A pesquisa em educação tem se destacado cada vez mais, refletindo a necessidade de encontrar práticas inovadoras para tornar o processo de ensino e aprendizagem mais eficaz,. mais significativos e acolhedor para os estudantes. Uma revisão bibliográfica revelou diversas abordagens e temáticas exploradas por pesquisadores nesse contexto. Entre as principais tendências educacionais identificadas, destacam-se a interdisciplinaridade, a pesquisa qualitativa e as tecnologias, que foram objetos de estudo nesta pesquisa. Ao examinar obras de autores especializados nessas temáticas, este estudo discute as implicações dessas tendências para a prática pedagógica e os desafios enfrentados pelos educadores na contemporaneidade. As tendências na pesquisa buscam elucidar os problemas existentes e apontar possíveis soluções, partindo da premissa de que esses temas estão diretamente relacionados a contextos baseados na prática e na intervenção. O objetivo primordial é aprimorar os resultados educacionais e promover a equidade no ambiente escolar. Essa abordagem proativa busca não apenas identificar questões, mas também contribuir para a evolução constante do ambiente educacional, destacando a necessidade de práticas inovadoras, intervenções eficazes e uma abordagem equitativa para fortalecer a qualidade do ensino e proporcionar experiências de aprendizagem mais enriquecedoras para os estudantes.
Primary cilia are sensory organelles crucial for cell signaling during development and organ homeostasis. Cilia arise from centrosomes and their formation and function is governed by numerous factors. Through our studies on Townes-Brocks Syndrome (TBS), a rare disease linked to abnormal cilia formation in human fibroblasts, we uncovered the leucine-zipper protein LUZP1 as an interactor of truncated SALL1, a dominantly-acting protein causing the disease. Using TurboID proximity labeling and pulldowns, we show that LUZP1 associates with factors linked to centrosome and actin filaments. Here, we show that LUZP1 is a cilia regulator. It localizes around the centrioles and to actin cytoskeleton. Loss of LUZP1 reduces F-actin levels, facilitates ciliogenesis and alters Sonic Hedgehog signaling, pointing to a key role in cytoskeleton-cilia interdependency. Truncated SALL1 increases the ubiquitin proteasome-mediated degradation of LUZP1. Together with other factors, alterations in LUZP1 may be contributing to TBS etiology. ; Grants which have funded this research: BFU2017-84653-P (MINECO/FEDER, EU) SEV-2016-0644 (Severo Ochoa Excellence Program) 765445-EU (UbiCODE Program) SAF2017-90900-REDT (UBIRed Program) IT634-13 (Basque Country Government)
International audience ; BACterial Hosts for production of Bioac-tive phenolics from bERRY fruits (BacHBerry) was a 3-year project funded by the Seventh Framework Programme (FP7) of the European Union that ran between November 2013 and October 2016. The overall aim of the project was to establish a sustainable and economically-feasible strategy for the production This article is written by the BacHBerry consortium (www. bachberry.eu) and represents the collective effort of all participating institutions. The authors are therefore listed in alphabetical order. Electronic supplementary material The online version of this article (
International audience ; BACterial Hosts for production of Bioac-tive phenolics from bERRY fruits (BacHBerry) was a 3-year project funded by the Seventh Framework Programme (FP7) of the European Union that ran between November 2013 and October 2016. The overall aim of the project was to establish a sustainable and economically-feasible strategy for the production This article is written by the BacHBerry consortium (www. bachberry.eu) and represents the collective effort of all participating institutions. The authors are therefore listed in alphabetical order. Electronic supplementary material The online version of this article (
International audience ; BACterial Hosts for production of Bioac-tive phenolics from bERRY fruits (BacHBerry) was a 3-year project funded by the Seventh Framework Programme (FP7) of the European Union that ran between November 2013 and October 2016. The overall aim of the project was to establish a sustainable and economically-feasible strategy for the production This article is written by the BacHBerry consortium (www. bachberry.eu) and represents the collective effort of all participating institutions. The authors are therefore listed in alphabetical order. Electronic supplementary material The online version of this article (
International audience ; BACterial Hosts for production of Bioac-tive phenolics from bERRY fruits (BacHBerry) was a 3-year project funded by the Seventh Framework Programme (FP7) of the European Union that ran between November 2013 and October 2016. The overall aim of the project was to establish a sustainable and economically-feasible strategy for the production This article is written by the BacHBerry consortium (www. bachberry.eu) and represents the collective effort of all participating institutions. The authors are therefore listed in alphabetical order. Electronic supplementary material The online version of this article (
