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The evolution of Society for Ecological Restoration's principles and standardscounter-response to Gann et al
In response to our recent article (Higgs et al. 2018) in these pages, George Gann and his coauthors defended the Society for Ecological Restoration (SER) International Standards, clarified several points, and introduced some new perspectives. We offer this counter-response to address some of these perspectives. More than anything, our aims are in sharpening the field of restoration in a time of rapid scaling-up of interest and effort, and support further constructive dialogue going forward. Our perspective remains that there is an important distinction needed between "Standards" and "Principles" that is largely unheeded by Gann et al. (2018). We encourage SER to consider in future iterations of its senior policy document to lean on principles first, and then to issue advice on standards that meet the needs of diverse conditions and social, economic, and political realities.
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The burgeoning recognition and accommodation of the social supply of drugs in international criminal justice systems: An eleven-nation comparative overview
© 2018 Background: It is now commonly accepted that there exists a form of drug supply, that involves the non-commercial supply of drugs to friends and acquaintances for little or no profit, which is qualitatively different from profit motivated 'drug dealing proper'. 'Social supply' as it has become known, has a strong conceptual footprint in the United Kingdom, shaped by empirical research, policy discussion and its accommodation in legal frameworks. Though scholarship has emerged in a number of contexts outside the UK, the extent to which social supply has developed as an internationally recognised concept in criminal justice contexts is still unclear. Methods: Drawing on an established international social supply research network across eleven nations, this paper provides the first assessment of social supply as an internationally relevant concept. Data derives from individual and team research stemming from Australia, Belgium, Canada, Czech Republic, Finland, Germany, Hong Kong, the Netherlands, England and Wales, and the United States, supported by expert reflection on research evidence and analysis of sentencing and media reporting in each context. In situ social supply experts addressed a common set of questions regarding the nature of social supply for their particular context including: an overview of social supply research activity, reflection on the extent that differentiation is accommodated in drug supply sentencing frameworks; evaluating the extent to which social supply is recognised in legal discourse and in sentencing practices and more broadly by e.g. criminal justice professionals in the public sphere. A thematic analysis of these scripts was undertaken and emergent themes were developed. Whilst having an absence of local research, New Zealand is also included in the analysis as there exists a genuine discursive presence of social supply in the drug control and sentencing policy contexts in that country. Results: Findings suggest that while social supply has been found to exist as a real and distinct behaviour, its acceptance and application in criminal justice systems ranges from explicit through to implicit. In the absence of dedicated guiding frameworks, strong use is made of discretion and mitigating circumstances in attempts to acknowledge supply differentiation. In some jurisdictions, there is no accommodation of social supply, and while aggravating factors can be applied to differentiate more serious offences, social suppliers remain subject to arbitrary deterrent sentencing apparatus. Conclusion: Due to the shifting sands of politics, mood, or geographical disparity, reliance on judicial discretion and the use of mitigating circumstances to implement commensurate sentences for social suppliers is no longer sufficient. Further research is required to strengthen the conceptual presence of social supply in policy and practice as a behaviour that extends beyond cannabis and is relevant to users of all drugs. Research informed guidelines and/or specific sentencing provisions for social suppliers would provide fewer possibilities for inconsistency and promote more proportionate outcomes for this fast-growing group.
