Einzelbesprechungen
In: Zeitschrift für Nationalökonomie: Journal of economics, Band 20, Heft 3-4, S. 450-500
ISSN: 2304-8360
204 Ergebnisse
Sortierung:
In: Zeitschrift für Nationalökonomie: Journal of economics, Band 20, Heft 3-4, S. 450-500
ISSN: 2304-8360
Glycosylation is a topic of intense current interest in the development of biopharmaceuticals because it is related to drug safety and efficacy. This work describes results of an interlaboratory study on the glycosylation of the Primary Sample (PS) of NISTmAb, a monoclonal antibody reference material. Seventy-six laboratories from industry, university, research, government, and hospital sectors in Europe, North America, Asia, and Australia submitted a total of 103 reports on glycan distributions. The principal objective of this study was to report and compare results for the full range of analytical methods presently used in the glycosylation analysis of mAbs. Therefore, participation was unrestricted, with laboratories choosing their own measurement techniques. Protein glycosylation was determined in various ways, including at the level of intact mAb, protein fragments, glycopeptides, or released glycans, using a wide variety of methods for derivatization, separation, identification, and quantification. Consequently, the diversity of results was enormous, with the number of glycan compositions identified by each laboratory ranging from 4 to 48. In total, one hundred sixteen glycan compositions were reported, of which 57 compositions could be assigned consensus abundance values. These consensus medians provide community-derived values for NISTmAb PS. Agreement with the consensus medians did not depend on the specific method or laboratory type. The study provides a view of the current state-of-the-art for biologic glycosylation measurement and suggests a clear need for harmonization of glycosylation analysis methods.
BASE
In: Kosakowska-Berezecka , N , Besta , T , Bosson , J K , Jurek , P , Vandello , J A , Best , D L , Wlodarczyk , A , Safdar , S , Zawisza , M , Zadkowska , M , Sobiecki , J , Agyemang , C B , Akbas , G , Ammirati , S , Anderson , J , Anjum , G , Aruta , J J B R , Ashraf , M , Bakaityte , A , Bi , C , Becker , M , Bender , M , Berxulli , D , Bosak , J , Daalmans , S , Dandy , J , de Lemus , S , Dvorianchikov , N , Etchezahar , E , Froehlich , L , Gavreliuc , A , Gavreliuc , D , Gomez , A , Greijdanus , H , Grigoryan , A , Hale , M-L , Hamer , H , Hoorens , V , Hutchings , P B , Jensen , D H , Kelmendi , K , Khachatryan , N , Kinahan , M , Kozlowski , D , Lauri , M A , Li , J , Maitner , A T , Makashvili , A , Mancini , T , Martiny , S E , Dordevic , J M , Moreno-Bella , E , Moscatelli , S , Moynihan , A B , Muller , D , Ochoa , D , Adebayo , S O , Pacilli , M G , Palacio , J , Patnaik , S , Pavlopoulos , V , Piterova , I , Puzio , A , Pyrkosz-Pacyna , J , Renteria-Perez , E , Rousseaux , T , Sainz , M , Salvati , M , Samekin , A , Garcia-Sanchez , E , Schindler , S , Sherbaji , S , Sobhie , R , Sulejmanovic , D , Sullivan , K E , Torre , B , Torres , C , Ungaretti , J , Valshtein , T , Van Laar , C , van der Noll , J , Vasiutynskyi , V , Vohra , N , Zapata-Calvente , A L & Zukauskiene , R 2020 , ' Country-level and individual-level predictors of men's support for gender equality in 42 countries ' , European Journal of Social Psychology , vol. 50 , no. 6 , pp. 1276-1291 . https://doi.org/10.1002/ejsp.2696
Men sometimes withdraw support for gender equality movements when their higher gender status is threatened. Here, we expand the focus of this phenomenon by examining it cross-culturally, to test if both individual- and country-level variables predict men's collective action intentions to support gender equality. We tested a model in which men's zero-sum beliefs about gender predict reduced collective action intentions via an increase in hostile sexism. Because country-level gender equality may threaten men's higher gender status, we also examined whether the path from zero-sum beliefs to collective action intentions was stronger in countries higher in gender equality. Multilevel modeling on 6,734 men from 42 countries supported the individual-level mediation model, but found no evidence of moderation by country-level gender equality. Both country-level gender equality and individual-level zero-sum thinking independently predicted reductions in men's willingness to act collectively for gender equality.
