Evaluating the Potential for Urban Underground Space Development in China: Evidence from 732 Cities
In: JCIT-D-23-01785
91 Ergebnisse
Sortierung:
In: JCIT-D-23-01785
SSRN
In: Computers and electronics in agriculture: COMPAG online ; an international journal, Band 220, S. 108891
ISSN: 1872-7107
In: Environmental science and pollution research: ESPR, Band 26, Heft 1, S. 855-866
ISSN: 1614-7499
In: Zeitschrift für Metallkunde, Band 94, Heft 8, S. 886-891
In: MICROC-D-21-03593
SSRN
In: Computers and electronics in agriculture: COMPAG online ; an international journal, Band 209, S. 107858
In: Computers and Electronics in Agriculture, Band 165, S. 104942
In: info:eu-repo/semantics/altIdentifier/doi/10.2147/OTT.S164149
Jie Zheng,1,2,* Fuao Cao,3,* Xiaopei Huang,4,* Kuvaneshan Ramen,2 Xiaowen Xu,3 Yan Zhu,5 Wenjun Chang,4 Yunfeng Shan,2 Aizhen Guo1 1Department of General Medicine, Yangpu Hosptial, Tongji University School of Medicine, Shanghai 200090, People's Republic of China; 2Department of General Surgery, First Affiliated Hospital, Wenzhou Medical University, Zhejiang 325015, People's Republic of China; 3Department of Colorectal Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, People's Republic of China; 4Department of Environmental Hygiene, Second Military Medical University, Shanghai 200433, People's Republic of China; 5Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai 200433, People's Republic of China *These authors contributed equally to this work Purpose: Eyes absent homologue 2 (EYA2), which functions as a transcription activator and phosphatase, plays an important role in several types of cancer. However, the impact of EYA2 in colorectal cancer (CRC) remains elusive. Patients and methods: We evaluated the significance of EYA2 expression in the development and progression of CRC in a large cohort, including 922 CRC cases. EYA2 protein expression was determined via immunohistochemistry in colorectal tissues. The correlation between EYA2 expression and CRC occurrence was investigated in tumor tissue and the adjacent normal tissues. Factors contributing to CRC prognosis were evaluated using Kaplan–Meier and Cox model analyses. Results: EYA2 expression was progressively lower in the adjacent normal tissue, adenomas, primary tumor and the metastatic CRC (all P<0.05). Furthermore, EYA2 expression had significant associations with disease stage, differentiation grade, and number of resected lymph nodes (all P<0.001). Compared with patients with EYA2-high tumors, those with EYA2-low tumors had shorter disease-free survival (hazard ratio [HR], 2.347; 95% CI, 1.665–3.308) and disease-specific survival (HR, 3.560; 95% CI, 2.055–6.167) in multivariate Cox analysis, after adjusting confounding factors such as tumor-node-metastasis stage and grade. In particular, patients with stage II or III EYA2-low CRC might be harmed by postoperative chemotherapy. Conclusion: EYA2 expression was generally reduced in CRC. Higher EYA2 expression can predict a more favorable prognosis for CRC. Keywords: colorectal cancer, EYA2, immunohistochemistry, prognosis, chemotherapy
BASE
In: Ecotoxicology and environmental safety: EES ; official journal of the International Society of Ecotoxicology and Environmental safety, Band 135, S. 216-224
ISSN: 1090-2414
In: Computers and electronics in agriculture: COMPAG online ; an international journal, Band 220, S. 108857
ISSN: 1872-7107
In: Progress in nuclear energy: the international review journal covering all aspects of nuclear energy, Band 107, S. 100-109
ISSN: 0149-1970
In: Computers and electronics in agriculture: COMPAG online ; an international journal, Band 219, S. 108786
In: Ecotoxicology and environmental safety: EES ; official journal of the International Society of Ecotoxicology and Environmental safety, Band 259, S. 115060
ISSN: 1090-2414
In: Computers and electronics in agriculture: COMPAG online ; an international journal, Band 198, S. 107087
In: Environmental science and pollution research: ESPR, Band 27, Heft 15, S. 17910-17922
ISSN: 1614-7499