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ABSTRACTThis paper presents the findings of a major survey of independent living schemes (ILS) by the Joint Unit for Social Services Research. The survey covered 149 schemes, accommodating 349 people in four different parts of the country. Detailed information is given on the characteristics of the schemes and on the characteristics of their occupants. Four different management models are defined using the evidence from the survey, and key features of the ILS population are identified.

[EN] Imatinib is a synthetic tyrosinase inhibitor that is employed for the treatment of some kinds of human cancer. This drug has a low phototoxicity towards DNA, but its pyridylpyrimidine (1) fragment by itself exhibits significant phototoxicitiy. The intrinsic mechanism that leads to the enhanced photosafety of Imatinib is not yet known. Here, the properties of the excited state and interchromophoric interactions of Imatinib have been explored by using ultrafast laser flash photolysis and agarose electrophoresis studies. An intramolecular charge separation was directly observed for the irradiated Imatinib, which accounts for the relaxation of its excited state. An anionic form of pyridylpyrimidine (1) was deduced from the results of time-resolved resonance Raman spectra and by quenching experimental studies on compound 1 and diaminotoluene. In contrast, compound 1 efficiently transformed into triplet excited states with a long lifetime, which explained the phototoxicity associated with this fragment. This work provides insight into how to design drugs with lower phototoxicitiy or improved photostability by using interchromophoric interactions. ; This work was supported by Natural Science Foundation of China (21773151) and Shantou University Initial Funding (NTF16010). The Support from the Hong Kong Research Grants Council grants GRF 17307916, AoE/P-03/08, SEG HKU/07, The University of Hong Kong Development Fund 2013-2014 project "New Ultrafast Spectroscopy Experiments for Shared Facilities", the Spanish Government (CTQ2015-70164-P and BES-2013-066566) are also acknowledged. ; Li, M.; Yan, Z.; Zhu, R.; Phillips, DL.; Aparici-Espert, MI.; Lhiaubet, VL.; Miranda Alonso, MÁ. (2018). Enhanced Drug Photosafety by Interchromophoric Interaction Due to Intramolecular Charge Separation. Chemistry - A European Journal. 24(25):6654-6659. https://doi.org/10.1002/chem.201800716 ; S ; 6654 ; 6659 ; 24 ; 25 ; Patel, S. (2013). Long-term efficacy of imatinib for treatment of metastatic GIST. Cancer Chemotherapy and ...

Since the publication of the International Programme on Chemical Safety (IPCS) Harmonized Scheme for Mutagenicity Testing, there have been a number of publications addressing test strategies for mutagenicity. Safety assessments of substances with regard to genotoxicity are generally based on a combination of tests to assess effects on three major end points of genetic damage associated with human disease: gene mutation, clastogenicity and aneuploidy. It is now clear from the results of international collaborative studies and the large databases that are currently available for the assays evaluated that no single assay can detect all genotoxic substances. The World Health Organization therefore decided to update the IPCS Harmonized Scheme for Mutagenicity Testing as part of the IPCS project on the Harmonization of Approaches to the Assessment of Risk from Exposure to Chemicals. The approach presented in this paper focuses on the identification of mutagens and genotoxic carcinogens. Selection of appropriate in vitro and in vivo tests as well as a strategy for germ cell testing are described.

The idea of policy is ripe for critical reappraisal. Whilst the context for policy making changes constantly, multiple questions endure, such as how policy is conceived and why; what is taken for granted and what gets problematised; and how policy should be informed, analysed and understood. This book identifies key topics within the policy arena and subjects them to theoretical and practical analysis. It explores the meaning and framing of policy, and examines its practice from the micro- to the supra-national levels, using illustrative case studies to demonstrate how policy is contested, shaped and accounted for. Given the significance of policy as a means to organise and direct social, economic and political life, this book presents the case for a critical restatement of its origins, development and form - without which we risk being caught up in a cycle of change without understanding why or how. The book presents a productive encounter between the three themes of meanings, politics and practices, themes normally not brought together in a single text. It emphasizes the multiplicity of perspectives that can be directed towards understanding the policy world, opening up new ground as well as visiting anew some familiar terrain. Targeted at upper undergraduate and postgraduate students and their teachers, it will also be of interest to researchers and policy actors wanting insight to their project

Background: The Global Fund to Fight AIDS, Tuberculosis and Malaria was founded in 2002 as a public-private partnership between governments, the private sector, civil society, and populations affected by the three diseases. A key principle of the Global Fund is country ownership in accessing funding through "engagement of in-country stakeholders, including key and vulnerable populations, communities, and civil society." Research documenting whether diverse stakeholders are actually engaged and on how stakeholder engagement affects processes and outcomes of grant applications is limited.Objective: To examine representation during the 2017 Global Fund application process in the Democratic Republic of the Congo (DRC) and Uganda and the benefits and drawbacks of partnership to the process.Methods: We developed a mixed-methods social network survey to measure network structure and assess perceptions of how working together in partnership with other individuals/organizations affected perceived effectiveness, efficiency, and country ownership of the application process. Surveys were administered from December 2017–May 2018, initially to a set of central actors, followed by any individuals named during the surveys (up to 10) as collaborators. Network analyses were conducted using R.Findings: Collaborators spanning many organizations and expertise areas contributed to the 2017 applications (DRC: 152 nodes, 237 ties; Uganda: 118 nodes, 241 ties). Participation from NGOs and civil society representatives was relatively strong, with most of their ties being to different organization types, Uganda (63%), and DRC (67%), highlighting their collaborative efforts across the network. Overall, the perceived benefits of partnership were high, including very strong ratings for effectiveness in both countries. Perceived drawbacks of partnership were minimal; however, less than half of respondents thought partnership helped reduce transaction costs or financial costs, suggesting an inclusive and participatory process may come with short-term efficiency tradeoffs.Conclusions: Social network analysis can be useful for identifying who is included and excluded from the process, which can support efforts to ensure stronger, more meaningful engagement in future Global Fund application processes.

