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He and his brother-in-law, Mr. Phoenix, would like to send their sons to the Academy in Middletown. ; Transcription by Joseph Byrne. Transcriptions may be subject to error.

Please work to improve his son's (Alfred Stanley) orthography (spelling). ; Transcription by Joseph Byrne. Transcriptions may be subject to error.

Regarding his son's (Thomas A. Cameron) expenses; has not heard from Partridge; please let him know how his son is doing.

Ephraim Talbot writes from Providence, Rhode Island, to Alden Partridge in Norwich, Vermont, regarding his son, Henry J. Talbot; if Henry has made sufficient progress at Partridge's academy, please allow him to return home; but otherwise he does "not wish to see him as yet." ; Transcriptions may be subject to error.

Hopes his son, Daniel Pinckney Johnston, and D. C. Webb and Morton Waring have all arrived safely at the Academy; writes of his son's course of education; if his son is to march with the cadets to Plattsburgh, please see that he has the proper clothing; sends regards to his son. ; Mentions pedestrian excursions.

Accepts a position at the Academy as instructor to defray his expenses for attending. ; Transcriptions may be subject to error.

Aaron Hobart thanks Alden Partridge for the pamphlets (presumably about Partridge's academy in Norwich, Vermont) that were sent to him in Washington, D.C. ; Transcription by L. Gregory Curtis, NU'77, MSIA'07. Transcriptions may be subject to error.

Regarding the appointment of Cadet (Michael F.?) Van De Venter as a lieutenant in the 2nd Infantry. ; Transcription by Joseph Byrne. Transcriptions may be subject to error.

Has never said anything to anyone injurious to Partridge; does not like the store and tailor monopolies there; thinks an officer of higher rank should superintend and be present there. ; Transcriptions may be subject to error. Dewitt Clinton was Governor of New York from 1817-1822.

Has receeived Partridge's "sketch" of principles to govern the academy and will bring them to Congress next session; his son has received an appointment to West Point and together they hope to visit in September. ; Transcription by Joseph Byrne. Transcriptions may be subject to error.

Encloses copy of letter from academic staff to William Crawford (Secretary of War); directs as to underage cadet furloughs; regulations approved 3 January 1815 are suspended pending General Swift's opinion. ; Letter from Mansfield, Ellicot, Empie, Berard, Zoeller and Douglass enclosed. This letter protests allowing officers unassociated with the academy to draw cadets as assistants before they have completed their education. James Monroe (1758-1831) was the fifth president of the United States of America. Transcription by Mary Margaret Groberg. Transcriptions may be subject to error.

A letter report issued by the General Accounting Office with an abstract that begins "Pursuant to a legislative requirement, GAO reviewed the Air Force's engineering and manufacturing development program for the F-22 aircraft, focusing on: (1) the extent to which the F-22 development program is meeting its performance, schedule, and cost goals; (2) whether the Air Force is likely to complete the development program as planned without exceeding the cost limitation established by the act; and (3) whether GAO had access to sufficient information to make informed judgments on matters covered in this report."

Inhalt: - I. Einleitung - II. Stand der Ratifikationen und Erklärungen im Sinne von Art. 22 sowie Statistik zu den Individualbeschwerden - III. Aufbau des Übereinkommens - IV. Individualbeschwerden - V. Fazit

Prolonged seizures (status epilepticus, SE) may drive hippocampal dysfunction and epileptogenesis, at least partly, through an elevation in neurogenesis, dysregulation of migration and aberrant dendritic arborization of newly-formed neurons. MicroRNA-22 was recently found to protect against the development of epileptic foci, but the mechanisms remain incompletely understood. Here, we investigated the contribution of microRNA-22 to SE-induced aberrant adult neurogenesis. SE was induced by intraamygdala microinjection of kainic acid (KA) to model unilateral hippocampal neuropathology in mice. MicroRNA-22 expression was suppressed using specific oligonucleotide inhibitors (antagomir-22) and newly-formed neurons were visualized using the thymidine analog iodo-deoxyuridine (IdU) and a green fluorescent protein (GFP)-expressing retrovirus to visualize the dendritic tree and synaptic spines. Using this approach, we quantified differences in the rate of neurogenesis and migration, the structure of the apical dendritic tree and density and morphology of dendritic spines in newly-formed neurons.SE resulted in an increased rate of hippocampal neurogenesis, including within the undamaged contralateral dentate gyrus (DG). Newly-formed neurons underwent aberrant migration, both within the granule cell layer and into ectopic sites. Inhibition of microRNA-22 exacerbated these changes. The dendritic diameter and the density and average volume of dendritic spines were unaffected by SE, but these parameters were all elevated in mice in which microRNA-22 was suppressed. MicroRNA-22 inhibition also reduced the length and complexity of the dendritic tree, independently of SE. These data indicate that microRNA-22 is an important regulator of morphogenesis of newly-formed neurons in adults and plays a role in supressing aberrant neurogenesis associated with SE. ; Science Foundation Ireland (13/SIRG/2098, 17/CDA/4708 and 16/TIDA/4059 to TE, 13/SIRG/2114 to EJ-M, 17/TIDA/5002 to CR, 13/IA/1891 and 16/RC/3948 to DH and co-funded under the European Regional Development Fund and by FutureNeuro Industry partners) from the Health Research Board (HRA-POR-2015-1243 to TE); European Union Seventh Framework Programme (FP7/2007–2013) under grant agreement n 602130 (to DH), from the H2020 Marie Skłowdowksa-Curie Actions Individual Fellowship (753527 to EB), from the European Union's Horizon 2020; Comunidad de Madrid to MM-P, from Fundación ''La Caixa'' to JM-R and from Areces Foundation C-XVIII and the Minister of Science and Universities of Spain BFU2014-53654-P to MM-P ; Peer Reviewed