Suchergebnisse

The INHAND Proposal (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) has been operational since 2005. A Global Editorial Steering Committee (GESC) manages the overall objectives of the project and the development of harmonized terminology for each organ system is the responsibility of the Organ Working Groups (OWG), drawing upon experts from North America, Europe and Japan.Great progress has been made with 9 systems published to date – Respiratory, Hepatobiliary, Urinary, Central/Peripheral Nervous Systems, Male Reproductive and Mammary, Zymbals, Clitoral and Preputial Glands in Toxicologic Pathology and the Integument and Soft Tissue and Female Reproductive System in the Journal of Toxicologic Pathology as supplements and on a web site – www.goreni.org. INHAND nomenclature guides offer diagnostic criteria and guidelines for recording lesions observed in rodent toxicity and carcinogenicity studies. The guides provide representative photo-micrographs of morphologic changes, information regarding pathogenesis, and key references. During 2012, INHAND GESC representatives attended meetings with representatives of the FDA Center for Drug Evaluation and Research (CDER), Clinical Data Interchange Standards Consortium (CDISC), and the National Cancer Institute (NCI) Enterprise Vocabulary Services (EVS) to begin incorporation of INHAND terminology as preferred terminology for SEND (Standard for Exchange of Nonclinical Data) submissions to the FDA. The interest in utilizing the INHAND nomenclature, based on input from industry and government toxicologists as well as information technology specialists, suggests that there will be wide acceptance of this nomenclature. The purpose of this publication is to provide an update on the progress of INHAND.

Cell and tissue polarization is fundamental for plant growth and morphogenesis. The polar, cellular localization ofArabidopsisPIN-FORMED (PIN) proteins is crucial for their function in directional auxin transport. The clustering of PIN polar cargoes within the plasma membrane has been proposed to be important for the maintenance of their polar distribution. However, the more detailed features of PIN clusters and the cellular requirements of cargo clustering remain unclear. Here, we characterized PIN clusters in detail by means of multiple advanced microscopy and quantification methods, such as 3D quantitative imaging or freeze-fracture replica labeling. The size and aggregation types of PIN clusters were determined by electron microscopy at the nanometer level at different polar domains and at different developmental stages, revealing a strong preference for clustering at the polar domains. Pharmacological and genetic studies revealed that PIN clusters depend on phosphoinositol pathways, cytoskeletal structures and specific cell-wall components as well as connections between the cell wall and the plasma membrane. This study identifies the role of different cellular processes and structures in polar cargo clustering and provides initial mechanistic insight into the maintenance of polarity in plants and other systems. ; European Research Council (ERC) 742985 Comision Nacional de Investigacion Cientifica y Tecnologica CONICYT-PAI 82130047 European Union (EU) 291734

Dieses Werk präsentiert interdisziplinäre und internationale Zugänge zur Transkulturalität aus Philosophie, Politikwissenschaft, Ethnomusikologie, Popularmusikforschung, Gender und Queer-Studies, Musikwissenschaft, Musikpädagogik, Postcolonial Studies, Migrationsforschung und Minderheitenforschung. Es sind die nachhaltigen Ergebnisse einer Ringvorlesung an der Universität für Musik und darstellende Kunst Wien-mdw aus den Jahren 2014-2018, bei der Wissenschaft und Kunst in einen fruchtbaren Dialog traten.

The ERASMUS+ grant program of the European Union under grant no. 2014-1-DE01-KA203-00624 has funded the creation of the resource. Neither the European Commission nor the project's national funding agency DAAD are responsible for the content or liable for any losses or damage resulting of the use of these resources

The creation of the resource has been (partially) funded by the ERASMUS+ grant program of the European Union under grant no. 2014-1-DE01-KA203-00624. Neither the European Commission nor the project's national funding agency DAAD are responsible for the content or liable for any losses or damage resulting from the use of this resource.