BACKGROUND: Over the last few decades, esophageal cancer incidence and mortality trends varied substantially across Europe, with important differences between sexes and the two main histological subtypes, squamous cell carcinoma (ESCC) and adenocarcinoma (EAC). PATIENTS AND METHODS: To monitor recent esophageal cancer mortality trends and to compute short-term predictions in the European Union (EU) and selected European countries, we analyzed data provided by the World Health Organization (WHO) for 1980-2011. We also analyzed incidence trends and relative weights of ESCC and EAC across Europe using data from Cancer Incidence in Five Continents. RESULTS: Long-term decreasing trends were observed for male esophageal cancer mortality in several southern and western European countries, whereas in central Europe mortality increased until the mid-1990s and started to stabilize or decline over the last years. In some eastern and northern countries, the rates were still increasing. Mortality among European women remained comparatively low and showed stable or decreasing trends in most countries. Between 2000-2004 and 2005-2009, esophageal cancer mortality declined by 7% (from 5.34 to 4.99/100 000) in EU men, and by 3% (from 1.12 to 1.09/100 000) in EU women. Predictions to 2015 show persistent declines in mortality rates for men in the EU overall, and stable rates for EU women, with rates for 2015 of 4.5/100 000 men (about 22 300 deaths) and 1.1/100 000 women (about 7400 deaths). In northern Europe, EAC is now the predominant histological type among men, while for European women ESCC is more common and corresponding rates are still increasing in several countries. CONCLUSION(S): The observed trends reflect the variations in alcohol drinking, tobacco smoking and overweight across European countries.
Background: Over the last few decades, esophageal cancer incidence and mortality trends varied substantially across Europe, with important differences between sexes and the two main histological subtypes, squamous cell carcinoma (ESCC) and adenocarcinoma (EAC). Patients and methods: To monitor recent esophageal cancer mortality trends and to compute short-term predictions in the European Union (EU) and selected European countries, we analyzed data provided by the World Health Organization (WHO) for 1980–2011. We also analyzed incidence trends and relative weights of ESCC and EAC across Europe using data from Cancer Incidence in Five Continents. Results: Long-term decreasing trends were observed for male esophageal cancer mortality in several southern and western European countries, whereas in central Europe mortality increased until the mid-1990s and started to stabilize or decline over the last years. In some eastern and northern countries, the rates were still increasing. Mortality among European women remained comparatively low and showed stable or decreasing trends in most countries. Between 2000–2004 and 2005–2009, esophageal cancer mortality declined by 7% (from 5.34 to 4.99/100 000) in EU men, and by 3% (from 1.12 to 1.09/100 000) in EU women. Predictions to 2015 show persistent declines in mortality rates for men in the EU overall, and stable rates for EU women, with rates for 2015 of 4.5/100 000 men (about 22 300 deaths) and 1.1/100 000 women (about 7400 deaths). In northern Europe, EAC is now the predominant histological type among men, while for European women ESCC is more common and corresponding rates are still increasing in several countries. Conclusion(s): The observed trends reflect the variations in alcohol drinking, tobacco smoking and overweight across European countries.
In: Mark , K M , McNamara , K , Gribble , R J , Rhead , R D , Sharp , M-L , Stevelink , S , Schwartz , A , Castro , C & Fear , N T 2019 , ' The health and well-being of LGBTQ serving and ex-serving personnel : a narrative review ' , International Review of Psychiatry , vol. 31 , no. 1 , pp. 75-94 . https://doi.org/10.1080/09540261.2019.1575190
The relaxation of discriminatory policies against lesbian, gay, bisexual, transgender, and queer (LGBTQ) service personnel has led to increased diversity among military populations. Given this increase, it is important to assess sexual and gender minority groups' health and well-being in the context of military service. This narrative review assessed these outcomes in LGBTQ military personnel. The electronic databases OVID Medline, PsycInfo, and Embase were searched for papers published between January 2000 and July 2018. Thirty papers were included. In line with life course model, studies aligned with four themes: (1) mental health and well-being; (2) stigma and healthcare utilization; (3) sexual trauma; and (4) physical health. These themes highlighted that LGBTQ military personnel and veterans have poorer mental health and well-being; report more stigma and barriers to mental healthcare, which reduces uptake of accessed healthcare services; experience more sexual trauma; and have poorer physical health than heterosexual military personnel and veterans. However, there are substantial gaps in the current evidence for this population. Future research should aim to address limitations of the literature, and to ensure that data on LGBTQ personnel and veterans is collected as standard.
In a recent editorial in the journal Nature Sustainability, the editors raised the concern that journal submissions on water studies appear too similar. The gist of the editorial: "too many publications and not enough ideas." In this response, we contest this notion, and point to the numerous new ideas that result from taking a broader view of the water science field. Drawing inspiration from a recently hosted conference geared at transcending traditional disciplinary silos and forging new paradigms for water research, we are, in fact, enthusiastic and optimistic about the ways scientists are investigating political, economic, historical, and cultural intersections toward more just and sustainable human-water relations and ways of knowing.
This paper reviews different approaches to modelling the energy transition towards a zero carbon economy. It identifies a number of limitations in current approaches such as a lack of consideration of out-of-equilibrium situations (like an energy transition) and non-linear feedbacks. To tackle those issues, the new open source integrated assessment model pymedeas is introduced, which allows the exploration of the design and planning of appropriate strategies and policies for decarbonizing the energy sector at World and EU level. The main novelty of the new open-source model is that it addresses the energy transition by considering biophysical limits, availability of raw materials, and climate change impacts. This paper showcases the model capabilities through several simulation experiments to explore alternative pathways for the renewable transition. In the selected scenarios of this work, future shortage of fossil fuels is found to be the most influential factor of the simulations system evolution. Changes in efficiency and climate change damages are also important determinants influencing model outcomes.
This paper reviews different approaches to modelling the energy transition towards a zero carbon economy. It identifies a number of limitations in current approaches such as a lack of consideration of out-of-equilibrium situations (like an energy transition) and non-linear feedbacks. To tackle those issues, the new open source integrated assessment model pymedeas is introduced, which allows the exploration of the design and planning of appropriate strategies and policies for decarbonizing the energy sector at World and EU level. The main novelty of the new open-source model is that it addresses the energy transition by considering biophysical limits, availability of raw materials, and climate change impacts. This paper showcases the model capabilities through several simulation experiments to explore alternative pathways for the renewable transition. In the selected scenarios of this work, future shortage of fossil fuels is found to be the most influential factor of the simulations system evolution. Changes in efficiency and climate change damages are also important determinants influencing model outcomes.
This paper reviews different approaches to modelling the energy transition towards a zero carbon economy. It identifies a number of limitations in current approaches such as a lack of consideration of out-of-equilibrium situations (like an energy transition) and non-linear feedbacks. To tackle those issues, the new open source integrated assessment model pymedeas is introduced, which allows the exploration of the design and planning of appropriate strategies and policies for decarbonizing the energy sector at World and EU level. The main novelty of the new open-source model is that it addresses the energy transition by considering biophysical limits, availability of raw materials, and climate change impacts. This paper showcases the model capabilities through several simulation experiments to explore alternative pathways for the renewable transition. In the selected scenarios of this work, future shortage of fossil fuels is found to be the most influential factor of the simulations system evolution. Changes in efficiency and climate change damages are also important determinants influencing model outcomes.
This paper reviews different approaches to modelling the energy transition towards a zero carbon economy. It identifies a number of limitations in current approaches such as a lack of consideration of out-of-equilibrium situations (like an energy transition) and non-linear feedbacks. To tackle those issues, the new open source integrated assessment model pymedeas is introduced, which allows the exploration of the design and planning of appropriate strategies and policies for decarbonizing the energy sector at World and EU level. The main novelty of the new open-source model is that it addresses the energy transition by considering biophysical limits, availability of raw materials, and climate change impacts. This paper showcases the model capabilities through several simulation experiments to explore alternative pathways for the renewable transition. In the selected scenarios of this work, future shortage of fossil fuels is found to be the most influential factor of the simulations system evolution. Changes in efficiency and climate change damages are also important determinants influencing model outcomes.
