Suchergebnisse

We present geometric and dynamical modeling of the broad line region (BLR) for the multi-wavelength reverberation mapping campaign focused on NGC 5548 in 2014. The data set includes photometric and spectroscopic monitoring in the optical and ultraviolet, covering the H beta, Civ, and Ly alpha broad emission lines. We find an extended disk-like H beta BLR with a mixture of near-circular and outflowing gas trajectories, while the Civand Ly alpha BLRs are much less extended and resemble shell-like structures. There is clear radial structure in the BLR, with Civand Ly alpha emission arising at smaller radii than the H beta emission. Using the three lines, we make three independent black hole mass measurements, all of which are consistent. Combining these results gives a joint inference of log(10) (M-BH/M-circle dot) = 7.64(-0.18)(+0.21). We examine the effect of using the V band instead of the UV continuum light curve on the results and find a size difference that is consistent with the measured UV-optical time lag, but the other structural and kinematic parameters remain unchanged, suggesting that theVband is a suitable proxy for the ionizing continuum when exploring the BLR structure and kinematics. Finally, we compare the H beta results to similar models of data obtained in 2008 when the active galactic nucleus was at a lower luminosity state. We find that the size of the emitting region increased during this time period, but the geometry and black hole mass remained unchanged, which confirms that the BLR kinematics suitably gauge the gravitational field of the central black hole. ; National Aeronautics & Space Administration (NASA) AST-1908952 AST-1814440 Space Telescope Science Institute National Science Foundation (NSF) AST-1211916 Packard Foundation through a Packard Fellowship AST-1412315 AST-1907208 Space Telescope Science Institute 17-ATP17-0141 19-ATP19-0188 NRF grant HST-AR-15018 HST-AR-14556 Korean Government 2020R1A2C3011091 Independent Research Fund Denmark DFF 8021-00130 NASA ADAP grant 80NSSC19K1016 National Science Foundation (NSF) Eberly Research Fellowship from The Pennsylvania State University Eberly College of Science AST-1909297 Center for Exoplanets Pennsylvania State University Eberly College of Science Pennsylvania Space Grant Consortium TABASGO Foundation Christopher R. Redlich Fund Miller Institute for Basic Research in Science (U.C. Berkeley)

BACKGROUND: We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry. METHODS: Meta-analyses included summary estimates based on Cox models of twelve datasets using ~10.4 million variants for 96,661 women with breast cancer and 7697 events (breast cancer-specific deaths). Oestrogen receptor (ER)-specific analyses were based on 64,171 ER-positive (4116) and 16,172 ER-negative (2125) patients. We evaluated the probability of a signal to be a true positive using the Bayesian false discovery probability (BFDP). RESULTS: We did not find any variant associated with breast cancer-specific mortality at P < 5 × 10-8. For ER-positive disease, the most significantly associated variant was chr7:rs4717568 (BFDP = 7%, P = 1.28 × 10-7, hazard ratio [HR] = 0.88, 95% confidence interval [CI] = 0.84-0.92); the closest gene is AUTS2. For ER-negative disease, the most significant variant was chr7:rs67918676 (BFDP = 11%, P = 1.38 × 10-7, HR = 1.27, 95% CI = 1.16-1.39); located within a long intergenic non-coding RNA gene (AC004009.3), close to the HOXA gene cluster. CONCLUSIONS: We uncovered germline variants on chromosome 7 at BFDP < 15% close to genes for which there is biological evidence related to breast cancer outcome. However, the paucity of variants associated with mortality at genome-wide significance underpins the challenge in providing genetic-based individualised prognostic information for breast cancer patients. ; BCAC is funded by Cancer Research UK [C1287/A16563 and C1287/A10118], the European Union's Horizon 2020 Research and Innovation Programme (Grant numbers 634935 and 633784 for BRIDGES and B-CAST, respectively), and by the European Community's Seventh Framework Programme under grant agreement number 223175 (Grant number HEALTH-F2-2009-223175) (COGS).