Marx after Stalin
In: Critique: journal of socialist theory, Band 20, Heft 1, S. 105-129
ISSN: 1748-8605
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In: Critique: journal of socialist theory, Band 20, Heft 1, S. 105-129
ISSN: 1748-8605
A lipid profile resistant to oxidative damage is an inherent trait associated with animal lifespan. However, there is a lack of lipidomic studies on human longevity. Here we use mass spectrometry based technologies to detect and quantify 137 ether lipids to define a phenotype of healthy humans with exceptional lifespan. Ether lipids were chosen because of their antioxidant properties and ability to modulate oxidative stress. Our results demonstrate that a specific ether lipid signature can be obtained to define the centenarian state. This profile comprises higher level of alkyl forms derived from phosphatidylcholine with shorter number of carbon atoms and double bonds; and decreased content in alkenyl forms from phosphatidylethanolamine with longer chain length and higher double bonds. This compositional pattern suggests that ether lipids from centenarians are more resistant to lipid peroxidation, and that ether lipid signature expresses an optimized feature associated with exceptional human longevity. These results are in keeping with the free radical theory of aging ; We acknowledge funding from the Spanish Ministry of Education and Science (ref. SAF2013–44663-R), and from the 'Red Tematica de Investigación Cooperativa en Envejecimiento y Fragilidad' (RETICEF) (ref. ISCIII2012-RED-43-029) to J.V.; and from the Spanish Ministry of Economy and Competitiveness/Institute of Health Carlos III (ref. PI14/ 00328), and the Autonomous Government of Catalonia, Department of Health (ref. SLT002/16/00250) and Department of Business and Knowledge (ref. 2017SGR696) to R.P. This study has been co-financed by FEDER funds from the European Union ("Una manera de hacer Europa")
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In: UNSW Human Rights Clinic I July 2019
SSRN
Working paper
In biological systems lipids generate membranes and have a key role in cell signaling and energy storage. Therefore, there is a wide diversity of molecular lipid expressed at the compositional level in cell membranes and organelles, as well as in tissues, whose lipid distribution remains unclear. Here, we report a mass spectrometry study of lipid abundance across 7 rat tissues, detecting and quantifying 652 lipid molecular species from the glycerolipid, glycerophospholipid, fatty acyl, sphingolipid, sterol lipid and prenol lipid categories. Our results demonstrate that every tissue analyzed presents a specific lipid distribution and concentration. Thus, glycerophospholipids are the most abundant tissue lipid, they share a similar tissue distribution but differ in particular lipid species between tissues. Sphingolipids are more concentrated in the renal cortex and sterol lipids can be found mainly in both liver and kidney. Both types of white adipose tissue, visceral and subcutaneous, are rich in glycerolipids but differing the amount. Acylcarnitines are mainly in the skeletal muscle, gluteus and soleus, while heart presents higher levels of ubiquinone than other tissues. The present study demonstrates the existence of a rat tissue-specific fingerprint. ; We acknowledge funding from the Spanish Ministry of Economy and Competitiveness (ref. PI1400328), and the Autonomous Government of Catalonia (ref. 2017SGR696) to RP. This study has been co-financed by FEDER funds from the European Union (Una manera de hacer Europa). IP was supported by a University of Lleida Predoctoral Fellowship. RC was supported by a Generalitat of Catalonia Predoctoral Fellowship.
