Suchergebnisse

Context. A group of trans-Neptunian objects (TNOs) are dynamically related to the dwarf planet 136108 Haumea. Ten of them show strong indications of water ice on their surfaces, are assumed to have resulted from a collision, and are accepted as the only known TNO collisional family. Nineteen other dynamically similar objects lack water ice absorptions and are hypothesized to be dynamical interlopers. Aims. We have made observations to determine sizes and geometric albedos of six of the accepted Haumea family members and one dynamical interloper. Ten other dynamical interlopers have been measured by previous works. We compare the individual and statistical properties of the family members and interlopers, examining the size and albedo distributions of both groups. We also examine implications for the total mass of the family and their ejection velocities. Methods. We use far-infrared space-based telescopes to observe the target TNOs near their thermal peak and combine these data with optical magnitudes to derive sizes and albedos using radiometric techniques. Using measured and inferred sizes together with ejection velocities, we determine the power-law slope of ejection velocity as a function of effective diameter. Results. The detected Haumea family members have a diversity of geometric albedos 0.3-0.8, which are higher than geometric albedos of dynamically similar objects without water ice. The median geometric albedo for accepted family members is pV = 0.48-0.18 +0.28, compared to 0.08-0.05 +0.07 for the dynamical interlopers. In the size range D = 175-300 km, the slope of the cumulative size distribution is q = 3.2-0.4 +0.7 for accepted family members, steeper than the q = 2.0 ± 0.6 slope for the dynamical interlopers with D < 500 km. The total mass of Haumea's moons and family members is 2.4% of Haumea's mass. The ejection velocities required to emplace them on their current orbits show a dependence on diameter, with a power-law slope of 0.21-0.50. © ESO 2018. ; Part of this work was supported by the German DLR project number 50 OR 1108. T.M., C.K., P.S., and R.D. acknowledge that the research leading to these results has received funding from the European Union's Horizon 2020 Research and Innovation Programme, under Grant Agreement no 687378. A.P. acknowledges the grant LP2012-31 of the Hungarian Academy of Sciences. N.P. acknowledges funding by the Portuguese FCT - Foundation for Science and Technology (ref: SFRH/BGCT/113686/2015). CITEUC is funded by Portuguese National Funds through FCT - Foundation for Science and Technology (project: UID/Multi/00611/2013) and FEDER - European Regional Development Fund through COMPETE 2020 - Operational Programme Competitiveness and Internationalisation (project: POCI-01-0145-FEDER-006922). C.K. has been supported by the K-125015 and GINOP-2.3.2-15-2016-00003 grants of the National Research, Development and Innovation Office (NKFIH, Hungary).

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. ; A stellar occultation by Pluto was observed on 2020 June 6 with the 1.3 m and 3.6 m telescopes located at Devasthal, Nainital, India, using imaging systems in the I and H bands, respectively. From this event, we derive a surface pressure for Pluto's atmosphere of psurf=12.23-0.38+0.65 μbar. This shows that Pluto's atmosphere has been in a plateau phase since mid-2015, a result which is in excellent agreement with the Pluto volatile transport model of Meza et al. This value does not support the pressure decrease reported by independent teams, based on occultations observed in 2018 and 2019 by Young et al. and Arimatsu et al., respectively. © 2021. The Author(s). Published by the American Astronomical Society. ; The authors are grateful to the Directors of ARIES and IIA for granting time under Directors' Discretionary Time allotment for observing this event. The authors also thank the staff of the Devasthal Observatory and the IR Group at TIFR for their help during observations. The work leading to these results has received funding from the European Research Council under the European Community's H2020 2014-2021 ERC Grant Agreement no. 669416 "Lucky Star." Research at PRL and IIST is supported by the Department of Space, Government of India. M.A., G.B.-R., F.B.-R., and R.V.-M. thank CNPq and CAPES for grants 313144/2020-6, 314772/2020-0, 465376/2014-2, and Process 88887.310463/2018-00—Project 88887.571156/2020-00. R.V.-M. also thanks grant CNPq 304544/2017-6. P.S-S. acknowledges financial support by the Spanish grant AYA-RTI2018-098657-J-I00 "LEO-SBNAF" (MCIU/AEI/FEDER, UE). ; With funding from the Spanish government through the Severo Ochoa Centre of Excellence accreditation SEV-2017-0709. ; Peer reviewed

