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This pathbreaking book illuminates the politics of issue resolution within the European community by evaluating and comparing competing models of decision making across twenty-two policy issues. Written by American and Dutch scholars in the field, the book will be of great interest to students of comparative politics, public policy analysts, mathematic modelers, and all those concerned with the development of the European Community.Contributors: Bruce Bueno de Mesquita, Samuel Eldersveld, Jacek Kugler, A. F. K. Organski, Roy Pierce, Frans N. Stokman, Jan M. M. Van den Bos, Reinier Van Costen, John H. P. Williams

[Background] Population demography and gene flow among African groups, as well as the putative archaic introgression of ancient hominins, have been poorly explored at the genome level. ; [Results] Here, we examine 15 African populations covering all major continental linguistic groups, ecosystems, and lifestyles within Africa through analysis of whole-genome sequence data of 21 individuals sequenced at deep coverage. We observe a remarkable correlation among genetic diversity and geographic distance, with the hunter-gatherer groups being more genetically differentiated and having larger effective population sizes throughout most modern-human history. Admixture signals are found between neighbor populations from both hunter-gatherer and agriculturalists groups, whereas North African individuals are closely related to Eurasian populations. Regarding archaic gene flow, we test six complex demographic models that consider recent admixture as well as archaic introgression. We identify the fingerprint of an archaic introgression event in the sub-Saharan populations included in the models (~ 4.0% in Khoisan, ~ 4.3% in Mbuti Pygmies, and ~ 5.8% in Mandenka) from an early divergent and currently extinct ghost modern human lineage. ; [Conclusion] The present study represents an in-depth genomic analysis of a Pan African set of individuals, which emphasizes their complex relationships and demographic history at population level. ; This study was funded by the Spanish MINECO grants CGL-2013-44351-P, CGL-2016-75389-P, and the "Unidad de Excelencia Maria de Maeztu" MDM2014-0370. BLG was supported with a Beatriu de Pinós (BP-DGR 2014) fellowship. O.L. was supported by a Ramón y Cajal grant from the Spanish Ministerio de Economia y Competitividad (MEIC) with reference RYC-2013-14797, a BFU2015-68759-P (MEIC/FEDER) grant and the support of Secretaria d'Universitats i Recerca del Departament d'Economia i Coneixement de la Generalitat de Catalunya (GRC 2017 SGR 937). O.L. also acknowledges the Spanish Ministry of Economy, Industry and Competitiveness (MEIC) to the EMBL partnership; Centro de Excelencia Severo Ochoa; CERCA Programme / Generalitat de Catalunya; the Spanish Ministry of Economy, Industry and Competitiveness (MEIC) through the Instituto de Salud Carlos III; Generalitat de Catalunya through Departament de Salut and Departament d'Empresa i Coneixement; the co-financing by the Spanish Ministry of Economy, Industry and Competitiveness (MEIC) with funds from the European Regional Development Fund (ERDF) corresponding to the 2014-2020 Smart Growth Operating Program. GSV was supported by a FI (2017FI_B2 00010) scholarship. LFKK was supported by an FPI fellowship associated with BFU2014-55090-P (MINECO/FEDER, UE). VNP was financially supported by the Ministry of Health, Government of Catalonia [grant SLT002/16/00496] and a grant from Otto A. Malmi Foundation (Finland). TMB is supported by BFU2017-86471-P (MINECO/FEDER, UE), U01 MH106874 grant, Howard Hughes International Early Career, Obra Social >La Caixa> and Secretaria d'Universitats i Recerca and CERCA Programme del Departament d'Economia i Coneixement de la Generalitat de Catalunya (GRC 2017 SGR 880).

Human monkeypox is a zoonotic smallpox-like disease caused by an orthopoxvirus of interhuman transmissibility too low to sustain spread in susceptible populations. In February 1997, 88 cases of febrile pustular rash were identified for the previous 12 months in 12 villages of the Katako-Kombe Health Zone, Democratic Republic of Congo (attack rate = 22 per 1,000; case-fatality rate = 3.7%). Seven were active cases confirmed by virus isolation. Orthopoxvirus- neutralizing antibodies were detected in 54% of 72 patients who provided serum and 25% of 59 wild-caught animals, mainly squirrels. Hemagglutination-inhibition assays and Western blotting detected antibodies in 68% and 73% of patients, respectively. Vaccinia vaccination, which protects against monkeypox, ceased by 1983 after global smallpox eradication, leading to an increase in the proportion of susceptible people.

