Suchergebnisse

The Indian state of Punjab, which initially benefited greatly from the green revolution, has suffered from a dramatic rise in agrarian suicides for several decades. We use a carefully constructed sample of over 1,000 farmers in the epicentre, and build a three-stage model of agricultural production decisions across multiple input and multiple output choices, indebtedness from multiple sources and suicide via an IPWRA (inverse probability weighted regression adjustment) treatment model to trace the potential roots of the situation. Results show that the use of informal credit from commission agents by farmers accounts for 10 percentage points (or 20%) of all suicides in our sample, regardless of other household factors and choices.

In this study, the layer-by-layer (LbL) assembly method was employed to modify a commercial polyethersulfone (PES) membrane by successive adsorption of chitosan and alginate as cationic and anionic polyelectrolytes. To enhance anti-biofouling property, pure, PEG mixed and PEGylated AgCl/TiO2 xerogels were incorporated solely in the top layer of the LbL-modified membranes. Organic and biological foulings were addressed separately using alginate and Escherichia coli bacteria suspensions as the organic and biological model foulants, respectively. LbL-modifying the commercial PES membrane successively with chitosan and alginate polyelectrolyte multilayers prevented organic fouling extensively. In addition, we found that AgCl/TiO2-incorporated membranes show higher water permeability and improved resistance to biological fouling as compared to the PES membrane. Silver amounts in consecutively collected permeate samples were quantified by ICP-MS analysis to assess the stability of AgCl/TiO2-incorporated layers. Silver loss per filtration cycle followed an increasing trend initially, up to a filtration volume totaling 3000L/m2, leading to 4.2% reduction in the immobilized silver amount. After that, silver loss per filtration cycle stabilized at ~7.44μg/L, which extrapolates to ~265 days time-span for the remaining silver to be released at a filtration rate of ~1000L/m2 h. Antibacterial activity tests showed that AgCl/TiO2-incorporated layers do not permit bacterial growth on the membrane surface. ; European Union (246039)

Objective: The primary goal of this study was to test the hypothesis that wearing the 3.7 kg vest portion of a radiological shielding garment (a "lead") significantly increases lower back and shoulder muscle activity in quasistatic erect and forward-flexed postures. Secondarily, the authors examined the effects of gender and forward-flexed posture as well as their interactions with lead use. Background: The use of a lead is mandatory for interventionalists during surgical procedures. Because the vest portion of a lead weighs considerably more than normal clothing, there is concern that its use increases the risk of developing back and shoulder pain. Method: In a repeated-measures study design, 19 young healthy male and female adults assumed standardized erect or forward-flexed postures, both with and without wearing the vest portion of a lead. Shoulder and lower back muscle activity was measured via surface electromyography, normalized by maximum voluntary contraction values. Data were analyzed using general linear models and repeated-measures ANOVA (significant for p < .05). Results: Use of the lead did not result in a significant increase in muscle activity in the lower back or shoulders, despite perceived increases in effort and discomfort. Posture proved to be the most significant secondary factor affecting activity in the lower back, and participant gender proved insignificant. Conclusion: Short-term use of the lead does not appear to contribute to the incidence of back pain or injury in interventionalists. Avoiding flexed postures could more directly reduce the likelihood of pain or injury. Application: Potential applications include assessing and improving operating room ergonomics for physicians.