Open Access article, published by EDP Sciences, under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ; Context. From 1988 to 2016, several stellar occultations have been observed to characterise Pluto's atmosphere and its evolution. From each stellar occultation, an accurate astrometric position of Pluto at the observation epoch is derived. These positions mainly depend on the position of the occulted star and the precision of the timing. Aims. We present 19 Pluto's astrometric positions derived from occultations from 1988 to 2016. Using Gaia DR2 for the positions of the occulted stars, the accuracy of these positions is estimated at 2-10 mas, depending on the observation circumstances. From these astrometric positions, we derive an updated ephemeris of Pluto's system barycentre using the NIMA code. Methods. The astrometric positions were derived by fitting the light curves of the occultation by a model of Pluto's atmosphere. The fits provide the observed position of the centre for a reference star position. In most cases other publications provided the circumstances of the occultation such as the coordinates of the stations, timing, and impact parameter, i.e. the closest distance between the station and centre of the shadow. From these parameters, we used a procedure based on the Bessel method to derive an astrometric position. Results. We derive accurate Pluto's astrometric positions from 1988 to 2016. These positions are used to refine the orbit of Pluto'system barycentre providing an ephemeris, accurate to the milliarcsecond level, over the period 2000-2020, allowing for better predictions for future stellar occultations.© J. Desmars et al. 2019. ; Part of the research leading to these results has received funding from the European Research Council under the European Community's H2020 (2014 2020/ERC Grant Agreement No. 669416 >LUCKY STAR>). This work has made use of data from the European Space Agency (ESA) mission Gaia (https://www.cosmos.esa.int/gaia), processedby the Gaia Data Processing and Analysis Consortium (DPAC, https://www.cosmos.esa.int/web/gaia/dpac/consortium).Funding for the DPAC has been provided by national institutions, in particular the institutions participating in the Gaia Multilateral Agreement. J.I.B.C. acknowledges CNPq grant 308150/2016-3. M.A. thanks CNPq (Grants 427700/2018-3, 310683/2017-3 and 473002/2013-2) and FAPERJ (Grant E-26/111.488/2013). G.B.R. is thankful for the support of the CAPES (203.173/2016) and FAPERJ/PAPDRJ (E26/200.464/2015-227833) grants. This study was financed in part by the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior -Brasil (CAPES) -Finance Code 001. F.B.R. acknowledges CNPq grant 309578/2017-5. A.R.G-J thanks FAPESP proc. 2018/11239-8. R.V-M thanks grants: CNPq-304544/2017-5, 401903/2016-8, Faperj: PAPDRJ-45/2013 and E-26/203.026/2015 P.S.-S. acknowledges financial support by the European Union's Horizon 2020 Research and Innovation Programme, under Grant Agreement no 687378, as part of the project > Small Bodies Near and Far> (SBNAF). ; Peer Reviewed

Context. From 1988 to 2016, several stellar occultations have been observed to characterise Pluto's atmosphere and its evolution. From each stellar occultation, an accurate astrometric position of Pluto at the observation epoch is derived. These positions mainly depend on the position of the occulted star and the precision of the timing. Aims. We present 19 Pluto's astrometric positions derived from occultations from 1988 to 2016. Using Gaia DR2 for the positions of the occulted stars, the accuracy of these positions is estimated at 2-10 mas, depending on the observation circumstances. From these astrometric positions, we derive an updated ephemeris of Pluto's system barycentre using the NIMA code. Methods. The astrometric positions were derived by fitting the light curves of the occultation by a model of Pluto's atmosphere. The fits provide the observed position of the centre for a reference star position. In most cases other publications provided the circumstances of the occultation such as the coordinates of the stations, timing, and impact parameter, i.e. the closest distance between the station and centre of the shadow. From these parameters, we used a procedure based on the Bessel method to derive an astrometric position. Results. We derive accurate Pluto's astrometric positions from 1988 to 2016. These positions are used to refine the orbit of Pluto'system barycentre providing an ephemeris, accurate to the milliarcsecond level, over the period 2000-2020, allowing for better predictions for future stellar occultations.© J. Desmars et al. 2019. ; Part of the research leading to these results has received funding from the European Research Council under the European Community's H2020 (2014 2020/ERC Grant Agreement No. 669416 >LUCKY STAR>). This work has made use of data from the European Space Agency (ESA) mission Gaia (https://www.cosmos.esa.int/gaia), processedby the Gaia Data Processing and Analysis Consortium (DPAC, https://www.cosmos.esa.int/web/gaia/dpac/consortium).Funding for the DPAC has been provided by national institutions, in particular the institutions participating in the Gaia Multilateral Agreement. J.I.B.C. acknowledges CNPq grant 308150/2016-3. M.A. thanks CNPq (Grants 427700/2018-3, 310683/2017-3 and 473002/2013-2) and FAPERJ (Grant E-26/111.488/2013). G.B.R. is thankful for the support of the CAPES (203.173/2016) and FAPERJ/PAPDRJ (E26/200.464/2015-227833) grants. This study was financed in part by the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior -Brasil (CAPES) -Finance Code 001. F.B.R. acknowledges CNPq grant 309578/2017-5. A.R.G-J thanks FAPESP proc. 2018/11239-8. R.V-M thanks grants: CNPq-304544/2017-5, 401903/2016-8, Faperj: PAPDRJ-45/2013 and E-26/203.026/2015 P.S.-S. acknowledges financial support by the European Union's Horizon 2020 Research and Innovation Programme, under Grant Agreement no 687378, as part of the project > Small Bodies Near and Far> (SBNAF). ; Peer Reviewed