BASE
In: Kosakowska-Berezecka , N , Besta , T , Bosson , J K , Jurek , P , Vandello , J A , Best , D L , Wlodarczyk , A , Safdar , S , Zawisza , M , Zadkowska , M , Sobiecki , J , Agyemang , C B , Akbas , G , Ammirati , S , Anderson , J , Anjum , G , Aruta , J J B R , Ashraf , M , Bakaityte , A , Bi , C , Becker , M , Bender , M , Berxulli , D , Bosak , J , Daalmans , S , Dandy , J , de Lemus , S , Dvorianchikov , N , Etchezahar , E , Froehlich , L , Gavreliuc , A , Gavreliuc , D , Gomez , A , Greijdanus , H , Grigoryan , A , Hale , M-L , Hamer , H , Hoorens , V , Hutchings , P B , Jensen , D H , Kelmendi , K , Khachatryan , N , Kinahan , M , Kozlowski , D , Lauri , M A , Li , J , Maitner , A T , Makashvili , A , Mancini , T , Martiny , S E , Dordevic , J M , Moreno-Bella , E , Moscatelli , S , Moynihan , A B , Muller , D , Ochoa , D , Adebayo , S O , Pacilli , M G , Palacio , J , Patnaik , S , Pavlopoulos , V , Piterova , I , Puzio , A , Pyrkosz-Pacyna , J , Renteria-Perez , E , Rousseaux , T , Sainz , M , Salvati , M , Samekin , A , Garcia-Sanchez , E , Schindler , S , Sherbaji , S , Sobhie , R , Sulejmanovic , D , Sullivan , K E , Torre , B , Torres , C , Ungaretti , J , Valshtein , T , Van Laar , C , van der Noll , J , Vasiutynskyi , V , Vohra , N , Zapata-Calvente , A L & Zukauskiene , R 2020 , ' Country-level and Individual-level Predictors of Men's Support for Gender Equality in 42 Countries ' , European Journal of Social Psychology , vol. 50 , no. 6 , pp. 1276-1291 . https://doi.org/10.1002/ejsp.2696 ; ISSN:0046-2772
Men sometimes withdraw support for gender equality movements when their higher gender status is threatened. Here, we expand the focus of this phenomenon by examining it cross-culturally, to test if both individual- and country-level variables predict men's collective action intentions to support gender equality. We tested a model in which men's zero-sum beliefs about gender predict reduced collective action intentions via an increase in hostile sexism. Because country-level gender equality may threaten men's higher gender status, we also examined whether the path from zero-sum beliefs to collective action intentions was stronger in countries higher in gender equality. Multilevel modeling on 6,734 men from 42 countries supported the individual-level mediation model, but found no evidence of moderation by country-level gender equality. Both country-level gender equality and individual-level zero-sum thinking independently predicted reductions in men's willingness to act collectively for gender equality.
BASE
Glycosylation is a topic of intense current interest in the development of biopharmaceuticals because it is related to drug safety and efficacy. This work describes results of an interlaboratory study on the glycosylation of the Primary Sample (PS) of NISTmAb, a monoclonal antibody reference material. Seventy-six laboratories from industry, university, research, government, and hospital sectors in Europe, North America, Asia, and Australia submitted a total of 103 reports on glycan distributions. The principal objective of this study was to report and compare results for the full range of analytical methods presently used in the glycosylation analysis of mAbs. Therefore, participation was unrestricted, with laboratories choosing their own measurement techniques. Protein glycosylation was determined in various ways, including at the level of intact mAb, protein fragments, glycopeptides, or released glycans, using a wide variety of methods for derivatization, separation, identification, and quantification. Consequently, the diversity of results was enormous, with the number of glycan compositions identified by each laboratory ranging from 4 to 48. In total, one hundred sixteen glycan compositions were reported, of which 57 compositions could be assigned consensus abundance values. These consensus medians provide community-derived values for NISTmAb PS. Agreement with the consensus medians did not depend on the specific method or laboratory type. The study provides a view of the current state-of-the-art for biologic glycosylation measurement and suggests a clear need for harmonization of glycosylation analysis methods.
