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AbstractChildren's diets can have major implications for a wide range of diseases and their development outcomes. In Africa, micronutrient deficiency remains a major challenge and affects the health and development of vulnerable populations, especially children. A major effort to combat micronutrient deficiency has targeted biofortification of staple foods, with greatest potential being registered in the enrichment of, among others, sweetpotato with beta carotene—a precursor for vitamin A. However, overcoming vitamin A deficiency is made all the more complicated by children's general resistance to unfamiliar foods. We report the results of a field experiment in Nigerian schools designed to use behavioral techniques to promote consumption of an unfamiliar food: the pro-vitamin A rich orange-fleshed sweetpotato. We find that children eat more, on average, when the sweetpotato is introduced alongside behavioral nudges such as songs or association with aspirational figures. These results appear to conform to results found in a developed country context.

Objective: Neuropathic pain and fibromyalgia are two common and poorly understood chronic pain conditions that lack satisfactory treatments, cause substantial suffering and societal costs. Today, there are no biological markers on which to base chronic pain diagnoses, treatment choices or to understand the pathophysiology of pain for the individual patient. This study aimed to investigate cerebrospinal fluid (CSF) protein profiles potentially associated with fibromyalgia and neuropathic pain. Methods: CSF samples were collected from 25 patients with neuropathic pain (two independent sets, n=14 patients for discovery, and n=11 for verification), 40 patients with fibromyalgia and 134 controls without neurological disease from two different populations. CSF protein profiling of 55 proteins was performed using antibody suspension bead array technology. Results: We found increased levels of apolipoprotein C1 (APOC1) in CSF of neuropathic pain patients compared to controls and there was a trend for increased levels also in fibromyalgia patients. In addition, levels of ectonucleotide pyrophosphatase family member 2 (ENPP2, also referred to as autotaxin) were increased in the CSF of fibromyalgia patients compared to all other groups including patients with neuropathic pain. Conclusion: The increased levels of APOC1 and ENPP2 found in neuropathic pain and fibromyalgia patients may shed light on the underlying mechanisms of these conditions. Further investigation is required to elucidate their role in maintaining pain and other main symptoms of these disorders. ; Funding Agencies|Swedish Governmental Agency for Innovation SystemsVinnova; Swedish Research Council (Vetenskapsradet)Swedish Research Council; Uppsala University; KTH Center for Applied Precision Medicine (KCAP); Marie-Curie fellowship from the INSENS/FP7-PEOPLE-2013European Union (EU) [607616]; NEURO Sweden; AFA Insurance; ALF Grants, Region Ostergotland