Suchergebnisse

This work was carried out with financial support of the European Union's 7th Framework Programme FP7 2007-2013 under grant agreement no 244995 (BIOCLAIMS Project) to Karl-Franzens University, Graz, Austria (BWR), and Medical University, Graz, Austria (JMR) and of the Federal Ministry of Science, Research and Economy of Austria under grant agreement GZ 651.483/0001-II/2/2010 to Karl-Franzens University, Graz, Austria (BWR), and grant agreement GZ 651.484/0001-II/2/2010 to Medical University, Graz, Austria (JMR) for the BIOCLAIMS Project, and of the European Union's 5th Framework Programme under grant agreement no QLK1-CT-1999-00830 (VITAGE Project) to Karl-Franzens University, Graz, Austria (BWR), Institut National de la Recherch Agronomique, Clermont-Ferrand, France (ER), and Universitat Rovira I Virgili, Tarragona, Spain (JR), and of the Federal Ministry of Science, Research and Economy of Austria under grant agreement GZ 650.874/1-VI/2/2003 to Karl-Franzens University, Graz, Austria (BWR), for the VITAGE Project ; Background/ObjectivesGiven their role in female reproduction, the effects of progesterone on arginine and related amino acids, polyamines and NF-κB p65 activation were studied across the menstrual cycle.MethodsArginine, ornithine and citrulline as well as putrescine, spermidine, spermine, and N-acetyl-putrescine were determined in plasma, NF-κB p65 activation in peripheral blood mononuclear cells and progesterone in serum of 28 women at early (T1) and late follicular (T2) and mid (T3) and late (T4) luteal phase.ResultsArginine and related amino acids declined from T1 and T2 to T3 and T4, while progesterone increased. At T3, arginine, ornithine, and citrulline were inversely related with progesterone. Changes (ΔT3-T2) in arginine, ornithine, and citrulline were inversely related with changes (ΔT3-T2) in progesterone. Ornithine and citrulline were positively related with arginine, as were changes (ΔT3-T2) in ornithine and citrulline with changes (ΔT3-T2) in arginine. At T2, NF-κB p65 activation was ...

This work was carried out with financial support of the European Union's 7th Framework Programme FP7 2007-2013 under grant agreement no 244995 (BIOCLAIMS Project) to Karl-Franzens University, Graz, Austria (BWR), and Medical University, Graz, Austria (JMR) and of the Federal Ministry of Science, Research and Economy of Austria under grant agreement GZ 651.483/0001-II/2/2010 to Karl-Franzens University, Graz, Austria (BWR), and grant agreement GZ 651.484/0001-II/2/2010 to Medical University, Graz, Austria (JMR) for the BIOCLAIMS Project, and of the European Union's 5th Framework Programme under grant agreement no QLK1-CT-1999-00830 (VITAGE Project) to Karl-Franzens University, Graz, Austria (BWR), Institut National de la Recherch Agronomique, Clermont-Ferrand, France (ER), and Universitat Rovira I Virgili, Tarragona, Spain (JR), and of the Federal Ministry of Science, Research and Economy of Austria under grant agreement GZ 650.874/1-VI/2/2003 to Karl-Franzens University, Graz, Austria (BWR), for the VITAGE Project ; Background/ObjectivesGiven their role in female reproduction, the effects of progesterone on arginine and related amino acids, polyamines and NF-κB p65 activation were studied across the menstrual cycle.MethodsArginine, ornithine and citrulline as well as putrescine, spermidine, spermine, and N-acetyl-putrescine were determined in plasma, NF-κB p65 activation in peripheral blood mononuclear cells and progesterone in serum of 28 women at early (T1) and late follicular (T2) and mid (T3) and late (T4) luteal phase.ResultsArginine and related amino acids declined from T1 and T2 to T3 and T4, while progesterone increased. At T3, arginine, ornithine, and citrulline were inversely related with progesterone. Changes (ΔT3-T2) in arginine, ornithine, and citrulline were inversely related with changes (ΔT3-T2) in progesterone. Ornithine and citrulline were positively related with arginine, as were changes (ΔT3-T2) in ornithine and citrulline with changes (ΔT3-T2) in arginine. At T2, NF-κB p65 activation was positively related with arginine. Polyamines did not change and were not related to progesterone. All results described were significant at P < 0.001.ConclusionsThis study for the first time provides data, at the plasma and PBMC level, supporting a proposed regulatory node of arginine and related amino acids, progesterone and NF-κB p65 at luteal phase of the menstrual cycle, aimed at successful preparation of pregnancy.

International vergleichende empirische Studien haben gravierende Mängel im deutschen Schulsystem offen gelegt. Die erfolgreichen PISA-Länder zeigen, dass eine der wichtigsten Voraussetzungen für die Rückkehr in die internationale Leistungsspitze eine Umsteuerung im System ist. Nicht mehr durch detaillierte Richtlinien und Regelungen, sondern durch die Definition von Zielen, deren Einhaltung auch tatsächlich überprüft wird, muss der Staat für Qualität im Bildungswesen sorgen. Die Entwicklung von bundesweit gültigen Bildungsstandards auf der Basis von Kompetenzmodellen ist dabei ein zentrales Element. Ziel der vorliegenden Expertise ist zunächst, das Konzept der Bildungsstandards auf dem Hintergrund der internationalen bildungspolitischen und bildungswissenschaftlichen Diskussion fachlich zu klären und eine Rahmenkonzeption vorzulegen, die die Funktion von Bildungsstandards im Gesamtkontext von Bildungsmonitoring, Schulevaluation und programmspezifischer Evaluation beschreibt. Da Bildungsstandards so zu gestalten sind, dass sie zum Motor pädagogischer Gestaltung an unseren Schulen werden können, enthält die Expertise auch Überlegungen zu den Bedingungen ihrer erfolgreichen Implementation. Ferner beschreibt die Expertise die notwendige Infrastruktur für die Entwicklung und Evaluation von Bildungsstandards in Deutschland. (DIPF/Orig.)