Opening Remarks
In: Philippine political science journal, Band 5, Heft 7, S. 37-41
ISSN: 2165-025X
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In: Philippine political science journal, Band 5, Heft 7, S. 37-41
ISSN: 2165-025X
In: Philippine political science journal, Band 4, Heft 1-2, S. 1-2
ISSN: 2165-025X
In: Philippine political science journal, Band 4, Heft 5-6, S. 88-89
ISSN: 2165-025X
In: Philippine political science journal, Band 3, Heft 1, S. 93-107
ISSN: 2165-025X
In: Philippine political science journal, Band 3, Heft 2, S. 18-43
ISSN: 2165-025X
In: Philippine political science journal, Band 3, Heft 4, S. 18-43
ISSN: 2165-025X
In: Philippine political science journal, Band 3, Heft 3, S. 93-107
ISSN: 2165-025X
In: Southeast Asian affairs, Band 1976, Heft 1, S. 269-308
ISSN: 1793-9135
In: Southeast Asian affairs, Band 3, S. 269
ISSN: 0377-5437
In: Cuadernos del Centro de Estudios de Diseño y Comunicación, Heft 110
ISSN: 1853-3523
Actualmente, el juego es analizado como un elemento importante para motivar la interacción de usuarios en diferentes tipos de entornos. Este análisis ha derivado en promover diferentes estrategias para adaptar elementos propios de los juegos y los videojuegos en contextos que no están diseñados como tal, pero en los que se busca estimular la participación de los usuarios. Una estrategia al aplicar elementos de juego es considerar un modelo centrado en la experiencia del usuario. Sin embargo, para establecer un diseño de juego en contextos en donde prevalece el aspecto colaborativo, se requiere abordar estrategias específicas centradas en su relación con la comunidad a la que pertenece. Este artículo presenta el diseño de un entorno ludificado basado en el marco conceptual G.A.M.E. acrónimo de recopilación, análisis, modelado y ejecución (gathering, analysis, modeling and execution), aplicado a una comunidad de construcción colaborativa de conocimiento sobre Buenas Prácticas Hortícolas, complementado, además, con una interfaz física.
In: FRB International Finance Discussion Paper No. 1245
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Working paper
In: Journal of the International AIDS Society, Band 17, Heft 2(Suppl 1)
ISSN: 1758-2652
Cancer hereditario de mama y ovario; Pseudoexones; Variantes intrónicas profundas spliceogénicas ; Càncer hereditari de mama i d'ovari; Pseudoexons; Variants intròniques profundes spliceogèniques ; Hereditary breast ovarian cancer; Pseudoexons; Spliceogenic deep intronic variants ; The contribution of deep intronic splice-altering variants to hereditary breast and ovarian cancer (HBOC) is unknown. Current computational in silico tools to predict spliceogenic variants leading to pseudoexons have limited efficiency. We assessed the performance of the SpliceAI tool combined with ESRseq scores to identify spliceogenic deep intronic variants by affecting cryptic sites or splicing regulatory elements (SREs) using literature and experimental datasets. Our results with 233 published deep intronic variants showed that SpliceAI, with a 0.05 threshold, predicts spliceogenic deep intronic variants affecting cryptic splice sites, but is less effective in detecting those affecting SREs. Next, we characterized the SRE profiles using ESRseq, showing that pseudoexons are significantly enriched in SRE-enhancers compared to adjacent intronic regions. Although the combination of SpliceAI with ESRseq scores (considering ∆ESRseq and SRE landscape) showed higher sensitivity, the global performance did not improve because of the higher number of false positives. The combination of both tools was tested in a tumor RNA dataset with 207 intronic variants disrupting splicing, showing a sensitivity of 86%. Following the pipeline, five spliceogenic deep intronic variants were experimentally identified from 33 variants in HBOC genes. Overall, our results provide a framework to detect deep intronic variants disrupting splicing. ; This research was funded by the Spanish Instituto de Salud Carlos III (ISCIII) funding an initiative of the Spanish Ministry of Economy and Innovation, partially supported by European Regional Development FEDER Funds, grant numbers PI16/01218 and PI19/01303. AM-F contract is supported by the award ERAPERMED2019-215 granted by AECC FC and by ISCIII thorough AES 2019, both within the ERAPerMed framework". J.D.-V. contract is supported by the Secretariat for Universities and Research of the Ministry of Business and Knowledge of the Government of Catalonia and the European Social Fund.
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In: GEODRS-D-23-00788
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