Open Access article, published by EDP Sciences, under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.-- Open Access funding provided by Max Planck Society. ; Context Detailed studies of relativistic jets in active galactic nuclei (AGN) require high-fidelity imaging at the highest possible resolution. This can be achieved using very long baseline interferometry (VLBI) at radio frequencies, combining worldwide (global) VLBI arrays of radio telescopes with a space-borne antenna on board a satellite. Aims. We present multiwavelength images made of the radio emission in the powerful quasar S5 0836+710, obtained using a global VLBI array and the antenna Spektr-R of the RadioAstron mission of the Russian Space Agency, with the goal of studying the internal structure and physics of the relativistic jet in this object. Methods. The RadioAstron observations at wavelengths of 18 cm, 6 cm, and 1.3 cm are part of the Key Science Program for imaging radio emission in strong AGN. The internal structure of the jet is studied by analyzing transverse intensity profiles and modeling the structural patterns developing in the flow. Results. The RadioAstron images reveal a wealth of structural detail in the jet of S5 0836+710 on angular scales ranging from 0.02 mas to 200 mas. Brightness temperatures in excess of 1013 K are measured in the jet, requiring Doppler factors of 100 for reconciling them with the inverse Compton limit. Several oscillatory patterns are identified in the ridge line of the jet and can be explained in terms of the Kelvin Helmholtz (KH) instability. The oscillatory patterns are interpreted as the surface and body wavelengths of the helical mode of the KH instability. The interpretation provides estimates of the jet Mach number and of the ratio of the jet to the ambient density, which are found to be Mj 12 and 0:33. The ratio of the jet to the ambient density should be conservatively considered an upper limit because its estimate relies on approximations. © L. Vega-García et al. 2020 ; L.V.G. is a member of the International Max Planck Research School (IMPRS) for Astronomy and Astrophysics at the Universities of Bonn and Cologne. The RadioAstron project is led by the Astro Space Center of the Lebedev Physical Institute of the Russian Academy of Sciences and the Lavochkin Scientific and Production Association under a contract with the State Space Corporation ROSCOSMOS, in collaboration with partner organizations in Russia and other countries. This research is based on observations correlated at the Bonn Correlator, jointly operated by the Max Planck Institute for Radio Astronomy (MPIfR), and the Federal Agency for Cartography and Geodesy (BKG). The European VLBI Network is a joint facility of European, Chinese, South African and other radio astronomy institutes funded by their national research councils. The National Radio Astronomy Observatory is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc. Thanks to Phillip Edwards and Alan Roy for the useful comments about the paper. M.P. has been supported by the Spanish Ministerio de Economia y Competitividad (grants AYA2015-66899-C2-1-P and AYA2016-77237-C3-3-P) and the Generalitat Valenciana (grant PROMETEOII/2014/069). This work was partially supported by the COST Action MP0904 Black Holes in a Violent Universe. G.B. acknowledges financial support under the INTEGRAL ASI-INAF agreement 2013-025-R.1. T.S. was supported by the Academy of Finland projects 274477, 284495, and 312496. I.A. acknowledges support by a Ramon y Cajal grant of the Ministerio de Economia, Industria y Competitividad (MINECO) of Spain. The research at the IAA-CSIC was partly supported by the MINECO through grants AYA2016-80889-P, AYA2013-40825-P, and AYA2010-14844. Y.Y.K. was supported in part by the government of the Russian Federation (agreement 05.Y09.21.0018) and the Alexander von Humboldt Foundation. ; Peer reviewed

The effectiveness of existing policies to control antimicrobial resistance is not yet fully understood. A strengthened evidence base is needed to inform effective policy interventions across countries with different income levels and the human health and animal sectors. We examine three policy domains—responsible use, surveillance, and infection prevention and control—and consider which will be the most effective at national and regional levels. Many complexities exist in the implementation of such policies across sectors and in varying political and regulatory environments. Therefore, we make recommendations for policy action, calling for comprehensive policy assessments, using standardised frameworks, of cost-effectiveness and generalisability. Such assessments are especially important in low-income and middle-income countries, and in the animal and environmental sectors. We also advocate a One Health approach that will enable the development of sensitive policies, accommodating the needs of each sector involved, and addressing concerns of specific countries and regions.