Table A.1 is only available at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/625/A46 ; Aims. We studied the rotational properties of the dwarf planet Makemake. Methods. The photometric observations were carried out at different telescopes between 2006 and 2017. Most of the measurements were acquired in BVRI broad-band filters of a standard Johnson-Cousins photometric system. Results. We found that Makemake rotates more slowly than was previously reported. A possible lightcurve asymmetry suggests a double-peaked period of P = 22.8266 ± 0.0001 h. A small peak-to-peak lightcurve amplitude in R-filter A = 0.032 ± 0.005 mag implies an almost spherical shape or near pole-on orientation. We also measured BVRI colours and the R-filter phase-angle slope and revised the absolute magnitudes. The absolute magnitude of Makemake has remained unchanged since its discovery in 2005. No direct evidence of a newly discovered satellite was found in our photometric data; however, we discuss the possible existence of another larger satellite.© ESO 2019 ; J.L.O., R.D., and P.S.-S acknowledges financial support from the State Agency for Research of the Spanish MCIU through the >Center of Excellence Severo Ochoa> award for the Instituto de Astrofisica de Andalucia (SEV-2017-0709). Funding from MINECO project AYA2017-89637-R is acknowledged. Part of the research leading to these results has received funding from the European Union's Horizon 2020 Research and Innovation Programme, under Grant Agreement no 687378, as part of the project >Small Bodies Near and Far> (SBNAF). R.Ya.I., V.R.A., and V.T.Z. are grateful to the Shota Rustaveli National Science Foundation grant FR-18-1193 for the partial financial support. D.P. has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement n. 664931. I.V.R. and A.V.S. were partly supported by the programme BR05236322 of the Ministry of Education and Science of the Republic of Kazakhstan and the scientific and technical program BR05336383 >Applied scientific research in the field of space activities>. ; Peer Reviewed

The combination of visible and thermal data from the ground and astrophysics space missions is key to improving the scientific understanding of near-Earth, main-belt, trojans, centaurs, and trans-Neptunian objects. To get full information on a small sample of selected bodies we combine different methods and techniques: lightcurve inversion, stellar occultations, thermophysical modelling, radiometric methods, radar ranging and adaptive optics imaging. The SBNAF project will derive size, spin and shape, thermal inertia, surface roughness, and in some cases bulk densities and even internal structure and composition, for objects out to the most distant regions in the Solar System. The applications to objects with ground-truth information allows us to advance the techniques beyond the current state-of-the-art and to assess the limitations of each method. We present results from our project's first phase: the analysis of combined Herschel-KeplerK2 data and Herschel-occultation data for TNOs; synergy studies on large MBAs from combined high-quality visual and thermal data; establishment of well-known asteroids as celestial calibrators for far-infrared, sub-millimetre, and millimetre projects; first results on near-Earth asteroids properties from combined lightcurve, radar and thermal measurements, as well as the Hayabusa-2 mission target characterisation. We also introduce public web-services and tools for studies of small bodies in general. © 2017 COSPAR ; The research leading to these results has received funding from the European Union's Horizon 2020 Research and Innovation Programme, under Grant Agreement no. 687378.

