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This paper seeks reports on the way economic principles, formulae and discourse inform biological research on antimicrobial resistance (AMR) in the life sciences. AMR, it can be argued, has become the basis for performing certain forms of 'economic imaginary'. Economic imaginaries are ways of projecting and materially restructuring economic and political orders through motifs, metaphors, images and practices. The paper contributes to critical social science and humanities research on the socio-economic underpinning of biological discourse. The performance of economy in this context can be seen to follow two key trajectories. The first trajectory, discussed at length in this paper, might be described as 'economies of resistance'. Here the language of market economics structures and frames microbiological explanations of bacterial resistance. This can be illustrated through, for example, biological theories of 'genetic capitalism' where capitalism itself is seen to furnish microbial life with modes of economic behaviour and conduct. 'Economies of resistance' are evidence of the naturalisation of socio-economic structures in expert understandings of AMR. The methodological basis of this paper lies in a historical genealogical investigation into the use of economic and market principles in contemporary microbiology. The paper reports on a corpus of published academic sources identified through the use of keywords, terms, expressions and metaphors linked to market economics. Search terms included, but were not limited to: 'trade-off', 'investment', 'market/s', 'investment', 'competition', 'cooperation', 'economy', 'capital/ism', 'socialist/ism', etc. 'Economies of resistance' complements a second distinct trajectory that can be seen to flow in the opposite direction from biology to economic politics (the 'resistance of economies'). Here, economic imaginaries of microbial life are redeployed in large-scale debates about the nature of economic life, about the future of the welfare state, industrial strategy, and about the politics of migration and race, etc. 'Economies of resistance' and the 'resistance of economies' are not unrelated but, instead, they are mutually constituting dynamics in the co-production of AMR. In attempting to better understand this co-production, the paper draws upon literatures on the biopolitics of immunity in political philosophy and Science and Technology Studies (STS).

When the scientific method yields discoveries that imperil people's lifestyle or worldviews or impinge on corporate vested interests, the public and political response can be anything but favorable. Sometimes the response slides into overt denial of scientific facts, although this denial is often claimed to involve "skepticism". We outline the distinction between true skepticism and denial with several case studies. We propose some guidelines to enable researchers to differentiate legitimate critical engagement from bad-faith harassment, and to enable members of the public to pursue their skeptical engagement and critique without such engagement being mistaken for harassment.

Interphase microtubule organization is critical for cell function and tissue architecture. In general, physical mechanisms are sufficient to drive microtubule organization in single cells, whereas cells within tissues are thought to utilize signalling mechanisms. By improving the imaging and quantitation of microtubule alignment within developing Drosophila embryos, here we demonstrate that microtubule alignment underneath the apical surface of epithelial cells follows cell shape. During development, epidermal cell elongation and microtubule alignment occur simultaneously, but by perturbing cell shape, we discover that microtubule organization responds to cell shape, rather than the converse. A simple set of microtubule behaviour rules is sufficient for a computer model to mimic the observed responses to changes in cell surface geometry. Moreover, we show that microtubules colliding with cell boundaries zip-up or depolymerize in an angle-dependent manner, as predicted by the model. Finally, we show microtubule alignment responds to cell shape in diverse epithelia. ; This work was supported by grant BB/K00056X/1 from the UK Biotechnology, Biological Sciences Research Council. Gurdon Institute core funding was provided by the Wellcome Trust (092096) and Cancer Research UK (C6946/A14492). L.C. was supported by the Royal Society of Edinburgh/Scottish Government.

Francisco José Eiroa-Orosa has received funding from the European Union's Framework Programme for Research and Innovation Horizon 2020 (2014–2020) under the Marie Sklodowska-Curie Grant Agreement No 654808.

When the scientific method yields discoveries that imperil people's lifestyle or worldviews or impinge on corporate vested interests, the public and political response can be anything but favorable. Sometimes the response slides into overt denial of scientific facts, although this denial is often claimed to involve "skepticism". We outline the distinction between true skepticism and denial with several case studies. We propose some guidelines to enable researchers to differentiate legitimate critical engagement from bad-faith harassment, and to enable members of the public to pursue their skeptical engagement and critique without such engagement being mistaken for harassment.

When the scientific method yields discoveries that imperil people's lifestyle or worldviews or impinge on corporate vested interests, the public and political response can be anything but favorable. Sometimes the response slides into overt denial of scientific facts, although this denial is often claimed to involve "skepticism". We outline the distinction between true skepticism and denial with several case studies. We propose some guidelines to enable researchers to differentiate legitimate critical engagement from bad-faith harassment, and to enable members of the public to pursue their skeptical engagement and critique without such engagement being mistaken for harassment. ; peerReviewed ; publishedVersion

Abstract
We test a set of inequalities in choice probabilities, shown to be necessary and sufficient for random utility by Falmagne (1978). We run an experiment in which each of 141 participants chooses six times from each doubleton or larger subset of a universe of five lotteries. We compute Bayes factors in favour of random utility, versus an alternative with unrestricted choice probabilities. There is strong evidence that a large majority of participants satisfy random utility; however, there is strong evidence against random utility for four participants. Results are fairly robust to the choice of prior.