As the world's social-environmental problems increasingly extend across boundaries, both disciplinary and political, there is a growing need for interdisciplinarity, not only in research per se, but also in doctoral education. We present the common pitfalls of interdisciplinary research in doctoral education, illustrating approaches towards solutions using the Nordic Centre for Research on Marine Ecosystems and Resources under Climate Change (NorMER) research network as a case study. We provide insights and detailed examples of how to overcome some of the challenges of conducting interdisciplinary research within doctoral studies that can be applied within any doctoral/postdoctoral education programme, and beyond. Results from a selfevaluation survey indicate that early-career workshops, annual meetings and research visits to other institutions were the most effective learning mechanisms, whereas single discipline-focused courses and coursework were among the least effective learning mechanisms. By identifying the strengths and weaknesses of components of NorMER, this case study can inform the design of future programmes to enhance interdisciplinarity in doctoral education, as well as be applied to science collaboration and academic research in general

Throughout their careers, social scientists must come up with compelling research topics, decide when and where to publish, and revise their manuscripts for publication. Despite the importance of these skills, they are seldom if ever addressed in the course of graduate training. Heavy emphasis is placed on conducting research, and other core activities such as teaching also receive attention, yet fundamental academic practices are left almost entirely in the shadows.Practicing Sociology brings together a range of leading sociologists to reflect on their work and demystify this tacit knowledge. In conversational and engaging essays, they provide practical guidance and hard-won wisdom for readers at any stage of their scholarly careers. The book's three sections explore the art of finding new research questions, best practices in publishing, and how to make the most out of the peer review process. Contributors' distinctive voices come through as they recount their frustrations and failures as well as the joys of the sociological craft. They provide a range of perspectives, underscoring that there is no one "right" way to practice sociology but a constellation of different approaches that together give the field its vitality.Practicing Sociology features a team of skilled scholars including Peter Bearman, Paul J. DiMaggio, Wendy Espeland, Marion Fourcade, Shamus Rahman Khan, Eric Klinenberg, Michèle Lamont, Jennifer Lee, Mignon Moore, Mario Small, Duncan Watts, and many more

Versión editorial disponible en: http://hdl.handle.net/10261/239013 ; The novel coronavirus SARS-CoV-2, which in humans leads to the disease COVID-19, has caused global disruption and more than 1.5 million fatalities since it first emerged in late 2019. As we write, infection rates are currently at their highest point globally and are rising extremely rapidly in some areas due to more infectious variants. The primary viral target is the cellular receptor angiotensin-converting enzyme2 (ACE2). Recent sequence analyses of the ACE2 gene predicts that many nonhuman primates are also likely to be highly susceptible to infection. However, the anticipated risk is not equal across the Order. Furthermore, some taxonomic groups show high ACE2 amino acid conservation, while others exhibit high variability at this locus. As an example of the latter, analyses of strepsirrhine primate ACE2 sequences to date indicate large variation among lemurs and lorises compared to other primate clades despite low sampling effort. Here, we report ACE2 gene and protein sequences for 71 individual strepsirrhines, spanning 51 species and 19 genera. Our study reinforces previous results and finds additional variability in other strepsirrhine species, and suggests several clades of lemurs have high potential susceptibility to SARS-CoV-2 infection. Troublingly, some species, including the rare and Endangered aye-aye (Daubentonia madagascariensis), as well as those in the genera Avahi and Propithecus, may be at high risk. Given that lemurs are endemic to Madagascar and among the primates at highest risk of extinction globally, further understanding of the potential threat of COVID-19 to their health should be a conservation priority. All feasible actions should be taken to limit their exposure to SARS-CoV-2. ; ADM is supported by the Natural Sciences and Engineering Research Council of Canada (NSERC Discovery Grant) and Canada Research Chairs Program. MCJ's postdoctoral appointment is supported by funding from the Natural Environment Research Council (NERC NE/T000341/1). IG and MG acknowledge the support of the Spanish Ministry of Science and Innovation through the Instituto de Salud Carlos III and the 2014–2020 Smart Growth Operating Program, to the EMBL partnership and cofinancing with the European Regional Development Fund (MINECO/FEDER, BIO2015-71792-P). We also acknowledge the support of the Centro de Excelencia Severo Ochoa, and the Generalitat de Catalunya through the Departament de Salut, Departament d'Empresa i Coneixement and the CERCA Programme. TMB is supported by funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement No. 864203), BFU2017-86471-P (MINECO/FEDER, UE), "Unidad de Excelencia María de Maeztu", funded by the AEI (CEX2018-000792-M), Howard Hughes International Early Career, Obra Social "La Caixa" and Secretaria d'Universitats i Recerca and CERCA Programme del Departament d'Economia i Coneixement de la Generalitat de Catalunya (GRC 2017 SGR 880). PSA thanks the National Institutes of Health (R35GM130333) for financial support. E.L is supported by CGL2017- 82654-P (MINECO/FEDER,UE). EDJ and OF's contributions were supported by funds from Howard Hughes Medical Institute and the Rockefeller University. Chris Smith drew the images for Figure 1. The authors would like to thank the Veterinary and Zoology staff at Wildlife Reserves Singapore for their help in obtaining the tissue samples, as well as the Lee Kong Chian Natural History Museum for storage and provision of the tissue samples. ; No