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An application of Extended Normalisation Process Theory in a randomised controlled trial of a complex social intervention: Process evaluation of the Strengthening Families Programme (10-14) in Wales, UK
This is the final version of the article. Available from Elsevier via the DOI in this record. ; Purpose: Process evaluations generate important data on the extent to which interventions are delivered as intended. However, the tendency to focus only on assessment of pre-specified structural aspects of fidelity has been criticised for paying insufficient attention to implementation processes and how intervention-context interactions influence programme delivery. This paper reports findings from a process evaluation nested within a randomised controlled trial of the Strengthening Families Programme 10-14 (SFP 10-14) in Wales, UK. It uses Extended Normalisation Process Theory to theorise how interaction between SFP 10-14 and local delivery systems - particularly practitioner commitment/capability and organisational capacity - influenced delivery of intended programme activities: fidelity (adherence to SFP 10-14 content and implementation requirements); dose delivered; dose received (participant engagement); participant recruitment and reach (intervention attendance). Methods: A mixed methods design was utilised. Fidelity assessment sheets (completed by practitioners), structured observation by researchers, and routine data were used to assess: adherence to programme content; staffing numbers and consistency; recruitment/retention; and group size and composition. Interviews with practitioners explored implementation processes and context. Results: Adherence to programme content was high - with some variation, linked to practitioner commitment to, and understanding of, the intervention's content and mechanisms. Variation in adherence rates was associated with the extent to which multi-agency delivery team planning meetings were held. Recruitment challenges meant that targets for group size/composition were not always met, but did not affect adherence levels or family engagement. Targets for staffing numbers and consistency were achieved, though capacity within multi-agency networks reduced over time. Conclusions: Extended Normalisation Process Theory provided a useful framework for assessing implementation and explaining variation by examining intervention-context interactions. Findings highlight the need for process evaluations to consider both the structural and process components of implementation to explain whether programme activities are delivered as intended and why. ; The research was funded by the National Prevention Research Initiative (https://www.mrc.ac.uk/research/initiatives/national-prevention-research-initiative-npri/; Award no. G0802128). Funding partners are: Alzheimer's Research Trust; Alzheimer's Society; Biotechnology and Biological Sciences Research Council; British Heart Foundation; Cancer Research UK; Chief Scientist Office, Scottish Government Health Directorate; Department of Health; Diabetes UK; Economic and Social Research Council; Engineering and Physical Sciences Research Council; Health & Social Care Research & Development Office for Northern Ireland; Medical Research Council; The Stroke Association; Welsh Government; and World Cancer Research Fund. The Welsh Government provided c.£675k of partnership funding, to cover the cost of implementation in three trial areas, and the associated training and support provided by the Cardiff Strengthening Families Programme team. Further support from Welsh Government provided £208 k to cover programme delivery in six trial sites from August 2011-July 2012. The Cardiff Strengthening Families Programme team also provided financial support for programme delivery and trial recruitment in schools. The work was undertaken with the support of The Centre for the Development and Evaluation of Complex Interventions for Public Health Improvement (DECIPHer), a UKCRC Public Health Research Centre of Excellence. Joint funding (MR/KO232331/1) from the British Heart Foundation, Cancer Research UK, Economic and Social Research Council, Medical Research Council, the Welsh Government and the Wellcome Trust, under the auspices of the UK Clinical Research Collaboration, is gratefully acknowledged. Laurence Moore was funded by the Medical Research Council (MC_UU_12017/14) and Chief Scientist Office at the Scottish Government Health Directorates (SPHSU14). SEWTU is funded by Welsh Government.
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Probabilistic Tsunami Hazard and Risk Analysis: A Review of Research Gaps
Tsunamis are unpredictable and infrequent but potentially large impact natural disasters. To prepare, mitigate and prevent losses from tsunamis, probabilistic hazard and risk analysis methods have been developed and have proved useful. However, large gaps and uncertainties still exist and many steps in the assessment methods lack information, theoretical foundation, or commonly accepted methods. Moreover, applied methods have very different levels of maturity, from already advanced probabilistic tsunami hazard analysis for earthquake sources, to less mature probabilistic risk analysis. In this review we give an overview of the current state of probabilistic tsunami hazard and risk analysis. Identifying research gaps, we offer suggestions for future research directions. An extensive literature list allows for branching into diverse aspects of this scientific approach. © Copyright © 2021 Behrens, Løvholt, Jalayer, Lorito, Salgado-Gálvez, Sørensen, Abadie, Aguirre-Ayerbe, Aniel-Quiroga, Babeyko, Baiguera, Basili, Belliazzi, Grezio, Johnson, Murphy, Paris, Rafliana, De Risi, Rossetto, Selva, Taroni, Del Zoppo, Armigliato, Bureš, Cech, Cecioni, Christodoulides, Davies, Dias, Bayraktar, González, Gritsevich, Guillas, Harbitz, Kânoǧlu, Macías, Papadopoulos, Polet, Romano, Salamon, Scala, Stepinac, Tappin, Thio, Tonini, Triantafyllou, Ulrich, Varini, Volpe and Vyhmeister. ; This article is based upon work from COST Action CA18109 AGITHAR, supported by COST (European Cooperation in Science and Technology). VB and PC obtained support through the VES20 Inter-Cost LTC 20020 project. MS-G obtained support through the Severo Ochoa Centers of Excellence Program (Ref. CEX 2018–000797-S). TU acknowledges funding from the European Union's Horizon 2020 research and innovation program (ChEESE project, Grant Agreement No. 823844).
