Suchergebnisse

Abstract Background Accurate, high-throughput genotyping allows the fine characterization of genetic ancestry. Here we applied recently developed statistical and computational techniques to the question of African ancestry in African Americans by using data on more than 450,000 single-nucleotide polymorphisms (SNPs) genotyped in 94 Africans of diverse geographic origins included in the HGDP, as well as 136 African Americans and 38 European Americans participating in the Atherosclerotic Disease Vascular Function and Genetic Epidemiology (ADVANCE) study. To focus on African ancestry, we reduced the data to include only those genotypes in each African American determined statistically to be African in origin. Results From cluster analysis, we found that all the African Americans are admixed in their African components of ancestry, with the majority contributions being from West and West-Central Africa, and only modest variation in these African-ancestry proportions among individuals. Furthermore, by principal components analysis, we found little evidence of genetic structure within the African component of ancestry in African Americans. Conclusions These results are consistent with historic mating patterns among African Americans that are largely uncorrelated to African ancestral origins, and they cast doubt on the general utility of mtDNA or Y-chromosome markers alone to delineate the full African ancestry of African Americans. Our results also indicate that the genetic architecture of African Americans is distinct from that of Africans, and that the greatest source of potential genetic stratification bias in case-control studies of African Americans derives from the proportion of European ancestry.

ObjectiveThis article examines the effects of southern culture on the attitudes and political predisposition of southern African Americans.MethodUsing unique survey data, with large oversamples of African Americans, this article explores whether southern blacks have a more positive opinion of the American system than African Americans who reside outside the south.ResultsWe find a "southern effect" occurs among African Americans. Southern blacks express more support for traditionally defined American political and social values than nonsouthern blacks; however, this gap is less than a third the size of the regional gap among whites.ConclusionTogether, these findings suggest a complex interplay of race and region on political values and raise profound normative concerns. A group that arguably stands at a greater disadvantage in the political system expresses higher levels of support for that system.

Importance Precision medicine is an approach to detecting, treating, and managing disease that is based on individual variation in genetic, environmental, and lifestyle factors. Precision medicine is expected to reduce health disparities, but this will be possible only if studies have adequate representation of racial minorities. Objective It is critical to anticipate the rates at which individuals from diverse populations are likely to participate in precision medicine studies as research initiatives are being developed. We evaluated the likelihood of participating in a clinical study for precision medicine. Design, Setting, Participants Observational study conducted between October 2010 and February 2011 in a national sample of African Americans. Main Outcome Measure Intentions to participate in a government sponsored study that involves providing a biospecimen and generates data that could be shared with other researchers to conduct future studies. Results One third of respondents would participate in a clinical study for precision medicine. Only gender had a significant independent association with participation intentions. Men had a 1.86 (95% CI = 1.11, 3.12, p = 0.02) increased likelihood of participating in a precision medicine study compared to women in the model that included overall barriers and facilitators. In the model with specific participation barriers, distrust was associated with a reduced likelihood of participating in the research described in the vignette (OR = 0.57, 95% CI = 0.34, 0.96, p = 0.04). Conclusion and Relevance African Americans may have low enrollment in PMI research. As PMI research is implemented, extensive efforts will be needed to ensure adequate representation. Additional research is needed to identify optimal ways of ethically describing precision medicine studies to ensure sufficient recruitment of racial minorities.

"Scholars have paid relatively little attention to the highbrow, middlebrow, and popular periodicals that African Americans read and discussed regularly during the Jim Crow era-publications such as the Chicago Defender, the Crisis, Ebony, and the Half-Century Magazine. Jim Crow Networks considers how these magazines and newspapers, and their authors, readers, advertisers, and editors worked as part of larger networks of activists and thinkers to advance racial uplift and resist racism during the first half of the twentieth century. As Eurie Dahn demonstrates, authors like James Weldon Johnson, Nella Larsen, William Faulkner, and Jean Toomer wrote in the context of interracial and black periodical networks, which shaped the literature they produced and their concerns about racial violence. This original study also explores the overlooked intersections between the black press and modernist and Harlem Renaissance texts, and highlights key sites where readers and writers worked toward bottom-up sociopolitical changes during a period of legalized segregation"--

One of the main goals of the Committee on the Status of Blacks (CSB) is to assess how well African-American political scientists are faring in the discipline. Given the nature of the academy, we believe an important element for success is effective mentoring. Our position is supported by the American Political Science Association (APSA) which established a Task Force on Mentoring in 2002 to address issues facing underrepresented groups within the profession. One of the initiatives is a Mentor Database designed to connect interested minority graduate students and minority faculty with political scientists who are willing to share their experiences and knowledge and give their advice and council to participants. The Committee is supportive of this initiative whose goal is to help underrepresented groups have satisfying professional careers.

The political maturing of African-American scholars & community leaders is traced. African Americans' quest to become part of mainstream US politics while maintaining identication with their homeland parallels similar efforts by other ethnic groups. The sociopolitical movements of Marcus Garvey, Malcolm X, & others demonstrate that African Americans have witnessed & participated in their share of nationalist & ethnocentric movements, but the American Society of African Culture has yielded the most significant institutional impact because it has challenged the US government to consider black Americans for political appointments. Continuing obstacles that African Americans confront as they assume a transnational ethnicity are considered. M. Maguire