest, Hungary; Hautambulanz & Rothhaar Study Ctr, Berlin, Germany; Univ Naples Federico II, Dept Pharm, Naples, Italy; Univ Hosp Kinshasa, ENT Dept, Kinshasa, DEM REP CONGO; Monash Univ, Alfred Hosp, Dept Allergy Immunol & Resp Med, Melbourne, Vic, Australia;Monash Univ, Cent Clin Sch, Melbourne, Vic, Australia; Tokyo Natl Hosp, Natl Hosp Org, Tokyo, Japan; Nippon Med Sch, Dept Otolaryngol, Tokyo, Japan; Ctr Hosp Univ Pediat Charles de Gaulle, Ouagadougou, Burkina Faso; Univ Vet Med, Messerli Res Inst, Dept Comparat Med, Vienna, Austria;Med Univ, Vienna, Austria; EFA European Federat Allergy & Airways Dis Patien, Brussels, Belgium; Charles Univ Prague, Fac Med, Dept Immunol & Allergol, Plzen, Czech Republic;Charles Univ Prague, Fac Hosp Pilsen, Plzen, Czech Republic; Ajou Univ, Dept Allergy & Clin Immunol, Sch Med, Suwon, South Korea; Univ Grenoble Alpes, Lab HP2, Grenoble, France;INSERM, U1042, Grenoble, France;CHU Grenoble, Grenoble, France; CUF Porto Hosp & Inst, Allergy Unit, Porto, Portugal;Univ Porto, Ctr Res Hlth Technol & Informat Syst, CINTESIS, Porto, Portugal; Philipps Univ Marburg, Univ Hosp Marburg, Sect Rhinol & Allergy, Dept Otorhinolaryngol Head & Neck Surg, Marburg, Germany; Farmacias Holon, Lisbon, Portugal; Ctr Empowering Patients & Communities, Faulkland, Somerset, England; Childrens Hosp Srebrnjak, Zagreb, Croatia;Univ JJ Strossmayer, Sch Med, Osijek, Croatia; Univ Hosp Sv Ivan Rilski, Sofia, Bulgaria; Univ Aberdeen, Acad Ctr Primary Care, Aberdeen, Scotland;Res Real Life, Cambridge, England; Univ Crete, Dept Otorhinolaryngol, Sch Med, Iraklion, Greece; Karolinska Univ Hosp, Dept Nephrol & Endocrinol, Stockholm, Sweden; Univ Cattolica Sacro Cuore, Allergy Unit, Presidio Columbus, Rome, Italy;IRCCS Oasi Maria SS, Troina, Italy; Univ Parana, Hosp Clin, Curitiba, Parana, Brazil; Emek Med Ctr, Div Allergy Asthma & Clin Immunol, Afula, Israel; Univ Edinburgh, Allergy & Resp Res Grp, Edinburgh, Midlothian, Scotland; Assoc Finnish Pharmacists, Helsinki, Finland; Ctr Medicodocente Trinidad & Clin El Avila, Allergy & Clin Immunol Dept, Caracas, Venezuela; Soc Paraguaya Alergia Asma & Inmunol, Asuncion, Paraguay; Univ Fed Sao Paulo, Dept Pediat, Div Allergy Clin Immunol & Rheumatol, Sao Paulo, Brazil; EHEE, Dromahair, Ireland; Euro Asian Resp Soc, Kyrgyzstan Natl Ctr Cardiol & Internal Med, Bishkek, Kyrgyzstan; Univ Hosp Olomouc, Dept Resp Med, Olomouc, Czech Republic; Univ Sao Paulo, Fac Med, Hosp Clin, Pulm Div,Heart Inst InCor, Sao Paulo, Brazil; Hvidovre Univ Hosp, Dept Resp Med, Copenhagen, Denmark;Univ Copenhagen, Copenhagen, Denmark; RNSA, Brussieu, France; Sidkkids Hosp, Toronto, ON, Canada;Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada; Med Univ Graz, Dept ENT, Graz, Austria; Univ Barcelona, IDIBAPS, Pneumol & Allergy Dept, CIBERES, Barcelona, Spain;Univ Barcelona, IDIBAPS, Clin & Expt Resp Immunoallergy, Barcelona, Spain; Med Univ Vienna, Ctr Pathophysiol Infectiol & Immunol, Dept Pathophysiol & Allergy Res, Div Immunopathol, Vienna, Austria;NRC Inst Immunol FMBA Russia, Moscow, Russia;Sechenov First Moscow State Med Univ, Dept Clin Immunol & Allergy, Lab Immunopathol, Moscow, Russia; Leiden Univ, Dept Publ Hlth & Primary Care, Med Ctr, Leiden, Netherlands;Univ Med Ctr, Dept Obstet & Gynaecol, Erasmus MC, Rotterdam, Netherlands; Catholic Univ Louvain, Ctr Hosp Univ UCL Namur, Dept Chest Med, Yvoir, Belgium; AUSL Reggio Emilia, Arcispedale SMaria Nuova IRCCS, Pulm Unit, Dept Med Specialties, Reggio Emilia, Italy; CNR, Pulm Environm Epidemiol Unit, Inst Clin Physiol, Pisa, Italy;CNR, Inst Biomed & Mol Immunol A Monroy, Palermo, Italy; Nova Southeastern Univ, Ft Lauderdale, FL 33314 USA; Univ Klinikum Dusseldorf, HNO Klin, Dept Otorhinolaryngol, Dusseldorf, Germany; Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Otolaryngol, Singapore, Singapore; McMaster Univ, Dept Med Clin Immunol & Allergy, Hamilton, ON, Canada; Univ N Carolina, Eshelman Sch Pharm, Chapel Hill, NC 27515 USA; CHUL, Malad Infect & Immunitaires, Quebec City, PQ, Canada; Cyprus Univ Technol, Cyprus Int Inst Environm & Publ Hlth Assoc Harvar, Limassol, Cyprus;Hosp Archbishop Makarios III, Dept Pediat, Nicosia, Cyprus; Celal Bayar Univ, Fac Med, Dept Pulm Dis, Manisa, Turkey; Allergy & Asthma Inst, Islamabad, Pakistan; Red Cross Childrens Hosp, Dept Paediat & Child Hlth, Cape Town, South Africa;Univ Cape Town, MRC, Unit Child & Adolescent Hlth, Cape Town, South Africa; Bull DSAS, Echirolles, France; Univ Catolica Cordoba, Cordoba, Argentina; Beijing TongRen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China;Beijing Inst Otolaryngol, Beijing, Peoples R China; Guangzhou Med Univ, Affiliated Hosp 1, Guangzhou Inst Resp Dis, State Key Lab Resp Dis, Guangzhou, Guangdong, Peoples R China; Univ Clin Resp & Allerg Dis, Golnik, Slovenia; BMC

DOI

10.1186/s13601-019-0279-2

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