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Open Access#6912020

NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies:Comparison of Results from Diverse Analytical Methods

In: De Leoz , M L A , Duewer , D L , Fung , A , Liu , L , Yau , H K , Potter , O , Staples , G O , Furuki , K , Frenkel , R , Hu , Y , Sosic , Z , Zhang , P , Altmann , F , Gru Nwald-Grube , C , Shao , C , Zaia , J , Evers , W , Pengelley , S , Suckau , D , Wiechmann , A , Resemann , A , Jabs , W , Beck , A , Froehlich , J W , Huang , C , Li , Y , Liu , Y , Sun , S , Wang , Y , Seo , Y , An , H J , Reichardt , N C , Ruiz , J E , Archer-Hartmann , S , Azadi , P , Bell , L , Lakos , Z , An , Y , Cipollo , J F , Pucic-Bakovic , M , Štambuk , J , Lauc , G , Li , X , Wang , P G , Bock , A , Hennig , R , Rapp , E , Creskey , M , Cyr , T D , Nakano , M , Sugiyama , T , Leung , P K A , Link-Lenczowski , P , Jaworek , J , Yang , S , Zhang , H , Kelly , T , Klapoetke , S , Cao , R , Kim , J Y , Lee , H K , Lee , J Y , Yoo , J S , Kim , S R , Suh , S K , de Haan , N , Falck , D , Lageveen-Kammeijer , G S M , Wuhrer , M , Emery , R J , Kozak , R P , Liew , L P , Royle , L , Urbanowicz , P A , Packer , N H , Song , X , Everest-Dass , A , Lattová , E , Cajic , S , Alagesan , K , Kolarich , D , Kasali , T , Lindo , V , Chen , Y , Goswami , K , Gau , B , Amunugama , R , Jones , R , Stroop , C J M , Kato , K , Yagi , H , Kondo , S , Yuen , C T , Harazono , A , Shi , X , Magnelli , P E , Kasper , B T , Mahal , L , Harvey , D J , O'Flaherty , R , Rudd , P M , Saldova , R , Hecht , E S , Muddiman , D C , Kang , J , Bhoskar , P , Menard , D , Saati , A , Merle , C , Mast , S , Tep , S , Truong , J , Nishikaze , T , Sekiya , S , Shafer , A , Funaoka , S , Toyoda , M , de Vreugd , P , Caron , C , Pradhan , P , Tan , N C , Mechref , Y , Patil , S , Rohrer , J S , Chakrabarti , R , Dadke , D , Lahori , M , Zou , C , Cairo , C , Reiz , B , Whittal , R M , Lebrilla , C B , Wu , L , Guttman , A , Szigeti , M , Kremkow , B G , Lee , K H , Sihlbom , C , Adamczyk , B , Jin , C , Karlsson , N G , Örnros , J , Larson , G , Nilsson , J , Meyer , B , Wiegandt , A , Komatsu , E , Perreault , H , Bodnar , E D , Said , N , Francois , Y N , Leize-Wagner , E , Maier , S , Zeck , A , Heck , A J R , Yang , Y , Haselberg , R , Yu , Y Q , Alley , W , Leone , J W , Yuan , H & Stein , S E 2020 , ' NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies : Comparison of Results from Diverse Analytical Methods ' , MCP : Molecular & cellular proteomics , vol. 19 , no. 1 , pp. 11-30 . https://doi.org/10.1074/mcp.RA119.001677

De Leoz, Maria Lorna A; Duewer, David L; Fung, Adam; Liu, Lily; Yau, Hoi Kei; Potter, Oscar; Staples, Gregory O; Furuki, Kenichiro

De Leoz, Maria Lorna A; Duewer, David L; Fung, Adam; Liu, Lily; Yau, Hoi Kei; Potter, Oscar; Staples, Gregory O; Furuki, Kenichiro; Frenkel, Ruth; Hu, Yunli; Sosic, Zoran; Zhang, Peiqing; Altmann, Friedrich; Gru Nwald-Grube, Clemens; Shao, Chun; Zaia, Joseph; Evers, Waltraud; Pengelley, Stuart; Suckau, Detlev; Wiechmann, Anja; Resemann, Anja; Jabs, Wolfgang; Beck, Alain; Froehlich, John W; Huang, Chuncui; Li, Yan; Liu, Yaming; Sun, Shiwei; Wang, Yaojun; Seo, Youngsuk; An, Hyun Joo; Reichardt, Niels Christian; Ruiz, Juan Echevarria; Archer-Hartmann, Stephanie; Azadi, Parastoo; Bell, Len; Lakos, Zsuzsanna; An, Yanming; Cipollo, John F; Pucic-Bakovic, Maja; Štambuk, Jerko; Lauc, Gordan; Li, Xu; Wang, Peng George; Bock, Andreas; Hennig, René; Rapp, Erdmann; Creskey, Marybeth; Cyr, Terry D; Nakano, Miyako; Sugiyama, Taiki; Leung, Pui King Amy; Link-Lenczowski, Paweł; Jaworek, Jolanta; Yang, Shuang; Zhang, Hui; Kelly, Tim; Klapoetke, Song; Cao, Rui; Kim, Jin Young; Lee, Hyun Kyoung; Lee, Ju Yeon; Yoo, Jong Shin; Kim, Sa Rang; Suh, Soo Kyung; de Haan, Noortje; Falck, David; Lageveen-Kammeijer, Guinevere S.M; Wuhrer, Manfred; Emery, Robert J; Kozak, Radoslaw P; Liew, Li Phing; Royle, Louise; Urbanowicz, Paulina A; Packer, Nicolle H; Song, Xiaomin; Everest-Dass, Arun; Lattová, Erika; Cajic, Samanta; Alagesan, Kathirvel; Kolarich, Daniel; Kasali, Toyin; Lindo, Viv; Chen, Yuetian; Goswami, Kudrat; Gau, Brian; Amunugama, Ravi; Jones, Richard; Stroop, Corné J.M; Kato, Koichi; Yagi, Hirokazu; Kondo, Sachiko; Yuen, C. T; Harazono, Akira; Shi, Xiaofeng; Magnelli, Paula E; Kasper, Brian T; Mahal, Lara; Harvey, David J; O'Flaherty, Roisin; Rudd, Pauline M; Saldova, Radka; Hecht, Elizabeth S; Muddiman, David C; Kang, Jichao; Bhoskar, Prachi; Menard, Daniele; Saati, Andrew; Merle, Christine; Mast, Steven; Tep, Sam; Truong, Jennie; Nishikaze, Takashi; Sekiya, Sadanori; Shafer, Aaron; Funaoka, Sohei; Toyoda, Masaaki; de Vreugd, Peter; Caron, Cassie; Pradhan, Pralima; Tan, Niclas Chiang; Mechref, Yehia; Patil, Sachin; Rohrer, Jeffrey S; Chakrabarti, Ranjan; Dadke, Disha; Lahori, Mohammedazam; Zou, Chunxia; Cairo, Christopher; Reiz, Béla; Whittal, Randy M; Lebrilla, Carlito B; Wu, Lauren; Guttman, Andras; Szigeti, Marton; Kremkow, Benjamin G; Lee, Kelvin H; Sihlbom, Carina; Adamczyk, Barbara; Jin, Chunsheng; Karlsson, Niclas G; Örnros, Jessica; Larson, Göran; Nilsson, Jonas; Meyer, Bernd; Wiegandt, Alena; Komatsu, Emy; Perreault, Helene; Bodnar, Edward D; Said, Nassur; Francois, Yannis Nicolas; Leize-Wagner, Emmanuelle; Maier, Sandra; Zeck, Anne; Heck, Albert J.R; Yang, Yang; Haselberg, Rob; Yu, Ying Qing; Alley, William; Leone, Joseph W; Yuan, Hua; Stein, Stephen E

