Suchergebnisse

When China invited the Latin American countries to participate in the Belt and Road Initiative, it fuelled expectations of a much closer and more productive relationship with the region. In practice, however, there is little evidence that this was happening even before the coronavirus disease 2019 pandemic. The article shows that neither the policy statements by China nor the trends in economic relations indicate a substantive change in Sino–Latin American relations and that the Belt and Road Initiative represents a repackaging of existing relations and the continuation of trends that have been underway since the global financial crisis. (JCCA/GIGA)

Haohan Zhou,1,2,* Jiayi Tian,3,* Hongyu Sun,1 Jiaying Fu,1 Nan Lin,1 Danni Yuan,1 Li Zhou,3 Meihui Xia,3 Liankun Sun1 1Key Laboratory of Pathobiology, Ministry of Education, Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun, 130021, People's Republic of China; 2Department of Orthopaedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, 200000, People's Republic of China; 3First Hospital, Jilin University, Changchun, 130021, People's Republic of China*These authors contributed equally to this workCorrespondence: Liankun Sun, Key Laboratory of Pathobiology, Ministry of Education, Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun, 130021, People's Republic of China, Email sunlk@jlu.edu.cn Meihui Xia, First Hospital, Jilin University, Changchun, 130021, People's Republic of China, Email xiamh@jlu.edu.cnPurpose: Magnetic iron oxide nanoparticle (MNP) drug delivery system is a novel promising therapeutic option for cancer treatment. Material issues such as fabrication and functionalized modification have been investigated; however, pharmacologic mechanisms of bare MNPs inside cancer cells remain obscure. This study aimed to explore a systems pharmacology approach to understand the reaction of the whole cell to MNPs and suggest drug selection in MNP delivery systems to exert synergetic or additive anti-cancer effects.Methods: HeLa and SiHa cell lines were used to estimate the properties of bare MNPs in cervical cancer through 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) and enzyme activity assays and cellular fluorescence imaging. A systems pharmacology approach was utilized by combining bioinformatics data mining with clinical data analysis and without a predefined hypothesis. Key genes of the MNP onco-pharmacologic mechanism in cervical cancer were identified and further validated through transcriptome analysis with quantitative reverse transcription PCR ...

China has been gradually shifting away from its traditional non-interference approach in development initiatives. This is particularly notable in the implementation of the China–Pakistan Economic Corridor (CPEC), a mega-development scheme that China is advancing in Pakistan. In this case, China's aid and investment entail extensive interference in Pakistan's internal affairs, forcing Pakistan to alter policies, regulations, and institutional arrangements over its political and economic governance, along with directly engaging with non-governmental actors in the country. Such acts of interference are largely orientated toward centralizing the decision-making and execution process in Pakistan over the CPEC, thereby facilitating its implementation in a manner profitable for Chinese stakeholders. This approach can be regarded as China's promotion of autocracy in a 'pragmatic' way. (J Contemp China/GIGA)