Mellin transform in bicomplex space and its application
In: Studia Universitatis Babeş-Bolyai. Mathematica, Band 62, Heft 2, S. 217-232
ISSN: 2065-961X
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In: Studia Universitatis Babeş-Bolyai. Mathematica, Band 62, Heft 2, S. 217-232
ISSN: 2065-961X
Reprogramming is a dynamic process that can result in multiple pluripotent cell types emerging from divergent paths. Cell surface protein expression is a particularly desirable tool to categorize reprogramming and pluripotency as it enables robust quantification and enrichment of live cells. Here we use cell surface proteomics to interrogate mouse cell reprogramming dynamics and discover CD24 as a marker that tracks the emergence of reprogramming-responsive cells, while enabling the analysis and enrichment of transgene-dependent (F-class) and -independent (traditional) induced pluripotent stem cells (iPSCs) at later stages. Furthermore, CD24 can be used to delineate epiblast stem cells (EpiSCs) from embryonic stem cells (ESCs) in mouse pluripotent culture. Importantly, regulated CD24 expression is conserved in human pluripotent stem cells (PSCs), tracking the conversion of human ESCs to more naive-like PSC states. Thus, CD24 is a conserved marker for tracking divergent states in both reprogramming and standard pluripotent culture. ; We thank Kento Onishi for providing EpiSC samples. We also thank Dr Jeff Wrana and Dr Dan Trcka for providing secondary DOX-inducible reprogramming system to allow further validation of our findings. We would also like to acknowledge the assistance and support of laboratory colleagues and collaborators. This work has been supported by a GL2 grant from Ontario Government (AN) and a CIHR Grant to P.W.Z. N.S. is the recipient of the NSERC Vanier Canada Graduate Scholarship. A.N. is Tier 1 Canada Research Chair in Stem Cells and Regeneration. P.W.Z. is the Canada Research Chair in Stem Cell Bioengineering. ; Sí
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In: Bulletin of the World Health Organization: the international journal of public health = Bulletin de l'Organisation Mondiale de la Santé, Band 88, Heft 7, S. 556-559
ISSN: 1564-0604
In: Bulletin of the World Health Organization: the international journal of public health, Band 84, Heft 1, S. 72-77
ISSN: 0042-9686, 0366-4996, 0510-8659
In: Signs: journal of women in culture and society, Band 30, Heft 2, S. 1731-1735
ISSN: 1545-6943
Currently, there are no harmonized guidelines which govern skin banking in the Asia Pacific region. Therefore, skin banks are either unregulated or rely on their nation's legislation or international accreditation to uphold their quality standards. A new set of skin banking guidelines was developed through a comprehensive review and collation of best international practices for the Asia Pacific Burn Association (APBA) members, from donor screening and testing, to skin recovery, processing, storage and distribution, and quality assurance. National regulatory requirements reviewed include the European directives, Australia's Therapeutic Goods Administration and Singapore's tissue banking standards. Further technical and quality management recommendations are referenced from the American Association of Tissue Banks (AATB), the United States Food and Drug Administration standards and guidance documents, various relevant European guides, Japanese Society of Tissue Transplantation guidelines and the Asia Pacific Association of Surgical Tissue Banking. Adapted mainly from the AATB standards, the new Asia Pacific Burn Association Guidelines for Skin Banking in Therapeutic Applications offer a comprehensive manual, addressing: governance and contracts; staff responsibilities; quality management; facilities, equipment and supplies management; donor consent and testing; and recommendations of good practices pertaining to skin recovery, processing, storage and distribution. Besides complementing current generic regulations, they provide technical specifications of major aspects unaddressed in most legislations. This inaugural set of new regional skin banking guidelines would be a start for regional members of the APBA to adopt, and will hopefully culminate in a set of standards so that, in the long run, skin allografts from this region can be of similar quality, which can simplify import process and facilitate the exchange of allografts between members.