Glycosylation is a topic of intense current interest in the development of biopharmaceuticals because it is related to drug safety and efficacy. This work describes results of an interlaboratory study on the glycosylation of the Primary Sample (PS) of NISTmAb, a monoclonal antibody reference material. Seventy-six laboratories from industry, university, research, government, and hospital sectors in Europe, North America, Asia, and Australia submitted a total of 103 reports on glycan distributions. The principal objective of this study was to report and compare results for the full range of analytical methods presently used in the glycosylation analysis of mAbs. Therefore, participation was unrestricted, with laboratories choosing their own measurement techniques. Protein glycosylation was determined in various ways, including at the level of intact mAb, protein fragments, glycopeptides, or released glycans, using a wide variety of methods for derivatization, separation, identification, and quantification. Consequently, the diversity of results was enormous, with the number of glycan compositions identified by each laboratory ranging from 4 to 48. In total, one hundred sixteen glycan compositions were reported, of which 57 compositions could be assigned consensus abundance values. These consensus medians provide community-derived values for NISTmAb PS. Agreement with the consensus medians did not depend on the specific method or laboratory type. The study provides a view of the current state-of-the-art for biologic glycosylation measurement and suggests a clear need for harmonization of glycosylation analysis methods.

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Open Access#6922019

NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods

De Leoz, Maria Lorna A; Duewer, David L; Fung, A. (Adam); Liu, L. (Lily); Yau, H. (Hoi Kei); Potter, O. (Oscar); Staples, Gregory O; Furuki, K. (Kenichiro)

De Leoz, Maria Lorna A; Duewer, David L; Fung, A. (Adam); Liu, L. (Lily); Yau, H. (Hoi Kei); Potter, O. (Oscar); Staples, Gregory O; Furuki, K. (Kenichiro); Frenkel, R. (Ruth); Hu, Y. (Yunli); Sosic, Z. (Zoran); Zhang, P. (Peiqing); Altmann, F. (Friedrich); Gru«nwald-Grube, C. (Clemens); Shao, C. (Chun); Zaia, J. (Joseph); Evers, W. (Waltraud); Pengelley, S. (Stuart); Suckau, D. (Detlev); Wiechmann, A. (Anja); Resemann, A. (Anja); Jabs, W. (Wolfgang); Beck, A. (Alain); Froehlich, John W; Huang, C. (Chuncui); Li, Y. (Yan); Liu, Y. (Yaming); Sun, S. (Shiwei); Wang, Y. (Yaojun); Seo, Y. (Youngsuk); An, H. (Hyun Joo); Reichardt, N. (Niels-Christian); Ruiz, J. (Juan Echevarria); Archer-Hartmann, S. (Stephanie); Azadi, P. (Parastoo); Bell, L. (Len); Lakos, Z. (Zsuzsanna); An, Y. (Yanming); Cipollo, John F; Pucic-Bakovic, M. (Maja); Štambuk, J. (Jerko); Lauc, G. (Gordan); Li, X. (Xu); Wang, P. (Peng George); Bock, A. (Andreas); Hennig, R. (René); Rapp, E. (Erdmann); Creskey, M. (Marybeth); Cyr, Terry D; Nakano, M. (Miyako); Sugiyama, T. (Taiki); Leung, P. (Pui-King Amy); Link-Lenczowski, P. (Paweł); Jaworek, J. (Jolanta); Yang, S. (Shuang); Zhang, H. (Hui); Kelly, T. (Tim); Klapoetke, S. (Song); Cao, R. (Rui); Kim, J. (Jin Young); Lee, H. (Hyun Kyoung); Lee, J. (Ju Yeon); Yoo, J. (Jong Shin); Kim, S. (Sa-Rang); Suh, S. (Soo-Kyung); de Haan, N. (Noortje); Falck, D. (David); Lageveen-Kammeijer, Guinevere S. M; Wuhrer, M. (Manfred); Emery, Robert J; Kozak, Radoslaw P; Liew, L. (Li Phing); Royle, L. (Louise); Urbanowicz, Paulina A; Packer, Nicolle H; Song, X. (Xiaomin); Everest-Dass, A. (Arun); Lattová, E. (Erika); Cajic, S. (Samanta); Alagesan, K. (Kathirvel); Kolarich, D. (Daniel); Kasali, T. (Toyin); Lindo, V. (Viv); Chen, Y. (Yuetian); Goswami, K. (Kudrat); Gau, B. (Brian); Amunugama, R. (Ravi); Jones, R. (Richard); Stroop, Corné J. M; Kato, K. (Koichi); Yagi, H. (Hirokazu); Kondo, S. (Sachiko); Yuen, C. T; Harazono, A. (Akira); Shi, X. (Xiaofeng); Magnelli, Paula E; Kasper, Brian T; Mahal, L. (Lara); Harvey, David J; O'Flaherty, R. (Roisin); Rudd, Pauline M; Saldova, R. (Radka); Hecht, Elizabeth S; Muddiman, David C; Kang, J. (Jichao); Bhoskar, P. (Prachi); Menard, D. (Daniele); Saati, A. (Andrew); Merle, C. (Christine); Mast, S. (Steven); Tep, S. (Sam); Truong, J. (Jennie); Nishikaze, T. (Takashi); Sekiya, S. (Sadanori); Shafer, A. (Aaron); Funaoka, S. (Sohei); Toyoda, M. (Masaaki); de Vreugd, P. (Peter); Caron, C. (Cassie); Pradhan, P. (Pralima); Tan, N. (Niclas Chiang); Mechref, Y. (Yehia); Patil, S. (Sachin); Rohrer, Jeffrey S; Chakrabarti, R. (Ranjan); Dadke, D. (Disha); Lahori, M. (Mohammedazam); Zou, C. (Chunxia); Cairo, C. (Christopher); Reiz, B. (Béla); Whittal, Randy M; Lebrilla, Carlito B; Wu, L. (Lauren); Guttman, A. (Andras); Szigeti, M. (Marton); Kremkow, Benjamin G; Lee, Kelvin H; Sihlbom, C. (Carina); Adamczyk, B. (Barbara); Jin, C. (Chunsheng); Karlsson, Niclas G; Örnros, J. (Jessica); Larson, G. (Göran); Nilsson, J. (Jonas); Meyer, B. (Bernd); Wiegandt, A. (Alena); Komatsu, E. (Emy); Perreault, H. (Helene); Bodnar, Edward D; Said, N. (Nassur); Yannis François (yfrancois@unistra.fr), Y. (Yannis); Leize-Wagner, E. (Emmanuelle); Maier, S. (Sandra); Zeck, A. (Anne); Heck, Albert J. R; Yang, Y. (Yang); Haselberg, R. (Rob); Yu, Y. (Ying Qing); Alley, W. (William); Leone, Joseph W; Yuan, H. (Hua); Stein, Stephen E

Glycosylation is a topic of intense current interest in the development of biopharmaceuticals since it is related to drug safety and efficacy. This work describes results of an interlaboratory study on the glycosylation of the Primary Sample (PS) of NISTmAb, a monoclonal antibody reference material. Seventy-six laboratories from industry, university, research, government, and hospital sectors in Europe, North America, Asia, and Australia submitted a total of 103 reports on glycan distributions. The principal objective of this study was to report and compare results for the full range of analytical methods presently used in the glycosylation analysis of mAbs. Therefore, participation was unrestricted, with laboratories choosing their own measurement techniques. Protein glycosylation was determined in various ways, including at the level of intact mAb, protein fragments, glycopeptides, or released glycans, using a wide variety of methods for derivatization, separation, identification, and quantification. Consequently, the diversity of results was enormous, with the number of glycan compositions identified by each laboratory ranging from 4 to 48. In total, one hundred sixteen glycan compositions were reported, of which 57 compositions could be assigned consensus abundance values. These consensus medians provide community-derived values for NISTmAb PS. Agreement with the consensus medians did not depend on the specific method or laboratory type. The study provides a view of the current state-of-the-art for biologic glycosylation measurement and suggests a clear need for harmonization of glycosylation analysis methods.