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A lipid profile resistant to oxidative damage is an inherent trait associated with animal lifespan. However, there is a lack of lipidomic studies on human longevity. Here we use mass spectrometry based technologies to detect and quantify 137 ether lipids to define a phenotype of healthy humans with exceptional lifespan. Ether lipids were chosen because of their antioxidant properties and ability to modulate oxidative stress. Our results demonstrate that a specific ether lipid signature can be obtained to define the centenarian state. This profile comprises higher level of alkyl forms derived from phosphatidylcholine with shorter number of carbon atoms and double bonds; and decreased content in alkenyl forms from phosphatidylethanolamine with longer chain length and higher double bonds. This compositional pattern suggests that ether lipids from centenarians are more resistant to lipid peroxidation, and that ether lipid signature expresses an optimized feature associated with exceptional human longevity. These results are in keeping with the free radical theory of aging. ; We acknowledge funding from the Spanish Ministry of Education and Science (ref. SAF2013–44663-R), and from the 'Red Tematica de Investigación Cooperativa en Envejecimiento y Fragilidad' (RETICEF) (ref. ISCIII2012-RED-43-029) to J.V.; and from the Spanish Ministry of Economy and Competitiveness/Institute of Health Carlos III (ref. PI14/00328), and the Autonomous Government of Catalonia, Department of Health (ref. SLT002/16/00250) and Department of Business and Knowledge (ref. 2017SGR696) to R.P. This study has been co-financed by FEDER funds from the European Union ("Una manera de hacer Europa"). I.P. was supported by a University of Lleida Predoctoral Fellowship. K.H. was supported by a Dementia Australia Research Foundation Scholarship.
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A species-specific lipidome profile is an inherent feature linked to longevity in the animal kingdom. However, there is a lack of lipidomic studies on human longevity. Here, we use mass spectrometry-based lipidomics to detect and quantify 151 sphingolipid molecular species and use these to define a phenotype of healthy humans with exceptional life span. Our results demonstrate that this profile specifically comprises a higher content of complex glycosphingolipids (hexosylceramides and gangliosides), and lower levels of ceramide species from the de novo pathway, sphingomyelin and sulfatide; while for ceramide-derived signaling compounds, their content remains unchanged. Our findings suggest that structural glycosphingolipids may be more relevant to achieve the centenarian condition than signaling sphingolipids. ; We acknowledge funding from the Spanish Ministry of Science, Innovation and Universities (RTI2018-099200-B-I00) and the Generalitat of Catalonia, Agency for management of University and Research Grants (2017SGR696) and Department of Health (SLT002/16/00250) to R.P., and Spanish Ministry of Education and Science (SAF2013-44663-R) and the 'Red Tematica de Investigación Cooperativa en Envejecimiento y Fragilidad' (RETICEF) (ISCIII2012-RED-43-029) to J.V. This study has been co-financed by FEDER funds from the European Union ("A way to build Europe"). I.P. was supported by a University of Lleida Predoctoral Fellowship. K.H. was supported by a Dementia Australia Research Foundation Scholarship.
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In: Edinburgh Readings on the Ancient World
In: ERAW
Introducing students to current controversies over the nature of the ancient economy, this volume brings together twelve influential studies by leading experts in the field. In 1973, Moses Finley unveiled a comprehensive model of the economic underpinnings of classical civilisation. Since then, supporters and critics have turned the study of the ancient economy into what has been called 'an academic battleground'. In recent years, however, a growing number of scholars have aimed to move the debate beyond partisan controversies. This volume takes stock of these developments. Embracing a wide range of interdisciplinary perspectives derived from ecology, economics and cultural studies and drawing on literary, documentary and archaeological evidence, the contributions address crucial issues from agricultural production, the uses of money and the creation of markets to the scale of long-distance trade and economic growth in the Greek and Roman periods. In a general introduction and separate headnotes for each chapter, the editors provide a concise survey of recent debates, seeking to situate the different contributions in the broader context of contemporary scholarship. This is the first collection of its kind. It is designed to acquaint beginners as well as more advanced students with a variety of thematic and methodological approaches to the study of economic processes in the ancient world. All terms in foreign or ancient languages have been translated into English or explained in a comprehensive glossary. An up-to-date bibliographical essay covering pertinent scholarship in English offers guidance for further reading and the preparation of term papers