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The first view of delta Scuti and gamma Doradus stars with the TESS mission
We present the first asteroseismic results for δ Scuti and γ Doradus stars observed in Sectors 1 and 2 of the TESS mission. We utilize the 2-min cadence TESS data for a sample of 117 stars to classify their behaviour regarding variability and place them in the Hertzsprung-Russell diagram using Gaia DR2 data. Included within our sample are the eponymous members of two pulsator classes, γ Doradus and SX Phoenicis. Our sample of pulsating intermediate-mass stars observed by TESS also allows us to confront theoretical models of pulsation driving in the classical instability strip for the first time and show that mixing processes in the outer envelope play an important role. We derive an empirical estimate of 74 per cent for the relative amplitude suppression factor as a result of the redder TESS passband compared to the Kepler mission using a pulsating eclipsing binary system. Furthermore, our sample contains many high-frequency pulsators, allowing us to probe the frequency variability of hot young δ Scuti stars, which were lacking in the Kepler mission data set, and identify promising targets for future asteroseismic modelling. The TESS data also allow us to refine the stellar parameters of SX Phoenicis, which is believed to be a blue straggler. © 2019 The Author(s) ; We thank the referee for useful comments and discussions. This paper includes data collected by the TESS mission. Funding for the TESS mission is provided by the NASA Explorer Program. Funding for the TESS Asteroseismic Science Operations Centre is provided by the Danish National Re-search Foundation (Grant agreement no.: DNRF106), ESA PRODEX (PEA 4000119301), and Stellar Astrophysics Centre (SAC) at Aarhus University. We thank the TESS and TASC/TASOC teams for their support of this work. This research has made use of the SIMBAD data base, operated at CDS, Strasbourg, France. Some of the data presented in this paper were obtained from the Mikulski Archive for Space Telescopes (MAST). STScI is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-2655. Funding for the Stellar Astrophysics Centre is provided by The Danish National Research Foundation (Grant agreement no.: DNRF106). MC was supported by FCT -Fundacao para a Ciencia e a Tecnologia through national funds and by FEDER through COMPETE2020 -Programa Operacional Competitividade e Internacionalizacao by these grants: UID/FIS/04434/2019, PTDC/FIS-AST/30389/2017, and POCI-01-0145-FEDER-030389. MC is supported in the form of work contract funded by national funds through FCT (CEECIND/02619/2017). JDD acknowledges support from the Polish National Science Center (NCN), grant no. 2018/29/B/ST9/02803. AGH acknowledges funding support from Spanish public funds for research under projects ESP201787676-2-2 and ESP2015-65712-C5-5-R of the Spanish Ministry of Science and Education. FKA gratefully acknowledges funding through grant 2015/18/A/ST9/00578 of the Polish National Science Centre (NCN). JPe acknowledges funding support from the NSF REU program under grant number PHY-1359195. APi and KK acknowledge support provided by the Polish National Science Center (NCN) grant No. 2016/21/B/ST9/01126. This project has been supported by the Lendulet Program of the Hungarian Academy of Sciences, project No. LP2018-7/2018, and by the support provided from the National Research, Development and Innovation Fund of Hungary, financed under the K16 funding scheme, project No. 115709. JCS acknowledges funding support from Spanish public funds for research under projects ESP2017-87676-2-2 and ESP2015-65712-C5-5-R, and from project RYC2012-09913 under the 'Ramon y Cajal' program of the Spanish Ministry of Science and Education. The research leading to these results has (partially) received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement N.670519: MAMSIE), from the KULeuven Research Council (grant C16/18/005: PARADISE), from the Research Foundation Flanders (FWO) under grant agreement G0H5416N (ERC Runner Up Project), as well as from the BELgian federal Science Policy Office (BELSPO) through PRODEX grant PLATO. SBF acknowledges support by the Spanish State Research Agency (AEI) through project No. 