Suchergebnisse

Biographical sketch.--The Flood.--The passage of the Red Sea.--Moses, character and death.--The voice of God.--The character of Paul.--The Crusade.--The Battle of Salbertrann.--The French Revolution.--Napoleon.--Napoleon and Christ.--Murat.--The passage of the Splugen.--The retreat from Russia.--Rome.--The Battle of Monmouth.--General Greene's retreat.--Democracy.--Ascent of Mount Tahawus.--The Indian and his daughter.--The influence of nature.--The music of the sea.--The American eagle.--True standard of morality. ; Mode of access: Internet.

NOTCH1 is a prevalent signaling pathway in T cell acute lymphoblastic leukemia (T-ALL), but crucial NOTCH1 downstream signals and target genes contributing to T-ALL pathogenesis cannot be retrospectively analyzed in patients and thus remain ill defined. This information is clinically relevant, as initiating lesions that lead to cell transformation and leukemia-initiating cell (LIC) activity are promising therapeutic targets against the major hurdle of T-ALL relapse. Here, we describe the generation in vivo of a human T cell leukemia that recapitulates T-ALL in patients, which arises de novo in immunodeficient mice reconstituted with human hematopoietic progenitors ectopically expressing active NOTCH1. This T-ALL model allowed us to identify CD44 as a direct NOTCH1 transcriptional target and to recognize CD44 overexpression as an early hallmark of preleukemic cells that engraft the BM and finally develop a clonal transplantable T-ALL that infiltrates lymphoid organs and brain. Notably, CD44 is shown to support crucial BM niche interactions necessary for LIC activity of human T-ALL xenografts and disease progression, highlighting the importance of the NOTCH1/CD44 axis in T-ALL pathogenesis. The observed therapeutic benefit of anti-CD44 antibody administration in xenotransplanted mice holds great promise for therapeutic purposes against T-ALL relapse. ; Ministerio de Economia y Competitividad (MINECO) PLE-2009-0110, SAF2010-15106, SAF2013-44857-R, and SAF2016-75442-R (Agencia Estatal de Investigacion/European Regional Development Fund, European Union), the Fundacion Sandra Ibarra, the Fundacion Asociacion Espanola Contra el Cancer (AECC CI13131229), the Instituto de Salud Carlos III (RTICC RD06/0014/1012), and the European Union Seventh Framework Programme (FP7/2007-20013) ThymiStem project (602587). Institutional grants from the Fundacion Ramon Areces and Banco de Santander ; Peer Reviewed

This article addresses the question of the regional impact of the Ten-T strategy in the Fehmarnbelt region (a region stretching from Malmö to Hamburg), a topic which seems overlooked in the actual discussions on green corridors at the UE level. It presents academic discussions on the matter and sets them in perspective with the current plans for developing a transport corridor across the region and the perception regional transport planning practitioners have on the matter. This article discusses the capacities of those actors to deal with questions regarding the exploitation of Ten-T infrastructure for the benefit of their region. The regional level can also be relevant for integration of sustainable transport solution to the local economic system at a level that national authorities do not have the resources to address. Finally, this article discusses how a regional anchoring allows for the adaptation of such a general EU policy to the local context so that targeted solutions are also adequate for the regions.

Phd & Post-doc position at Lund University´s Centre for Sustainability Studies: We are looking for candidates to work with us on an exciting project on glaciers and human-nature relations. We have a fully-funded PhD position and a postdoc position in Sustainability Science at LUCSUS/Lund University for the research project entitled NATURICE- Exploring plural values of human-nature relationships in glacierized … Read more Oops! These two vacancies accidentally didn´t make it to the last newsletter: