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"A century of injustice" was written originally in Dutch by J.C. Smuts. under title: Een eeuw van onrecht. cf. S.G. Millin. General Smuts, 1936, v. 1, p. 113-115. ; Mode of access: Internet.

The tropical rainforest has a high level of biodiversity and plays an important role as a stable ecosystem. However, an anthropogenic disturbance took place in some parts of the tropical rainforest. The recovery of the disturbed forest is less scientifically understood. Therefore, this study aims to examine the recuperation process of vegetation in Fef, Tambrauw Regency, and West Papua, in Indonesia by comparing the composition of primary forest life forms as control of the natural, five-year disturbed, and seven-year disturbed forest. The results showed that the species diversity in the primary forest was not significantly different from the seven-year disturbed forest while the five-year disturbed forest was significantly different from the two types mentioned earlier. Moreover, the similarity index showed that the primary and seven-year disturbed forest were identical and both were different from the five-year disturbed forest. In addition, eight life forms were enumerated, viz. bamboo, climber, fern, herb, rattan, shrub, small tree, and large tree in which they were dynamic during the post-disturbance compared to primary forest. The residual forests should therefore be part of the intention of local people and government, in other not to exploit the forests by allowing the disturbed forests to recuperate naturally.

INTRODUCTION: Tuberous Sclerosis Complex (TSC) is a multi-system genetic disorder with various TSC-Associated Neuropsychiatric Disorders (TAND) that significantly impact the mental health and wellbeing of individuals with TSC and their caregivers. TAND represents the number one concern to families worldwide, yet is highly under-identified and under-treated. The clinician-administered TAND-Checklist (Lifetime version, TAND-L) has improved identification of TAND in clinical settings. However, many individuals with TSC and their caregivers still have difficulty accessing suitable support for diagnosis and evidence-informed interventions. The TANDem study is a community-based participatory research project with a broad range of TSC stakeholders aimed at reducing the TAND identification and treatment gap. OBJECTIVES: Participatory research identified three priority next steps: 1) development and validation of a self-report, quantified version of the TAND Checklist (TAND-SQ) and building the TAND-SQ into a smartphone application, 2) generation of consensus clinical recommendations for the identification and treatment of TAND, to be incorporated as a TAND toolkit on the app, and 3) establishment of a global TAND consortium through networking, capacity-building and public engagement activities. METHODS: TANDem is a four-year project, and includes 24 consortium members from 10 countries representing all World Health Organization regions. Collaborators represent five stakeholder groups (family representatives, technology experts, clinical experts, non-profit organisations and researchers). Here we outline the project study protocol in detail, describing the scientific rationale, the project aims and objectives, the methods involved in participant recruitment, multi-site and multi-phase data collection, data analysis, ethical considerations including informed consent, data protection, privacy and confidentiality considerations related to the European Union General Data Protection Regulation and the USA Health Insurance ...

This non-interventional post-authorisation safety study (PASS) assessed the long-term safety of everolimus in patients with tuberous sclerosis complex (TSC) who participated in the TuberOus SClerosis registry to increase disease Awareness (TOSCA) clinical study and received everolimus for the licensed indications in the European Union. The rate of adverse events (AEs), AEs that led to dose adjustments or treatment discontinuation, AEs of potential clinical interest, treatment-related AEs (TRAEs), serious AEs (SAEs), and deaths were documented. One hundred seventy-nine patients were included in the first 5 years of observation; 118 of 179 patients had an AE of any grade, with the most common AEs being stomatitis (7.8%) and headache (7.3%). AEs caused dose adjustments in 56 patients (31.3%) and treatment discontinuation in nine patients (5%). AEs appeared to be more frequent and severe in children. On Tanner staging, all patients displayed signs of age-appropriate sexual maturation. Twenty-two of 106 female (20.8%) patients had menstrual cycle disorders. The most frequent TRAEs were stomatitis (6.7%) and aphthous mouth ulcer (5.6%). SAEs were reported in 54 patients (30.2%); the most frequent SAE was pneumonia (>3% patients; grade 2, 1.1%, and grade 3, 2.8%). Three deaths were reported, all in patients who had discontinued everolimus for more than 28 days, and none were thought to be related to everolimus according to the treating physicians. The PASS sub-study reflects the safety and tolerability of everolimus in the management of TSC in real-world routine clinical practice.