Obtained from Haematologica/the Hematology Journal website http://www.haematologica.org ; Peripheral T-cell lymphomas are very aggressive hematologic malignancies for which there is no targeted therapy. New, rational approaches are necessary to improve the very poor outcome in these patients. Phosphatidylinositol- 3-kinase is one of the most important pathways in cell survival and proliferation. We hypothesized that phosphatidylinositol- 3-kinase inhibitors could be rationally selected drugs for treating peripheral T-cell lymphomas. Several phosphatidylinositol-3-kinase isoforms were inhibited genetically (using small interfering RNA) and pharmacologically (with CAL-101 and GDC-0941 compounds) in a panel of six peripheral and cutaneous T-cell lymphoma cell lines. Cell viability was measured by intracellular ATP content; apoptosis and cell cycle changes were checked by flow cytometry. Pharmacodynamic biomarkers were assessed by western blot. The PIK3CD gene, which encodes the δ isoform of phosphatidylinositol-3-kinase, was overexpressed in cell lines and primary samples, and correlated with survival pathways. However, neither genetic nor specific pharmacological inhibition of phosphatidylinositol-3-kinase δ affected cell survival. In contrast, the pan-phosphatidylinositol-3-kinase inhibitor GDC-0941 arrested all T-cell lymphoma cell lines in the G1 phase and induced apoptosis in a subset of them. We identified phospho-GSK3b and phospho-p70S6K as potential biomarkers of phosphatidylinositol-3-kinase inhibitors. Interestingly, an increase in ERK phosphorylation was observed in some GDC-0941-treated T-cell lymphoma cell lines, suggesting the presence of a combination of phosphatidylinositol-3-kinase and MEK inhibitors. A highly synergistic effect was found between the two inhibitors, with the combination enhancing cell cycle arrest at G0/G1 in all T-cell lymphoma cell lines, and reducing cell viability in primary tumor T cells ex vivo. These results suggest that the combined treatment of pan-phosphatidylinositol-3-kinase + MEK inhibitors could be more effective than single phosphatidylinositol-3-kinase inhibitor treatment, and therefore, that this combination could be of therapeutic value for treating peripheral and cutaneous T-cell lymphomas. ; This work was supported by grants from the Asociación Española Contra el Cáncer, Fondo de Investigaciones Sanitarias (PI051623, PI052800 and PI080856), RTICC (RD06/0020/0107) and Ministerio de Ciencia e Innovación (SAF2008-0387-1). EMS is supported by a grant from the Department of Education, Universities and Research of the Basque Government (BFI08.207). MSB is supported by a Contract Miguel Servet from Fondo de Investigaciones Sanitarias (CP11/00018)

Open Access article, published by EDP Sciences, under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ; Context. The tenuous nitrogen (N2) atmosphere on Pluto undergoes strong seasonal effects due to high obliquity and orbital eccentricity, and has recently (July 2015) been observed by the New Horizons spacecraft. Aims. The main goals of this study are (i) to construct a well calibrated record of the seasonal evolution of surface pressure on Pluto and (ii) to constrain the structure of the lower atmosphere using a central flash observed in 2015. Methods. Eleven stellar occultations by Pluto observed between 2002 and 2016 are used to retrieve atmospheric profiles (density, pressure, temperature) between altitude levels of ∼5 and ∼380 km (i.e. pressures from ∼10 μbar to 10 nbar). Results. (i) Pressure has suffered a monotonic increase from 1988 to 2016, that is compared to a seasonal volatile transport model, from which tight constraints on a combination of albedo and emissivity of N2 ice are derived. (ii) A central flash observed on 2015 June 29 is consistent with New Horizons REX profiles, provided that (a) large diurnal temperature variations (not expected by current models) occur over Sputnik Planitia; and/or (b) hazes with tangential optical depth of ∼0.3 are present at 4-7 km altitude levels; and/or (c) the nominal REX density values are overestimated by an implausibly large factor of ∼20%; and/or (d) higher terrains block part of the flash in the Charon facing hemisphere.© E. Meza et al. 2019 ; The work leading to these results has received funding from the European Research Council under the European Community's H2020 2014-2020 ERC Grant Agreement no 669416 >Lucky Star>. E.M. thanks support from Concytec-Fondecyt-PE and GA, FC-UNI for providing support during the 2012 July 18 occultation. B.S. thanks S. Para for partly supporting this research though a donation, J. P. Beaulieu for helping us accessing to the Hobart Observatory facilities and B. Warner, B. L. Gary, C. Erickson, H. Reitsema, L. Albert, P. J. Merritt, T. Hall, W. J. Romanishin, Y. J. Choi for providing data during the 2007 March 18 occultation. M.A. thanks CNPq (Grants 427700/2018-3, 310683/2017-3 and 473002/2013-2) and FAPERJ (Grant E-26/111.488/2013). J.L.O. thanks support from grant AYA2017-89637-R. P.S.S. acknowledges financial support from the European Union's Horizon 2020 Research and Innovation Programme, under Grant Agreement no 687378, as part of the project > Small Bodies Near and Far> (SBNAF). J.L.O., R.D., P.S.S. and N.M. acknowledge financial support from the State Agency for Research of the Spanish MCIU through the > Center of Excellence Severo Ochoa> award for the Instituto de Astrofisica de Andalucia (SEV-2017-0709). F.B.R. acknowledges CNPq support process 309578/2017-5. G.B.R. thanks support from the grant CAPES-FAPERJ/PAPDRJ (E26/203.173/2016). J.I.B.C. acknowledges CNPq grant 308150/2016-3. R.V.M. thanks the grants: CNPq-304544/2017-5, 401903/2016-8, and Faperj: PAPDRJ-45/2013 and E-26/203.026/2015. B.M. thanks the CAPES/Cofecub-394/2016-05 grant and CAPES/Brazil -Finance Code 001. B.M. and A.R.G.J. were financed in part by the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior -Brasil (CAPES) -Finance Code 001. TRAPPIST-North is a project funded by the University of Liege, in collaboration with Cadi Ayyad University of Marrakech (Morocco). TRAPPIST-South is a project funded by the Belgian Fonds (National) de la Recherche Scientifique (F.R.S.-FNRS) under grant FRFC 2.5.594.09. F, with the participation of the Swiss National Science Foundation (FNS/SNSF). VSD, SPL, TRM and ULTRACAM are all supported by the STFC. K.G. acknowledges help from the team of Archenhold-Observatory, Berlin, and A. R. thanks G. Roman (Granada) for help during the observation of the 2016 July 19 occultation. A.J.C.T. acknowledges support from the Spanish Ministry Project AYA2015-71718-R (including EU funds). ; Peer Reviewed