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Open Access#6932020

Multiplicity dependence of J/ψ production at midrapidity in pp collisions at √s = 13 TeV

Acharya, S; Adamová, D; Adler, A; Adolfsson, J; Aggarwal, M.M; Aglieri Rinella, G; Agnello, M; Agrawal, N

Acharya, S; Adamová, D; Adler, A; Adolfsson, J; Aggarwal, M.M; Aglieri Rinella, G; Agnello, M; Agrawal, N; Ahammed, Z; Ahmad, S; Ahn, S.U; Akbar, Z; Akindinov, A; Al-Turany, M; Alam, S.N; Albuquerque, D.S.D; Aleksandrov, D; Alessandro, B; Alfanda, H.M; Alfaro Molina, R; Ali, B; Ali, Y; Alici, A; Alizadehvandchali, N; Alkin, A; Alme, J; Alt, T; Altenkamper, L; Altsybeev, I; Anaam, M.N; Andrei, C; Andreou, D; Andronic, A; Angeletti, M; Anguelov, V; Anson, C; Antičić, T; Antinori, F; Antonioli, P; Apadula, N; Aphecetche, L; Appelshäuser, H; Arcelli, S; Arnaldi, R; Arratia, M; Arsene, I.C; Arslandok, M; Augustinus, A; Averbeck, R; Aziz, S; Azmi, M.D; Badalà, A; Baek, Y.W; Bagnasco, S; Bai, X; Bailhache, R; Bala, R; Balbino, A; Baldisseri, A; Ball, M; Balouza, S; Banerjee, D; Barbera, R; Barioglio, L; Barnaföldi, G.G; Barnby, L.S; Barret, V; Bartalini, P; Bartels, C; Barth, K; Bartsch, E; Baruffaldi, F; Bastid, N; Basu, S; Batigne, G; Batyunya, B; Bauri, D; Bazo Alba, J.L; Bearden, I.G; Beattie, C; Bedda, C; Behera, N.K; Belikov, I; Bell Hechavarria, A.D.C; Bellini, F; Bellwied, R; Belyaev, V; Bencedi, G; Beole, S; Bercuci, A; Berdnikov, Y; Berenyi, D; Bertens, R.A; Berzano, D; Besoiu, M.G; Betev, L; Bhasin, A; Bhat, I.R; Bhat, M.A; Bhatt, H; Bhattacharjee, B; Bianchi, A; Bianchi, L; Bianchi, N; Bielčík, J; Bielčíková, J; Bilandzic, A; Biro, G; Biswas, R; Biswas, S; Blair, J.T; Blau, D; Blume, C; Boca, G; Bock, F; Bogdanov, A; Boi, S; Bok, J; Boldizsár, L; Bolozdynya, A; Bombara, M; Bonomi, G; Borel, H; Borissov, A; Bossi, H; Botta, E; Bratrud, L; Braun-Munzinger, P; Bregant, M; Broz, M; Bruna, E; Bruno, G.E; Buckland, M.D; Budnikov, D; Buesching, H; Bufalino, S; Bugnon, O; Buhler, P; Buncic, P; Buthelezi, Z; Butt, J.B; Bysiak, S.A; Caffarri, D; Caliva, A; Calvo Villar, E; Camacho, J.M.M; Camacho, R.S; Camerini, P; Canedo, F.D.M; Capon, A.A; Carnesecchi, F; Caron, R; Castillo Castellanos, J; Castro, A.J; Casula, E.A.R; Catalano, F; Ceballos Sanchez, C; Chakraborty, P; Chandra, S; 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Measurements of the inclusive J/ψ yield as a function of charged-particle pseudorapidity density dNch/dη in pp collisions at √s = 13 TeV with ALICE at the LHC are reported. The J/ψ meson yield is measured at midrapidity (|y|<0.9) in the dielectron channel, for events selected based on the charged-particle multiplicity at midrapidity (|η|<1) and at forward rapidity ( -3.7 < η < -1.7 and 2.8 < η < 5.1); both observables are normalized to their corresponding averages in minimum bias events. The increase of the normalized J/ψ yield with normalized dNch/dη is significantly stronger than linear and dependent on the transverse momentum. The data are compared to theoretical predictions, which describe the observed trends well, albeit not always quantitatively. ; A.I. Alikhanyan National Science Laboratory (Yerevan Physics Institute) Foundation (ANSL), State Committee of Science and World Federation of Scientists (WFS), Armenia; Austrian Academy of Sciences, Austrian Science Fund (FWF): [M 2467-N36] and Nationalstiftung für Forschung, Technologie und Entwicklung, Austria; Ministry of Communications and High Technologies, National Nuclear Research Center, Azerbaijan; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Financiadora de Estudos e Projetos (Finep), Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) and Universidade Federal do Rio Grande do Sul (UFRGS), Brazil; Ministry of Education of China (MOEC), Ministry of Science & Technology of China (MSTC) and National Natural Science Foundation of China (NSFC), China; Ministry of Science and Education and Croatian Science Foundation, Croatia; Centro de Aplicaciones Tecnológicas y Desarrollo Nuclear (CEADEN), Cubaenergía, Cuba; The Ministry of Education, Youth and Sports of the Czech Republic, Czech Republic; Danish Council for Independent Research Natural Sciences, the Villum Fonden and Danish National Research Foundation (DNRF), Denmark; Helsinki Institute of Physics (HIP), Finland; Commissariat à l'Énergie Atomique (CEA) and Institut National de Physique Nucléaire et de Physique des Particules (IN2P3) and Centre National de la Recherche Scientifique (CNRS), France; Bundesministerium für Bildung und Forschung (BMBF) and GSI Helmholtzzentrum für Schwerionenforschung GmbH, Germany; General Secretariat for Research and Technology, Ministry of Education, Research and Religions, Greece; National Research Development and Innovation Office, Hungary; Department of Atomic Energy, Government of India (DAE), Department of Science and Technology, Government of India (DST), University Grants Commission, Government of India (UGC) and Council of Scientific and Industrial Research (CSIR), India; Indonesian Institute of Science, Indonesia; Centro Fermi - Museo Storico della Fisica e Centro Studi e Ricerche Enrico Fermi and Istituto Nazionale di Fisica Nucleare (INFN), Italy; Institute for Innovative Science and Technology, Nagasaki Institute of Applied Science (IIST), Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) and Japan Society for the Promotion of Science (JSPS) KAKENHI, Japan; Consejo Nacional de Ciencia (CONACYT) y Tecnología, through Fondo de Cooperación Internacional en Ciencia y Tecnología (FONCICYT) and Dirección General de Asuntos del Personal Academico (DGAPA, UNAM), Mexico; Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO), Netherlands; The Research Council of Norway, Norway; Commission on Science and Technology for Sustainable Development in the South (COMSATS), Pakistan; Pontificia Universidad Católica del Perú, Peru; Ministry of Science and Higher Education, National Science Centre and WUT ID-UB, Poland; Korea Institute of Science and Technology Information and National Research Foundation of Korea (NRF), Republic of Korea; Ministry of Education and Scientific Research, Institute of Atomic Physics and Ministry of Research and Innovation and Institute of Atomic Physics, Romania; Joint Institute for Nuclear Research (JINR), Ministry of Education and Science of the Russian Federation, National Research Center "Kurchatov Institute", Russian Science Foundation and Russian Foundation for Basic Research, Russia; Ministry of Education, Science, Research and Sport of the Slovak Republic, Slovakia; National Research Foundation of South Africa, South Africa; Swedish Research Council (VR) and Knut & Alice Wallenberg Foundation (KAW), Sweden; European Organization for Nuclear Research, Switzerland; Suranaree University of Technology (SUT), National Science and Technology Development Agency (NSDTA) and Office of the Higher Education Commission under NRU project of Thailand, Thailand; Turkish Atomic Energy Agency (TAEK), Turkey; National Academy of Sciences of Ukraine, Ukraine; Science and Technology Facilities Council (STFC), United Kingdom; National Science Foundation of the United States of America (NSF) and United States Department of Energy, Office of Nuclear Physics (DOE NP), United States of America.