WOS: 000388677600001 ; PubMed ID: 27667586 ; In countries from which Crimean-Congo haemorrhagic fever (CCHF) is absent, the causative virus, CCHF virus (CCHFV), is classified as a hazard group 4 agent and handled in containment level (CL)-4. In contrast, most endemic countries out of necessity have had to perform diagnostic tests under biosafety level (BSL)-2 or -3 conditions. In particular, Turkey and several of the Balkan countries have safely processed more than 100 000 samples over many years in BSL-2 laboratories. It is therefore advocated that biosafety requirements for CCHF diagnostic procedures should be revised, to allow the tests required to be performed under enhanced BSL-2 conditions with appropriate biosafety laboratory equipment and personal protective equipment used according to standardized protocols in the countries affected. Downgrading of CCHFV research work from CL-4, BSL-4 to CL-3, BSL-3 should also be considered. ; European Commission under Health Cooperation Work Program of 7th Framework Program [260427] ; Funding was received through CCH Fever Network (Collaborative Project) supported by the European Commission under the Health Cooperation Work Program of the 7th Framework Program (grant agreement no. 260427) (http://www.cch-fever.eu/). The views expressed by state-employed American co-authors are their personal views, and do not necessarily represent the views of the US government agencies they work for. The views expressed by the ECDC coauthor are his personal views, and do not necessarily represent the views of the European agency he is working for.

Using a broad international comparative perspective spanning multiple countries across South America, Europe and Africa, contributors explore resident-led self-building for low- and middle-income groups in urban areas. Although social, economic and urban prosperity differs across these contexts, there exists a recurring, cross-continental, tension between formal governance and self-regulation. Contributors examine the multifaceted regulation dilemmas of self-building under the conditions of modernisation and consider alternative methods of institutionalisation, place-making and urban design, reconceptualising the moral and managerial ownership of the city. Innovative in scope, this book provides an array of globalised solutions for navigating regulatory tensions in order to optimise sustainable development for the future

In differentiated cells, aging is associated with hypermethylation of DNA regions enriched in repressive histone post-translational modifications. However, the chromatin marks associated with changes in DNA methylation in adult stem cells during lifetime are still largely unknown. Here, DNA methylation profiling of mesenchymal stem cells (MSCs) obtained from individuals aged 2 to 92 yr identified 18,735 hypermethylated and 45,407 hypomethylated CpG sites associated with aging. As in differentiated cells, hypermethylated sequences were enriched in chromatin repressive marks. Most importantly, hypomethylated CpG sites were strongly enriched in the active chromatin mark H3K4me1 in stem and differentiated cells, suggesting this is a cell type-independent chromatin signature of DNA hypomethylation during aging. Analysis of scedasticity showed that interindividual variability of DNA methylation increased during aging in MSCs and differentiated cells, providing a new avenue for the identification of DNA methylation changes over time. DNA methylation profiling of genetically identical individuals showed that both the tendency of DNA methylation changes and scedasticity depended on nongenetic as well as genetic factors. Our results indicate that the dynamics of DNA methylation during aging depend on a complex mixture of factors that include the DNA sequence, cell type, and chromatin context involved and that, depending on the locus, the changes can be modulated by genetic and/or external factors. ; We thank Ronnie Lendrum for manuscript preparation and Tim Triche Jr. for his invaluable advice. This work has been financially supported by the Plan Nacional de I+D+I 2008-2011/2013-2016/FEDER (PI11/01728 to A.F.F., PI 12/0615 to J.A.R., PI10/0449 to P.M., and PI11/0119 to C.B.); the ISCIII-Subdirección General de Evaluación y Fomento de la Investigación (Miguel Servet contracts CP11/00131 to A.F.F. and CP07/0059 to C.B.); the Spanish Ministry of Health (PS09/02454 and PI12/01080 to M.F.F.); the Spanish National Research Council (CSIC; 200820I172 to M.F.F.); IUOPA (to C.F. and G.F.B.); Fundacion Cientifica de la AECC (to R.G.U. and P.M.); Fundación Ramón Areces (to M.F.F.); and FICYT (to E.G.T.). J.G.-C. receives funding from the Fondo de Investigaciones Sanitarias (FIS; PI05/2217 and PI08/0029) and the Madrid Regional Government (S-BIO-0204-2006 and S2010/BMD-2420). J.A.R. receives funding from the Fondo de Investigaciones Sanitarias (ISCIII-FIS PI 12/0615). P.M. is also supported by MINECO (SAF2013/43065), ERANET E-Rare (PI112/03112), and Fundación Sandra Ibarra. P.M. also acknowledges support from Obra Social "La Caixa/Fundacio Josep Carreras." The IUOPA is supported by the Obra Social Cajastur, Spain. ; Sí

This book addresses some of the challenges posed by the globalization of higher education. It examines the emergence and resulting challenges of English as Lingua Franca (ELF) and of the decision to use English as the Medium of Instruction (EMI) as part of a strategic policy of internationalization. It looks at survival challenges caused by globalization and expansion, the diversity challenge, the concept of marginality and how marginality can lead to creativity, teaching and encouraging entrepreneurialism, the tools needed for internationalizing higher education in developing countries, innovative approaches, the intelligent use of technology, and finally, the value of non-constraint engagement in driving teaching and course quality improvements. The expansion of higher education and the increasingly international body of students and staff continue to inspire and drive the development of global higher education systems. Whilst these systems began locally, many are now engaging with the challenges of retaining their local flavour whilst embracing the march of globalisation. The challenge is to find local solutions that also meet the requirements of the rapid development of what might be termed the 'massification' of international higher education. This book reflects these contemporary challenges through its variety of topics taken from countries as diverse as Hong Kong, Panama, South Africa, USA and Saudi Arabia. The topics are as diverse as some of the local solutions but each chapter represents a response to a rapidly changing global landscape.

After Niebuhr's death in 1831, the title includes "Auctoritate Academiae litterarum regiae borussicae continuata". ; The volumes containing respectively Dexippus [and other writers], Procopius, Agathias, Leo diaconus [and other writers], Ioannes Cantacuzenus, are numbered Pars I, II, III, XI, and XX on general t.-p. ; Each volume and part has also special t.-p. except v.31, pt.4. ; Contents: [v. 1] Agathiae Myrinaei Historiarum libri V cum versione latina et annotationibus B. Vulcanii. B. G. Niebuhrius graeca recensuit. Accendunt Agathiae Epigrammata. 1828.--[v. 2, pt. 1-3] Ioannis Cantacuzeni eximperatoris Historiarum libri IV. Cura L. Schopeni. 1828-1832.--[v. 3] Leonis diaconi Caloënsis Historiae libri X et liber de velitatione bellica Nicephori Augusti e recensione C. B. Hasii. Addita eiusdem versione . Accedunt Theodosii Acroases de Creta capta e rec. F. Iacobsii et Luitprandi legatio cum allis libellis qui Nicephori Phoca et Ioannis Tzimiscis historiam illustrant. 1828.--[v. 4, pt. 1-3] Nicephori Gregorae Byzantina historia . Cura L. Schopeni. 1829-1885.--[v. 5] Constantini Porphyrogeniti imperatoris. [pt. 1-2] De ceremoniis aulae byzantinae libri II . [pt. 3] De thematibus et de administrando imperio. Accedit Hieroclis Synecdemus . Recognovit I. Bekkerus. 1829-1840.--[v. 6, pt. 1-2] Georgius Syncellus et Nicephorus Cp. ex recensione Guil. Dindorfii. 1829.--[v. 7] Dexippi Eunapii, Petri Patricii, Prisci, Malchi, Menandri Historiarum quae supersunt e recensione I. Bekkeri et B. G. Niebuhrii . Accedunt Eclogae Photii ex Olympiodoro, Candido, Nonnoso et Theophane, et procopii sophistae Panegyricus, Prisciani Panegyricus . 1829.--[v. 8] Ioannis Malalae Chronographia ex rec. L. Dindorfii. 1831.--[v. 9, pt. 1-2] Chronicon paschale . rec. L. Dindorfius. 1831.--[v. 10, pt. 1-3] Procopius ex rec. Guil. Dindorfii. 1833-8.--[v. 11] Ducae, Michaelis Ducae nepotis, Historia byzantina. Recognovit . I. Bekkerus. 1834.--[v. 12] Theophylacti Simocattae Historiarum libri VIII. Recognovit I. Bekkerus. Genesius ex recognitione C. Lachmanni. 1834.--[v. 13] Nicetae Choniatae Historia ex rec. I. Bekkeri. 1850.--[v. 14, pt. 1-2] Georgii Pachymeris De Michaele et Andronico Palaeologis libri XIII. Recognovit I. Bekkerus. 1835.--[v. 15] Ioannis Cinnami Epitome rerum ab Ioanne et Alexio Comnenis gestarum . recensuit A. Meineke. 1836.--[v. 16] Nicephori Bryennii Commentarii. Recognovit A. Meineke. 1836.--[v. 17] Michaelis Glycae Annales. Recognovit I. Bekkerus. 1836.--[v. 18] Merobaudes et Corippus. Recognovit I. Bekkerus. 1836.--[v. 19] Constantini Manassis Breviarium historiae metricum. Recognovit I. Bekkerus. Ioelis Chronographia compendiaria. Recognovit I. Bekkerus. Georgii Acropolitae Annales. Recognovit I. Bekkerus. 1837. 3 pts. in 1 v.--[v. 20] Zosimus ex recognitione I. Bekkeri. 1837.--[v. 21] Ioannes Lydus ex recognitione I. Bekkeri. 1837.--[v. 22] Pauli Silentiarii Descriptio S. Sophiae et ambonis ex recognitione I. Bekkeri. Georgii Pisidae Expeditio persica, Bellum avaricum, Heraclias. Recognovit I. Bekkerus. Sancti Nicephori . Breviarium rerum post Mauricium gestarum. Recognovit I. Bekkerus. 1837. 3 pts. in 1 v.--[v. 23] Theophanes continuatus, Ioannes Cameniata, Symeon Magister [i.e. Pseudo-Symeon Georgius Monachus ex recognitione I. Bekkeri. 1838.--[v. 24, pt. 1-2] Georgius Cedrenus Ioannis Scylitzae ope ab I. Bekkero suppletus et emendatus. 1838-9.--[v. 25] Georgius Phrantzes, Ioannes Cananus, Ioannes Anagnostes ex recensione I. Bekkeri. 1838.--[v. 26] Georgii, Codini Curopalatae De officialibus palatii cpolitani et de officiis magnae ecclesiae liber. Ex recognitione I. Bekkeri. 1839.--[v. 27] Georgii Codini Excerpta de antiquitatibus constantinopolitanis ex recognitione I. Bekkeri. 1843.--[v. 28] Annae Comnenae Alexiadis libri XV . [pt. 1] recensuit . L. Schopenus. [pt. 2] recensuit L. Schopeni . commentarios indices addidit A. Referscheid. 1839-1878.--[v. 29, pt. 1-2] Theophanis Chronographia ex recensione I. Classeni. 1839-1841. (pt. 2: Praecedit Anastasii bibliothecarii Historia ecclesiastica ex recensione I. Bekkeri.).--[v. 30] Ephraemius ex recognitione I. Bekkeri. 1840.--[v. 31] Ioannis Zonarae. [pt. 1-2] Annales ex recensione M. Pinderi. [pt. 3-4] Epitomae historiarum libri XVIII ex recensione Pinderi edidit Theodorus Büttner-Wobst. 1841-1897.--[v. 32] Leonis Grammatici Chronographia. Ex recognitione I. Bekkeri. Accedit Eustathii De capta Thessalonica liber. 1842.--[v. 33] Laonici Chalcocondylae Atheniensis Historiarum libri X ex recognitione I. Bekkerus. 1849.--[v. 34] Historia politica et patriarchica Constantinopoleos. Epirotica. Recognovit I. Bekkerus. 1849.--[v. 35] Michaelis Attaliotae Historia. Recognovit I. Bekkerus. 1853. ; Vol. 50 is a Photocopy. ; Vol. 4, pt.3 is a Photocopy. ; Vol. 24 is a Photocopy. ; Mode of access: Internet.

