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The androgen receptor is a transcription factor that plays a key role in the development of prostate cancer, and its interactions with general transcription regulators are therefore of potential therapeutic interest. The mechanistic basis of these interactions is poorly understood due to the intrinsically disordered nature of the transactivation domain of the androgen receptor and the generally transient nature of the protein-protein interactions that trigger transcription. Here, we identify a motif of the transactivation domain that contributes to transcriptional activity by recruiting the C-terminal domain of subunit 1 of the general transcription regulator TFIIF. These findings provide molecular insights into the regulation of androgen receptor function and suggest strategies for treating castration-resistant prostate cancer. ; This work was supported by IRB, ICREA (X.S.), Obra Social "la Caixa" (E.D.M., E.S., and X.S.), MINECO (BIO2012-31043 and BIO2015-70092-R to X.S., BIO2014-53095-P to G.D.F.), Marató de TV3 (102030 to X.S. and 102031 to E.E.-P), the COFUND program of the European Commission (C.D.S.), the European Research Council (CONCERT, contract number 648201 to X.S.), the Ramón y Cajal program of MICINN (RYC-2011-07873 to C.W.B.), the Serra Hunter Program (E.E.-P.), AGAUR (SGR-2014-56RR14 to E.E.-P), and FEDER (G.D.F.). I.H. was supported by funding from the Chief Scientist's Office of the Scottish Government (ETM-258, ETM-382). IRB Barcelona is the recipient of a Severo Ochoa Award of Excellence from MINECO (Government of Spain).

Gregor Wiedemann evaluates text mining applications for social science studies with respect to conceptual integration of consciously selected methods, systematic optimization of algorithms and workflows, and methodological reflections relating to empirical research. In an exemplary study, he introduces workflows to analyze a corpus of around 600,000 newspaper articles on the subject of "democratic demarcation" in Germany. He provides a valuable resource for innovative measures to social scientists and computer scientists in the field of applied natural language processing. Contents • Qualitative Data Analysis in a Digital World • Computer-Assisted Text Analysis in the Social Sciences • Integrating Text Mining Applications for Complex Analysis • Democratic Demarcation in Germany • V-TM - A Methodological Framework for Social Sciences • Integrating Qualitative and Computational Text Analysis Target Groups • Researchers and students in the fields of social sciences, digital humanities and communication science, scientists interested in innovative text analysis methods, computer scientists in interdisciplinary projects or research fields working with large amounts of textual data The Author Gregor Wiedemann holds a doctoral degree from Leipzig University, Germany. He is the coordinator of the discipline-specific working groups in the CLARIN-D project, which develops a European virtual research infrastructure for digital language data analysis in the social sciences and humanities

The role of knowledge in the policy process remains a central theoretical puzzle in policy analysis and political science. This article argues that an important yet missing piece of this puzzle is the systematic exploration of the political use of policy knowledge. While much of the recent debate has focused on the question of how the substantive use of knowledge can improve the quality of policy choices, our understanding of the political use of knowledge and its effects in the policy process has remained deficient in key respects. A revised conceptualization of the political use of knowledge is introduced that emphasizes how conflicting knowledge can be used to contest given structures of policy authority. This allows the analysis to differentiate between knowledge creep and knowledge shifts as two distinct types of knowledge effects in the policy process. While knowledge creep is associated with incremental policy change within existing policy structures, knowledge shifts are linked to more fundamental policy change in situations when the structures of policy authority undergo some level of transformation. The article concludes by identifying characteristics of the administrative structure of policy systems or sectors that make knowledge shifts more or less likely.

Mistrust of scientific evidence and government-issued guidelines is increasingly correlated with political affiliation. Survey evidence has documented skepticism in a diverse set of issues including climate change, vaccine hesitancy, and, most recently, COVID-19 risks. Less well understood is whether these beliefs alter high-stakes behavior. Combining GPS data for 2.7 million smartphone users in Florida and Texas with 2016 U.S. presidential election precinct-level results, we examine how conservative-media dismissals of hurricane advisories in 2017 influenced evacuation decisions. Likely Trump-voting Florida residents were 10 to 11 percentage points less likely to evacuate Hurricane Irma than Clinton voters (34% versus 45%), a gap not present in prior hurricanes. Results are robust to fine-grain geographic controls, which compare likely Clinton and Trump voters living within 150 m of each other. The rapid surge in media-led suspicion of hurricane forecasts-and the resulting divide in self-protective measures-illustrates a large behavioral consequence of science denialism.

Mistrust of scientific evidence and government-issued guidelines is increasingly correlated with political affiliation. Survey evidence has documented skepticism in a diverse set of issues including climate change, vaccine hesitancy, and, most recently, COVID-19 risks. Less well understood is whether these beliefs alter high-stakes behavior. Combining GPS data for 2.7 million smartphone users in Florida and Texas with 2016 U.S. presidential election precinct-level results, we examine how conservative-media dismissals of hurricane advisories in 2017 influenced evacuation decisions. Likely Trump-voting Florida residents were 10 to 11 percentage points less likely to evacuate Hurricane Irma than Clinton voters (34% versus 45%), a gap not present in prior hurricanes. Results are robust to fine-grain geographic controls, which compare likely Clinton and Trump voters living within 150 m of each other. The rapid surge in media-led suspicion of hurricane forecasts-and the resulting divide in self-protective measures-illustrates a large behavioral consequence of science denialism.

