Suchergebnisse

Este artículo analiza las nuevas formas de comunicación y sensibilización, en concreto en el ámbito digital a través de un estudio de caso de la marca de moda de lujo ECOALF, única en el mundo por su aportación al sector a través de la limpieza de los océanos. El uso de la expresión ilimitada que realiza ECOALF a través de medios digitales desemboca en la concienciación medioambiental, mensaje clave de su estrategia online. Se trata de una práctica corporativamente responsable en el medio digital, en especial de sus redes sociales, con las que se comunica interactivamente e inspira al prosumidor. Se profundizará en cómo transmite su propósito empresarial y sus buenas prácticas corporativas a través de Instagram, Facebook, Twitter,así como de su página web. Se procede a través de la aplicación de una metodología cualitativa, utilizando procesos de categorización, apoyada en el análisis del discurso y el softwareNVIVO11 donde se han analizado las publicaciones onlinede la compañía de sus primeros cinco años. Como conclusión se descubre cómo, a través de herramientas de comunicación digitales, una empresa de moda convierte su proceso de producción en material audiovisual de alfabetización mediática y digital que están estrechamente vinculadas además de la concienciación medioambiental a nivel mundial para diferentes consumidores de: moda, de redes sociales, ecologistas, líderes culturales y cazadores de tendencias entre otros.

The purpose of this paper is to establish a discussion on the real effect of tax exemptions, as the only mechanism for attracting the productive fabric and generating employment in the country's municipalities. Methodologically, a mixed type investigation was carried out, with the application of semi-structured interviews to secretaries, advisers and directors of the finance and planning areas in a group of municipalities of the Provinces of Sabana Centro and Sabana Occidente, in the Department of Cundinamarca, and Tundama and Sugamuxi, in the Department of Boyacá. Likewise, an analysis of the exemptions included in the tax statutes and of the collection of ICA and property taxes, on which this type of actions are generally applied, was carried out. From the work carried out, it is established that in the municipalities with the most success in attracting new companies, the use of tax exemptions is just one more element of a broader public policy strategy, which seeks to improve the general conditions of competitiveness. ; El presente artículo tiene como propósito plantear una discusión sobre el efecto real de las exenciones tributarias, como único mecanismo para la atracción de tejido productivo y la generación de empleo en los municipios del país. Metodológicamente, se adelantó una investigación de tipo mixto, con la aplicación de entrevistas semiestructuradas a secretarios, asesores y directores de las áreas de hacienda y planeación en un grupo de municipios de las Provincias de Sabana Centro y Sabana Occidente, en el Departamento de Cundinamarca, y Tundama y Sugamuxi, en el Departamento de Boyacá. Igualmente, se adelantó un análisis de las exenciones incluidas en los estatutos tributarios y de la recaudación de los impuestos ICA y predial, sobre los cuales se aplican generalmente este tipo de acciones. Del trabajo realizado, se establece que, en los municipios de más éxito, en la atracción de nuevas empresas, la utilización de las exenciones tributarias es solo un elemento más de una estrategia más amplia de ...

Although the number of marinas along shorelines has significantly increased during the last years, there is a lack of studies on mobile epifauna associated to floating pontoons or infauna inhabiting soft bottoms of marinas. Artificial hard substrate (lateral surface of pontoons) and soft substrate (sediment) were sampled in 42 marinas along the Iberian Peninsula and Northern Africa and 48 different species of molluscs were found. Species richness and Shannon diversity values were higher in sediments than in hard substrates; multivariate analyses also revealed differences in species composition and trophic guilds between these two habitats. The most abundant species on the hard substrate were Mytilus galloprovincialis and Musculus subpictus, and Corbula gibba and Parvicardium exiguum in sediments. Although filter feeders were dominant in both habitats, herbivorous species were only found on the hard substrate while deposit feeders were restricted to sediments. As diversity, abundance and trophic patterns were not always consistent for all localities, a local scale effect must be considered in environmental programs for marinas. None exotic mollusc was detected, so this study provides baseline information necessary as a first step in monitoring programmes for early detection of new incoming exotic species. Faunistic knowledge is mandatory to provide local governments, policy makers and authorities with readily accessible species datasets and ecological information. This should be a priority to address an integrated and sustainable management of marinas. ; Ministerio de Ciencia, Innovación y Universidades CGL 2017-82739-P ; FEDER