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Open Access#6942020

Search for a common baryon source in high-multiplicity pp collisions at the LHC

Acharya, S; Adamová, D; Adler, A; Adolfsson, J; Aggarwal, M.M; Aglieri Rinella, G; Agnello, M; Agrawal, N

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We report on the measurement of the size of the particle-emitting source from two-baryon correlations with ALICE in high-multiplicity pp collisions at √s = 13 TeV. The source radius is studied with low relative momentum p–p, pbar-pbar, p–Λ , and pbar-Λbar pairs as a function of the pair transverse mass m_T considering for the first time in a quantitative way the effect of strong resonance decays. After correcting for this effect, the radii extracted for pairs of different particle species agree. This indicates that protons, antiprotons, Λ s, and Λbar s originate from the same source. Within the measured m_T range (1.1–2.2) GeV/c^2 the invariant radius of this common source varies between 1.3 and 0.85 fm. These results provide a precise reference for studies of the strong hadron–hadron interactions and for the investigation of collective properties in small colliding systems. ; A. I. Alikhanyan National Science Laboratory (Yerevan Physics Institute) Foundation (ANSL), State Committee of Science and World Federation of Scientists (WFS), Armenia; Austrian Academy of Sciences, Austrian Science Fund (FWF): [M 2467-N36] and Nationalstiftung für Forschung, Technologie und Entwicklung, Austria; Ministry of Communications and High Technologies, National Nuclear Research Center, Azerbaijan; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Financiadora de Estudos e Projetos (Finep), Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) and Universidade Federal do Rio Grande do Sul (UFRGS), Brazil; Ministry of Education of China (MOEC), Ministry of Science & Technology of China (MSTC) and National Natural Science Foundation of China (NSFC), China; Ministry of Science and Education and Croatian Science Foundation, Croatia; Centro de Aplicaciones Tecnológicas y Desarrollo Nuclear (CEADEN), Cubaenergía, Cuba; Ministry of Education, Youth and Sports of the Czech Republic, Czech Republic; The Danish Council for Independent Research | Natural Sciences, the Villum Fonden and Danish National Research Foundation (DNRF), Denmark; Helsinki Institute of Physics (HIP), Finland; Commissariat à l'Énergie Atomique (CEA) and Institut National de Physique Nucléaire et de Physique des Particules (IN2P3) and Centre National de la Recherche Scientifique (CNRS), France; Bundesministerium für Bildung und Forschung (BMBF) and GSI Helmholtzzentrum für Schwerionenforschung GmbH, Germany; General Secretariat for Research and Technology, Ministry of Education, Research and Religions, Greece; National Research Development and Innovation Office, Hungary; Department of Atomic Energy, Government of India (DAE), Department of Science and Technology, Government of India (DST), University Grants Commission, Government of India (UGC) and Council of Scientific and Industrial Research, India (CSIR), India; Indonesian Institute of Science, Indonesia; Centro Fermi - Museo Storico della Fisica e Centro Studi e Ricerche Enrico Fermi and Istituto Nazionale di Fisica Nucleare (INFN), Italy; Institute for Innovative Science and Technology, Nagasaki Institute of Applied Science (IIST), Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) and Japan Society for the Promotion of Science (JSPS) KAKENHI, Japan; Consejo Nacional de Ciencia (CONACYT) y Tecnología, through Fondo de Cooperación Internacional en Ciencia y Tecnología (FONCICYT) and Dirección General de Asuntos del Personal Academico (DGAPA), Mexico; Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO), Netherlands; The Research Council of Norway, Norway; Commission on Science and Technology for Sustainable Development in the South (COMSATS), Pakistan; Pontificia Universidad Católica del Perú, Peru; Ministry of Science and Higher Education, National Science Centre and WUT ID-UB, Poland; Korea Institute of Science and Technology Information and National Research Foundation of Korea (NRF), Republic of Korea; Ministry of Education and Scientific Research, Institute of Atomic Physics and Ministry of Research and Innovation and Institute of Atomic Physics, Romania; Joint Institute for Nuclear Research (JINR), Ministry of Education and Science of the Russian Federation, National Research Centre Kurchatov Institute, Russian Science Foundation and Russian Foundation for Basic Research, Russia; Ministry of Education, Science, Research and Sport of the Slovak Republic, Slovakia; National Research Foundation of South Africa, South Africa; Swedish Research Council (VR) and Knut and Alice Wallenberg Foundation (KAW), Sweden; European Organization for Nuclear Research, Switzerland; Suranaree University of Technology (SUT), National Science and Technology Development Agency (NSDTA) and Office of the Higher Education Commission under NRU project of Thailand, Thailand; Turkish Atomic Energy Agency (TAEK), Turkey; National Academy of Sciences of Ukraine, Ukraine; Science and Technology Facilities Council (STFC), United Kingdom; National Science Foundation of the United States of America (NSF) and United States Department of Energy, Office of Nuclear Physics (DOE NP), United States of America

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Open Access#6952020

Transverse-momentum and event-shape dependence of D-meson flow harmonics in Pb–Pb collisions at √sNN = 5.02 TeV

Acharya, S; Adamová, D; Adler, A; Adolfsson, J; Aggarwal, M.M; Aglieri Rinella, G; Agnello, M; Agrawal, N

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The elliptic and triangular flow coefficients v2 and v3 of prompt D0, D+, and D*+ mesons were measured at midrapidity (|y|<0.8) in Pb–Pb collisions at the centre-of-mass energy per nucleon pair of √sNN = 5.02 TeV with the ALICE detector at the LHC. The D mesons were reconstructed via their hadronic decays in the transverse momentum interval 1

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Open Access#6962020

Pion–kaon femtoscopy and the lifetime of the hadronic phase in Pb−Pb collisions at √sNN = 2.76 TeV

Acharya, S; Adamová, D; Adler, A; Adolfsson, J; Aggarwal, M.M; Agha, S; Aglieri Rinella, G; Agnello, M