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Frontmatter -- Contents -- Acknowledgements -- Preface -- Introduction -- Part I: Emergence -- Introduction -- 1. Poststructuralism and Modern European Philosophy -- 2. From Marxism to Poststructuralism -- 3. From Structuralism to Poststructuralism -- Part II: Methods -- Introduction -- 4. A History of the Method: Examining Foucault's Research Methodology -- 5. Derrida, Deconstruction and Method -- 6. Écriture Féminine -- 7. Schizoanalysis: An Incomplete Project -- Part III: Themes -- Structure and Subject -- Introduction -- 8. Structure and Subject -- 9. How do we Recognise the Subject? -- 10. Foucault: The Culture of Self, Subjectivity and Truth-telling Practices -- Language and Text -- Introduction -- 11. Derrida's Language: Play, Différance and (Con)text -- 12. Hélène Cixous and the Play of Language -- 13. Luce Irigaray: An Ode to A-(Luce) -- Form and Institution -- Introduction -- 14. Photography and Poststructuralism: The Indexical and Iconic Sign System -- 15. Deleuze and the Image of Film Theory -- 16. The Museum of Now -- 17. Institutions, Semiotics and the Politics of Subjectivity -- Resistance and Limit -- Introduction -- 18. 'Here and Nowhere': Poststructuralism, Resistance and Utopia -- 19. The Powers of the Outside in Deleuze and Cixous -- 20. Politics in-between Nihilism and History -- Part IV: Trajectories -- Introduction -- 21. The Receptions of Poststructuralism -- 22. From Liberation Theory to Postcolonial Theory: The Poststructuralist Turn -- 23. The Pharmacology of Poststructuralism: An Interview with Bernard Stiegler -- Conclusion: Poststructuralism Today? -- Notes on the Contributors -- Index
In: Signs: journal of women in culture and society, Band 27, Heft 3, S. 933-938
ISSN: 1545-6943
This paper provides an overview of the last 40 years of use, and in many cases abuse, of the natural resources in Catalonia, a country that is representative of European countries in general, and especially those in the Mediterranean region. It analyses the use of natural resources made by mining, agriculture, livestock, logging, fishing, nature tourism, and energy production and consumption. This use results in an ecological footprint, i.e., the productive land and sea surface required to generate the consumed resources and absorb the resulting waste, which is about seven times the amount available, a very high number but very similar to other European countries. This overexploitation of natural resources has a huge impact on land and its different forms of cover, air, and water. For the last 25 years, forests and urban areas have each gained almost 3% more of the territory at the expense of agricultural land; those municipalities bordering the sea have increased their number of inhabitants and activity, and although they only occupy 6.7% of the total surface area, they account for 43.3% of the population; air quality has stabilized since the turn of the century, and there has been some improvement in the state of aquatic ecosystems, but still only 36% are in good condition, while the remainder have suffered morphological changes and different forms of nonpoint source pollution; meanwhile the biodiversity of flora and fauna remains still under threat. Environmental policies do not go far enough so there is a need for revision of the legislation related to environmental impact and the protection of natural areas, flora, and fauna. The promotion of environmental research must be accompanied by environmental education to foster a society which is more knowledgeable, has more control and influence over the decisions that deeply affect it. Indeed, nature conservation goes hand in hand with other social and economic challenges that require a more sustainable vision. Today's problems with nature derive from the current economic model, which is environmentally unsustainable in that it does not take into account environmental impacts. Lastly, we propose a series of reasonable and feasible priority measures and actions related to each use made of the country's natural resources, to the impacts they have had, and to their management, in the hope that these can contribute to improving the conservation and management of the environment and biodiversity and move towards sustainability.
