Suchergebnisse

Reproducción digital. Madrid : Ministerio de Defensa. Subdirección General de Publicaciones y Patrimonio Cultural, 2020 ; Incluye índices.

Nicht identisch mit VD18 10379207, dort: am Textende "Augustus R. P.", hier "Augustus."

This paper takes an integrated analysis approach to explore the options available for a UK homeowner to reduce their domestic emissions to the level advised by the UK governments Committee on Climate Change of 20% of those associated with a typical house in 1990. It uses proven thermal models of a typical house and low carbon heating systems to estimate the emissions associated with domestic heating and electricity consumption from a number of combinations of low carbon micro generation technologies. The amount of additional low carbon electricity needed to offset these emissions to the desired level was then calculated. The capacity of photo voltaic panels needed to generate it was then estimated. This has been done over a range of different grid carbon intensities and the resulting configurations have been subjected to energy analysis and financial appraisal. An environmental life cycle assessment was also undertaken to see if there were any unacceptable environmental consequences of an owner adopting any of the options. The research shows that in all cases operational GHG target can be met, but that emissions associated with the production of the systems is variable, meaning that with current technology a 25% house is more likely. It has also been shown that given current subsidies the installation of some of the proposed systems should be financially attractive to the home owner. ?

© 2020 by the authors. ; Hereditary breast and/or ovarian cancer is a highly heterogeneous disease with more than 10 known disease-associated genes. In the framework of the BRIDGES project (Breast Cancer Risk after Diagnostic Gene Sequencing), the RAD51C gene has been sequenced in 60,466 breast cancer patients and 53,461 controls. We aimed at functionally characterizing all the identified genetic variants that are predicted to disrupt the splicing process. Forty RAD51C variants of the intron-exon boundaries were bioinformatically analyzed, 20 of which were selected for splicing functional assays. To test them, a splicing reporter minigene with exons 2 to 8 was designed and constructed. This minigene generated a full-length transcript of the expected size (1062 nucleotides), sequence, and structure (Vector exon V1- RAD51C exons_2-8- Vector exon V2). The 20 candidate variants were genetically engineered into the wild type minigene and functionally assayed in MCF-7 cells. Nineteen variants (95%) impaired splicing, while 18 of them produced severe splicing anomalies. At least 35 transcripts were generated by the mutant minigenes: 16 protein-truncating, 6 in-frame, and 13 minor uncharacterized isoforms. According to ACMG/AMP-based standards, 15 variants could be classified as pathogenic or likely pathogenic variants: c.404G > A, c.405-6T > A, c.571 + 4A > G, c.571 + 5G > A, c.572-1G > T, c.705G > T, c.706-2A > C, c.706-2A > G, c.837 + 2T > C, c.905-3C > G, c.905-2A > C, c.905-2_905-1del, c.965 + 5G > A, c.1026 + 5_1026 + 7del, and c.1026 + 5G > T. ; PD: MPGV: DFE: MdlH and EAV have received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement no. 634935. EAV lab is supported by grants from the Spanish Ministry of Science and Innovation, Plan Nacional de I + D+I 2013–2016, ISCIII (PI17/00227) co-funded by FEDER from Regional Development European Funds (European Union) and from the Consejería de Educación, Junta de Castilla y León, ref. CSI242P18 (actuación cofinanciada P.O. FEDER 2014–2020 de Castilla y León). MdlH is supported by grants from the Spanish Ministry of Science and Innovation, Plan Nacional de I + D+I 2013–2016, ISCIII (PI15/00059) co-funded by FEDER from Regional Development European Funds (European Union).

"H.A.S.C. no. 113-66." ; Shipping list no.: 2014-0154-P ; Includes bibliographical references ; Mode of access: Internet.

"H.A.S.C. no. 112-153." ; Shipping list no.: 2013-0093-P. ; Includes bibliographical references. ; Mode of access: Internet.