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In this paper, the first femtoscopic analysis of pion–kaon correlations at the LHC is reported. The analysis was performed on the Pb–Pb collision data at √sNN = 2.76 TeV recorded with the ALICE detector. The non-identical particle correlations probe the spatio-temporal separation between sources of different particle species as well as the average source size of the emitting system. The sizes of the pion and kaon sources increase with centrality, and pions are emitted closer to the centre of the system and/or later than kaons. This is naturally expected in a system with strong radial flow and is qualitatively reproduced by hydrodynamic models. ALICE data on pion–kaon emission asymmetry are consistent with (3+1)-dimensional viscous hydrodynamics coupled to a statistical hadronisation model, resonance propagation, and decay code THERMINATOR 2 calculation, with an additional time delay between 1 and 2 fm/c for kaons. The delay can be interpreted as evidence for a significant hadronic rescattering phase in heavy-ion collisions at the LHC. ; A. I. Alikhanyan National Science Laboratory (Yerevan Physics Institute) Foundation (ANSL), State Committee of Science and World Federation of Scientists (WFS), Armenia; Austrian Academy of Sciences, Austrian Science Fund (FWF): [M 2467-N36] and Nationalstiftung für Forschung, Technologie und Entwicklung, Austria; Ministry of Communications and High Technologies, National Nuclear Research Center, Azerbaijan; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Financiadora de Estudos e Projetos (Finep), Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) and Universidade Federal do Rio Grande do Sul (UFRGS), Brazil; Ministry of Education of China (MOEC), Ministry of Science & Technology of China (MSTC) and National Natural Science Foundation of China (NSFC), China; Ministry of Science and Education and Croatian Science Foundation, Croatia; Centro de Aplicaciones Tecnológicas y Desarrollo Nuclear (CEADEN), Cubaenergía, Cuba; The Ministry of Education, Youth and Sports of the Czech Republic, Czech Republic; The Danish Council for Independent Research Natural Sciences, the Villum Fonden and Danish National Research Foundation (DNRF), Denmark; Helsinki Institute of Physics (HIP), Finland; Commissariat à l'Énergie Atomique (CEA) and Institut National de Physique Nucléaire et de Physique des Particules (IN2P3) and Centre National de la Recherche Scientifique (CNRS), France; Bundesministerium für Bildung und Forschung (BMBF) and GSI Helmholtzzentrum für Schwerionenforschung GmbH, Germany; General Secretariat for Research and Technology, Ministry of Education, Research and Religions, Greece; National Research Development and Innovation Office, Hungary; Department of Atomic Energy, Government of India (DAE), Department of Science and Technology, Government of India (DST), University Grants Commission, Government of India (UGC) and Council of Scientific and Industrial Research (CSIR), India; Indonesian Institute of Sciences, Indonesia; Centro Fermi - Museo Storico della Fisica e Centro Studi e Ricerche Enrico Fermi and Istituto Nazionale di Fisica Nucleare (INFN), Italy; Institute for Innovative Science and Technology, Nagasaki Institute of Applied Science (IIST), Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) and Japan Society for the Promotion of Science (JSPS) KAKENHI, Japan; Consejo Nacional de Ciencia y Tecnología (CONACYT), through Fondo de Cooperación Internacional en Ciencia y Tecnología (FONCICYT) and Dirección General de Asuntos del Personal Academico (DGAPA), Mexico; Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO), Netherlands; The Research Council of Norway, Norway; Commission on Science and Technology for Sustainable Development in the South (COMSATS), Pakistan; Pontificia Universidad Católica del Perú, Peru; Ministry of Science and Higher Education, National Science Centre and WUT ID-UB, Poland; Korea Institute of Science and Technology Information and National Research Foundation of Korea (NRF), Republic of Korea; Ministry of Education and Scientific Research, Institute of Atomic Physics and Ministry of Research and Innovation and Institute of Atomic Physics, Romania; Joint Institute for Nuclear Research (JINR), Ministry of Education and Science of the Russian Federation, National Research Centre Kurchatov Institute, Russian Science Foundation and Russian Foundation for Basic Research, Russia; Ministry of Education, Science, Research and Sport of the Slovak Republic, Slovakia; National Research Foundation of South Africa, South Africa; Swedish Research Council (VR) and Knut & Alice Wallenberg Foundation (KAW), Sweden; European Organization for Nuclear Research, Switzerland; Suranaree University of Technology (SUT), National Science and Technology Development Agency (NSDTA) and Office of the Higher Education Commission under NRU project of Thailand, Thailand; Turkish Atomic Energy Agency (TAEK), Turkey; National Academy of Sciences of Ukraine, Ukraine; Science and Technology Facilities Council (STFC), United Kingdom; National Science Foundation of the United States of America (NSF) and United States Department of Energy, Office of Nuclear Physics (DOE NP), United States of America.

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Centrality dependence of J/ψ and ψ(2S) production and nuclear modification in p-Pb collisions at √sNN = 8.16 TeV

Acharya, S; Adamová, D; Adler, A; Adolfsson, J; Aggarwal, M. M; Agha, S; Aglieri Rinella, G; Agnello, M

