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In: Routledge Revivals Series
First published in 1985, the programme described in this book had developed over 25 years at the Royal Newcastle Hospital, Australia. It grew in response to the practical needs of patients who, having been treated by conventional means, were left with residual disabilities to a degree that their return to the community was jeopardised.
In: Routledge Studies in Innovation, Organizations and Technology Series
In: Texte 2024, 57
In: Ressortforschungsplan of the Federal Ministry for the Environment, Nature Conservation, Nuclear Safety and Consumer Protection
The entry of pharmaceuticals into the aquatic environment has become a major concern in environmental research and has gained increasing public interest. Pharmaceuticals, both human and veterinary, find their way into water bodies through various routes such as wastewater treatment plants and agricultural activities, posing risks to aquatic organisms. In particular, hormone-active substances have been identified as potential threats, even at low concentrations in water. These pharmaceutical residues are known to persist in the environment and may cause adverse effects on non-target organisms. The objective of this project was to develop a tailored testing strategy for assessing the environmental risk of novel hormonal active substances, focusing on synthetic progestins and glucocorticoids, to aquatic organisms. In the initial phase of the project, a comprehensive literature review was conducted to gather and evaluate existing findings on the effects of these substances. Based on the literature review, two candidate substances representing both substance classes were selected for further study. Two long-term laboratory experiments were conducted using aquatic vertebrates, and an additional study with an aquatic invertebrate was carried out for the progestin. Dienogest and Dexamethasone were selected to represent progestins and glucocorticoids, respectively. For Dienogest, a Zebrafish one generation reproduction test (ZEOGRT) was performed, and a Chironomid Life Cycle Test was conducted for the invertebrates. For Dexamethasone, only the Zebrafish study was conducted. The experiments involved exposing the organisms to different concentrations of the test substances and measuring various endpoints related to growth, reproduction, and survival. The physical water parameters were monitored to ensure stable test conditions. For Dienogest, the results showed that it had no significant effects on the parental generation (F 0) of zebrafish but adversely affected the fertility and early larval survival in the first filial generation (F1 ). Hatching success of the second filial generation (F 2) was also reduced. Based on the endpoint hatching success of the second filial generation (F2 ), which was the most sensitive endpoint throughout the study, the overall NOEC of the ZEOGRT was determined to be 3.51 ng Dienogest/L and the LOEC was 10.3 ng Dienogest/L. In the Chironomid study, no effects were observed, indicating a lack of biological impact. Regarding Dexamethasone, it caused reduced growth in both F 0 and F1 generations of zebrafish, with males being more affected. However, reproductive capability and other endpoints were not negatively impacted. Based on the endpoint growth in terms of wet weight and total length the NOEC was determined to be 10.5 μg Dexamethasone/L. The LOEC was set at 34.7 μg Dexamethasone/L. The results indicate that synthetic progestins, such as Dienogest, can have similar effects to potent endocrine substances like estrogens and androgens. However, the underlying mechanism remain unclear. On the other hand, glucocorticoid exposure, specifically Dexamethasone, had effects on the growth of fish across different life stages, but did not significantly affect reproductive performance or sex ratios. The studies suggest that fish are more sensitive to endocrine impacts compared to other aquatic organisms, however, in order to identify the underlying mode of action, additional methodological approaches, such as innovative Omics methods or the immune challenge, could provide valuable information on the molecular effects of the substances. Thus, further research is necessary to improve the identification of underlying mechanisms and their acceptance in the regulatory context.
Drawing from existing theory, policy, practice and speculative design about how cities may evolve, the book illustrates key concepts using case studies that respond to the complex relationships between human and non-human others (such as animals and plants, as well as soil, rivers, data and sensors) in urban space.
In: Contemporary studies in economic and financial analysis volume 112B
The digital revolution and automation are accelerating changes in the labour market and in workplace skills. Affected by changes in international economics and opportunities for employment, in the workplace individuals seek to acquire relevant skills and retain transferable skills to be employable and to remain in employment. Contemporary Challenges in Social Science and Management Part A and B explore in detail the theoretical competency framework to address these gaps and shortages in different disciplines and sectors. The global drivers of change are analysed and the opportunities and challenges for skills development are investigated, include the transition from education to employment in knowledge-based sectors in different countries. Enriched and strengthened with European case studies of real-life situations providing a practical and industry insights, the volumes collate experts in Economics, Finance, Public Policy, Human Resources, and Risk management, contributing on employability, labour markets, sustainability, and skills of the future from across the globe. Contemporary Studies in Economic and Financial Analysis publishes a series of current and relevant themed volumes within the fields of economics and finance. Both disciplinary and interdisciplinary studies are welcome.
In: Modern British histories
How did ideas of masculinity shape the British legal profession and the wider expectations of the white-collar professional? Brotherhood of Barristers examines the cultural history of the Inns of Court - four legal societies whose rituals of symbolic brotherhood took place in their supposedly ancient halls. These societies invented traditions to create a sense of belonging among members - or, conversely, to marginalize those who did not fit the profession's ideals. Ren Pepitone examines the legal profession's efforts to maintain an exclusive, masculine culture in the face of sweeping social changes across the nineteenth and twentieth centuries. Utilizing established sources such as institutional records alongside diaries, guidebooks, and newspapers, this book looks afresh at the gendered operations of Victorian professional life. Brotherhood of Barristers incorporates a diverse array of historical actors, from the bar's most high-flying to struggling law students, disbarred barristers, political radicals, and women's rights campaigners.
In: Cambridge elements. Elements in global China
This Element traces the history of and recent developments in the unstable relationship between global civil society (GCS) and China. It analyses the normative impacts GCS has had on China - including the Chinese state and domestic civil society - and the possibilities created by Beijing's new 'going out' policies for Chinese civil society groups. It examines the rhetoric and reality of GCS as an emancipatory project and argues that 'universal values' underpinned by principles of human rights and democracy have gained currency in China despite official resistance from the government. It argues that while the Chinese party-state is keen to benefit from GCS engagement, Beijing is also determined to minimize any impact outside groups might have on regime security. The Element concludes with some observations about future research directions and the internationalization of Chinese civil society.
In: Schriftenreihe der ÖFEB-Sektion Sozialpädagogik
Fremdunterbringung in stationären Erziehungshilfen und Rückkehr ins Familiensystem stellen Jugendliche und deren Familien vor gravierende Transformationsherausforderungen. Dabei geht es um Zugehörigkeiten und Abgrenzungen, relative Autonomie und relative Abhängigkeit. Die Autorin geht basierend auf einem qualitativen Forschungsprojekt der Frage nach, wie Familienmitglieder Rückkehrprozesse erleben und dabei 'Familie(n)' laufend herstellen. Sie analysiert die Wechselwirkungen der Handlungen, Gefühle und Erklärungen von jungen Menschen und Eltern in Zusammenspiel mit den Aktivitäten der Fachakteur*innen sowie den rechtlich codierten Strukturen der Kinder- und Jugendhilfe. In der empirisch und theoretisch ausgerichteten Arbeit werden wichtige Diskussionen der Kinder- und Jugendhilfeforschung mit aktuellen Konzepten der Familienforschung verknüpft. Insbesondere wird ein relationales Modell zu Sorge/Care in privater Verantwortung und in Strukturen der Interventionen der staatlichen Kinder- und Jugendhilfe entwickelt. Darüber hinaus werden Anregungen für die Praxis zur Verfügung gestellt
In: UC Press voices revived
This title is part of UC Press's Voices Revived program, which commemorates University of California Press's mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1975. This title is part of UC Press's Voices Revived