EXPOsOMICS is a European Union funded project that aims to develop a novel approach to the assessment of exposure to high priority environmental pollutants, by characterizing the external and the internal components of the exposome. It focuses on air and water contaminants during critical periods of life. To this end, the project centres on 1) exposure assessment at the personal and population levels within existing European short and long-term population studies, exploiting available tools and methods which have been developed for personal exposure monitoring (PEM); and 2) multiple "omic" technologies for the analysis of biological samples (internal markers of external exposures). The search for the relationships between external exposures and global profiles of molecular features in the same individuals constitutes a novel advancement towards the development of "next generation exposure assessment" for environmental chemicals and their mixtures. The linkage with disease risks opens the way to what are defined here as 'exposome-wide association studies' (EWAS).

Evidence of widening inequalities in later life raises concerns about the ways in which older adults might experience forms of social exclusion. Such concerns are evident in all societies as they seek to come to terms with the unprecedented ageing of their populations. Taking a broad international perspective, this highly topical book casts light on patterns and processes that either place groups of older adults at risk of exclusion or are conducive to their inclusion. Leading international experts challenge traditional understandings of exclusion in relation to ageing in From Exclusion to Inclusion in Old Age. They also present new evidence of the interplay between social institutions, policy processes, personal resources and the contexts within which ageing individuals live to show how this shapes inclusion or exclusion in later life. Dealing with topics such as globalisation, age discrimination and human rights, intergenerational relationships, poverty, and migration, the book is essential reading for anyone interested in ageing issues

INTRODUCTION: Understanding how to deliver interventions more effectively is a growing emphasis in Global Health. Simultaneously, health system strengthening is a key component to improving delivery. As a result, it is challenging to evaluate programme implementation while reflecting real-world complexity. We present our experience in using a health systems modelling approach as part of a mixed-methods evaluation and describe applications of these models. METHODS: We developed a framework for how health systems translate financial inputs into health outcomes, with in-country and international experts. We collated available data to measure framework indicators and developed models for malaria in Democratic Republic of the Congo (DRC), and tuberculosis in Guatemala and Senegal using Bayesian structural equation modelling. We conducted several postmodelling analyses: measuring efficiency, assessing bottlenecks, understanding mediation, analysing the cascade of care and measuring subnational effectiveness. RESULTS: The DRC model indicated a strong relationship between shipment of commodities and utilisation thereof. In Guatemala, the strongest model coefficients were more evenly distributed. Results in Senegal varied most, but pathways related to community care had the strongest relationships. In DRC, we used model results to estimate the end-to-end cost of delivering commodities. In Guatemala, we used model results to identify potential bottlenecks and understand mediation. In Senegal, we used model results to identify potential weak links in the cascade of care, and explore subnationally. CONCLUSION: This study demonstrates a complementary modelling approach to traditional evaluation methods. Although these models have limitations, they can be applied in a variety of ways to gain greater insight into implementation and functioning of health service delivery.

Starting in the early 1990s, journalists and scholars began responding to and trying to take account of new technologies and their impact on our lives. By the end of the decade, the full-fledged study of cyberculture had arrived. Today, there exists a large body of critical work on the subject, with cutting-edge studies probing beyond the mere existence of virtual communities and online identities to examine the social, cultural, and economic relationships that take place online.Taking stock of the exciting work that is being done and positing what cyberculture's future might look like, Critical Cyberculture Studies brings together a diverse and multidisciplinary group of scholars from around the world to assess the state of the field. Opening with a historical overview of the field by its most prominent spokesperson, it goes on to highlight the interests and methodologies of a mobile and creative field, providing a much-needed how-to guide for those new to cyberstudies. The final two sections open up to explore issues of race, class, and gender and digital media's ties to capital and commerce-from the failure of dot-coms to free software and the hacking movement.This flagship book is a must-read for anyone interested in the dynamic and increasingly crucial study of cyberculture and new technologies

As the drive towards creating age-friendly cities grows, this important book provides a comprehensive survey of theories and policies aimed at improving the quality of life of older people living in urban areas. In this book, part of the Ageing in a Global Context series, leading international researchers critically assess the problems and the potential of designing age-friendly environments. The book considers the different ways in which cities are responding to population ageing, the different strategies for developing age-friendly communities, and the extent to which older people themselves can be involved in the co-production of age-friendly policies and practices. The book includes a manifesto for the age-friendly movement, focused around tackling social inequality and promoting community empowerment