What could be the future of rational choice for crime prevention? / Benoit Leclerc and Danielle M. Reynald -- Does situational crime prevention require a rational offender? / Richard Wortley and Nick Tilley -- Hot criminology or what Homer's Odyssea can teach criminologists about decision making / Jean-Louis van Gelder -- Theorising forensic science : a model for crime prevention / Paul Knepper -- A baseline model of deterrence / Matthew Manning -- Another look at person-situation interaction : what offenders are sensitive to what situational crime prevention measures? / Henk Elffers and Danielle M. Reynald
In this issue, we discuss heritage construction processes by focusing on configurations in which territory and identity seem intertwined. We propose to distinguish between "identity territories" and/or "territorialized identities". The collected contributions explore specific cases from South America (Argentina, Brazil, Mexico, Colombia, and Peru), Africa (Turkey, Niger, and Nubia), Asia (China) and the Indian Ocean. They highlight the effects of scales, the issues of territorial control and access to natural resources, and outline ways in which the relationship between tourism, the commodification of heritage and nationalist discourses can be traced. Combining an interdisciplinary approach across many geographical areas, this thematic issue explores one of the central mechanisms of heritage-making: the inherent tensions generated by the injunction of a correspondence between territories and identities. ; Research co-funded by the following projects : MSCA-RISE 2015 ODYSSEA ; ANR-12-CULT-005 FABRIQ'AM ; CAPES-Cofecub Sh 811-14
Este artigo apresenta uma pesquisa realizada de forma participativa na Amazônia brasileira, na região de Santarém, Pará. O objetivo foi entender como as grandes mudanças socioambientais estão afetando os agricultores familiares. Nos últimos 20 anos, a agricultura familiar, na área de estudo, tem sido confrontada com a rápida expansão de monoculturas de grande escala, principalmente o cultivo de soja. Como parte do Observatório Socioambiental Odyssea, pesquisadores acadêmicos e organizações de agricultura familiar firmaram uma parceria para coproduzir dados que poderiam ser estrategicamente úteis para estas organizações. Um processo de coconstrução de demandas por conhecimento permitiu o estabelecimento de prioridades e a definição da estratégia de coleta de dados. Três níveis de análise foram escolhidos para permitir uma compreensão integrada das dinâmicas das mudanças socioambientais: o nível do território do Planalto de Santarém, o nível da comunidade rural (lugar de vida reconhecido pelos agricultores) e as famílias dos agricultores. Jovens pesquisadores comunitários aplicaram um questionário através de um aplicativo de celular com 544 famílias nos municípios de Santarém, Mojuí dos Campos e Belterra. Anteriormente, foram realizadas reuniões nas comunidades rurais e aplicados questionários com representantes de 32 comunidades. Os dados foram coletados entre abril e junho de 2019. Os pesquisadores comunitários e acadêmicos se reuniram então para duas sessões coletivas de análise e interpretação de dados, em julho e outubro de 2019. Os dados foram padronizados e limpos usando o software SPSS, entre setembro e dezembro de 2019. Os metadados e bancos de dados estão disponíveis no dataverse do CIRAD.
