Principles and Methods for the Assessment of Risk from Essential Trace Elements: Environmental Health Criteria Series, No 228

Abstract

The risk assessment approach described in this monograph applies only to essential trace elements (ETEs) involved in human health and not to non-essential elements. The purpose of this monograph is to provide the scientific principles that support the concept of an ''acceptable range of oral intake'' (AROI), which uses a ''homeostatic model'' for determining the range of dietary intakes for essential trace elements (ETEs) that meet the nutritional requirements of a healthy population and avoid excess intakes. To facilitate comparisons, AROIs are discussed in relation to other risk assessment a