The ejecta composition is an open question in gamma-ray burst (GRB) physics . Some GRBs possess a quasi-thermal spectral component in the time-resolved spectral analysis , suggesting a hot fireball origin. Others show a featureless non-thermal spectrum known as the Band function , consistent with a synchrotron radiation origin and suggesting that the jet is Poynting-flux dominated at the central engine and probably in the emission region as well . There are also bursts showing a sub-dominant thermal component and a dominant synchrotron component , suggesting a probable hybrid jet composition . Here, we report an extraordinarily bright GRB 160625B, simultaneously observed in gamma-ray and optical wavelengths, whose prompt emission consists of three isolated episodes separated by long quiescent intervals, with the durations of each sub-burst being approximately 0.8 s, 35 s and 212 s, respectively. Its high brightness (with isotropic peak luminosity L ≈ 4 × 10 erg s) allows us to conduct detailed time-resolved spectral analysis in each episode, from precursor to main burst and to extended emission. The spectral properties of the first two sub-bursts are distinctly different, allowing us to observe the transition from thermal to non-thermal radiation between well-separated emission episodes within a single GRB. Such a transition is a clear indication of the change of jet composition from a fireball to a Poynting-flux-dominated jet. ; B.-B.Z. thanks Y.-Z. Fan, Y.-Z. Wang, H. Wang, K. D. Alexander and D. Lazzati for helpful discussions. We are grateful to K. Hurley, I. Mitrofanov, A. Sanin, M. Litvak and W. Boynton for the use of Mars Odyssey data in the triangulation. We acknowledge the use of the public data from the Swift and Fermi data archives. B.-B. Z. and A.J. C.-T. acknowledge support from the Spanish Ministry Projects AYA2012-39727-C03-01 and AYA2015-71718-R. Part of this work made use of B.-B.Z.'s personal Interactive Data Language (IDL) code library ZBBIDL and personal Python library ZBBPY. The computation resources used in this work are owned by Scientist Support LLC. B.Z. acknowledges NASA NNX14AF85G and NNX15AK85G for support. Z. G. D. acknowledges the National Natural Science Foundation of China(NSFC) (grant 11573014). Y.-D. H. acknowledges support by China Scholarships Council (grant 201406660015). Mini-MegaTORTORA belongs to Kazan Federal University, and the work is performed according to the Russian Government Program of Competitive Growth of Kazan Federal University. A. P., E.M., P. M. and A.V. are grateful to the Russian Foundation for Basic Research (grant 17-02-01388) for partial support. A. P. and S.B.P. acknowledge joint BRICS (Brazil, Russia, India, China and South Africa) grant RFBR 17-52-80139 and 388-ProFChEAP for partial support. R. I. is grateful to grant RUSTAVELI FR/379/6300/ 14 for partial support. Observations on Mini-MegaTORTORA are supported by the Russian Science Foundation (grant 14-50-00043). A.V.F. and A. M. thank the Russian Science Foundation (grant 14-50-00043). L.M. and A.F.Z. acknowledge support from INTA-CEDEA ESAt personnel hosting the Pi of the Sky facility at the BOOTES-1 station. H. G. and X.-Y.W. acknowledge NSFC (grants 11603003 and 11625312, respectively). Z. G. D., X.-F. W., B.Z., X.-Y. W.,L.S. and F.-W.Z. are also supported by the 973 program (grant 2014CB845800). F.-W.Z. is also supported in part by the NSFC (grants U1331101 and 11163003), the Guangxi Natural Science Foundation (grant 2013GXNSFAA019002) and the project of outstanding young teachers' training in higher education institutions of Guangxi. L.S. acknowledges support by the NSFC (grant 11103083) and the Joint NSFC-ISF Research Program (grant 11361140349). S.O. acknowledges the support of the Leverhulme Trust. S.J. acknowledges support from Korea Basic Science Research Program through NRF-2014R1A6A3A03057484 and NRF-2015R1D1A4A01020961, and I. H. P. through NRF-2015R1A2A1A01006870 and NRF-2015R1A2A1A15055344. R. A., D. F. and D. S. acknowledge support from RSF (grant 17-12-01378). A. K. acknowledges the Science and Education Ministry of Kazakhstan (grant 0075/GF4).