Autophagy is an evolutionarily ancient process whereby eukaryotic cells eliminate disposable or potentially dangerous cytoplasmic material, to support bioenergetic metabolism and adapt to stress. Accumulating evidence indicates that autophagy operates as a critical quality control mechanism for the maintenance of hepatic homeostasis in both parenchymal (hepatocytes) and non-parenchymal (stellate cells, sinusoidal endothelial cells, Kupffer cells) compartments. In line with this notion, insufficient autophagy has been aetiologically involved in the pathogenesis of multiple liver disorders, including alpha-1-antitrypsin deficiency, Wilson disease, non-alcoholic steatohepatitis, liver fibrosis and hepatocellular carcinoma. Here, we critically discuss the importance of functional autophagy for hepatic physiology, as well as the mechanisms whereby defects in autophagy cause liver disease. ; Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT), CONICYT FONDECYT: 3180427, 1140549, 1180186. Breakthrough Level 2 grant from the US DoD, Breast Cancer Research Program (BCRP): BC180476P1. Dept. of Radiation Oncology at Weill Cornell Medicine (New York, US). Lytix (Oslo, Norway). Phosplatin (New York, US). Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT), CONICYT FONDAP: 15150012. Takeda Pharmaceutical Company Ltd. P09-015-F. European Commission RD MSCA-RISE: 734749. Michael J Fox Foundation for Parkinson's Research - Target Validation grant: 9277. FONDEF: ID16I10223, D11E1007. Office of Naval Research: N62909-16-1-2003. United States Department of Defense, Air Force Office of Scientific Research (AFOSR): FA9550-16-1-0384. ALSRP Therapeutic Idea Award: AL150111. Muscular Dystrophy Association: 382453. CONICYT Brazil: 441921/2016-7. Ligue contre le Cancer (equipe labellisee). French National Research Agency (ANR). French National Research Agency (ANR). Fondation ARC pour la Recherche sur le Cancer. Region Ile-de-France. Chancelerie des universites de Paris (Legs Poix), Fondation pour la Recherche Medicale (FRM) European Research Area Network on Cardiovascular Diseases (ERACVD, MINOTAUR) Gustave Roussy Odyssea, the European Union Horizon 2020 Project Oncobiome Fondation Carrefour Institut National du Cancer (INCA) France: GDW20171100085, GDW20181100051. Inserm (HTE). Inserm Transfert, Institut Universitaire de France. Leducq Foundation. LabEx Immuno-Oncology. RHU Torino Lumiere. Seerave Foundation. SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE). SIRIC Cancer Research and Personalized Medicine (CARPEM).
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) ; Empresa Brasileira de Pesquisa Agropecuaria - Embrapa ; UK Government Darwin Initiative ; Nature Conservancy ; UK Natural Environment Research Council (NERC) ; H2020-MSCA-RISE-2015 ; CNPq: 574008/2008-0 ; Empresa Brasileira de Pesquisa Agropecuaria - Embrapa: SEG: 02.08.06.005.00 ; UK Government Darwin Initiative: 17-023 ; UK Natural Environment Research Council (NERC): NE/ F01614X/1 ; UK Natural Environment Research Council (NERC): NE/G000816/1 ; UK Natural Environment Research Council (NERC): NE/K016431/1 ; UK Natural Environment Research Council (NERC): NE/P004512/1 ; H2020-MSCA-RISE-2015: 691053-ODYSSEA ; CNPq: PELD-RAS 441659/2016-0 ; CNPq: 458022/2013-6 ; CNPq: 305054/ 2016-3 ; Wildfires produce substantial CO2 emissions in the humid tropics during El Nino-mediated extreme droughts, and these emissions are expected to increase in coming decades. Immediate carbon emissions from uncontrolled wildfires in human-modified tropical forests can be considerable owing to high necromass fuel loads. Yet, data on necromass combustion duringwildfires are severely lacking. Here, we evaluated necromass carbon stocks before and after the 2015-2016 El Nino in Amazonian forests distributed along a gradient of prior human disturbance. We then used Landsat-derived burn scars to extrapolate regional immediate wildfire CO2 emissions during the 20152016 El Nino. Before the El Nino, necromass stocks varied significantly with respect to prior disturbance and were largest in undisturbed primary forests (30.2 +/- 2.1 Mg ha(-1), mean +/- s. e.) and smallest in secondary forests (15.6 +/- 3.0 Mg ha(-1)). However, neither prior disturbance nor our proxy of fire intensity (median char height) explained necromass losses due towildfires. In our 6.5 million hectare (6.5 Mha) study region, almost 1 Mha of primary (disturbed and undisturbed) and 20 000 ha of secondary forest burned during the 2015-2016 ElNino. Covering less than 0.2% of Brazilian Amazonia, thesewildfires resulted in expected immediate CO2 emissions of approximately 30 Tg, three to four times greater than comparable estimates fromglobal fire emissions databases. Uncontrolled understoreywildfires in humid tropical forests during extreme droughts are a large and poorly quantified source of CO2 emissions. This article is part of a discussion meeting issue 'The impact of the 2015/2016 El Nino on the terrestrial tropical carbon cycle: patterns, mechanisms and implications'.
