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Nepal has been strongly influenced by the COVID-19 pandemic and struggling to contain it with multiple interventions. We assessed the spatiotemporal dynamics of COVID-19 in the context of various restrictions imposed to contain the disease transmission by employing prospective spatiotemporal analysis with SaTScan statistics. We explored active and emerging disease clusters using the prospective space-time scanning with the Discrete Poisson model for two time periods using COVID-19 cases reported to the Ministry of Health and Population (MoHP), Government of Nepal during 23 January – 21 July, and 23 January – 29 November 2020 taking the cutoff date of 21 July (end date of nationwide lockdown). The results revealed that COVID-19 dynamics in the early transmission stage were slower and confined to a few districts. However, since the third week of April, transmission spread rapidly across the districts of Madhesh and Sudurpaschim Provinces. Despite nationwide lockdown, nine statistically significant active and emerging clusters were detected between 23 January and 21 July 2020, whereas seven emerging clusters were observed for an extended period to 29 November. After lifting the nationwide lockdown, COVID-19 clusters developed had a many-fold higher relative risk than during the lockdown period. The most likely cluster was located in the capital city, the Kathmandu valley, making it the highest-risk active cluster since August. Movement restriction appears to be the most effective non-pharmaceutical intervention against the COVID-19 in countries with limited health care facilities. Our findings could be valuable to the health authorities within Nepal and beyond to better allocate resources and improve interventions on the pandemic for containing it efficiently.

Onchocerciasis is diagnosed by detecting microfilariae in skin snips or by detecting OV16 IgG4 antibodies in blood by either enzyme linked immunosorbent assay (ELISA) or a rapid diagnostic test (RDT). Here, we compare the sensitivity and specificity of these three tests in persons with epilepsy living in an onchocerciasis endemic region in the Democratic Republic of Congo. Skin snips and blood samples were collected from 285 individuals for onchocerciasis diagnosis. Three tests were performed: the OV16 RDT (SD Bioline) and the OV16 ELISA both on serum samples, and microscopic detection of microfilariae in skin snips. The sensitivity and specificity of each test was calculated with the combined other tests as a reference. Microfilariae were present in 105 (36.8%) individuals, with a median of 18.5 (6.5&ndash ; 72.0) microfilariae/skin snip. The OV16 RDT and OV16 ELISA were positive in, respectively, 112 (39.3%) and 143 (50.2%) individuals. The OV16 ELISA had the highest sensitivity among the three tests (83%), followed by the OV16 RDT (74.8%) and the skin snip (71.4%). The OV16 RDT had a higher specificity (98.6%) compared to the OV16 ELISA (84.8%). Our study confirms the need to develop more sensitive tests to ensure the accurate detection of ongoing transmission before stopping elimination efforts.

This collection provides a comparative analysis of development-induced migration in India and China, with a particular focus on displacement caused by urbanization and dam construction. The contributors include scholars from both countries working in academia and consultancy positions.

"This volume explores how we theorize, politicise, and practice peace and conflict discourses in the social sciences. As concepts, peace and conflict are intricately interwoven into a web of complementary discourses where states and other actors are able to negotiate, deliberate, and arbitrate their differences short of the overt and covert use of physical violence. The essays in this volume reflect this eclecticism: they reflect on concerns of contemporary conflicts in world politics; the dissection of the ideas of peace and power; the way peace studies join with global agencies; peace and conflict in connection to geopolitics and identity; the domestic basis of conflict in India and the South Asian theatre including class, social cleavages and gender. Further they also process elements like globalization, media, communication and films that help us engage with the popular tropes and discursive construction of the reality that play critical roles in how peace and violence are articulated and acted upon by the elites and the masses in societies. This volume will be of great interest to scholars and researchers of political science, international relations theory, peace and conflict studies, public policy, area studies. It will also be a key resource for bureaucrats, policy makers, think tanks and practitioners working in the field of international relations"--

Neuro-inflammation may be associated with onchocerciasis-associated epilepsy (OAE) but thus far very few immunological studies have been performed in children with this form of epilepsy. In a pilot study we measured the cytokine levels in cerebrospinal fluid (CSF) of persons with OAE from Maridi, South Sudan, and from Mosango, Democratic Republic of the Congo (DRC) and compared these results with cytokine levels in CSF of Africans with non-OAE neurological disorders, and Europeans with epilepsy or other neurological conditions. The following cytokines were studied: IL-6, TNF-α, IL1-β, IL-5, IL-4, IL-13, CCL3 (Mip-1α), VEGF-C, VCAM-1. No cytokine was significantly associated with OAE, although a lower IL-13 level was observed in CSF of persons with OAE compared to African controls. Observed cytokine profiles and neuro-inflammation may be the consequence of long-standing epilepsy, concomitant infections and malnutrition. Ideally cytokine levels should be determined in a prospective study in serum and CSF collected at the time of onset of the first seizures.

Onchocerciasis is diagnosed by detecting microfilariae in skin snips or by detecting OV16 IgG4 antibodies in blood by either enzyme linked immunosorbent assay (ELISA) or a rapid diagnostic test (RDT). Here, we compare the sensitivity and specificity of these three tests in persons with epilepsy living in an onchocerciasis endemic region in the Democratic Republic of Congo. Skin snips and blood samples were collected from 285 individuals for onchocerciasis diagnosis. Three tests were performed: the OV16 RDT (SD Bioline) and the OV16 ELISA both on serum samples, and microscopic detection of microfilariae in skin snips. The sensitivity and specificity of each test was calculated with the combined other tests as a reference. Microfilariae were present in 105 (36.8%) individuals, with a median of 18.5 (6.5–72.0) microfilariae/skin snip. The OV16 RDT and OV16 ELISA were positive in, respectively, 112 (39.3%) and 143 (50.2%) individuals. The OV16 ELISA had the highest sensitivity among the three tests (83%), followed by the OV16 RDT (74.8%) and the skin snip (71.4%). The OV16 RDT had a higher specificity (98.6%) compared to the OV16 ELISA (84.8%). Our study confirms the need to develop more sensitive tests to ensure the accurate detection of ongoing transmission before stopping elimination efforts.