BACKGROUND: Statins have pleiotropic effects on lipid metabolism. The relationship between these effects and future cardiovascular events is unknown. We characterized the changes in lipids upon pravastatin treatment and defined the relationship with risk reduction for future cardiovascular events. METHODS: Plasma lipids (n = 342) were measured in baseline and 1-year follow-up samples from a Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) study subcohort (n = 4991). The associations of changes in lipids with treatment and cardiovascular outcomes were investigated using linear and Cox regression. The effect of treatment on future cardiovascular outcomes was examined by the relative risk reduction (RRR). RESULTS: Pravastatin treatment was associated with changes in 206 lipids. Species containing arachidonic acid were positively associated while phosphatidylinositol species were negatively associated with pravastatin treatment. The RRR from pravastatin treatment for cardiovascular events decreased from 23.5% to 16.6% after adjustment for clinical risk factors and change in LDL-cholesterol (LDL-C) and to 3.0% after further adjustment for the change in the lipid ratio PI(36:2)/PC(38:4). Change in PI(36:2)/PC(38:4) mediated 58% of the treatment effect. Stratification of patients into quartiles of change in PI(36:2)/PC(38:4) indicated no benefit of pravastatin in the fourth quartile. CONCLUSION: The change in PI(36:2)/PC(38:4) predicted benefit from pravastatin, independent of change in LDL-C, demonstrating its potential as a biomarker for monitoring the clinical benefit of statin treatment in secondary prevention. TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry identifier ACTRN12616000535471. FUNDING: Bristol-Myers Squibb; NHMRC grants 211086, 358395, and 1029754; NHMRC program grant 1149987; NHMRC fellowship 108026; and the Operational Infrastructure Support Program of the Victorian government of Australia.
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In: Jayawardana , K S , Mundra , P A , Giles , C , Barlow , C K , Nestel , P J , Barnes , E H , Kirby , A , Thompson , P , Sullivan , D R , Alshehry , Z H , Mellett , N A , Huynh , K , McConville , M J , Zoungas , S , Hillis , G S , Chalmers , J , Woodward , M , Marschner , I C , Wong , G , Kingwell , B A , Simes , J , Tonkin , A M , Meikle , P J & behalf of the LIPID Study Investigators 2019 , ' Changes in plasma lipids predict pravastatin efficacy in secondary prevention ' , JCI Insight , vol. 4 , no. 13 , :e12843 . https://doi.org/10.1172/jci.insight.128438
BACKGROUND. Statins have pleiotropic effects on lipid metabolism. The relationship between these effects and future cardiovascular events is unknown. We characterized the changes in lipids upon pravastatin treatment and defined the relationship with risk reduction for future cardiovascular events. METHODS. Plasma lipids (n = 342) were measured in baseline and 1-year follow-up samples from a Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) study subcohort (n = 4991). The associations of changes in lipids with treatment and cardiovascular outcomes were investigated using linear and Cox regression. The effect of treatment on future cardiovascular outcomes was examined by the relative risk reduction (RRR). RESULTS. Pravastatin treatment was associated with changes in 206 lipids. Species containing arachidonic acid were positively associated while phosphatidylinositol species were negatively associated with pravastatin treatment. The RRR from pravastatin treatment for cardiovascular events decreased from 23.5% to 16.6% after adjustment for clinical risk factors and change in LDL-cholesterol (LDL-C) and to 3.0% after further adjustment for the change in the lipid ratio PI(36:2)/ PC(38:4). Change in PI(36:2)/PC(38:4) mediated 58% of the treatment effect. Stratification of patients into quartiles of change in PI(36:2)/PC(38:4) indicated no benefit of pravastatin in the fourth quartile. CONCLUSION. The change in PI(36:2)/PC(38:4) predicted benefit from pravastatin, independent of change in LDL-C, demonstrating its potential as a biomarker for monitoring the clinical benefit of statin treatment in secondary prevention. TRIAL REGISTRATION. Australian New Zealand Clinical Trials Registry identifier ACTRN12616000535471. FUNDING. Bristol-Myers Squibb; NHMRC grants 211086, 358395, and 1029754; NHMRC program grant 1149987; NHMRC fellowship 108026; and the Operational Infrastructure Support Program of the Victorian government of Australia.