Pro-apoptotic multi-domain proteins of the BCL2 family such as BAX and BAK are well known for their important role in the induction of mitochondrial outer membrane permeabilization (MOMP), which is the rate-limiting step of the intrinsic pathway of apoptosis. Human or mouse cells lacking both BAX and BAK (due to a double knockout, DKO) are notoriously resistant to MOMP and cell death induction. Here we report the surprising finding that BAX/BAK DKO cells proliferate less than control cells expressing both BAX and BAK (or either BAX or BAK) when they are driven into tetraploidy by transient exposure to the microtubule inhibitor nocodazole. Mechanistically, in contrast to their BAX/BAK-sufficient controls, tetraploid DKO cells activate a senescent program, as indicated by the overexpression of several cyclin-dependent kinase inhibitors and the activation of β-galactosidase. Moreover, DKO cells manifest alterations in ionomycin-mobilizable endoplasmic reticulum (ER) Ca2+ stores and store-operated Ca2+ entry that are affected by tetraploidization. DKO cells manifested reduced expression of endogenous sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2a (Serca2a) and transfection-enforced reintroduction of Serca2a, or reintroduction of an ER-targeted variant of BAK into DKO cells reestablished the same pattern of Ca2+ fluxes as observed in BAX/BAK-sufficient control cells. Serca2a reexpression and ER-targeted BAK also abolished the tetraploidy-induced senescence of DKO cells, placing ER Ca2+ fluxes downstream of the regulation of senescence by BAX/BAK. In conclusion, it appears that BAX/BAK prevent the induction of a tetraploidizationassociated senescence program. Speculatively, this may contribute to the low incidence of cancers in BAX/BAK DKO mice and explain why human cancers rarely lose the expression of both BAX and BAK. ; Beatriz Galindo senior program of the Spanish Ministry of Universities Junta de Castilla y Leon CCVC8485 Ligue contre le Cancer (equipe labellisee) French National Research Agency (ANR) AMMICa US23/CNRS UMS3655 Association "Ruban Rose" Region Ile-de-France Fondation pour la Recherche Medicale Equipex Onco-Pheno-Screen European Joint Programme on Rare Diseases (EJPRD) Gustave Roussy Odyssea European Commission Fondation Carrefour Institut National du Cancer (INCA) France Inserm (HTE) Institut Universitaire de France LabEx Immuno-Oncology ANR-18-IDEX-0001 Leducq Foundation Cancer Research ASPIRE Award from the Mark Foundation Programme de cooperation ECO-Sud C17S02 RHU Torino Lumiere Seerave Foundation SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE) SIRIC Cancer Research and Personalized Medicine (CARPEM) Spanish Government RTI2018-099298-B-100 Junta de Castilla y Leon CA9751 Programa Estrategico IBGM, Junta de Castilla y Leon, Spain CCVC8485 ; Versión publicada - versión final del editor
İrlanda'nın İngiltere ile arasındaki kökleri on ikinci yüzyıla uzanan sömürge ilişkisi göz önüne alındığında İrlandalı yazarların İngiliz edebiyat kanonunda kapladığı yer dikkat çekicidir. Bağımsızlığını kazandığı 1921 tarihine kadar İngiltere'nin sömürgelerinden biri olarak kimlik mücadelesi veren İrlanda'nın bu durumu, son zamanlarda yaygınlık kazanan sömürge kuramları içerisinde çoğunlukla göz ardı edilmiştir. Gerek batıda yer alması gerekse İngiltere'ye jeografik olarak çok yakın olması nedeniyle İrlanda'nın sömürge konumu bu ülkeye özel sonuçlar doğurmuştur. İrlandalılar yüzyıllarca Avrupa'nın Keltik zencileri olarak görülmüş, politik