A simple transfer function that can predict the breakup length of a pressure-modulated capillary jet is rigorously deduced from first principles. In this paper, the initial velocity modulation of a stimulated jet is given in terms of its pressure amplitude by means of a generalized Bernoulli equation, which in turn is connected to the breakup time through a two-mode linear analysis. The predicted breakup length is compared against experimental results with water jets emerging from a thin 1 mm-diameter orifice for different pressure modulations. These experiments agree better with the presented theoretical prediction than with a previously established model. ; Spanish Government under Contract No. FIS2011-25161 ; Junta de Andalucía under Contract Nos. P09-FQM-4584 and P11- FQM-7919 ; EPSRC-UK (Grant No. EP/H018913/1) ; Royal Society ; John Fell Oxford University Press (OUP) Research Fund

We report on the synthesis of undoped ∼5 μm YSZ-Ni porous thin films prepared by reactive pulsed DC magnetron sputtering at an oblique angle of incidence. Pre-calcination of the amorphous unmodified precursor layers followed by reduction produces a film consisting of uniformly distributed tilted columnar aggregates having extensive three-phase boundaries and favorable gas diffusion characteristics. Similarly prepared films doped with 1.2 at.% Au are also porous and contain highly dispersed gold present as Ni-Au alloy particles whose surfaces are strongly enriched with Au. With hydrogen as fuel, the performance of the undoped thin film anodes is comparable to that of 10–20 times thicker typical commercial anodes. With a 1:1 steam/carbon feed, the un-doped anode cell current rapidly falls to zero after 60 h. In striking contrast, the initial performance of the Au-doped anode is much higher and remains unaffected after 170 h. Under deliberately harsh conditions the performance of the Au-doped anodes decreases progressively, almost certainly due to carbon deposition. Even so, the cell maintains some activity after 3 days operation in dramatic contrast with the un-doped anode, which stops working after only three hours of use. The implications and possible practical application of these findings are discussed. ; European Union 298300 ; Ministerio de Economía y Competitividad MAT2013‐40852R, 201560E055

Uniform, highly porous, columnar thin films incorporating YSZ and NiO prepared by magnetron sputtering with deposition at glancing incidence exhibited stoichiometries close to that of the Y–Zr–Ni sputter target. Characterization by means of SEM, XRD, XPS and RBS revealed that the uniformly distributed nickel component in the as-deposited films consisted of NiO, and that the YSZ component was essentially amorphous. Annealing such films at 850 °C in hydrogen resulted in crystallization of the YSZ phase with preservation of the columnar morphology, while the NiO underwent reduction to metallic Ni, which partially segregated to the film surface. The hydrogen-annealed thin film anodes exhibited high conductivity, comparable to that of conventionally-prepared anodes, in both hydrogen and hydrogen/water mixtures at temperatures relevant to SOFC operation. They were also robust against strain-induced separation from the substrate under limited thermal cycling in both oxidizing and reducing atmospheres and are promising candidates for use as anodes in their own right and as strain-accommodating buffer layers between conventional anodes and the electrolyte for use in SOFC applications. ; European Union FP7/2007-2013 ; Fuel Cells and Hydrogen Joint Technology Initiative 298300 ; Ministerio de Economía, Industria y Competitividad MAT2013-40852R

