Intro -- Foreword -- Contents -- Contributors -- 1: Introduction to Cannabis Use Disorders -- Introduction -- Epidemiology of CUD -- The Endocannabinoid System (ECS) -- Translational Aspects -- Clinical Manifestations -- Developmental Aspects of CUD -- Treatment -- References -- 2: Epidemiology of Cannabis Use Disorder -- Introduction -- US Estimates and Trends -- National Surveys -- Prevalence and Trends in Cannabis Use -- Prevalence and Trends in Cannabis Use Disorder -- Risk Factors -- Subgroup Differences -- Psychiatric Comorbidity -- Impact of Cannabis Policy -- Discussion -- References -- 3: Genetic Aspects of Cannabis Use Disorder -- Introduction -- Heritability: Family Aggregation and Twin Studies -- Candidate Gene and Hypothesis-Based Studies of CUD -- Dopamine Genes -- Cannabinoid Genes -- ABCB1 Transporters -- Clock Genes -- GWAS Studies -- Whole Genome Sequencing -- Epigenetics in CUD -- Future Directions -- References -- 4: The Endogenous Cannabinoid System: A Cadre of Potential Therapeutic Targets -- Introduction -- Types of Cannabinoids -- Phytocannabinoids -- Synthetic Cannabinoids -- Endocannabinoids -- Endocannabinoid Metabolism -- Cannabinoid Receptors -- References -- 5: Cannabidiol and Cannabis Use Disorder -- Epidemiological, Social, Economic, and Health Impact of Cannabis Use Disorders -- Therapeutic Management of CUD -- Rationale or Justification for Testing the Efficacy of Cannabidiol in CUD -- Antipsychotic-Like Effects of CBD -- Anxiolytic-Like Effects of CBD -- Antidepressant-Like Effects of CBD -- Neuroprotective Properties of CBD -- Neurochemical Mechanisms Underlying CBD Effects -- CBD Lacks Potential as a Drug of Abuse -- CBD and Drug Use Disorders -- CBD and Cannabis Use Disorders -- Conclusions and Future Directions -- References.
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