ve kültürel söylem içerisinde "öteki" olarak nitelendirilmiştir. Politik ve kültürel alanda kimliğini geri kazanmak isteyen İrlandalılar on dokuzuncu yüzyılda W. B. Yeats ve Douglas Hyde gibi yazar ve şairlerin öncülük ettiği bir edebiyat ve kültür hareketi başlatmışlardır. İrlanda dilini ve kültürünü canlandırmayı amaçlayan bu hareket politik bağımsızlık mücadelesini ve milliyetçilik hareketini ateşlemesi açısından önemlidir. Bu tezin amacı, yalnızca İngiliz edebiyat kanonunda değil, bütün dünya edebiyatı içerisinde modernizmin ikonu olarak baş tacı edilen ve İrlandalı bir yazar olan James Joyce'un Ulysses adlı romanındaki yenilikçi modernist yazım tekniklerini yazarın İrlanda milliyetçiliğine ve İngiliz emperyalizmine karşı politik duruşunun ifadesi olarak incelemektir. Son zamanlara kadar apolitik bir yazar olarak ele alınan ve eserleri modernist akım içerisinde genellikle sadece yapısal olarak incelenen James Joyce'un Ulysses'te uyguladığı anlatım teknikleri ve romanın diyalojik ve karnivalesk yapısı yazarın politik ve ideolojik tavrının bir sonucudur. Tezin birinci bölümünde James Joyce'un İrlanda'da on dokuzuncu yüzyılın başında ortaya çıkan Keltik Uyanış Hareketine yaklaşımı incelenmiştir. Joyce'un politik tavrını belirginleştirmesi bakımından, yazarın bu hareket içerisindeki yeri irdelenmeden önce İrlanda ve İngiltere arasındaki sömürge ilişkisi politik ve kültürel açılardan ele alınmış, yüzyıllar içerisinde Avrupa'da, özellikle de İngiltere'de oluşturulan İrlanda sterotipi ortaya konulmuştur. Yazarın ideolojik duruşu romanlarından örnekler verilerek irdelenmiştir. Tezin ikinci bölümünde Ulysses'in yenilikçi dil ve anlatım teknikleri Mikhail Bakhtin'in "diyalojizm", "polifoni", "karnivalesk" ve "kronotop" kavramları çerçevesinde incelenmiştir. Birçok ideolojinin ve sesin polifonik bir anlatım yapısı içerisinde sunulması ve hiçbir idelojiye, yazarın ideolojisi de dahil olmak üzere, ayrıcalık tanınarak ön plana çıkartılmaması Joyce'un hem İrlanda milliyetçiliği hem de İngiliz emperyalizminin benimsediği "ben ve öteki" dikotomisine bir karşı çıkıştır. Yazarın dil ve anlatım tekniklerinde uyguladığı yapıbozum geleneksel edebiyat anlayışını yıkmakla beraber, birey ve tarih ilişkisine de yeni bir yaklaşım getirmiştir. Her türlü hiyerarşinin ve dikotominin alaşağı edildiği Ulysses'te olaylar İrlanda'nın Dublin kentinde 14 Haziran 1914 tarihinde sadece bir gün içerisinde geçmesine rağmen, roman gerçekte bütün bir insanlığa ve tüm zamanlara ayna tutar. Böylece, yerel bir noktadan yola çıkarak evrensel bir boyuta ulaşır. Merkezden dışarıya doğru ilerleyen yapısıyla her türlü merkeziyetçi ve tekelci söylemlere başkaldırır. Üçüncü bölümde ise Ulysses'in İrlandalı kimliği mercek altına alınmıştır. Romandaki ana karakterler İrlanda tarihi ve Keltik mitolojisi ile paralellikler kurularak incelenmiştir. Adını Homeros'un Odyssea adlı epiğinden alan Ulysses yakın zamanlara kadar bu epikle paralellik kurularak ele alınmıştır. Oysa ki, romanın baş kahramanları olan Yahudi Leopold Bloom, Katolik İrlandalı Stephen Dedalus ve İspanyol kökenli Molly Bloom İrlanda'nın kavim ve göç tarihindeki belirgin ilişkilere ışık tutar. Sonuç olarak, bu çalışmada James Joyce'un Ulysses adlı romanı, yazarın İrlanda milliyetçiliği ve İngiliz emperyalizmi söylemlerine ve her türlü dikotomilere karşı ortaya koyduğu politik ve ideolojik bir başkaldırı olarak incelenmiş, eserin diyalojik, polifonik ve karnivalesk yapısı ile radikal yazım teknikleri yeni okumalar ışığında değerlendirilmiştir.
