Suchergebnisse

ObjectivesAdvancements in mental health research depend upon continuing development of the data landscape, including the creation of population cohorts that combine different types of data from a variety of sources. The present project aimed to produce a new, multi-faceted mental health e-cohort to benefit further research.
ApproachTaking advantage of a standing research resource – the SHARE Scotland research register (N ~ 285,000) – we administered an online survey of mental health, treatment use and wellbeing. Over 10,000 individuals (Mean age = 57.16 years; 63% female) took part in the survey; all participants consented to secure linkage of their routinely-collected health records with questionnaire data and over 90% also consented to the research use of genetic data gained from diverted blood samples. We linked questionnaire responses with routinely-collected health data and genetic data within a Trusted Research Environment to create a large cohort enhanced for mental health research.
ResultsIn this presentation we describe the cohort, summarise responses to the mental health questionnaire and give some example research uses of the linked data. Focussing on depression, we contrast the prevalence of self-reported diagnoses of depression (27% of the sample) with diagnostic codes from routinely-collected hospital admission and national prescribing data and examine predictors of each.
ConclusionsCombining mental health questionnaire data, longitudinal health records, and genetic data creates new opportunities for mental health research and allows researchers to compare the utility of each data source. By making this new e-cohort available to other researchers we hope to drive advancements in mental health research.

As online relationship education programs continue to grow in prevalence, there emerges a need for anonymous feedback that is useful for improving content and processes that program participants experience. Additionally, as micro-content is used to educate others on relationship knowledge and skills, qualitative feedback can help explore the most appropriate means of content delivery. This paper reports on qualitative feedback that was organized and coded using thematic analysis. These themes provide clear input for structuring online content for all relationship education programs, including those structured in abbreviated "micro-content" formats.

Acknowledgements ICP acknowledges funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement No: 787203 REALM). MN acknowledges support from the Austrian Science Fund (FWF), grant No. J4211- N29. ; Peer reviewed ; Publisher PDF

Eucalypts are among the highest emitters of biogenic volatile organic compounds, yet there is relatively little data available from field studies of this genus. Emissions of isoprene, monoterpenes and the short-chained carbonyls formaldehyde, acetaldehyde and acetone were determined from four species (Eucalyptus camaldulensis, Eucalyptus globulus, Eucalyptus grandis, and Eucalytpus viminalis) in Australia. A smaller comparative study was conducted on E. camaldulensis in south-eastern Australia. Carbonyl emissions, reported here for the first time from eucalypts, were generally comparable with rates reported for other species, with diurnal emissions peaking at about 4, 75 and 34 nmol m-2 min-1 for acetone, formaldehyde and acetaldehyde respectively. There was wide variation in diurnal isoprene and monoterpene emissions between species, but under standard conditions, isoprene emissions were much lower than previous reports. Conversely, standard emission rates of monoterpenes were as much as six times greater than previous reports for some species. Emission of each carbonyl was correlated with its ambient concentration across different species, but more weakly related to temperature. Acetaldehyde emission in particular was significantly correlated with transpiration, but not with sap flow or with ethanol concentrations in xylem sap, suggesting fermentation within the leaf and stomatal conductance are primary controlling processes. Differences in acetaldehyde exchange velocities between sites, in addition to transpiration differences, suggest stomata may indeed exert long term emission regulation, in contrast to compounds for which no biological sink exists.

Acknowledgements We would like to thank Wenlong Huang, Giuseppe D'Agostino and the staff of the University of Aberdeen Medical Research Facility for their help and advice with the animal tests. AMcE was funded by BBSRC project grant (BB/N017544/1) and EH was funded by Medical Research Scotland (PhD-719-2013). PB and DW are funded by the Scottish Government Rural and Environment Science and Analytical Services Division to the Rowett Institute. Association studies were conducted using the UK Biobank Resource: application number 4844 and was supported by a Wellcome Trust Strategic Award 'Stratifying Resilience and Depression Longitudinally' (STRADL) (Reference 104036/Z/14/Z). Dedicated to the memory of my brother Angus MacKenzie (1963-2018). ; Non peer reviewed ; Publisher PDF

We are grateful to the families who took part in GS:SFHS, general practitioners and the Scottish School of Primary Care for their help in recruitment, and the whole GS:SFHS team that includes academic researchers, clinic staff, laboratory technicians, clerical workers, IT staff, statisticians and research managers. The research reported here, and the genotyping of GS:SFHS samples was funded by the Wellcome Trust, (Wellcome Trust Strategic Award 'STratifying Resilience and Depression Longitudinally' (STRADL) Reference 104036/Z/14/Z) and by the Medical Research Council. SF acknowledges support from the National Institute of Mental Health, USA (R01MH113619; R01MH116147) and the consortium for Psychopathology and Allostatic load across the Life Span (PALS; https://www.pals-network.org) AMM acknowledges the financial support received from the Dr. Mortimer and Theresa Sackler Foundation. IJD and AMM are members of The University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology, part of the cross council Lifelong Health and Wellbeing Initiative (MR/K026992/1). Generation Scotland received core support from the Chief Scientist Office of the Scottish Government Health Directorates (CZD/16/6) and the Scottish Funding Council (HR03006). Funding from the Biotechnology and Biological Sciences Research Council and Medical Research Council is gratefully acknowledged. ; Peer reviewed ; Publisher PDF