The relationship between the Spanish and later the Guatemalan state with the Mayan Indians over the past four centuries is a fundamental component of Guatemalan political history. Since the beginnings of the nation, when the Mayans were political and military entities of power and independence with whom the Spanish had to come to terms; to the 1944-1954 "Revolutionary Era," when Indian communities were finally conceded limited social, economic, and political rights; and the period from 1979 to 1984 in which the military regimes killed "tens of thousands by some estimates as high as 80,000" Indians; the Indian population has been persistently in the consciousness of national officials.

Las elecciones generales del 82 supusieron por primera vez desde el cambio político del 76 el freno del abstencionismo. En Galicia se dio un incremento significativo de la participación electoral, aunque todavía Galicia continúe siendo una isla de apatía electoral comparada con el resto de España. Se consideras este fenómeno abstencionista gallego desde dos perspectivas : las variables que han contribuido a mantener alto el nivel de abstención y las variables que han contribuido a aumentar la participación. Dichas variables son : municipios industrializados/no industrializados ; zonas rurales/urbanas ; zonas costeras/de interior ; el peso de los partidos contendientes en las distintas zonas

The paper deals with the debate on the General Economic Equilibrium (GEE) in the 1930s in Vienna and at the London School of Economics and offers an interpretation of it different from that of the traditional narratives. It interprets the debate as a renewed confrontation between the two different classical methodological paths of research in GEE, the Paretian and the Walrasian ones. What emerges from this examination is a picture of different approaches and theories in competition, in particular on the issue of the relationship between theory and the real world. This was the fundamental issue at stake. Herein lies also the interest in those distant controversies for the current debate in economics.

El siguiente artículo da a conocer algunos aspectos generales de la estampa en cuanto a sus características físicas, temas, comercio y usos desde el siglo XVI hasta los primeros años del XIX en el Nuevo Reino de Granada. El hallazgo de documentos en archivos y de imágenes impresas europeas, llegadas durante la época colonial, ha permitido aportar nueva información en torno a estas obras, de diversas temáticas religiosas y civiles, que tuvieron significativa importancia en la evangelización y en la propagación de mensajes, como objetos devocionales, elementos decorativos y simbólicos, ilustradores de libros, al igual que como fuentes de inspiración y conocimiento para artesanos.

The present research work has an analysis of how the estimation of income is handled in the budget of the Decentralized Autonomous Government Municipality of Ambato, in terms of its calculation basis, and valuation. It is important to indicate that this study consists of analyzing the incidence and effectiveness of implementing a model for the formulation of a general income fund, making the Directorates that make up the Municipality of Ambato an active part in the generation of economic resources for the Institution, besides generating awareness in each of the employees and workers of the commitment we have when creating resources, to be responsible and organized in front of each of the competencies that have been delivered to the different dependencies of the municipality, this being a means technical assistance for the improvement of fiscal sustainability, that is, the fiscal capacity to generate income, the execution of expenses, the management of financing, including indebtedness, and the proper management of assets, liabilities and assets, of a public nature and management by results. The methodology used by this project is predominantly quantitative, and the types of research that were used are: field research applied to the actors directly involved in the preparation of the budget of the Decentralized Autonomous Government Municipality of Ambato, and a bibliographical investigation of topics related to This studio. Likewise, as part of the research process, a survey was applied to obtain data, which once tabulated were subjected to an analysis and interpretation of the author, in the same way the application of the statistical technique T-student for the verification of the hypothesis of this research work, under the independent variable General Income Fund, and the dependent variable Fiscal Sustainability. ; El presente trabajo de investigación tiene un análisis de cómo hoy por hoy se maneja la obtención de la estimación de ingresos en el presupuesto del Gobierno Autónomo Descentralizado Municipalidad de Ambato, en cuanto a su base de cálculo, y valoración. Es importante indicar que este estudio consiste en analizar la incidencia y eficacia de implementar un modelo para la formulación de un fondo general de ingresos, haciendo que las Direcciones que conforman la Municipalidad de Ambato sean parte activa en la generación de recursos económicos para la Institución, además de generar conciencia en cada uno de los empleados y trabajadores del compromiso que tenemos al momento de crear recursos, a ser responsables y organizados frente a cada una de las competencias que han sido entregadas a las diferentes dependencias de la municipalidad, siendo este un medio técnico para la mejora de la sostenibilidad fiscal, es decir, a la capacidad fiscal de generación de ingresos, la ejecución de gastos, el manejo del financiamiento, incluido el endeudamiento, y la adecuada gestión de los activos, pasivos y patrimonios de carácter público y gestión por resultados. La metodología que emplea este proyecto es predominantemente cuantitativa, y los tipos de investigación que se emplearon son: investigación de campo aplicada a los actores directamente involucrados en la elaboración del presupuesto del Gobierno Autónomo Descentralizado Municipalidad de Ambato, y una investigación bibliográfica de temas relacionados con este estudio. Asimismo, como parte del proceso de investigación se aplicó una encuesta para la obtención de datos, los cuáles una vez tabulados se sujetaron a un análisis e interpretación de la autora, de la misma manera la aplicación de la técnica estadística T-student para la comprobación de la hipótesis de este trabajo de investigación, bajo la variable independiente Fondo General de Ingresos, y la variable dependiente Sostenibilidad Fiscal.