This paper reviews different approaches to modelling the energy transition towards a zero carbon economy. It identifies a number of limitations in current approaches such as a lack of consideration of out-of-equilibrium situations (like an energy transition) and non-linear feedbacks. To tackle those issues, the new open source integrated assessment model pymedeas is introduced, which allows the exploration of the design and planning of appropriate strategies and policies for decarbonizing the energy sector at World and EU level. The main novelty of the new open-source model is that it addresses the energy transition by considering biophysical limits, availability of raw materials, and climate change impacts. This paper showcases the model capabilities through several simulation experiments to explore alternative pathways for the renewable transition. In the selected scenarios of this work, future shortage of fossil fuels is found to be the most influential factor of the simulations system evolution. Changes in efficiency and climate change damages are also important determinants influencing model outcomes.
In: Sole , J , Samso , R , Garcia-Ladona , E , Garcia-Olivares , A , Ballabrera-Poy , J , Madurell , T , Turiel , A , Osychenkoa , O , Alvarez , D , Bardi , U , Baumann , M , Buchmann , K , Capellan-Perez , Cerny , M , Carpintero , O , De Blas , L , De Castro , C , De Lathouwer , J-D , Duce , C , Eggler , L , Enriquez , J M , Falsini , S , Feng , K , Ferreras , N , Frechoso , F , Hubacek , K , Jones , A , Kaclikova , R , Kerschner , C , Kimmich , C , Lobejon , L F , Lomas , P L , Martelloni , G , Mediavilla , M , Miguel , L J , Natalini , D , Nieto , J , Nikolaev , A , Parrado , G , Papagianni , S , Perissi , I , Ploiner , C , Radulov , L , Rodrigo , P , Sun , L & Theofilidi , M 2020 , ' Modelling the renewable transition : Scenarios and pathways for a decarbonized future using pymedeas, a new open-source energy systems model ' , Renewable & Sustainable Energy Reviews , vol. 132 , 110105 . https://doi.org/10.1016/j.rser.2020.110105 ; ISSN:1364-0321
This paper reviews different approaches to modelling the energy transition towards a zero carbon economy. It identifies a number of limitations in current approaches such as a lack of consideration of out-of-equilibrium situations (like an energy transition) and non-linear feedbacks. To tackle those issues, the new open source integrated assessment model pymedeas is introduced, which allows the exploration of the design and planning of appropriate strategies and policies for decarbonizing the energy sector at World and EU level. The main novelty of the new open-source model is that it addresses the energy transition by considering biophysical limits, availability of raw materials, and climate change impacts. This paper showcases the model capabilities through several simulation experiments to explore alternative pathways for the renewable transition. In the selected scenarios of this work, future shortage of fossil fuels is found to be the most influential factor of the simulations system evolution. Changes in efficiency and climate change damages are also important determinants influencing model outcomes.
OBJECTIVE: To generate a global reference for caesarean section (CS) rates at health facilities. DESIGN: Cross-sectional study. SETTING: Health facilities from 43 countries. POPULATION/SAMPLE: Thirty eight thousand three hundred and twenty-four women giving birth from 22 countries for model building and 10,045,875 women giving birth from 43 countries for model testing. METHODS: We hypothesised that mathematical models could determine the relationship between clinical-obstetric characteristics and CS. These models generated probabilities of CS that could be compared with the observed CS rates. We devised a three-step approach to generate the global benchmark of CS rates at health facilities: creation of a multi-country reference population, building mathematical models, and testing these models. MAIN OUTCOME MEASURES: Area under the ROC curves, diagnostic odds ratio, expected CS rate, observed CS rate. RESULTS: According to the different versions of the model, areas under the ROC curves suggested a good discriminatory capacity of C-Model, with summary estimates ranging from 0.832 to 0.844. The C-Model was able to generate expected CS rates adjusted for the case-mix of the obstetric population. We have also prepared an e-calculator to facilitate use of C-Model (www.who.int/reproductivehealth/publications/maternal_perinatal_health/c-model/en/). CONCLUSIONS: This article describes the development of a global reference for CS rates. Based on maternal characteristics, this tool was able to generate an individualised expected CS rate for health facilities or groups of health facilities. With C-Model, obstetric teams, health system managers, health facilities, health insurance companies, and governments can produce a customised reference CS rate for assessing use (and overuse) of CS. TWEETABLE ABSTRACT: The C-Model provides a customized benchmark for caesarean section rates in health facilities and systems.
ObjectiveTo generate a global reference for caesarean section (CS) rates at health facilities. DesignCross-sectional study. SettingHealth facilities from 43 countries. Population/SampleThirty eight thousand three hundred and twenty-four women giving birth from 22 countries for model building and 10045875 women giving birth from 43 countries for model testing. MethodsWe hypothesised that mathematical models could determine the relationship between clinical-obstetric characteristics and CS. These models generated probabilities of CS that could be compared with the observed CS rates. We devised a three-step approach to generate the global benchmark of CS rates at health facilities: creation of a multi-country reference population, building mathematical models, and testing these models. Main outcome measuresArea under the ROC curves, diagnostic odds ratio, expected CS rate, observed CS rate. ResultsAccording to the different versions of the model, areas under the ROC curves suggested a good discriminatory capacity of C-Model, with summary estimates ranging from 0.832 to 0.844. The C-Model was able to generate expected CS rates adjusted for the case-mix of the obstetric population. We have also prepared an e-calculator to facilitate use of C-Model (). ConclusionsThis article describes the development of a global reference for CS rates. Based on maternal characteristics, this tool was able to generate an individualised expected CS rate for health facilities or groups of health facilities. With C-Model, obstetric teams, health system managers, health facilities, health insurance companies, and governments can produce a customised reference CS rate for assessing use (and overuse) of CS. Tweetable abstractThe C-Model provides a customized benchmark for caesarean section rates in health facilities and systems. Tweetable abstract The C-Model provides a customized benchmark for caesarean section rates in health facilities and systems. ; NICHD NIH HHS ; World Health Organization ; Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Social Med, Av Bandeirantes, BR-3900 Ribeirao Preto, Brazil ; WHO, World Bank Special Programme Res Dev & Res Traini, UNDP UNFPA UNICEF WHO, Dept Reprod Hlth & Res, CH-1211 Geneva, Switzerland ; Univ Paris 05, Sorbonne Paris Cite, UMR 216, Inst Dev Res, Paris, France ; WHO Reg Off Amer, Women & Reprod Hlth CLAP WR, Latin Amer Ctr Perinatol, Montevideo, Uruguay ; Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA ; Paris Descartes Univ, Ctr Epidemiol & Biostat, Obstetr Perinatal & Pediat Epidemiol Res Team, Inserm U1153, Paris, France ; Natl Inst Publ Hlth, Ctr Populat Hlth Res, Cuernavaca, Morelos, Mexico ; Univ Technol, Fac Hlth, Sydney, NSW, Australia ; Natl Ctr Child Hlth & Dev, Dept Hlth Policy, Tokyo, Japan ; Ctr Rosarino Estudios Perinat, Rosario, Argentina ; Lindsay Stewart R&D Ctr, Off Res & Clin Audit, Royal Coll Obstetricians & Gynaecologists, London, England ; London Sch Hyg & Trop Med, Dept Hlth Serv Res & Policy, London WC1, England ; Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Shanghai Key Lab Childrens Environ Hlth,Minist Ed, Shanghai 200030, Peoples R China ; Univ Estadual Campinas, Sch Med Sci, Dept Obstet & Gynaecol, Campinas, SP, Brazil ; Family Hlth Bur, Minist Hlth, Colombo, Sri Lanka ; Fiocruz MS, ENSP, BR-21045900 Rio De Janeiro, Brazil ; Natl Inst Hlth & Welf, Helsinki, Finland ; Univ Tokyo, Grad Sch Med, Dept Paediat, Tokyo, Japan ; Bayer Krankenhausgesellschaft, Bayer Arbeitsgemeinschaft Qualitatssicherun Stati, Munich, Germany ; Khon Kaen Univ, Fac Med, Dept Obstet & Gynecol, Khon, Kaen, Thailand ; Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Obstet & Gynaecol, BR-14049 Ribeirao Preto, Brazil ; Minist Sante, Direct Sante Famille, Ouagadougou, Burkina Faso ; Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98195 USA ; Univ Mongolia, Hlth Sci, Sch Publ Hlth, Ulaanbaatar, Mongol Peo Rep ; GLIDE Tech Cooperat & Res, Ribeirao Preto, SP, Brazil ; Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Paediat, BR-14049 Ribeirao Preto, SP, Brazil ; Univ Calif San Francisco, Dept Obstet & Gynaecol & Global Hlth Sci, San Francisco, CA 94143 USA ; Khon Kaen Univ, Fac Publ Hlth, Dept Biostat & Demog, Khon Kaen, Thailand ; Univ Fed Sao Paulo, Sch Med Sao Paulo, Dept Obstet, Sao Paulo, Brazil ; Inter Amer Dev Bank, Social Protect & Hlth Div, Mexico City, DF, Mexico ; Fortis Mem Res Inst, Gurgaon, Haryana, India ; Hosp Nacl Itaugua, Itaugua, Paraguay ; Univ Fed Sao Paulo, Sch Med Sao Paulo, Dept Obstet, Sao Paulo, Brazil ; NICHD NIH HHS: T32 HD052460 ; World Health Organization: 001 ; Web of Science
ObjectiveTo generate a global reference for caesarean section (CS) rates at health facilities. DesignCross-sectional study. SettingHealth facilities from 43 countries. Population/SampleThirty eight thousand three hundred and twenty-four women giving birth from 22 countries for model building and 10045875 women giving birth from 43 countries for model testing. MethodsWe hypothesised that mathematical models could determine the relationship between clinical-obstetric characteristics and CS. These models generated probabilities of CS that could be compared with the observed CS rates. We devised a three-step approach to generate the global benchmark of CS rates at health facilities: creation of a multi-country reference population, building mathematical models, and testing these models. Main outcome measuresArea under the ROC curves, diagnostic odds ratio, expected CS rate, observed CS rate. ResultsAccording to the different versions of the model, areas under the ROC curves suggested a good discriminatory capacity of C-Model, with summary estimates ranging from 0.832 to 0.844. The C-Model was able to generate expected CS rates adjusted for the case-mix of the obstetric population. We have also prepared an e-calculator to facilitate use of C-Model (). ConclusionsThis article describes the development of a global reference for CS rates. Based on maternal characteristics, this tool was able to generate an individualised expected CS rate for health facilities or groups of health facilities. With C-Model, obstetric teams, health system managers, health facilities, health insurance companies, and governments can produce a customised reference CS rate for assessing use (and overuse) of CS. Tweetable abstractThe C-Model provides a customized benchmark for caesarean section rates in health facilities and systems. Tweetable abstract The C-Model provides a customized benchmark for caesarean section rates in health facilities and systems. ; NICHD NIH HHS ; World Health Organization ; Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Social Med, Av Bandeirantes, BR-3900 Ribeirao Preto, Brazil ; WHO, World Bank Special Programme Res Dev & Res Traini, UNDP UNFPA UNICEF WHO, Dept Reprod Hlth & Res, CH-1211 Geneva, Switzerland ; Univ Paris 05, Sorbonne Paris Cite, UMR 216, Inst Dev Res, Paris, France ; WHO Reg Off Amer, Women & Reprod Hlth CLAP WR, Latin Amer Ctr Perinatol, Montevideo, Uruguay ; Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA ; Paris Descartes Univ, Ctr Epidemiol & Biostat, Obstetr Perinatal & Pediat Epidemiol Res Team, Inserm U1153, Paris, France ; Natl Inst Publ Hlth, Ctr Populat Hlth Res, Cuernavaca, Morelos, Mexico ; Univ Technol, Fac Hlth, Sydney, NSW, Australia ; Natl Ctr Child Hlth & Dev, Dept Hlth Policy, Tokyo, Japan ; Ctr Rosarino Estudios Perinat, Rosario, Argentina ; Lindsay Stewart R&D Ctr, Off Res & Clin Audit, Royal Coll Obstetricians & Gynaecologists, London, England ; London Sch Hyg & Trop Med, Dept Hlth Serv Res & Policy, London WC1, England ; Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Shanghai Key Lab Childrens Environ Hlth,Minist Ed, Shanghai 200030, Peoples R China ; Univ Estadual Campinas, Sch Med Sci, Dept Obstet & Gynaecol, Campinas, SP, Brazil ; Family Hlth Bur, Minist Hlth, Colombo, Sri Lanka ; Fiocruz MS, ENSP, BR-21045900 Rio De Janeiro, Brazil ; Natl Inst Hlth & Welf, Helsinki, Finland ; Univ Tokyo, Grad Sch Med, Dept Paediat, Tokyo, Japan ; Bayer Krankenhausgesellschaft, Bayer Arbeitsgemeinschaft Qualitatssicherun