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The first reference work to explore the 2000-year history of political realism and reassess its place in today's worldDownload an ebook of the chapter abstracts and notes on contributors (pdf)Political realism is a highly diverse body of international relations theory. This substantial reference work examines political realism in terms of its history, its scientific methodology and its normative role in international affairs.Split into three sections, it covers the 2000-year canon of realism: the different schools of thought, the key thinkers and how it responds to foreign policy challenges faced by individual states and globally. It brings political realism up-to-date by showing where theory has failed to keep up with contemporary problems and suggests how it can be applied and adapted to fit our new, globalised world order.Key FeaturesThe first volume to offer a full, balanced guide to Political Realism: its history and its normative role in international affairsCovers the main thinkers, from Thucydides through Niccolò Machiavelli to Isaiah BerlinEngages with the major foreign policy issues of our times, such as strategic deterrence, nationalism, terrorism, cyber security, climate change, the open society and religionConsiders political realism in non-Western contexts, including Israel, Russia and ChinaIncludes political realism's ground-up growth and interpretation outwith Western contextsContributorsUriel Abulof, Tel-Aviv University, Israel.Christopher Adair-Toteff, Zeppelin University, Germany.Erica Benner, Yale University, USA.John Bew, King's College London, UK.Todd Breyfogle, Aspen Institute, Washington, D.C., USA.Joshua Cherniss, Georgetown University, USA.Alan Chong, S. Rajaratnam School of International Studies, Singapore.Lindsay P. Cohn, U.S. Naval War College, USA.Kody W. Cooper, University of Tennessee at Chattanooga, USA.Marzieh Kouhi Esfahani, Durham University, UK.Markus Fischer, California State University, Fullerton, USA.Richard Forno, University of Maryland, Baltimore County, USA.Stuart Gray, Politics at Washington and Lee University, USA.Robert Howse, New York University School of Law, USA.David Martin Jones, University of Queensland, Australia and King's College London, UK.Menno R. Kamminga, University of Groningen, Netherlands.Peter Iver Kaufman, University of North Carolina, Chapel Hill and University of Richmond, USA.David Kerr, Durham University, UK.Paul Kirkland, Carthage College, Wisconsin, USA.Douglas B. Klusmeyer, American University, Washington, DC, USA.Konstantinos Kostagiannis, University of Maastricht, Netherlands.Ayelet Haimson Lushkov, University of Texas at Austin, USA.Cecelia Lynch, University of California, Irvine, USA.David Mayers, Boston University, USA.Kenneth B. McIntyre, Sam Houston State University in Huntsville, Texas, USA.Neville Morley, University of Exeter, UK.John Mueller, Mershon Center for International Security Studies and Ohio State University, USA.Masashi Okuyama, International Geopolitica
This paper provides an overview of the last 40 years of use, and in many cases abuse, of the natural resources in Catalonia, a country that is representative of European countries in general, and especially those in the Mediterranean region. It analyses the use of natural resources made by mining, agriculture, livestock, logging, fishing, nature tourism, and energy production and consumption. This use results in an ecological footprint, i.e., the productive land and sea surface required to generate the consumed resources and absorb the resulting waste, which is about seven times the amount available, a very high number but very similar to other European countries. This overexploitation of natural resources has a huge impact on land and its different forms of cover, air, and water. For the last 25 years, forests and urban areas have each gained almost 3% more of the territory at the expense of agricultural land; those municipalities bordering the sea have increased their number of inhabitants and activity, and although they only occupy 6.7% of the total surface area, they account for 43.3% of the population; air quality has stabilized since the turn of the century, and there has been some improvement in the state of aquatic ecosystems, but still only 36% are in good condition, while the remainder have suffered morphological changes and different forms of nonpoint source pollution; meanwhile the biodiversity of flora and fauna remains still under threat. Environmental policies do not go far enough so there is a need for revision of the legislation related to environmental impact and the protection of natural areas, flora, and fauna. The promotion of environmental research must be accompanied by environmental education to foster a society which ismore knowledgeable, has more control and influence over the decisions that deeply affect it. Indeed, nature conservation goes hand in hand with other social and economic challenges that require a more sustainable vision. Today's problems with nature derive from the current ...