This collection contains papers relating to the Duane family and families related to the Duane family. The majority of the collection concerns the papers of James Duane, a prominent New York lawyer, patriot, and land developer. There is also a substantial number of papers relating to Duane's son, James Chatham Duane, a lawyer of Duanesburg and Schenectady, and of his son-in-law George William Featherstonhaugh. The collection also includes a substantial number of papers, largely correspondence, relating to other Duane family members, predominantly William North Duane Jr., great-great-grandson of James Duane, his mother Anne Dalliba Duane, and others. ; James Duane (1733-1797) also known as James the Jurist, was the son of Irishman Anthony Duane, who came to New York as an officer in the British Navy in 1698. After his father's death (ca. 1734), Duane became the ward of Robert Livingston. Duane fell in love with and married Livingston's daughter Mary in 1759. He took the bar and made a number of profitable real estate investments and was a prominent lawyer by the time of the American Revolution. He was a member of the Revolutionary Committee of New York, the Continental Congress, and was one of the signers of the Articles of Confederation. He was a member of the Constitutional Convention, served as mayor of the city of New York from 1794-1789, and as a U.S. District judge from 1789-1794. James Chatham Duane (1770-1842), son of James Duane, was a lawyer in Schenectady, New York. He married Marianne Bowers, daughter of Henry Bowers of New York City. Duane spent his life working on the development of the Duane estate at Duanesburg, both political changes, industrial unrest, financial panics, and anti-rent riots combined to decrease his holdings drastically.

