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AbstractA recent development in the UK television industry has been the emergence of satellite coverage of sporting events. This paper examines the relationship between broadcasting and football, culminating in the 1992 joint BBC and BSkyB contract to televise the English Premier League. A demand function is estimated which exteds the familiar model of attendance to incorporate television together with quadratic functions. We find that, although live transmission reduces attendance, the net financial consequences are positive for Premier League teams. Moreover, significant estimators are found for the quadratic functions of pricel earnings, distance, seasonal trend and length of Premier League status.

Fort Conger, located at Discovery Harbour in Lady Franklin Bay on northern Ellesmere Island, Nunavut, played an intrinsic role in several High Arctic expeditions between 1875 and 1935, particularly around 1900–10 during the height of the Race to the North Pole. Here are found the remains of historic voyages of exploration and discovery related to the 19th century expeditions of G.S. Nares and A.W. Greely, early 20th century expeditions of R.E. Peary, and forays by explorers, travelers, and government and military personnel. In the Peary era, Fort Conger's connection with indigenous people was amplified, as most of the expedition personnel who were based there were Inughuit from Greenland, and the survival strategies of the explorers were largely derived from Inughuit material cultural and environmental expertise. The complex of shelters at Fort Conger symbolizes an evolution from the rigid application of Western knowledge, as represented in the unsuitable prefabricated Greely expedition house designed in the United States, towards the pragmatic adaptation of Aboriginal knowledge represented in the Inughuit-influenced shelters that still stand today. Fort Conger currently faces various threats to its longevity: degradation of wooden structures through climate and weathering, bank erosion, visitation, and inorganic contami­nation. Its early history and links with Greenlandic Inughuit have suggested that the science of heritage preservation, along with management practices of monitoring, remediation of contamination, and 3D laser scanning, should be applied to maintain the site for future generations. ; Fort Conger, situé au Havre de la découverte, dans la baie Lady Franklin, au nord de l'île d'Ellesmere, au Nunavut, a joué un rôle intrinsèque dans plusieurs expéditions de l'Extrême-Arctique entre 1875 et 1935, surtout dans les années 1900 à 1910, à l'apogée de la course vers le pôle Nord. Nous trouvons ici les vestiges de voyages d'exploration et de découvertes historiques, vestiges qui se rapportent plus précisément aux expéditions de G.S. Nares et d'A.W. Greely au XIXe siècle, aux expéditions de R.E. Peary au début du XXe siècle et aux incursions de divers explorateurs, voyageurs, militaires et employés du gouvernement. À l'époque de R.E. Peary, les liens entretenus avec les Autochtones de Fort Conger se sont intensifiés, car une grande partie des membres de l'expédition étaient des Inughuits du Groenland, et les stratégies de survie des explorateurs dépendaient grandement de l'expertise matérielle, culturelle et environnementale des Inughuits. Le complexe d'abris qui se trouve au Fort Conger symbolise une évolution, où l'on a délaissé l'application rigide des connaissances occidentales, comme en atteste la maison préfabriquée inadaptée conçue aux États-Unis pour l'expédition Greely, pour aller vers une adaptation pragmatique des connaissances autochtones, comme l'illustrent les abris d'influence inughuite que l'on aperçoit toujours de nos jours. En ce moment, la longévité de Fort Conger est menacée en raison de la dégradation des structures en bois, dégradation attribuable à l'altération climatique et atmosphérique, à l'érosion des berges, aux visites et à la contamination inorganique. Les débuts de Fort Conger et ses liens avec les Inughuits groenlandais suggèrent qu'il y aurait lieu de mettre en application la science de la conservation du patrimoine, jumelée aux pratiques de gestion de la surveillance, de restauration des matériaux contaminés et de balayage laser 3D, afin d'assurer le maintien du site pour les générations à venir.

Policy frameworks and institutions for decarbonisation : the energy sector as 'litmus test' / Lynette Molyneaux and Keith Sue -- Technologies for decarbonising the electricity sector -- Wind energy / Nathan Steggel and David Osmond -- Solar photovoltaics / Andrew Blakers.

As of 1 May 2020, there had been 6808 confirmed cases of COVID-19 in Australia. Of these, 98 had died from the disease. The epidemic had been in decline since mid-March, with 308 cases confirmed nationally since 14 April. This suggests that the collective actions of the Australian public and government authorities in response to COVID-19 were sufficiently early and assiduous to avert a public health crisis – for now. Analysing factors that contribute to individual country experiences of COVID-19, such as the intensity and timing of public health interventions, will assist in the next stage of response planning globally. We describe how the epidemic and public health response unfolded in Australia up to 13 April. We estimate that the effective reproduction number was likely below one in each Australian state since mid-March and forecast that clinical demand would remain below capacity thresholds over the forecast period (from mid-to-late April).

As of 1 May 2020, there had been 6808 confirmed cases of COVID-19 in Australia. Of these, 98 had died from the disease. The epidemic had been in decline since mid-March, with 308 cases confirmed nationally since 14 April. This suggests that the collective actions of the Australian public and government authorities in response to COVID-19 were sufficiently early and assiduous to avert a public health crisis - for now. Analysing factors that contribute to individual country experiences of COVID-19, such as the intensity and timing of public health interventions, will assist in the next stage of response planning globally. We describe how the epidemic and public health response unfolded in Australia up to 13 April. We estimate that the effective reproduction number was likely below one in each Australian state since mid-March and forecast that clinical demand would remain below capacity thresholds over the forecast period (from mid-to-late April).

AbstractIntroduction: The extent of viral replication during acute HIV infection (AHI) influences HIV disease progression. However, information comparing viral load (VL) kinetics with and without antiretroviral therapy (ART) in AHI is limited. The knowledge gained could inform preventive strategies aimed at reducing VL during AHI and therapeutic strategies to alter the viral kinetics that may enhance the likelihood of achieving HIV remission.Methods: The analysis utilized VL data captured during the first year of HIV infection from two studies in Thailand: the RV217 study (untreated AHI, 30 participants and 412 visits) and the RV254 study (treated AHI, 235 participants and 2803 visits). Fiebig stages were I/II (HIV RNA+, HIV IgM−) and Fiebig III/IV (HIV IgM+, Western blot‐/indeterminate). Data were modelled utilizing spline effects within a linear mixed model, with a random intercept and slope to allow for between‐subject variability and adjustment for the differences in variability between studies. The number of knots in the quadratic spline basis functions was determined by comparing models with differing numbers of knots via the Akaike Information Criterion. Models were fit using PROC GLIMMIX in SAS v9.3.Results: At enrolment, there were 24 Fiebig I/II and 6 Fiebig III/IV individuals in the untreated group and 137 Fiebig I/II and 98 Fiebig III/IV individuals in the treated group. Overall, the median age was 27.5 years old, most were male (89%), and CRF01_AE was the most common HIV clade (76%). By day 12 (4 days after ART in RV254), the untreated group had a 2.7‐fold higher predicted mean VL level compared to those treated (predicted log VL 6.19 for RV217 and 5.76 for RV254, p = 0.05). These differences increased to 135‐fold by day 30 (predicted log VL 4.89 for RV217 and 2.76 for RV254) and 1148‐fold by day 120 (predicted log VL 4.68 for RV217 and 1.63 for RV254) (p < 0.0001 for both) until both curves were similarly flat at about day 150 (p = 0.17 between days 150 and 160). The VL trajectories were significantly different between Fiebig I/II and Fiebig III/IV participants when comparing the two groups and within the treated group (p < 0.001 for both).Conclusions: Initiating ART in AHI dramatically changed the trajectory of VL very early in the course of infection that could have implications for reducing transmission potential and enhancing responses to future HIV remission strategies. There is an urgency of initiating ART when acute infection is identified. New and inexpensive strategies to engage and test individuals at high risk for HIV as well as immediate treatment access will be needed to improve the treatment of acute infection globally.Clinical Trial Number: NCT00796146 and NCT00796263

UNLABELLED: Knowledge of the contemporary epidemiology of hepatitis C viral (HCV) infection among military personnel can inform potential Department of Defense screening policy. HCV infection status at the time of accession and following deployment was determined by evaluating reposed serum from 10,000 service members recently deployed to combat operations in Iraq and Afghanistan in the period 2007-2010. A cost model was developed from the perspective of the Department of Defense for a military applicant screening program. Return on investment was based on comparison between screening program costs and potential treatment costs avoided. The prevalence of HCV antibody-positive and chronic HCV infection at accession among younger recently deployed military personnel born after 1965 was 0.98/1000 (95% confidence interval 0.45-1.85) and 0.43/1000 (95% confidence interval 0.12-1.11), respectively. Among these, service-related incidence was low; 64% of infections were present at the time of accession. With no screening, the cost to the Department of Defense of treating the estimated 93 cases of chronic HCV cases from a single year's accession cohort was $9.3 million. Screening with the HCV antibody test followed by the nucleic acid test for confirmation yielded a net annual savings and a $3.1 million dollar advantage over not screening. CONCLUSIONS: Applicant screening will reduce chronic HCV infection in the force, result in a small system costs savings, and decrease the threat of transfusion-transmitted HCV infection in the battlefield blood supply and may lead to earlier diagnosis and linkage to care; initiation of an applicant screening program will require ongoing evaluation that considers changes in the treatment cost and practice landscape, screening options, and the epidemiology of HCV in the applicant/accession and overall force populations.

INTRODUCTION: Knowledge of the contemporary epidemiology of hepatitis B virus (HBV) infection among military personnel can inform potential Department of Defense (DoD) screening policy and infection and disease control strategies. MATERIALS AND METHODS: HBV infection status at accession and following deployment was determined by evaluating reposed serum from 10,000 service members recently deployed to combat operations in Iraq and Afghanistan in the period from 2007 to 2010. A cost model was developed from the perspective of the Department of Defense for a program to integrate HBV infection screening of applicants for military service into the existing screening program of screening new accessions for vaccine-preventable infections. RESULTS: The prevalence of chronic HBV infection at accession was 2.3/1,000 (95% CI: 1.4, 3.2); most cases (16/21, 76%) identified after deployment were present at accession. There were 110 military service-related HBV infections identified. Screening accessions who are identified as HBV susceptible with HBV surface antigen followed by HBV surface antigen neutralization for confirmation offered no cost advantage over not screening and resulted in a net annual increase in cost of $5.78 million. However, screening would exclude as many as 514 HBV cases each year from accession. CONCLUSIONS: Screening for HBV infection at service entry would potentially reduce chronic HBV infection in the force, decrease the threat of transfusion-transmitted HBV infection in the battlefield blood supply, and lead to earlier diagnosis and linkage to care; however, applicant screening is not cost saving. Service-related incident infections indicate a durable threat, the need for improved laboratory-based surveillance tools, and mandate review of immunization policy and practice.