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This paper provides an overview of the last 40 years of use, and in many cases abuse, of the natural resources in Catalonia, a country that is representative of European countries in general, and especially those in the Mediterranean region. It analyses the use of natural resources made by mining, agriculture, livestock, logging, fishing, nature tourism, and energy production and consumption. This use results in an ecological footprint, i.e., the productive land and sea surface required to generate the consumed resources and absorb the resulting waste, which is about seven times the amount available, a very high number but very similar to other European countries. This overexploitation of natural resources has a huge impact on land and its different forms of cover, air, and water. For the last 25 years, forests and urban areas have each gained almost 3% more of the territory at the expense of agricultural land; those municipalities bordering the sea have increased their number of inhabitants and activity, and although they only occupy 6.7% of the total surface area, they account for 43.3% of the population; air quality has stabilized since the turn of the century, and there has been some improvement in the state of aquatic ecosystems, but still only 36% are in good condition, while the remainder have suffered morphological changes and different forms of nonpoint source pollution; meanwhile the biodiversity of flora and fauna remains still under threat. Environmental policies do not go far enough so there is a need for revision of the legislation related to environmental impact and the protection of natural areas, flora, and fauna. The promotion of environmental research must be accompanied by environmental education to foster a society which is more knowledgeable, has more control and influence over the decisions that deeply affect it. Indeed, nature conservation goes hand in hand with other social and economic challenges that require a more sustainable vision. Today's problems with nature derive from the ...
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53 pages, 10 figures, 20 tables ; This paper provides an overview of the last 40 years of use, and in many cases abuse, of the natural resources in Catalonia, a country that is representative of European countries in general, and especially those in the Mediterranean region. It analyses the use of natural resources made by mining, agriculture, livestock, logging, fishing, nature tourism, and energy production and consumption. This use results in an ecological footprint, i.e., the productive land and sea surface required to generate the consumed resources and absorb the resulting waste, which is about seven times the amount available, a very high number but very similar to other European countries. This overexploitation of natural resources has a huge impact on land and its different forms of cover, air, and water. For the last 25 years, forests and urban areas have each gained almost 3% more of the territory at the expense of agricultural land; those municipalities bordering the sea have increased their number of inhabitants and activity, and although they only occupy 6.7% of the total surface area, they account for 43.3% of the population; air quality has stabilized since the turn of the century, and there has been some improvement in the state of aquatic ecosystems, but still only 36% are in good condition, while the remainder have suffered morphological changes and different forms of nonpoint source pollution; meanwhile the biodiversity of flora and fauna remains still under threat. Environmental policies do not go far enough so there is a need for revision of the legislation related to environmental impact and the protection of natural areas, flora, and fauna. The promotion of environmental research must be accompanied by environmental education to foster a society which is more knowledgeable, has more control and influence over the decisions that deeply affect it. Indeed, nature conservation goes hand in hand with other social and economic challenges that require a more sustainable vision. Today's problems with nature derive from the current economic model, which is environmentally unsustainable in that it does not take into account environmental impacts. Lastly, we propose a series of reasonable and feasible priority measures and actions related to each use made of the country's natural resources, to the impacts they have had, and to their management, in the hope that these can contribute to improving the conservation and management of the environment and biodiversity and move towards sustainability ; This research was funded by the Institut d'Estudis Catalans (IEC). With the funding support of the 'Severo Ochoa Centre of Excellence' accreditation (CEX2019-000928-S), of the Spanish Research Agency (AEI) ; Peer reviewed