Microestructura; Esclerosi múltiple; Tècnica de mitjana esfèrica ; Microestructura; Esclerosis múltiple; Técnica de la media esférica ; Microstructure; Multiple sclerosis; Spherical mean technique ; Background: Neurite orientation dispersion and density imaging (NODDI) and the spherical mean technique (SMT) are diffusion MRI methods providing metrics with sensitivity to similar characteristics of white matter microstructure. There has been limited comparison of changes in NODDI and SMT parameters due to multiple sclerosis (MS) pathology in clinical settings. Purpose: To compare group-wise differences between healthy controls and MS patients in NODDI and SMT metrics, investigating associations with disability and correlations with diffusion tensor imaging (DTI) metrics. Methods: Sixty three relapsing-remitting MS patients were compared to 28 healthy controls. NODDI and SMT metrics corresponding to intracellular volume fraction (vin), orientation dispersion (ODI and ODE), diffusivity (D) (SMT only) and isotropic volume fraction (viso) (NODDI only) were calculated from diffusion MRI data, alongside DTI metrics (fractional anisotropy, FA; axial/mean/radial diffusivity, AD/MD/RD). Correlations between all pairs of MRI metrics were calculated in normal-appearing white matter (NAWM). Associations with expanded disability status scale (EDSS), controlling for age and gender, were evaluated. Patient-control differences were assessed voxel-by-voxel in MNI space controlling for age and gender at the 5% significance level, correcting for multiple comparisons. Spatial overlap of areas showing significant differences were compared using Dice coefficients. Results: NODDI and SMT show significant associations with EDSS (standardised beta coefficient −0.34 in NAWM and −0.37 in lesions for NODDI vin; 0.38 and −0.31 for SMT ODE and vin in lesions; p < 0.05). Significant correlations in NAWM are observed between DTI and NODDI/SMT metrics. NODDI vin and SMT vin strongly correlated (r = 0.72, p < 0.05), likewise NODDI ODI and SMT ODE (r = −0.80, p < 0.05). All DTI, NODDI and SMT metrics detect widespread differences between patients and controls in NAWM (12.57% and 11.90% of MNI brain mask for SMT and NODDI vin, Dice overlap of 0.42). Data Conclusion: SMT and NODDI detect significant differences in white matter microstructure between MS patients and controls, concurring on the direction of these changes, providing consistent descriptors of tissue microstructure that correlate with disability and show alterations beyond focal damage. Our study suggests that NODDI and SMT may play a role in monitoring MS in clinical trials and practice. ; This study has received funding under the European Union's Horizon 2020 research and innovation programme under grant agreement No. 634541 (CDS-QuaMRI) and 666992. This study has also received support from the Engineering and Physical Sciences Research Council (EPSRC R006032/1, M020533/1, G007748, I027084, N018702), Spinal Research (UK), Wings for Life (Austria), Craig H. Neilsen Foundation (USA) for INSPIRED and UK Multiple Sclerosis Society (grants 892/08 and 77/2017). This study was supported by the National Institute for Health Research University College London Hospitals Biomedical Research Centre. FP was supported by a Guarantors of Brain post-doctoral non-clinical fellowship. AT was supported by an MRC grant (MR/S026088/1). EK was supported from the NIHR Great Ormond Street Hospital Biomedical Research Centre. FG was currently supported by the investigator-initiated PREdICT study at the Vall d'Hebron Institute of Oncology (Barcelona), funded by AstraZeneca and CRIS Cancer Foundation. AstraZeneca was not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication.

A novel antifouling coating of ultrafiltration (UF) commercial membranes, based on a polymerisable bicontinuous microemulsion (PBM) technique, was developed and tested for the first time in a membrane bioreactor (MBR) using an artificial model textile dye wastewater and compared with a commercial uncoated UF membrane. The results showed that the commercial MBR module faced severe fouling problems whereas the novel coated PBM MBR module reduced the fouling significantly. The analysis of fouling rate using a resistance model confirms that PBM coated membrane has a higher antifouling effect. The antimicrobial properties of the PBM membrane contributed by polymerisable cationic surfactant acryloyloxyundecyltriethylammonium bromide (AUTEAB) guaranteed an anti-biofouling effect preventing the growth of microorganisms on the membrane surface. In addition, the PBM MBR module showed 10±1% higher blue dye removal efficiency and a similar rate of COD removal efficiency of about 95±1% compared to commercial module. However, water permeability was slightly lower due to extra resistance of the PBM coating. Root mean squared (RMS) roughness measurement and analysis of AFM images confirmed that the stable novel membrane coating still existed and showed antimicrobial effect even after 105 days of operation. The results obtained demonstrated the potential of the low fouling PBM membrane. ; European Union within BioNexGen project (CP-FP-246039-2 EU-FP7)

This paper presents the estimation of a discrete freight transport chain choice model for Europe, which was developed for the European Union as part of the Transtools 3 project. The model describes nine different multi- and single mode chain alternatives of which three can be either container or non-containerised, and it segments freight into dry bulk, liquid bulk, containers and general cargo. The model was estimated on the basis of disaggregate data at the shipment level (Swedish CFS and French ECHO data). Several transport costs specifications and nesting structures were tested and elasticities compared with reference literature. It was found that freight models are characterised by heterogeneity, non-linearity in transport costs and hence Value of Times and non-constant rates of substitution. Not taking these elements into account will have consequences for the evaluation of transport policies using the freight transport model.