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The inclusive production of the J/ψ and ψ(2S) charmonium states is studied as a function of centrality in p-Pb collisions at a centre-of-mass energy per nucleon pair √sNN = 8.16 TeV at the LHC. The measurement is performed in the dimuon decay channel with the ALICE apparatus in the centre-of-mass rapidity intervals −4.46 < ycms < −2.96 (Pb-going direction) and 2.03 < ycms < 3.53 (p-going direction), down to zero transverse momentum (pT). The J/ψ and ψ(2S) production cross sections are evaluated as a function of the collision centrality, estimated through the energy deposited in the zero degree calorimeter located in the Pb-going direction. The pT-differential J/ψ production cross section is measured at backward and forward rapidity for several centrality classes, together with the corresponding average ⟨pT⟩ and ⟨pT^2⟩ values. The nuclear effects affecting the production of both charmonium states are studied using the nuclear modification factor. In the p-going direction, a suppression of the production of both charmonium states is observed, which seems to increase from peripheral to central collisions. In the Pb-going direction, however, the centrality dependence is different for the two states: the nuclear modification factor of the J/ψ increases from below unity in peripheral collisions to above unity in central collisions, while for the ψ(2S) it stays below or consistent with unity for all centralities with no significant centrality dependence. The results are compared with measurements in p-Pb collisions at √sNN = 5.02 TeV and no significant dependence on the energy of the collision is observed. Finally, the results are compared with theoretical models implementing various nuclear matter effects. ; A.I. Alikhanyan National Science Laboratory (Yerevan Physics Insti- tute) Foundation (ANSL), State Committee of Science and World Federation of Scientists (WFS), Armenia; Austrian Academy of Sciences, Austrian Science Fund (FWF): [M 2467- N36] and Nationalstiftung für Forschung, Technologie und Entwicklung, Austria; Ministry of Communications and High Technologies, National Nuclear Research Center, Azerbaijan; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Financiadora de Estudos e Projetos (Finep), Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) and Universidade Federal do Rio Grande do Sul (UFRGS), Brazil; Ministry of Education of China (MOEC), Ministry of Science & Technology of China (MSTC) and National Natural Science Foundation of China (NSFC), China; Ministry of Science and Education and Croatian Science Foundation, Croatia; Centro de Aplicaciones Tecnológi- cas y Desarrollo Nuclear (CEADEN), Cubaenergía, Cuba; Ministry of Education, Youth and Sports of the Czech Republic, Czech Republic; The Danish Council for Independent Research | Natural Sciences, the VILLUM FONDEN and Danish National Research Foun- dation (DNRF), Denmark; Helsinki Institute of Physics (HIP), Finland; Commissariat à l'Energie Atomique (CEA) and Institut National de Physique Nucléaire et de Physique des Particules (IN2P3) and Centre National de la Recherche Scientifique (CNRS), France; Bundesministerium für Bildung und Forschung (BMBF) and GSI Helmholtzzentrum für Schwerionenforschung GmbH, Germany; General Secretariat for Research and Technol- ogy, Ministry of Education, Research and Religions, Greece; National Research, Develop- ment and Innovation Office, Hungary; Department of Atomic Energy Government of India (DAE), Department of Science and Technology, Government of India (DST), University Grants Commission, Government of India (UGC) and Council of Scientific and Industrial Research (CSIR), India; Indonesian Institute of Science, Indonesia; Centro Fermi — MuseoStorico della Fisica e Centro Studi e Ricerche Enrico Fermi and Istituto Nazionale di Fisica Nucleare (INFN), Italy; Institute for Innovative Science and Technology, Nagasaki Insti- tute of Applied Science (IIST), Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) and Japan Society for the Promotion of Science (JSPS) KAK- ENHI, Japan; Consejo Nacional de Ciencia (CONACYT) y Tecnología, through Fondo de Cooperación Internacional en Ciencia y Tecnología (FONCICYT) and Dirección Gen- eral de Asuntos del Personal Academico (DGAPA), Mexico; Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO), Netherlands; The Research Council of Norway, Nor- way; Commission on Science and Technology for Sustainable Development in the South (COMSATS), Pakistan; Pontificia Universidad Católica del Perú, Peru; Ministry of Sci- ence and Higher Education, National Science Centre and WUT ID-UB, Poland; Korea Institute of Science and Technology Information and National Research Foundation of Ko- rea (NRF), Republic of Korea; Ministry of Education and Scientific Research, Institute of Atomic Physics and Ministry of Research and Innovation and Institute of Atomic Physics, Romania; Joint Institute for Nuclear Research (JINR), Ministry of Education and Science of the Russian Federation, National Research Centre Kurchatov Institute, Russian Science Foundation and Russian Foundation for Basic Research, Russia; Ministry of Education, Science, Research and Sport of the Slovak Republic, Slovakia; National Research Foun- dation of South Africa, South Africa; Swedish Research Council (VR) and Knut & Alice Wallenberg Foundation (KAW), Sweden; European Organization for Nuclear Research, Switzerland; Suranaree University of Technology (SUT), National Science and Technology Development Agency (NSDTA) and Office of the Higher Education Commission under NRU project of Thailand, Thailand; Turkish Atomic Energy Agency (TAEK), Turkey; Na- tional Academy of Sciences of Ukraine, Ukraine; Science and Technology Facilities Council (STFC), United Kingdom; National Science Foundation of the United States of America (NSF) and United States Department of Energy, Office of Nuclear Physics (DOE NP), United States of America.

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Production of ω mesons in pp collisions at √s =7 TeV

Acharya, S; Adamová, D; Adler, A; Adolfsson, J; Aggarwal, M. M; Agha, S; Aglieri Rinella, G; Agnello, M

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The invariant differential cross section of inclusive ω(782) meson production at midrapidity (|y| < 0.5) in pp collisions at √s = 7 TeV was measured with the ALICE detector at the LHC over a transverse momentum range of 2 < pT < 17 GeV/c. The ω meson was reconstructed via its ω → π+π−π0 decay channel. The measured ω production cross section is compared to various calculations: PYTHIA 8.2 Monash 2013 describes the data, while PYTHIA 8.2 Tune 4C overestimates the data by about 50%. A recent NLO calculation, which includes a model describing the fragmentation of the whole vector-meson nonet, describes the data within uncertainties below 6 GeV/c, while it overestimates the data by up to 50% for higher pT. The ω/π0 ratio is in agreement with previous measurements at lower collision energies and the PYTHIA calculations. In addition, the measurement is compatible with transverse mass scaling within the measured pT range and the ratio is constant with C^(ω/π0) = 0.67±0.03 (stat) ±0.04 (sys) above a transverse momentum of 2.5 GeV/c. ; A. I. Alikhanyan National Science Laboratory (Yerevan Physics Institute) Foundation (ANSL), State Committee of Science and World Federation of Scientists (WFS), Armenia; Austrian Academy of Sciences, Austrian Science Fund (FWF): [M 2467-N36] and Nationalstiftung für Forschung, Technologie und Entwicklung, Austria; Ministry of Communications and High Technologies, National Nuclear Research Center, Azerbaijan; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Financiadora de Estudos e Projetos (Finep), Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) and Universidade Federal do Rio Grande do Sul (UFRGS), Brazil; Ministry of Education of China (MOEC) , Ministry of Science & Technology of China (MSTC) and National Natural Science Foundation of China (NSFC), China; Ministry of Science and Education and Croatian Science Foundation, Croatia; Centro de Aplicaciones Tecnológicas y Desarrollo Nuclear (CEADEN), Cubaenergía, Cuba; Ministry of Education, Youth and Sports of the Czech Republic, Czech Republic; The Danish Council for Independent Research | Natural Sciences, the VILLUM FONDEN and Danish National Research Foundation (DNRF), Denmark; Helsinki Institute of Physics (HIP), Finland; Commissariat à l'Energie Atomique (CEA) and Institut National de Physique Nucléaire et de Physique des Particules (IN2P3) and Centre National de la Recherche Scientifique (CNRS), France; Bundesministerium für Bildung und Forschung (BMBF) and GSI Helmholtzzentrum für Schwerionenforschung GmbH, Germany; General Secretariat for Research and Technology, Ministry of Education, Research and Religions, Greece; National Research, Development and Innovation Office, Hungary; Department of Atomic Energy Government of India (DAE), Department of Science and Technology, Government of India (DST), University Grants Commission, Government of India (UGC) and Council of Scientific and Industrial Research (CSIR), India; Indonesian Institute of Science, Indonesia; Centro Fermi - Museo Storico della Fisica e Centro Studi e Ricerche Enrico Fermi and Istituto Nazionale di Fisica Nucleare (INFN), Italy; Institute for Innovative Science and Technology , Nagasaki Institute of Applied Science (IIST), Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) and Japan Society for the Promotion of Science (JSPS) KAKENHI, Japan; Consejo Nacional de Ciencia (CONACYT) y Tecnología, through Fondo de Cooperación Internacional en Ciencia y Tecnología (FONCICYT) and Dirección General de Asuntos del Personal Academico (DGAPA), Mexico; Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO), Netherlands; The Research Council of Norway, Norway; Commission on Science and Technology for Sustainable Development in the South (COMSATS), Pakistan; Pontificia Universidad Católica del Perú, Peru; Ministry of Science and Higher Education, National Science Centre and WUT ID-UB, Poland; Korea Institute of Science and Technology Information and National Research Foundation of Korea (NRF), Republic of Korea; Ministry of Education and Scientific Research, Institute of Atomic Physics and Ministry of Research and Innovation and Institute of Atomic Physics, Romania; Joint Institute for Nuclear Research (JINR), Ministry of Education and Science of the Russian Federation, National Research Centre Kurchatov Institute, Russian Science Foundation and Russian Foundation for Basic Research, Russia; Ministry of Education, Science, Research and Sport of the Slovak Republic, Slovakia; National Research Foundation of South Africa, South Africa; Swedish Research Council (VR) and Knut & Alice Wallenberg Foundation (KAW), Sweden; European Organization for Nuclear Research, Switzerland; Suranaree University of Technology (SUT), National Science and Technology Development Agency (NSDTA) and Office of the Higher Education Commission under NRU project of Thailand, Thailand; Turkish Atomic Energy Agency (TAEK), Turkey; National Academy of Sciences of Ukraine, Ukraine; Science and Technology Facilities Council (STFC), United Kingdom; National Science Foundation of the United States of America (NSF) and United States Department of Energy, Office of Nuclear Physics (DOE NP), United States of America.