A partir de 2019 medios de comunicación públicos y privados de Argentina comenzaron a incorporar la figura de editora de género. Con escasos antecedentes internacionales –la primera designación se produjo en The New York Times en 2017– el país se convirtió en un caso inédito en América Latina por haber incluido el nuevo perfil periodístico en 13 medios regionales y nacionales en el período 2019-2023. El análisis se sitúa en un contexto sociopolítico muy singular, donde confluyó la masividad del movimiento feminista con reacciones de sectores antifeministas y de la ultraderecha.
Desde un abordaje cualitativo se indaga en los factores que confluyeron en la creación del nuevo rol en los medios argentinos de acuerdo a tres niveles de análisis: el macroestructural, el institucional y el de las trayectorias profesionales de las periodistas que se desempeñaron en el cargo.
El artículo interroga también por los nexos entre este proceso de gestación del nuevo perfil periodístico y la búsqueda por legitimar roles y prácticas periodísticas que se hallen comprometidas con causas de derechos humanos.

In order to face the challenge of sustainable urban development on its own territory, China has chosen Singapore as its model and privileged partner. By analysing more than 20 years of cooperation, the aim of this article is to study what sort of vision and model for development China is pursuing, how the "Singaporean model" is imported and incorporated by Chinese stakeholders, and in what ways it is transforming the specificities in planning, building, and organising the country's cities. Our analysis covers two Sino-Singaporean urban operations that are currently leading the way in China: the Suzhou Industrial Park and the Tianjin eco-city. The incorporation of the Singaporean model into these two operations shows that the latter offers an effective way of linking economic development with urban production, and of enabling the building of orderly cities with good environmental standards. However, these advances have only been made possible by the capacity to take political and financial initiatives that are still exceptional in the country as a whole, and until now do not appear to be easily extendable to other Chinese cities. Moreover, the Sino-Singaporean view of urban development based on productivity and concentrating on supply, infrastructure, and technology encounters major limitations in terms of environmental sobriety and the cities' social integration. (China Perspect/GIGA)

In vielen Kommunen konnte bereits in den vergangenen Jahren durch kommunales Energiemanagement kontinuierlich der Einsatz von Wärme und Strom reduziert werden. Dies ist speziell auf die Aktivitäten der kommunalen Energiebeauftragten zurückzuführen. Das kommunale Energiemanagement, das zuerst in den späten 1980er- und frühen 1990er-Jahren in vielen großen Stadtverwaltungen eingeführt wurde, zielt insbesondere darauf ab, den Energieverbrauch in den eigenen Liegenschaften sowie bei der Straßenbeleuchtung zu reduzieren. Der Fokus wird dabei i.d.R. auf folgende Bereiche gerichtet: Der Großteil der in Städten und Gemeinden verbrauchten Endenergie in eigenen Liegenschaften wird für die Beheizung und die Stromversorgung aufgewendet. Energieeinspareffekte resultieren daher vor allem aus der Durchführung von energetisch relevanten Maßnahmen im kommunalen Gebäudebestand. Die Straßenbeleuchtung einschließlich Signalanlagen, auf die bis zu ein Drittel des kommunalen Endenergieverbrauchs entfallen kann, ist ein weiterer bedeutender Bereich. Endenergieeinsparungen sind auch im Beschaffungswesen zu realisieren. Diese betreffen vor allem die Anschaffung von EDV-Ausstattungen und Bürogeräten, aber auch die Innenraumbeleuchtung, Pumpen sowie Haushalts- und Reinigungsgeräte. Der Fuhrpark ist in diesem Kontext eine weitere Herausforderung. Für die Umsetzung von Maßnahmen der Energieeinsparung sind auch die Motivation und Information der Mitarbeiter in den Kommunalverwaltungen selbst wie auch der Bevölkerung und ortsansässigen Unternehmen im Hinblick auf die Änderung des Nutzerverhaltens sowie zum Einsatz von energiesparenden Techniken von zentraler Bedeutung. Dazu können von Kommunen unterschiedliche Kampagnen oder Schulungen durchgeführt werden. Die Beiträge der Referentinnen und Referenten sowohl bei den Veranstaltungen im Plenum als auch in den Workshops sind in diesem Band ausführlich dokumentiert.