BASE
Glycosylation is a topic of intense current interest in the development of biopharmaceuticals because it is related to drug safety and efficacy. This work describes results of an interlaboratory study on the glycosylation of the Primary Sample (PS) of NISTmAb, a monoclonal antibody reference material. Seventy-six laboratories from industry, university, research, government, and hospital sectors in Europe, North America, Asia, and Australia submitted a total of 103 reports on glycan distributions. The principal objective of this study was to report and compare results for the full range of analytical methods presently used in the glycosylation analysis of mAbs. Therefore, participation was unrestricted, with laboratories choosing their own measurement techniques. Protein glycosylation was determined in various ways, including at the level of intact mAb, protein fragments, glycopeptides, or released glycans, using a wide variety of methods for derivatization, separation, identification, and quantification. Consequently, the diversity of results was enormous, with the number of glycan compositions identified by each laboratory ranging from 4 to 48. In total, one hundred sixteen glycan compositions were reported, of which 57 compositions could be assigned consensus abundance values. These consensus medians provide community-derived values for NISTmAb PS. Agreement with the consensus medians did not depend on the specific method or laboratory type. The study provides a view of the current state-of-the-art for biologic glycosylation measurement and suggests a clear need for harmonization of glycosylation analysis methods.
BASE
In: De Leoz , M L A , Duewer , D L , Fung , A , Liu , L , Yau , H K , Potter , O , Staples , G O , Furuki , K , Frenkel , R , Hu , Y , Sosic , Z , Zhang , P , Altmann , F , Gru Nwald-Grube , C , Shao , C , Zaia , J , Evers , W , Pengelley , S , Suckau , D , Wiechmann , A , Resemann , A , Jabs , W , Beck , A , Froehlich , J W , Huang , C , Li , Y , Liu , Y , Sun , S , Wang , Y , Seo , Y , An , H J , Reichardt , N C , Ruiz , J E , Archer-Hartmann , S , Azadi , P , Bell , L , Lakos , Z , An , Y , Cipollo , J F , Pucic-Bakovic , M , Štambuk , J , Lauc , G , Li , X , Wang , P G , Bock , A , Hennig , R , Rapp , E , Creskey , M , Cyr , T D , Nakano , M , Sugiyama , T , Leung , P K A , Link-Lenczowski , P , Jaworek , J , Yang , S , Zhang , H , Kelly , T , Klapoetke , S , Cao , R , Kim , J Y , Lee , H K , Lee , J Y , Yoo , J S , Kim , S R , Suh , S K , de Haan , N , Falck , D , Lageveen-Kammeijer , G S M , Wuhrer , M , Emery , R J , Kozak , R P , Liew , L P , Royle , L , Urbanowicz , P A , Packer , N H , Song , X , Everest-Dass , A , Lattová , E , Cajic , S , Alagesan , K , Kolarich , D , Kasali , T , Lindo , V , Chen , Y , Goswami , K , Gau , B , Amunugama , R , Jones , R , Stroop , C J M , Kato , K , Yagi , H , Kondo , S , Yuen , C T , Harazono , A , Shi , X , Magnelli , P E , Kasper , B T , Mahal , L , Harvey , D J , O'Flaherty , R , Rudd , P M , Saldova , R , Hecht , E S , Muddiman , D C , Kang , J , Bhoskar , P , Menard , D , Saati , A , Merle , C , Mast , S , Tep , S , Truong , J , Nishikaze , T , Sekiya , S , Shafer , A , Funaoka , S , Toyoda , M , de Vreugd , P , Caron , C , Pradhan , P , Tan , N C , Mechref , Y , Patil , S , Rohrer , J S , Chakrabarti , R , Dadke , D , Lahori , M , Zou , C , Cairo , C , Reiz , B , Whittal , R M , Lebrilla , C B , Wu , L , Guttman , A , Szigeti , M , Kremkow , B G , Lee , K H , Sihlbom , C , Adamczyk , B , Jin , C , Karlsson , N G , Örnros , J , Larson , G , Nilsson , J , Meyer , B , Wiegandt , A , Komatsu , E , Perreault , H , Bodnar , E D , Said , N , Francois , Y N , Leize-Wagner , E , Maier , S , Zeck , A , Heck , A J R , Yang , Y , Haselberg , R , Yu , Y Q , Alley , W , Leone , J W , Yuan , H & Stein , S E 2020 , ' NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies : Comparison of Results from Diverse Analytical Methods ' , MCP : Molecular & cellular proteomics , vol. 19 , no. 1 , pp. 11-30 . https://doi.org/10.1074/mcp.RA119.001677