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This paper provides an overview of the last 40 years of use, and in many cases abuse, of the natural resources in Catalonia, a country that is representative of European countries in general, and especially those in the Mediterranean region. It analyses the use of natural resources made by mining, agriculture, livestock, logging, fishing, nature tourism, and energy production and consumption. This use results in an ecological footprint, i.e., the productive land and sea surface required to generate the consumed resources and absorb the resulting waste, which is about seven times the amount available, a very high number but very similar to other European countries. This overexploitation of natural resources has a huge impact on land and its different forms of cover, air, and water. For the last 25 years, forests and urban areas have each gained almost 3% more of the territory at the expense of agricultural land; those municipalities bordering the sea have increased their number of inhabitants and activity, and although they only occupy 6.7% of the total surface area, they account for 43.3% of the population; air quality has stabilized since the turn of the century, and there has been some improvement in the state of aquatic ecosystems, but still only 36% are in good condition, while the remainder have suffered morphological changes and different forms of nonpoint source pollution; meanwhile the biodiversity of flora and fauna remains still under threat. Environmental policies do not go far enough so there is a need for revision of the legislation related to environmental impact and the protection of natural areas, flora, and fauna. The promotion of environmental research must be accompanied by environmental education to foster a society which is Land 2021, 10, 144 3 of 53 more knowledgeable, has more control and influence over the decisions that deeply affect it. Indeed, nature conservation goes hand in hand with other social and economic challenges that require a more sustainable vision. Today's problems with nature derive from the current economic model, which is environmentally unsustainable in that it does not take into account environmental impacts. Lastly, we propose a series of reasonable and feasible priority measures and actions related to each use made of the country's natural resources, to the impacts they have had, and to their management, in the hope that these can contribute to improving the conservation and management of the environment and biodiversity and move towards sustainability. ; info:eu-repo/semantics/publishedVersion
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Background Surgery is the main modality of cure for solid cancers and was prioritised to continue during COVID-19 outbreaks. This study aimed to identify immediate areas for system strengthening by comparing the delivery of elective cancer surgery during the COVID-19 pandemic in periods of lockdown versus light restriction. Methods This international, prospective, cohort study enrolled 20 006 adult (≥18 years) patients from 466 hospitals in 61 countries with 15 cancer types, who had a decision for curative surgery during the COVID-19 pandemic and were followed up until the point of surgery or cessation of follow-up (Aug 31, 2020). Average national Oxford COVID-19 Stringency Index scores were calculated to define the government response to COVID-19 for each patient for the period they awaited surgery, and classified into light restrictions (index 60). The primary outcome was the non-operation rate (defined as the proportion of patients who did not undergo planned surgery). Cox proportional-hazards regression models were used to explore the associations between lockdowns and non-operation. Intervals from diagnosis to surgery were compared across COVID-19 government response index groups. This study was registered at ClinicalTrials.gov, NCT04384926. Findings Of eligible patients awaiting surgery, 2003 (10·0%) of 20 006 did not receive surgery after a median follow-up of 23 weeks (IQR 16–30), all of whom had a COVID-19-related reason given for non-operation. Light restrictions were associated with a 0·6% non-operation rate (26 of 4521), moderate lockdowns with a 5·5% rate (201 of 3646; adjusted hazard ratio [HR] 0·81, 95% CI 0·77–0·84; p<0·0001), and full lockdowns with a 15·0% rate (1775 of 11 827; HR 0·51, 0·50–0·53; p<0·0001). In sensitivity analyses, including adjustment for SARS-CoV-2 case notification rates, moderate lockdowns (HR 0·84, 95% CI 0·80–0·88; p<0·001), and full lockdowns (0·57, 0·54–0·60; p<0·001), remained independently associated with non-operation. Surgery beyond 12 weeks from diagnosis in patients without neoadjuvant therapy increased during lockdowns (374 [9·1%] of 4521 in light restrictions, 317 [10·4%] of 3646 in moderate lockdowns, 2001 [23·8%] of 11 827 in full lockdowns), although there were no differences in resectability rates observed with longer delays. Interpretation Cancer surgery systems worldwide were fragile to lockdowns, with one in seven patients who were in regions with full lockdowns not undergoing planned surgery and experiencing longer preoperative delays. Although short-term oncological outcomes were not compromised in those selected for surgery, delays and non-operations might lead to long-term reductions in survival. During current and future periods of societal restriction, the resilience of elective surgery systems requires strengthening, which might include protected elective surgical pathways and long-term investment in surge capacity for acute care during public health emergencies to protect elective staff and services. Funding National Institute for Health Research Global Health Research Unit, Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, Medtronic, Sarcoma UK, The Urology Foundation, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research.
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