In: Dudnik , A , Almeida , A F , Andrade , R , Avila , B , Banados , P , Barbay , D , Bassard , J-E , Benkoulouche , M , Bott , M , Braga , A , Breitel , D , Brennan , R , Bulteau , L , Chanforan , C , Costa , I , Costa , R S , Doostmohammadi , M , Faria , N , Feng , C , Fernandes , A , Ferreira , P , Ferro , R , Foito , A , Freitag , S , Garcia , G , Gaspar , P , Godinho-Pereira , J , Hamberger , B , Hartmann , A , Heider , H , Jardim , C , Julien-Laferriere , A , Kallscheuer , N , Kerbe , W , Kuipers , O P , Li , S , Love , N , Marchetti-Spaccamela , A , Marienhagen , J , Martin , C , Mary , A , Mazurek , V , Meinhart , C , Sevillano , D M , Menezes , R , Naesby , M , Norholm , M H H , Okkels , F T , Ottens , M & Solopova , A 2018 , ' BacHBerry : BACterial Hosts for production of Bioactive phenolics from bERRY fruits ' , Phytochemistry reviews , vol. 17 , no. 2 , pp. 291-326 . https://doi.org/10.1007/s11101-017-9532-2 ; ISSN:1568-7767
BACterial Hosts for production of Bioactive phenolics from bERRY fruits (BacHBerry) was a 3-year project funded by the Seventh Framework Programme (FP7) of the European Union that ran between November 2013 and October 2016. The overall aim of the project was to establish a sustainable and economically-feasible strategy for the production of novel high-value phenolic compounds isolated from berry fruits using bacterial platforms. The project aimed at covering all stages of the discovery and pre-commercialization process, including berry collection, screening and characterization of their bioactive components, identification and functional characterization of the corresponding biosynthetic pathways, and construction of Gram-positive bacterial cell factories producing phenolic compounds. Further activities included optimization of polyphenol extraction methods from bacterial cultures, scale-up of production by fermentation up to pilot scale, as well as societal and economic analyses of the processes. This review article summarizes some of the key findings obtained throughout the duration of the project.
In: Dudnik , A , Almeida , A F , Andrade , R , Avila , B , Bañados , P , Barbay , D , Bassard , J E , Benkoulouche , M , Bott , M , Braga , A , Breitel , D , Brennan , R , Bulteau , L , Chanforan , C , Costa , I , Costa , R S , Doostmohammadi , M , Faria , N , Feng , C , Fernandes , A , Ferreira , P , Ferro , R , Foito , A , Freitag , S , Garcia , G , Gaspar , P , Godinho-Pereira , J , Hamberger , B , Hartmann , A , Heider , H , Jardim , C , Julien-Laferriere , A , Kallscheuer , N , Kerbe , W , Kuipers , O P , Li , S , Love , N , Marchetti-Spaccamela , A , Marienhagen , J , Martin , C , Mary , A , Mazurek , V , Meinhart , C , Sevillano , D M , Menezes , R , Naesby , M , Nørholm , M H H , Okkels , F T , Oliveira , J , Ottens , M , Parrot , D , Pei , L , Rocha , I , Rosado-Ramos , R , Rousseau , C , Sagot , M F , dos Santos , C N , Schmidt , M , Shelenga , T , Shepherd , L , Silva , A R , da Silva , M H , Simon , O , Stahlhut , S G , Solopova , A , Sorokin , A , Stewart , D , Stougie , L , Su , S , Thole , V , Tikhonova , O , Trick , M , Vain , P , Veríssimo , A , Vila-Santa , A , Vinga , S , Vogt , M , Wang , L , Wang , L , Wei , W , Youssef , S , Neves , A R & Forster , J 2018 , ' BacHBerry : BACterial Hosts for production of Bioactive phenolics from bERRY fruits ' , Phytochemistry Reviews , vol. 17 , no. 2 , pp. 291-326 . https://doi.org/10.1007/s11101-017-9532-2
BACterial Hosts for production of Bioactive phenolics from bERRY fruits (BacHBerry) was a 3-year project funded by the Seventh Framework Programme (FP7) of the European Union that ran between November 2013 and October 2016. The overall aim of the project was to establish a sustainable and economically-feasible strategy for the production of novel high-value phenolic compounds isolated from berry fruits using bacterial platforms. The project aimed at covering all stages of the discovery and pre-commercialization process, including berry collection, screening and characterization of their bioactive components, identification and functional characterization of the corresponding biosynthetic pathways, and construction of Gram-positive bacterial cell factories producing phenolic compounds. Further activities included optimization of polyphenol extraction methods from bacterial cultures, scale-up of production by fermentation up to pilot scale, as well as societal and economic analyses of the processes. This review article summarizes some of the key findings obtained throughout the duration of the project.
BACterial Hosts for production of Bioactive phenolics from bERRY fruits (BacHBerry) was a 3-year project funded by the Seventh Framework Programme (FP7) of the European Union that ran between November 2013 and October 2016. The overall aim of the project was to establish a sustainable and economically-feasible strategy for the production of novel high-value phenolic compounds isolated from berry fruits using bacterial platforms. The project aimed at covering all stages of the discovery and pre-commercialization process, including berry collection, screening and characterization of their bioactive components, identification and functional characterization of the corresponding biosynthetic pathways, and construction of Gram-positive bacterial cell factories producing phenolic compounds. Further activities included optimization of polyphenol extraction methods from bacterial cultures, scale-up of production by fermentation up to pilot scale, as well as societal and economic analyses of the processes. This review article summarizes some of the key findings obtained throughout the duration of the project.