'ESP2017-87676-C5-1-R' and No MDM-2017-0737 Unidad de Excelencia `Maria de Maeztu'-Centro de Astrobiolog ' ia (CSICINTA). ZsB acknowledges the support provided from the National Research, Development and Innovation Fund of Hungary, financed under the PD1717 funding scheme, project no. PD-123910. DLB acknowledges support from the Whitaker Foundation. SC gratefully acknowledges funding through grant 2015/18/A/ST9/00578 of the Polish National Science Centre (NCN). CCL gratefully acknowledges support from the Natural Sciences and Engineering Research Council of Canada. GMM acknowledges funding by the STFC consolidated grant ST/R000603/1. RMO, SC, and DR were supported in this work by the 'Programme National de Physique Stellaire' (PNPS) of CNRS/INSU co-funded by CEA and CNES. IS acknowledges the partial support of projects DN 08-1/2016 and DN 18/13-12.12.2017. PS acknowledges financial support by the Polish NCN grant 2015/18/A/ST9/00578. MS acknowledges the Postdoc@MUNI project CZ.02.2.69/0.0/0.0/16-027/0008360. JPG, JRR, and MLM acknowledge funding support from Spanish public funds for research under project ESP2017-87676-C5-5-R and from the State Agency for Research of the Spanish MCIU through the 'Center of Excellence Severo Ochoa' award for the Instituto de Astrofisica de Andalucia (SEV-2017-0709). JAE acknowledges STFC for funding support (reference ST/N504348/1). LFM acknowledges the financial support from the DGAPA-UNAM under grant PAPIIT IN100918. DMk acknowledges his work as part of the research activity of the National Astronomical Research Institute of Thailand (NARIT), which is supported by the Ministry of Science and Technology of Thailand. MR acknowledges the support of the French Agence Nationale de la Recherche (ANR), under grant ESRR (ANR-16-CE31-0007-01). We acknowledge the International Space Science Institute (ISSI) for supporting the SoFAR international team http://www.issi.unibe.ch/teams/sofar/.TW acknowledges the NSFC of China (Grant Nos. 11873084 and 11521303) and YunnanApplied Basic Research Projects (GrantNo. 2017B008). IS acknowledges for a partial support of DN 08-1/2016 funded by the Bulgarian NSF. This work hasmade use of data from the European Space Agency (ESA) mission Gaia (https://www.cosmos.esa.int/gaia), processed by the Gaia Data Processing and Analysis Consortium (DPAC, ht tps://www.cosmos.esa.int/web/gaia/dpac/consortium).Funding for the DPAC has been provided by national institutions, in particular the institutions participating in the Gaia Multilateral Agreement. The research leading to these results has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement No. 670519: MAMSIE) and from the Fonds Wetenschappelijk Onderzoek - Vlaanderen (FWO) under the grant agreement G0H5416N (ERC Opvangproject). This research has made use of the VizieR catalogue access tool, CDS, Strasbourg, France (DOI:10.26093/cds/vizier). The original description of the VizieR service was published in A&AS 143, 23. This publication makes use of data products from the Two Micron All Sky Survey, which is a joint project of the University of Massachusetts and the Infrared Processing and Analysis Center/California Institute of Technology, funded by the National Aeronautics and Space Administration and the National Science Foundation.
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Primary stroke prevention worldwide: translating evidence into action
Stroke is the second leading cause of death and the third leading cause of disability worldwide and its burden is increasing rapidly in low-income and middle-income countries, many of which are unable to face the challenges it imposes. In this Health Policy paper on primary stroke prevention, we provide an overview of the current situation regarding primary prevention services, estimate the cost of stroke and stroke prevention, and identify deficiencies in existing guidelines and gaps in primary prevention. We also offer a set of pragmatic solutions for implementation of primary stroke prevention, with an emphasis on the role of governments and population-wide strategies, including task-shifting and sharing and health system re-engineering. Implementation of primary stroke prevention involves patients, health professionals, funders, policy makers, implementation partners, and the entire population along the life course.