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Z-boson production in p-Pb collisions at $$ \sqrt{s_{\mathrm{NN}}} $$ = 8.16 TeV and Pb-Pb collisions at $$ \sqrt{s_{\mathrm{NN}}} $$ = 5.02 TeV

Acharya, S; Adamová, D; Adler, A; Adolfsson, J; Aggarwal, M. M; Aglieri Rinella, G; Agnello, M; Agrawal, N

Acharya, S; Adamová, D; Adler, A; Adolfsson, J; Aggarwal, M. M; Aglieri Rinella, G; Agnello, M; Agrawal, N; Ahammed, Z; Ahmad, S; Ahn, S. U; Akbar, Z; Akindinov, A; Al-Turany, M; Alam, S. N; Albuquerque, D. S. D; Aleksandrov, D; Alessandro, B; Alfanda, H. M; Alfaro Molina, R; Ali, B; Ali, Y; Alici, A; Alizadehvandchali, N; Alkin, A; Alme, J; Alt, T; Altenkamper, L; Altsybeev, I; Anaam, M. N; Andrei, C; Andreou, D; Andronic, A; Angeletti, M; Anguelov, V; Anson, C; Antičić, T; Antinori, F; Antonioli, P; Apadula, N; Aphecetche, L; Appelshäuser, H; Arcelli, S; Arnaldi, R; Arratia, M; Arsene, I. C; Arslandok, M; Augustinus, A; Averbeck, R; Aziz, S; Azmi, M. D; Badalà, A; Baek, Y. W; Bagnasco, S; Bai, X; Bailhache, R; Bala, R; Balbino, A; Baldisseri, A; Ball, M; Balouza, S; Banerjee, D; Barbera, R; Barioglio, L; Barnaföldi, G. G; Barnby, L. S; Barret, V; Bartalini, P; Bartels, C; Barth, K; Bartsch, E; Baruffaldi, F; Bastid, N; Basu, S; Batigne, G; Batyunya, B; Bauri, D; Bazo Alba, J. 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Measurement of Z-boson production in p-Pb collisions at √sNN = 8.16 TeV and Pb-Pb collisions at √sNN = 5.02 TeV is reported. It is performed in the dimuon decay channel, through the detection of muons with pseudorapidity −4 20 GeV/c in the laboratory frame. The invariant yield and nuclear modification factor are measured for opposite-sign dimuons with invariant mass 60 < mμμ < 120 GeV/c2 and rapidity 2.5 < ycmsμμ< 4. They are presented as a function of rapidity and, for the Pb-Pb collisions, of centrality as well. The results are compared with theoretical calculations, both with and without nuclear modifications to the Parton Distribution Functions (PDFs). In p-Pb collisions the center-of-mass frame is boosted with respect to the laboratory frame, and the measurements cover the backward (−4.46 < ycmsμμ < −2.96) and forward (2.03 < ycmsμμ < 3.53) rapidity regions. For the p-Pb collisions, the results are consistent within experimental and theoretical uncertainties with calculations that include both free-nucleon and nuclear-modified PDFs. For the Pb-Pb collisions, a 3.4σ deviation is seen in the integrated yield between the data and calculations based on the free-nucleon PDFs, while good agreement is found once nuclear modifications are considered. ; A. I. Alikhanyan National Science Laboratory (Yerevan Physics Insti- tute) Foundation (ANSL), State Committee of Science and World Federation of Scientists (WFS), Armenia; Austrian Academy of Sciences, Austrian Science Fund (FWF): [M 2467- N36] and Nationalstiftung fu ̈r Forschung, Technologie und Entwicklung, Austria; Ministry of Communications and High Technologies, National Nuclear Research Center, Azerbaijan; Conselho Nacional de Desenvolvimento Cient ́ıfico e Tecnol ́ogico (CNPq), Financiadora de Estudos e Projetos (Finep), Fundac ̧ ̃ao de Amparo `a Pesquisa do Estado de S ̃ao Paulo (FAPESP) and Universidade Federal do Rio Grande do Sul (UFRGS), Brazil; Ministry of Education of China (MOEC) , Ministry of Science & Technology of China (MSTC) and National Natural Science Foundation of China (NSFC), China; Ministry of Science and Education and Croatian Science Foundation, Croatia; Centro de Aplicaciones Tecnol ́ogicas y Desarrollo Nuclear (CEADEN), Cubaenerg ́ıa, Cuba; Ministry of Education, Youth and Sports of the Czech Republic, Czech Republic; The Danish Council for Independent Re- search — Natural Sciences, the VILLUM FONDEN and Danish National Research Foun- dation (DNRF), Denmark; Helsinki Institute of Physics (HIP), Finland; Commissariat `a l'Energie Atomique (CEA) and Institut National de Physique Nucl ́eaire et de Physique des Particules (IN2P3) and Centre National de la Recherche Scientifique (CNRS), France; Bundesministerium fu ̈r Bildung und Forschung (BMBF) and GSI Helmholtzzentrum fu ̈r Schwerionenforschung GmbH, Germany; General Secretariat for Research and Technology, Ministry of Education, Research and Religions, Greece; National Research, Develop- ment and Innovation Office, Hungary; Department of Atomic Energy Government of India (DAE), Department of Science and Technology, Government of India (DST), University Grants Commission, Government of India (UGC) and Council of Scientific and Industrial Research (CSIR), India; Indonesian Institute of Science, Indonesia; Centro Fermi - Museo Storico della Fisica e Centro Studi e Ricerche Enrico Fermi and Istituto Nazionale di Fisica Nucleare (INFN), Italy; Institute for Innovative Science and Technology , Nagasaki Insti- tute of Applied Science (IIST), Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) and Japan Society for the Promotion of Science (JSPS) KAK- ENHI, Japan; Consejo Nacional de Ciencia (CONACYT) y Tecnolog ́ıa, through Fondo de Cooperaci ́on Internacional en Ciencia y Tecnolog ́ıa (FONCICYT) and Direcci ́on Gen- eral de Asuntos del Personal Academico (DGAPA), Mexico; Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO), Netherlands; The Research Council of Norway, Nor- way; Commission on Science and Technology for Sustainable Development in the South (COMSATS), Pakistan; Pontificia Universidad Cat ́olica del Peru ́, Peru; Ministry of Sci- ence and Higher Education, National Science Centre and WUT ID-UB, Poland; Korea Institute of Science and Technology Information and National Research Foundation of Ko- rea (NRF), Republic of Korea; Ministry of Education and Scientific Research, Institute of Atomic Physics and Ministry of Research and Innovation and Institute of Atomic Physics, Romania; Joint Institute for Nuclear Research (JINR), Ministry of Education and Science of the Russian Federation, National Research Centre Kurchatov Institute, Russian Science Foundation and Russian Foundation for Basic Research, Russia; Ministry of Education, Science, Research and Sport of the Slovak Republic, Slovakia; National Research Foun- dation of South Africa, South Africa; Swedish Research Council (VR) and Knut & Alice Wallenberg Foundation (KAW), Sweden; European Organization for Nuclear Research, Switzerland; Suranaree University of Technology (SUT), National Science and Technol- ogy Development Agency (NSDTA) and Office of the Higher Education Commission under NRU project of Thailand, Thailand; Turkish Atomic Energy Agency (TAEK), Turkey; Na- tional Academy of Sciences of Ukraine, Ukraine; Science and Technology Facilities Council (STFC), United Kingdom; National Science Foundation of the United States of America (NSF) and United States Department of Energy, Office of Nuclear Physics (DOE NP), United States of America