27 p.-4 tab. ; Background The expression of certain genes involved in response to oxidative stress is likely related to aging-related outcomes, such as frailty in old age. Given nutrition's substantial impact in aging and age-related diseases, one of its mechanisms might be through influencing gene expression. ; Objective This study aimed to investigate the association between nutrition and the expression of 15 genes related to cellular response to stress in older community-dwelling individuals. ; Methods A nested case-control study of 350 participants (mean ± SEM age: 76.5 ± 6.9 y, 42.9% men, 22% frail according to Fried's criteria) was selected from the Toledo Study for Healthy Aging. Blood-derived RNA was retro-transcribed into complementary DNA. TaqMan Arrays were used for determining gene expression. The Mini Nutritional Assessment (MNA) and the PREDIMED (PREvención con DIeta MEDiterranea) questionnaire measured nutritional status and adherence to the Mediterranean diet (MD), respectively. Data were reweighed so that inference from linear and logistic regression models applied to the original sampling population. ; Results Higher MNA scores were associated with higher expressions of the gene coding for sirtuin-1 (SIRT1), regardless of age, sex, and Charlson comorbidity score (P = 0.04) and even after adjusting for frailty status (P = 0.016) and level of adherence to the MD (P = 0.04). Malnutrition risk and SIRT1 gene expression were inversely associated (P = 0.0045) independently of frailty status (P = 0.0045) and level of adherence to the MD (P = 0.0075). ; Conclusions In older individuals, improvement in nutritional status is positively associated with SIRT1 gene expression independently of frailty status or adherence to the MD. These findings may provide potential biomarkers and targets for health interventions among the elderly. ; The research leading to these results has received funding from the European Union's Seventh Framework Programme (FP7/2007–2013) under grant agreement number 305483 (to LR-M)—FRAILOMIC Project, and from the Ministry of Economy and Competitiveness, cofinanced by FEDER funds (Instituto de Salud Carlos III), Spanish Government, grants PI15/01160 (to JA), PI15/00674 (to LR-M), and CIBERFES CB16/10/00464 (to LR-M). ; Peer reviewed

Chemoprevention is a pragmatic approach to reduce the risk of colorectal cancer, one of the leading causes of cancer-related death in western countries. In this regard, maslinic acid (MA), a pentacyclic triterpene extracted from wax-like coatings of olives, is known to inhibit proliferation and induce apoptosis in colon cancer cell lines without affecting normal intestinal cells. The present study evaluated the chemopreventive efficacy and associated mechanisms of maslinic acid treatment on spontaneous intestinal tumorigenesis in ApcMin/+ mice. Twenty-two mice were randomized into 2 groups: control group and MA group, fed with a maslinic acid–supplemented diet for six weeks. MA treatment reduced total intestinal polyp formation by 45% (P<0.01). Putative molecular mechanisms associated with suppressing intestinal polyposis in ApcMin/+ mice were investigated by comparing microarray expression profiles of MA-treated and control mice and by analyzing the serum metabolic profile using NMR techniques. The different expression phenotype induced by MA suggested that it exerts its chemopreventive action mainly by inhibiting cell-survival signaling and inflammation. These changes eventually induce G1-phase cell cycle arrest and apoptosis. Moreover, the metabolic changes induced by MA treatment were associated with a protective profile against intestinal tumorigenesis. These results show the efficacy and underlying mechanisms of MA against intestinal tumor development in the ApcMin/+ mice model, suggesting its chemopreventive potential against colorectal cancer. ; Financial support was provided by grant SAF2011-25726 and personal financial support (FPU program) from the Spanish government and also from the Red Temática de Investigación Cooperativa en Cáncer, Instituto de Salud Carlos III, Spanish Ministry of Science and Innovation & European Regional Development Fund "Una manera de hacer Europa" (ISCIII-RTICC grants RD06/0020/004 and RD06/0020/1019 and BIO2011-27069, MICINN). The authors have also received financial support from the AGAUR-Generalitat de Catalunya (grant 2009SGR1308, 2009 CTP 00026 and Icrea Academia Award 2010 granted to M.C.) and the European Commission (FP7) ETHERPATHS KBBE-grant agreement no. 22263. The authors thank the Bio-NMR EU project (Contract # 261863) for providing NMR access to the HWB-NMR facility. Finally, the authors are grateful for the financial support from Biomaslinic S.L. (Granada, Spain).