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Tidal disruption events (TDEs) are transient flares produced when a star is ripped apart by the gravitational field of a supermassive black hole (SMBH). We have observed a transient source in the western nucleus of the merging galaxy pair Arp 299 that radiated >1.5 × 10 erg at infrared and radio wavelengths but was not luminous at optical or x-ray wavelengths. We interpret this as a TDE with much of its emission reradiated at infrared wavelengths by dust. Efficient reprocessing by dense gas and dust may explain the difference between theoretical predictions and observed luminosities of TDEs. The radio observations resolve an expanding and decelerating jet, probing the jet formation and evolution around a SMBH. Copyright © 2018, American Association for the Advancement of Science ; S.M. acknowledges financial support from the Academy of Finland (pmject 8120503). The research leading to these mats has received funding from the European. Commission Seventh Framework Programme (FP/2007-2013) under grant agreement number & 227290, 283393 (RadioNc-t) and 60725 (HELP). AA., M.P.-T., N.R.-O. and R.H.T. acknowledge support from the Spanish MINECO through grants AYA2012-38491-002-02 and AYA2015 63939 C2 1 P. P.G.J. acknowledges support from European Research Council Consolidator Grant 647208. C.R.-C. acknowledges support by the Ministry of Economy, Development and Tourism's Millennium Science Initiative through grant 10120009, awarded to The Millennium. Institute of Astrophysics, MAS Chile, and from CONICYT through FONDECYT grant 3150238 and China-CON1CYT fund CAS160313. P.M. and M.A.A. acknowledge support from the ERC research grant CAMAP-250276, and partial support from the Spanish MINECO grant AYA2015-66889C2-1P Lard the local Valencia government ghat PROMETE0-11-2014069. FIE. acknowledges support from a Science Foundation Ireland-Royal Society University Research Fellowship. D.L.C. acknowledges support from grants ST/0001901/4 ST/J001368/1, ST/ K001051/1, and st/N0001138/1. P.V. acknowledges support from the National Research Foundation of South Africa. J.H. acknowledges financial support tom the Finis h ChAth ral Fouridation and the Virile), YIP and Kahle Vais8I8 Foundation. J.K. acknowledges financial support from the Academy of Finland (grant 311138).
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Background: The COVID-19 pandemic has disrupted routine hospital services globally. This study estimated the total number of adult elective operations that would be cancelled worldwide during the 12 weeks of peak disruption due to COVID-19. Methods: A global expert response study was conducted to elicit projections for the proportion of elective surgery that would be cancelled or postponed during the 12 weeks of peak disruption. A Bayesian β-regression model was used to estimate 12-week cancellation rates for 190 countries. Elective surgical case-mix data, stratified by specialty and indication (surgery for cancer versus benign disease), were determined. This case mix was applied to country-level surgical volumes. The 12-week cancellation rates were then applied to these figures to calculate the total number of cancelled operations. Results: The best estimate was that 28 404 603 operations would be cancelled or postponed during the peak 12 weeks of disruption due to COVID-19 (2 367 050 operations per week). Most would be operations for benign disease (90·2 per cent, 25 638 922 of 28 404 603). The overall 12-week cancellation rate would be 72·3 per cent. Globally, 81·7 per cent of operations for benign conditions (25 638 922 of 31 378 062), 37·7 per cent of cancer operations (2 324 070 of 6 162 311) and 25·4 per cent of elective caesarean sections (441 611 of 1 735 483) would be cancelled or postponed. If countries increased their normal surgical volume by 20 per cent after the pandemic, it would take a median of 45 weeks to clear the backlog of operations resulting from COVID-19 disruption. Conclusion: A very large number of operations will be cancelled or postponed owing to disruption caused by COVID-19. Governments should mitigate against this major burden on patients by developing recovery plans and implementing strategies to restore surgical activity safely.
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