This collection contains papers relating to the Duane family and families related to the Duane family. The majority of the collection concerns the papers of James Duane, a prominent New York lawyer, patriot, and land developer. There is also a substantial number of papers relating to Duane's son, James Chatham Duane, a lawyer of Duanesburg and Schenectady, and of his son-in-law George William Featherstonhaugh. The collection also includes a substantial number of papers, largely correspondence, relating to other Duane family members, predominantly William North Duane Jr., great-great-grandson of James Duane, his mother Anne Dalliba Duane, and others. ; James Duane (1733-1797) also known as James the Jurist, was the son of Irishman Anthony Duane, who came to New York as an officer in the British Navy in 1698. After his father's death (ca. 1734), Duane became the ward of Robert Livingston. Duane fell in love with and married Livingston's daughter Mary in 1759. He took the bar and made a number of profitable real estate investments and was a prominent lawyer by the time of the American Revolution. He was a member of the Revolutionary Committee of New York, the Continental Congress, and was one of the signers of the Articles of Confederation. He was a member of the Constitutional Convention, served as mayor of the city of New York from 1794-1789, and as a U.S. District judge from 1789-1794. James Chatham Duane (1770-1842), son of James Duane, was a lawyer in Schenectady, New York. He married Marianne Bowers, daughter of Henry Bowers of New York City. Duane spent his life working on the development of the Duane estate at Duanesburg, both political changes, industrial unrest, financial panics, and anti-rent riots combined to decrease his holdings drastically.

This collection contains papers relating to the Duane family and families related to the Duane family. The majority of the collection concerns the papers of James Duane, a prominent New York lawyer, patriot, and land developer. There is also a substantial number of papers relating to Duane's son, James Chatham Duane, a lawyer of Duanesburg and Schenectady, and of his son-in-law George William Featherstonhaugh. The collection also includes a substantial number of papers, largely correspondence, relating to other Duane family members, predominantly William North Duane Jr., great-great-grandson of James Duane, his mother Anne Dalliba Duane, and others. ; James Duane (1733-1797) also known as James the Jurist, was the son of Irishman Anthony Duane, who came to New York as an officer in the British Navy in 1698. After his father's death (ca. 1734), Duane became the ward of Robert Livingston. Duane fell in love with and married Livingston's daughter Mary in 1759. He took the bar and made a number of profitable real estate investments and was a prominent lawyer by the time of the American Revolution. He was a member of the Revolutionary Committee of New York, the Continental Congress, and was one of the signers of the Articles of Confederation. He was a member of the Constitutional Convention, served as mayor of the city of New York from 1794-1789, and as a U.S. District judge from 1789-1794. James Chatham Duane (1770-1842), son of James Duane, was a lawyer in Schenectady, New York. He married Marianne Bowers, daughter of Henry Bowers of New York City. Duane spent his life working on the development of the Duane estate at Duanesburg, both political changes, industrial unrest, financial panics, and anti-rent riots combined to decrease his holdings drastically.

This collection contains papers relating to the Duane family and families related to the Duane family. The majority of the collection concerns the papers of James Duane, a prominent New York lawyer, patriot, and land developer. There are also a substantial number of papers relating to Duane's son, James Chatham Duane, a lawyer of Duanesburg and Schenectady, and of his son-in-law George William Featherstonhaugh. The collection also includes a substantial number of papers, largely correspondence, relating to other Duane family members, predominantly William North Duane Jr., great-great-grandson of James Duane, his mother Anne Dalliba Duane, and others. ; James Duane (1733-1797) also known as James the Jurist, was the son of Irishman Anthony Duane, who came to New York as an officer in the British Navy in 1698. After his father's death (ca. 1734), Duane became the ward of Robert Livingston. Duane fell in love with and married Livingston's daughter Mary in 1759. He took the bar and made a number of profitable real estate investments and was a prominent lawyer by the time of the American Revolution. He was a member of the Revolutionary Committee of New York, the Continental Congress, and was one of the signers of the Articles of Confederation. He was a member of the Constitutional Convention, served as mayor of the city of New York from 1794-1789, and as a U.S. District judge from 1789-1794. James Chatham Duane (1770-1842), son of James Duane, was a lawyer in Schenectady, New York. He married Marianne Bowers, daughter of Henry Bowers of New York City. Duane spent his life working on the development of the Duane estate at Duanesburg, both political changes, industrial unrest, financial panics, and anti-rent riots combined to decrease his holdings drastically.