17 páginas, 6 figuras, 1 tabla. Material suplementario de este artículo online en: https://www.frontiersin.org/articles/10.3389/fcell.2021.770458/full#supplementary-material ; The serotonergic system of mammals innervates virtually all the central nervous system and regulates a broad spectrum of behavioral and physiological functions. In mammals, serotonergic neurons located in the rostral raphe nuclei encompass diverse sub-systems characterized by specific circuitry and functional features. Substantial evidence suggest that functional diversity of serotonergic circuits has a molecular and connectivity basis. However, the landscape of intrinsic developmental mechanisms guiding the formation of serotonergic sub-systems is unclear. Here, we employed developmental disruption of gene expression specific to serotonergic subsets to probe the contribution of the tyrosine kinase receptor ErbB4 to serotonergic circuit formation and function. Through an in vivo loss-of-function approach, we found that ErbB4 expression occurring in a subset of serotonergic neurons, is necessary for axonal arborization of defined long-range projections to the forebrain but is dispensable for the innervation of other targets of the serotonergic system. We also found that Erbb4-deletion does not change the global excitability or the number of neurons with serotonin content in the dorsal raphe nuclei. In addition, ErbB4-deficiency in serotonergic neurons leads to specific behavioral deficits in memory processing that involve aversive or social components. Altogether, our work unveils a developmental mechanism intrinsically acting through ErbB4 in subsets of serotonergic neurons to orchestrate a precise long-range circuit and ultimately involved in the formation of emotional and social memories. ; This work was supported by the CIDEGenT excellence research program of the Valencian government (CIDEGENT/2019/044) and by the Spanish Ministry of Science, Innovation and Universities (RTI 2018-100872-J-I00) as well as by the Young IBRO Regions Connecting Award to IDP and the ERC Consolidator Grant 101002203 to NF. Part of the equipment employed in this work has been funded by Generalitat Valenciana and co-financed with ERDF funds (OP ERDF of Comunitat Valenciana 2014-2020). ; Peer reviewed

Oblique angle deposition (OAD) is a powerful technique for the fabrication of porous nanostructured oxide thin films. OAD films typically present a columnar tilted nanostructure due to geometrical shadowing effects during the thin film growth. In this work, we study the fabrication of transparent and conducting indium tin oxide films (ITO) by OAD assisted by a microwave ECR plasma. The objective of assisting the deposition with a plasma discharge is to modify the growth mechanism of the OAD process introducing additional parameters to control the columnar microstructure, composition, porosity of the films. The results indicate the OAD ITO deposition assisted by the plasma discharge is a very effective process to develop in-plane structural anisotropy in the ITO nanocolumnar films what determines their electrical properties. ; Ministerio de Economía y Competitividad MAT2016-79866-R, MAT2013-40852-R, MAT2013-42900-P ; MINECO-CSIC 201560E055, IJCI-2014-21226 ; European Union 661480

Los objetivos de este proyecto de investigación son: - Aplicar los recursos de los contenidos, servicios y herramientas de las tecnologías emergentes digitales a la innovación educativa de carácter narrativo interdisciplinar en la Universidad y operar con las técnicas básicas para desarrollar actividades de enseñanza/aprendizaje en los entornos hipermedia. - Desarrollar aplicaciones digitales para la realización de materiales videográficos con móviles y tablets para democratizar el uso de las infraestructuras y Proyecto de Innovación Convocatoria 2016/2017 Proyecto 256 Realización de contenidos audiovisuales y de apps de vídeo para enseñanza semipresencial y online: el alumnado como creador de recursos educativos abiertos para campus virtuales y MOOC María Luisa García Guardia Facultad de Ciencias de la Información Departamento de Comunicación Audiovisual y Publicidad 2 equipamientos audiovisuales de las tecnologías emergentes de la comunicación. - Conocer los nuevos sistemas de aprendizaje masivo abierto en línea (MOOC) y la utilización de campus virtuales. - Facilitar la interacción didáctica de los profesores y de los alumnos, así como la interacción de los profesores entre ellos mismos y la de los alumnos entre sí, utilizando los contenidos, servicios y herramientas tecnológicas avanzadas para mejorar los procesos de trabajo cooperativo con la finalidad de potenciar un modelo de colaboración personalizado, en diferentes niveles de agrupamiento, basado en prácticas metodológicas activas que propicien la autonomía de aprendizaje y fomenten el pensamiento autónomo y crítico. - Proponer un modelo de innovación educativa interdisciplinar a través del descubrimiento de las relaciones de convergencia entre la Narrativa Audiovisual y otras materias, buscando su aplicabilidad a través de los contenidos audiovisuales e hipermedia. - Seleccionar y activar aquellos métodos, contenidos o estrategias educativas, transferidas de las materias en cuestión que se puedan compartir a través de criterios de interdisciplinariedad ...