Stati, Munich, Germany ; Khon Kaen Univ, Fac Med, Dept Obstet & Gynecol, Khon, Kaen, Thailand ; Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Obstet & Gynaecol, BR-14049 Ribeirao Preto, Brazil ; Minist Sante, Direct Sante Famille, Ouagadougou, Burkina Faso ; Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98195 USA ; Univ Mongolia, Hlth Sci, Sch Publ Hlth, Ulaanbaatar, Mongol Peo Rep ; GLIDE Tech Cooperat & Res, Ribeirao Preto, SP, Brazil ; Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Paediat, BR-14049 Ribeirao Preto, SP, Brazil ; Univ Calif San Francisco, Dept Obstet & Gynaecol & Global Hlth Sci, San Francisco, CA 94143 USA ; Khon Kaen Univ, Fac Publ Hlth, Dept Biostat & Demog, Khon Kaen, Thailand ; Univ Fed Sao Paulo, Sch Med Sao Paulo, Dept Obstet, Sao Paulo, Brazil ; Inter Amer Dev Bank, Social Protect & Hlth Div, Mexico City, DF, Mexico ; Fortis Mem Res Inst, Gurgaon, Haryana, India ; Hosp Nacl Itaugua, Itaugua, Paraguay ; Univ Fed Sao Paulo, Sch Med Sao Paulo, Dept Obstet, Sao Paulo, Brazil ; NICHD NIH HHS: T32 HD052460 ; World Health Organization: 001 ; Web of Science
Importance Cancer and other noncommunicable diseases (NCDs) are now widely recognized as a threat to global development. The latest United Nations high-level meeting on NCDs reaffirmed this observation and also highlighted the slow progress in meeting the 2011 Political Declaration on the Prevention and Control of Noncommunicable Diseases and the third Sustainable Development Goal. Lack of situational analyses, priority setting, and budgeting have been identified as major obstacles in achieving these goals. All of these have in common that they require information on the local cancer epidemiology. The Global Burden of Disease (GBD) study is uniquely poised to provide these crucial data. Objective To describe cancer burden for 29 cancer groups in 195 countries from 1990 through 2017 to provide data needed for cancer control planning. Evidence Review We used the GBD study estimation methods to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life-years (DALYs). Results are presented at the national level as well as by Socio-demographic Index (SDI), a composite indicator of income, educational attainment, and total fertility rate. We also analyzed the influence of the epidemiological vs the demographic transition on cancer incidence. Findings In 2017, there were 24.5 million incident cancer cases worldwide (16.8 million without nonmelanoma skin cancer [NMSC]) and 9.6 million cancer deaths. The majority of cancer DALYs came from years of life lost (97%), and only 3% came from years lived with disability. The odds of developing cancer were the lowest in the low SDI quintile (1 in 7) and the highest in the high SDI quintile (1 in 2) for both sexes. In 2017, the most common incident cancers in men were NMSC (4.3 million incident cases); tracheal, bronchus, and lung (TBL) cancer (1.5 million incident cases); and prostate cancer (1.3 million incident cases). The most common causes of cancer deaths and DALYs for men were TBL cancer (1.3 million deaths and 28.4 million DALYs), liver cancer (572 000 deaths and 15.2 million DALYs), and stomach cancer (542 000 deaths and 12.2 million DALYs). For women in 2017, the most common incident cancers were NMSC (3.3 million incident cases), breast cancer (1.9 million incident cases), and colorectal cancer (819 000 incident cases). The leading causes of cancer deaths and DALYs for women were breast cancer (601 000 deaths and 17.4 million DALYs), TBL cancer (596 000 deaths and 12.6 million DALYs), and colorectal cancer (414 000 deaths and 8.3 million DALYs). Conclusions and Relevance The national epidemiological profiles of cancer burden in the GBD study show large heterogeneities, which are a reflection of different exposures to risk factors, economic settings, lifestyles, and access to care and screening. The GBD study can be used by policy makers and other stakeholders to develop and improve national and local cancer control in order to achieve the global targets and improve equity in cancer care.