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Dielectron production in proton-proton and proton-lead collisions at √sNN = 5.02TeV

Acharya, S; Adamová, D; Adler, A; Adolfsson, J; Aggarwal, M. M; Aglieri Rinella, G; Agnello, M; Agrawal, N

Acharya, S; Adamová, D; Adler, A; Adolfsson, J; Aggarwal, M. M; Aglieri Rinella, G; Agnello, M; Agrawal, N; Ahammed, Z; Ahmad, S; Ahn, S. U; Akbar, Z; Akindinov, A; Al-Turany, M; Alam, S. N; Albuquerque, D. S. D; Aleksandrov, D; Alessandro, B; Alfanda, H. M; Alfaro Molina, R; Ali, B; Ali, Y; Alici, A; Alizadehvandchali, N; Alkin, A; Alme, J; Alt, T; Altenkamper, L; Altsybeev, I; Anaam, M. N; Andrei, C; Andreou, D; Andronic, A; Angeletti, M; Anguelov, V; Anson, C; Antičić, T; Antinori, F; Antonioli, P; Apadula, N; Aphecetche, L; Appelshäuser, H; Arcelli, S; Arnaldi, R; Arratia, M; Arsene, I. C; Arslandok, M; Augustinus, A; Averbeck, R; Aziz, S; Azmi, M. D; Badalà, A; Baek, Y. W; Bagnasco, S; Bai, X; Bailhache, R; Bala, R; Balbino, A; Baldisseri, A; Ball, M; Balouza, S; Banerjee, D; Barbera, R; Barioglio, L; Barnaföldi, G. G; Barnby, L. S; Barret, V; Bartalini, P; Bartels, C; Barth, K; Bartsch, E; Baruffaldi, F; Bastid, N; Basu, S; Batigne, G; Batyunya, B; Bauri, D; Bazo Alba, J. 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The first measurements of dielectron production at midrapidity (|η_e| < 0.8) in proton–proton and proton–lead collisions at √sNN = 5.02 TeV at the LHC are presented. The dielectron cross section is measured with the ALICE detector as a function of the invariant mass m_ee and the pair transverse momentum p_T,ee in the ranges m_ee < 3.5 GeV/c^2 and p_T,ee < 8 GeV/c, in both collision systems. In proton–proton collisions, the charm and beauty cross sections are determined at midrapidity from a fit to the data with two different event generators. This complements the existing dielectron measurements performed at √s = 7 and 13 TeV. The slope of the √s dependence of the three measurements is described by FONLL calculations. The dielectron cross section measured in proton–lead collisions is in agreement, within the current precision, with the expected dielectron production without any nuclear matter effects for e+e− pairs from open heavy-flavor hadron decays. For the first time at LHC energies, the dielectron production in proton–lead and proton–proton collisions are directly compared at the same √sNN via the dielectron nuclear modification factor RpPb. The measurements are compared to model calculations including cold nuclear matter effects, or additional sources of dielectrons from thermal radiation. ; A. I. Alikhanyan National Science Laboratory (Yerevan Physics Institute) Foundation (ANSL), State Committee of Science and World Federation of Scientists (WFS), Armenia; Austrian Academy of Sciences, Austrian Science Fund (FWF): [M 2467-N36] and Nationalstiftung für Forschung, Technologie und Entwicklung, Austria; Ministry of Communications and High Technologies, National Nuclear Research Center, Azerbaijan; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Financiadora de Estudos e Projetos (Finep), Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) and Universidade Federal do Rio Grande do Sul (UFRGS), Brazil; Ministry of Education of China (MOEC), Ministry of Science & Technology of China (MSTC) and National Natural Science Foundation of China (NSFC), China; Ministry of Science and Education and Croatian Science Foundation, Croatia; Centro de Aplicaciones Tecnológicas y Desarrollo Nuclear (CEADEN), Cubaenergía, Cuba; Ministry of Education, Youth and Sports of the Czech Republic, Czech Republic; The Danish Council for Independent Research | Natural Sciences, the VILLUM FONDEN and Danish National Research Foundation (DNRF), Denmark; Helsinki Institute of Physics (HIP), Finland; Commissariat à l'Energie Atomique (CEA) and Institut National de Physique Nucléaire et de Physique des Particules (IN2P3) and Centre National de la Recherche Scientifique (CNRS), France; Bundesministerium für Bildung und Forschung (BMBF) and GSI Helmholtzzentrum für Schwerionenforschung GmbH, Germany; General Secretariat for Research and Technology, Ministry of Education, Research and Religions, Greece; National Research, Development and Innovation Office, Hungary; Department of Atomic Energy Government of India (DAE), Department of Science and Technology, Government of India (DST), University Grants Commission, Government of India (UGC) and Council of Scientific and Industrial Research (CSIR), India; Indonesian Institute of Science, Indonesia; Centro Fermi - Museo Storico della Fisica e Centro Studi e Ricerche Enrico Fermi and Istituto Nazionale di Fisica Nucleare (INFN), Italy; Institute for Innovative Science and Technology, Nagasaki Institute of Applied Science (IIST), Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) and Japan Society for the Promotion of Science (JSPS) KAKENHI, Japan; Consejo Nacional de Ciencia (CONACYT) y Tecnología, through Fondo de Coop- eración Internacional en Ciencia y Tecnología (FONCICYT) and Dirección General de Asuntos del Personal Academico (DGAPA), Mexico; Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO), Netherlands; The Research Council of Norway, Norway; Commission on Science and Technology for Sustainable Development in the South (COM- SATS), Pakistan; Pontificia Universidad Católica del Perú, Peru; Ministry of Science and Higher Education, National Science Centre and WUT ID-UB, Poland; Korea Institute of Science and Technology Information and National Research Foundation of Korea (NRF), Republic of Korea; Ministry of Education and Scientific Research, Institute of Atomic Physics and Ministry of Research and Innovation and Institute of Atomic Physics, Romania; Joint Institute for Nuclear Research (JINR), Ministry of Education and Science of the Russian Federation, National Research Centre Kurchatov Institute, Russian Science Foundation and Russian Foundation for Basic Research, Russia; Ministry of Education, Science, Research and Sport of the Slovak Republic, Slovakia; National Research Foundation of South Africa, South Africa; Swedish Research Council (VR) and Knut & Alice Wallenberg Foundation (KAW), Sweden; European Organization for Nuclear Research, Switzerland; Suranaree University of Technology (SUT), National Science and Technology Development Agency (NSDTA) and Office of the Higher Edu- cation Commission under NRU project of Thailand, Thailand; Turkish Atomic Energy Agency (TAEK), Turkey; National Academy of Sciences of Ukraine, Ukraine; Science and Technology Facilities Council (STFC), United Kingdom; National Science Foundation of the USA (NSF) and United States Department of Energy, Office of Nuclear Physics (DOE NP), USA.

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