Glycosylation is a topic of intense current interest in the development of biopharmaceuticals because it is related to drug safety and efficacy. This work describes results of an interlaboratory study on the glycosylation of the Primary Sample (PS) of NISTmAb, a monoclonal antibody reference material. Seventy-six laboratories from industry, university, research, government, and hospital sectors in Europe, North America, Asia, and Australia submitted a total of 103 reports on glycan distributions. The principal objective of this study was to report and compare results for the full range of analytical methods presently used in the glycosylation analysis of mAbs. Therefore, participation was unrestricted, with laboratories choosing their own measurement techniques. Protein glycosylation was determined in various ways, including at the level of intact mAb, protein fragments, glycopeptides, or released glycans, using a wide variety of methods for derivatization, separation, identification, and quantification. Consequently, the diversity of results was enormous, with the number of glycan compositions identified by each laboratory ranging from 4 to 48. In total, one hundred sixteen glycan compositions were reported, of which 57 compositions could be assigned consensus abundance values. These consensus medians provide community-derived values for NISTmAb PS. Agreement with the consensus medians did not depend on the specific method or laboratory type. The study provides a view of the current state-of-the-art for biologic glycosylation measurement and suggests a clear need for harmonization of glycosylation analysis methods.
BASE
Glycosylation is a topic of intense current interest in the development of biopharmaceuticals since it is related to drug safety and efficacy. This work describes results of an interlaboratory study on the glycosylation of the Primary Sample (PS) of NISTmAb, a monoclonal antibody reference material. Seventy-six laboratories from industry, university, research, government, and hospital sectors in Europe, North America, Asia, and Australia submitted a total of 103 reports on glycan distributions. The principal objective of this study was to report and compare results for the full range of analytical methods presently used in the glycosylation analysis of mAbs. Therefore, participation was unrestricted, with laboratories choosing their own measurement techniques. Protein glycosylation was determined in various ways, including at the level of intact mAb, protein fragments, glycopeptides, or released glycans, using a wide variety of methods for derivatization, separation, identification, and quantification. Consequently, the diversity of results was enormous, with the number of glycan compositions identified by each laboratory ranging from 4 to 48. In total, one hundred sixteen glycan compositions were reported, of which 57 compositions could be assigned consensus abundance values. These consensus medians provide community-derived values for NISTmAb PS. Agreement with the consensus medians did not depend on the specific method or laboratory type. The study provides a view of the current state-of-the-art for biologic glycosylation measurement and suggests a clear need for harmonization of glycosylation analysis methods.