Haumea—one of the four known trans-Neptunian dwarf planets—is a very elongated and rapidly rotating body1, 2, 3. In contrast to other dwarf planets4, 5, 6, its size, shape, albedo and density are not well constrained. The Centaur Chariklo was the first body other than a giant planet known to have a ring system7, and the Centaur Chiron was later found to possess something similar to Chariklo's rings8, 9. Here we report observations from multiple Earth-based observatories of Haumea passing in front of a distant star (a multi-chord stellar occultation). Secondary events observed around the main body of Haumea are consistent with the presence of a ring with an opacity of 0.5, width of 70 kilometres and radius of about 2,287 kilometres. The ring is coplanar with both Haumea's equator and the orbit of its satellite Hi'iaka. The radius of the ring places it close to the 3:1 mean-motion resonance with Haumea's spin period—that is, Haumea rotates three times on its axis in the time that a ring particle completes one revolution. The occultation by the main body provides an instantaneous elliptical projected shape with axes of about 1,704 kilometres and 1,138 kilometres. Combined with rotational light curves, the occultation constrains the three-dimensional orientation of Haumea and its triaxial shape, which is inconsistent with a homogeneous body in hydrostatic equilibrium. Haumea's largest axis is at least 2,322 kilometres, larger than previously thought, implying an upper limit for its density of 1,885 kilograms per cubic metre and a geometric albedo of 0.51, both smaller than previous estimates1, 10, 11. In addition, this estimate of the density of Haumea is closer to that of Pluto than are previous estimates, in line with expectations. No global nitrogen- or methane-dominated atmosphere was detected. ; J.L.O. acknowledges funding from Spanish and Andalusian grants MINECO AYA-2014-56637-C2-1-P and J. A. 2012-FQM1776 as well as FEDER funds. Part of the research leading to these results received funding from the European Union's Horizon 2020 Research and Innovation Programme, under grant agreement no. 687378. B.S. acknowledges support from the French grants 'Beyond Neptune' ANR-08-BLAN-0177 and 'Beyond Neptune II' ANR-11-IS56-0002. Part of the research leading to these results has received funding from the European Research Council under the European Community's H2020 (2014-2020/ERC grant agreement no. 669416 'Lucky Star'). A.P. and R.S. have been supported by the grant LP2012-31 of the Hungarian Academy of Sciences. All of the Hungarian contributors acknowledge the partial support from K-125015 grant of the National Research, Development and Innovation Office (NKFIH). G.B.-R., F.B.-R., F.L.R., R.V.-M., J.I.B.C., M.A., A.R.G.-J. and B.E.M. acknowledge support from CAPES, CNPq and FAPERJ. J.C.G. acknowledges funding from AYA2015-63939-C2-2-P and from the Generalitat Valenciana PROMETEOII/2014/057. K.H. and P.P. were supported by the project RVO:67985815. The Astronomical Observatory of the Autonomous Region of the Aosta Valley acknowledges a Shoemaker NEO Grant 2013 from The Planetary Society. We acknowledge funds from a 2016 'Research and Education' grant from Fondazione CRT. We also acknowledge the Slovakian project ITMS no. 26220120029.