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Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study
Background Surgery is the main modality of cure for solid cancers and was prioritised to continue during COVID-19 outbreaks. This study aimed to identify immediate areas for system strengthening by comparing the delivery of elective cancer surgery during the COVID-19 pandemic in periods of lockdown versus light restriction. Methods This international, prospective, cohort study enrolled 20 006 adult (≥18 years) patients from 466 hospitals in 61 countries with 15 cancer types, who had a decision for curative surgery during the COVID-19 pandemic and were followed up until the point of surgery or cessation of follow-up (Aug 31, 2020). Average national Oxford COVID-19 Stringency Index scores were calculated to define the government response to COVID-19 for each patient for the period they awaited surgery, and classified into light restrictions (index 60). The primary outcome was the non-operation rate (defined as the proportion of patients who did not undergo planned surgery). Cox proportional-hazards regression models were used to explore the associations between lockdowns and non-operation. Intervals from diagnosis to surgery were compared across COVID-19 government response index groups. This study was registered at ClinicalTrials.gov, NCT04384926. Findings Of eligible patients awaiting surgery, 2003 (10·0%) of 20 006 did not receive surgery after a median follow-up of 23 weeks (IQR 16–30), all of whom had a COVID-19-related reason given for non-operation. Light restrictions were associated with a 0·6% non-operation rate (26 of 4521), moderate lockdowns with a 5·5% rate (201 of 3646; adjusted hazard ratio [HR] 0·81, 95% CI 0·77–0·84; p<0·0001), and full lockdowns with a 15·0% rate (1775 of 11 827; HR 0·51, 0·50–0·53; p<0·0001). In sensitivity analyses, including adjustment for SARS-CoV-2 case notification rates, moderate lockdowns (HR 0·84, 95% CI 0·80–0·88; p<0·001), and full lockdowns (0·57, 0·54–0·60; p<0·001), remained independently associated with non-operation. Surgery beyond 12 weeks from diagnosis in patients without neoadjuvant therapy increased during lockdowns (374 [9·1%] of 4521 in light restrictions, 317 [10·4%] of 3646 in moderate lockdowns, 2001 [23·8%] of 11 827 in full lockdowns), although there were no differences in resectability rates observed with longer delays. Interpretation Cancer surgery systems worldwide were fragile to lockdowns, with one in seven patients who were in regions with full lockdowns not undergoing planned surgery and experiencing longer preoperative delays. Although short-term oncological outcomes were not compromised in those selected for surgery, delays and non-operations might lead to long-term reductions in survival. During current and future periods of societal restriction, the resilience of elective surgery systems requires strengthening, which might include protected elective surgical pathways and long-term investment in surge capacity for acute care during public health emergencies to protect elective staff and services. Funding National Institute for Health Research Global Health Research Unit, Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, Medtronic, Sarcoma UK, The Urology Foundation, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research.
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Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study
Background Surgery is the main modality of cure for solid cancers and was prioritised to continue during COVID-19 outbreaks. This study aimed to identify immediate areas for system strengthening by comparing the delivery of elective cancer surgery during the COVID-19 pandemic in periods of lockdown versus light restriction. Methods This international, prospective, cohort study enrolled 20 006 adult (≥18 years) patients from 466 hospitals in 61 countries with 15 cancer types, who had a decision for curative surgery during the COVID-19 pandemic and were followed up until the point of surgery or cessation of follow-up (Aug 31, 2020). Average national Oxford COVID-19 Stringency Index scores were calculated to define the government response to COVID-19 for each patient for the period they awaited surgery, and classified into light restrictions (index 60). The primary outcome was the non-operation rate (defined as the proportion of patients who did not undergo planned surgery). Cox proportional-hazards regression models were used to explore the associations between lockdowns and non-operation. Intervals from diagnosis to surgery were compared across COVID-19 government response index groups. This study was registered at ClinicalTrials.gov, NCT04384926. Findings Of eligible patients awaiting surgery, 2003 (10·0%) of 20 006 did not receive surgery after a median follow-up of 23 weeks (IQR 16–30), all of whom had a COVID-19-related reason given for non-operation. Light restrictions were associated with a 0·6% non-operation rate (26 of 4521), moderate lockdowns with a 5·5% rate (201 of 3646; adjusted hazard ratio [HR] 0·81, 95% CI 0·77–0·84; p<0·0001), and full lockdowns with a 15·0% rate (1775 of 11 827; HR 0·51, 0·50–0·53; p<0·0001). In sensitivity analyses, including adjustment for SARS-CoV-2 case notification rates, moderate lockdowns (HR 0·84, 95% CI 0·80–0·88; p<0·001), and full lockdowns (0·57, 0·54–0·60; p<0·001), remained independently associated with non-operation. Surgery beyond 12 weeks from diagnosis in patients without neoadjuvant therapy increased during lockdowns (374 [9·1%] of 4521 in light restrictions, 317 [10·4%] of 3646 in moderate lockdowns, 2001 [23·8%] of 11827 in full lockdowns), although there were no differences in resectability rates observed with longer delays. Interpretation Cancer surgery systems worldwide were fragile to lockdowns, with one in seven patients who were in regions with full lockdowns not undergoing planned surgery and experiencing longer preoperative delays. Although short-term oncological outcomes were not compromised in those selected for surgery, delays and non-operations might lead to long-term reductions in survival. During current and future periods of societal restriction, the resilience of elective surgery systems requires strengthening, which might include protected elective surgical pathways and long- term investment in surge capacity for acute care during public health emergencies to protect elective staff and services. Funding National Institute for Health Research Global Health Research Unit, Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, Medtronic, Sarcoma UK, The Urology Foundation, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research.
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