BASE
BMWFW (Austria) ; FWF (Austria) ; FNRS (Belgium) ; FWO (Belgium) ; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) ; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) ; Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) ; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; MES (Bulgaria) ; CERN ; CAS (China) ; MoST (China) ; NSFC (China) ; COLCIENCIAS (Colombia) ; MSES (Croatia) ; CSF (Croatia) ; RPF (Cyprus) ; SENESCYT (Ecuador) ; MoER (Estonia) ; ERC IUT (Estonia) ; ERDF (Estonia) ; Academy of Finland (Finland) ; MEC (Finland) ; HIP (Finland) ; CEA (France) ; CNRS/IN2P3 (France) ; BMBF (Germany) ; DFG (Germany) ; HGF (Germany) ; GSRT (Greece) ; OTKA (Hungary) ; NIH (Hungary) ; DAE (India) ; DST (India) ; IPM (Iran) ; SFI (Ireland) ; INFN (Italy) ; MSIP (Republic of Korea) ; NRF (Republic of Korea) ; LAS (Lithuania) ; MOE (Malaysia) ; UM (Malaysia) ; BUAP (Mexico) ; CINVESTAV (Mexico) ; CONACYT (Mexico) ; LNS (Mexico) ; SEP (Mexico) ; UASLP-FAI (Mexico) ; MBIE (New Zealand) ; PAEC (Pakistan) ; MSHE (Poland) ; NSC (Poland) ; FCT (Portugal) ; JINR (Dubna) ; MON (Russia) ; RosAtom (Russia) ; RAS (Russia) ; RFBR (Russia) ; RAEP (Russia) ; MESTD (Serbia) ; SEIDI (Spain) ; CPAN (Spain) ; PCTI (Spain) ; FEDER (Spain) ; Swiss Funding Agencies (Switzerland) ; MST (Taipei) ; ThEPCenter (Thailand) ; IPST (Thailand) ; STAR (Thailand) ; NSTDA (Thailand) ; TUBITAK (Turkey) ; TAEK (Turkey) ; NASU (Ukraine) ; SFFR (Ukraine) ; STFC (United Kingdom) ; DOE (USA) ; NSF (USA) ; Marie-Curie program (European Union) ; European Research Council (European Union) ; Horizon 2020 Grant (European Union) ; Leventis Foundation ; A.P. Sloan Foundation ; Alexander von Humboldt Foundation ; Belgian Federal Science Policy Office ; Fonds pour la Formation a la Recherche dans l'Industrie et dans l'Agriculture (FRIA-Belgium) ; Agentschap voor Innovatie door Wetenschap en Technologie (IWT-Belgium) ; Ministry of Education, Youth and Sports (MEYS) of the Czech Republic ; Council of Science and Industrial Research, India ; HOMING PLUS program of the Foundation for Polish Science ; European Union, Regional Development Fund ; Mobility Plus program of the Ministry of Science and Higher Education ; National Science Center (Poland) ; Qatar National Research Fund ; Programa Severo Ochoa del Principado de Asturias ; EU-ESF ; Greek NSRF ; Rachadapisek Sompot Fund for Postdoctoral Fellowship, Chulalongkorn University (Thailand) ; Chulalongkorn Academic into Its 2nd Century Project Advancement Project (Thailand) ; Welch Foundation ; Weston Havens Foundation (USA) ; Horizon 2020 Grant (European Union): 675440 ; National Science Center (Poland): Harmonia 2014/14/M/ST2/00428 ; National Science Center (Poland): Opus 2014/13/B/ST2/02543 ; National Science Center (Poland): 2014/15/B/ST2/03998 ; National Science Center (Poland): 2015/19/B/ST2/02861 ; National Science Center (Poland): Sonata-bis 2012/07/E/ST2/01406 ; Welch Foundation: C-1845 ; A search for the production of events containing three W bosons predicted by the standard model is reported. The search is based on a data sample of proton-proton collisions at a center-of-mass energy of 13 TeV recorded by the CMS experiment at the CERN LHC and corresponding to a total integrated luminosity of 35.9 fb(-1). The search is performed in final states with three leptons (electrons or muons), or with two same-charge leptons plus two jets. The observed (expected) significance of the signal for (WWW -/+)-W-+/--W-+/- production is 0.60 (1.78) standard deviations, and the ratio of the measured signal yield to that expected from the standard model is 0.34(-0.34)(+0.62) . Limits are placed on three anomalous quartic gauge couplings and on the production of massive axionlike particles.
BASE