UK Natural Environment Research Council ; European Research Council Advanced Investigator Award (GEM-TRAIT) ; Nature Conservancy-Oxford Martin School Climate Partnership ; NERC ; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) ; Gordon and Betty Moore Foundation ; Sime Darby Foundation ; Project USA-NAS/PEER ; Project ReFlor FAPEMAT ; Empresa Brasileira de Pesquisa Agropecuaria - Embrapa ; European Research Council (H2020-MSCA-RISE-2015) ; UK government Darwin Initiative ; Nature Conservancy ; UK Natural Environment Research Council (NERC) ; Jackson Foundation ; UK Natural Environment Research Council: NE/P001092/1 ; European Research Council Advanced Investigator Award (GEM-TRAIT): 321131 ; NERC: NE/I014705/1 ; NERC: NE/K016369/1 ; NERC: NE/F005776/1 ; NERC: NE/K016385/1 ; NERC: NE/J011002/1 ; CNPq: 457914/2013-0/MCTI/ CNPq/FNDCT/LBA/ESECAFLOR ; CNPq: 403725/ 2012-7 ; CNPq: 441244/2016-5 ; CNPq: 457602/2012-0 ; Project USA-NAS/PEER: PGA-2000005316 ; Project ReFlor FAPEMAT: 0589267/2016 ; CNPq: 574008/2008-0 ; Empresa Brasileira de Pesquisa Agropecuaria - Embrapa: SEG: 02.08.06.005.00 ; European Research Council (H2020-MSCA-RISE-2015): 691053-ODYSSEA ; UK government Darwin Initiative: 17-023 ; UK Natural Environment Research Council (NERC): NE/F01614X/1 ; UK Natural Environment Research Council (NERC): NE/G000816/1 ; UK Natural Environment Research Council (NERC): NE/K016431/1 ; UK Natural Environment Research Council (NERC): NE/P004512/1 ; : PQ-2 ; Meteorological extreme events such as El Nino events are expected to affect tropical forest net primary production (NPP) and woody growth, but there has been no large-scale empirical validation of this expectation. We collected a large high-temporal resolution dataset (for 1-13 years depending upon location) of more than 172 000 stem growth measurements using dendrometer bands from across 14 regions spanning Amazonia, Africa and Borneo in order to test how much month-to-month variation in stand-level woody growth of adult tree stems (NPPstem) can be explained by seasonal variation and interannual meteorological anomalies. A key finding is that woody growth responds differently to meteorological variation between tropical forests with a dry season (where monthly rainfall is less than 100 mm), and aseasonal wet forests lacking a consistent dry season. In seasonal tropical forests, a high degree of variation in woody growth can be predicted from seasonal variation in temperature, vapour pressure deficit, in addition to anomalies of soil water deficit and shortwave radiation. The variation of aseasonal wet forest woody growth is best predicted by the anomalies of vapour pressure deficit, water deficit and shortwave radiation. In total, we predict the total live woody production of the global tropical forest biome to be 2.16 Pg C yr(-1), with an interannual range 1.96-2.26 Pg C yr(-1) between 1996-2016, and with the sharpest declines during the strong El Nino events of 1997/8 and 2015/6. There is high geographical variation in hotspots of El Nino-associated impacts, with weak impacts in Africa, and strongly negative impacts in parts of Southeast Asia and extensive regions across central and eastern Amazonia. Overall, there is high correlation (r = -0.75) between the annual anomaly of tropical forest woody growth and the annual mean of the El Nino 3.4 index, driven mainly by strong correlations with anomalies of soil water deficit, vapour pressure deficit and shortwave radiation. This article is part of the discussion meeting issue 'The impact of the 2015/2016 El Nino on the terrestrial tropical carbon cycle: patterns, mechanisms and implications'.