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There is mounting concern about declines in wildlife populations in many protected areas in Africa. Migratory ungulates are especially vulnerable to impacts of changing land use outside protected areas on their abundance. Range compression may compromise the capacity of migrants to cope with climatic variation, and accentuate both competitive interactions and predation. We analyzed the population dynamics of 11 ungulate species within Kenya's Nairobi National Park, and compared them to those in the adjoining Athi-Kaputiei Plains, where human settlements and other developments had expanded. The migratory wildebeest decreased from almost 30,000 animals in 1978 to around 5,000 currently but the migratory zebra changed little regionally. Hartebeest, impala, eland, Thomson's gazelle, Grant's gazelle, waterbuck, warthog and giraffe numbers declined regionally, whereas buffalo numbers expanded. Bimonthly counts indicated temporary movements of several species beyond the unfenced park boundaries, especially during very wet years and that few wildebeest entered the park during the dry season following exceptionally wet conditions in 1998. Wildebeest were especially vulnerable to anthropogenic impacts in their wet season dispersal range on the plains. Deterioration in grassland conditions in the park following high rainfall plus lack of burning may have discouraged these animals from using the park as a dry season refuge. Our findings emphasise the interdependency between the park and the plains for seasonal wildlife movements, especially in exceptionally dry or wet years. To effectively conserve these ungulates, we recommend implementation of the new land-use plan for the Athi-Kaputiei Plains by the county government; expansion of the land leasing program for biodiversity payments; collecting poacher's snares; negotiation and enforcement of easements, allowing both wildlife and livestock to move through the Athi-Kaputiei Plains, providing incentives for conservation to landowners; and improving grassland conditions within the park through controlled burning so that more wildlife can gain protection there.

Background Changing population-level exposure to modifiable risk factors is a key driver of changing cancer incidence. Understanding these changes is therefore vital when prioritising risk-reduction policies, in order to have the biggest impact on reducing cancer incidence. UK figures on the number of risk factor-attributable cancers are updated here to reflect changing behaviour as assessed in representative national surveys, and new epidemiological evidence. Figures are also presented by UK constituent country because prevalence of risk factor exposure varies between them. Methods Population attributable fractions (PAFs) were calculated for combinations of risk factor and cancer type with sufficient/convincing evidence of a causal association. Relative risks (RRs) were drawn from meta-analyses of cohort studies where possible. Prevalence of exposure to risk factors was obtained from nationally-representative population surveys. Cancer incidence data for 2015 was sourced from national data releases and, where needed, personal communications. PAF calculations were stratified by age, sex and risk factor exposure level and then combined to create summary PAFs by cancer type, sex and country. Results Nearly four in ten (37.7%) cancer cases in 2015 in the UK were attributable to known risk factors. The proportion was around two percentage points higher in UK males (38.6%) than in UK females (36.8%). Comparing UK countries, the attributable proportion was highest in Scotland (41.5% for persons) and lowest in England (37.3% for persons). Tobacco smoking contributed by far the largest proportion of attributable cancer cases, followed by overweight/obesity, accounting for 15.1% and 6.3% respectively of all cases in the UK in 2015. For 10 cancer types, including two of the five most common cancer types in the UK (lung cancer and melanoma skin cancer), more than 70% of UK cancer cases were attributable to known risk factors. Conclusion Tobacco and overweight/obesity remain the top contributors of attributable cancer cases. Tobacco smoking has the highest PAF because it greatly increases cancer risk and has a large number of cancer types associated with it. Overweight/obesity has the second-highest PAF because it affects a high proportion of the UK population and is also linked with many cancer types. Public health policy may seek to mitigate the level of harm associated with exposure, or reduce exposure levels – both approaches may effectively impact cancer incidence. Differences in PAFs between countries and sexes are primarily due to varying prevalence of exposure to risk factors, and varying proportions of specific cancer types. This variation in turn is affected by socio-demographic differences which drive differences in exposure to theoretically avoidable 'lifestyle' factors. PAFs at UK country level have not been available previously and they should be used by policymakers in devolved nations. PAFs are estimates based on the best available data, limitations in those data would generally bias toward underestimation of PAFs. Regular collection of risk factor exposure prevalence data which corresponds with epidemiological evidence is vital for analyses like this and should remain a priority for the UK Government and devolved Administrations. Keywords: cancer; risk factors; population attributable fractions; UK; tobacco; obesity; lifestyle; environmental

We show a method to control magnetic interfacial effects in multilayers with Dzyaloshinskii-Moriya interaction (DMI) using helium (He[Formula: see text]) ion irradiation. We report results from SQUID magnetometry, ferromagnetic resonance as well as Brillouin light scattering results on multilayers with DMI as a function of irradiation fluence to study the effect of irradiation on the magnetic properties of the multilayers. Our results show clear evidence of the He[Formula: see text] irradiation effects on the magnetic properties which is consistent with interface modification due to the effects of the He[Formula: see text] irradiation. This external degree of freedom offers promising perspectives to further improve the control of magnetic skyrmions in multilayers, that could push them towards integration in future technologies. ; This project 17FUN08 TOPS has received funding from the EMPIR programme co-financed by the Participating States and from the European Union's Horizon 2020 research and innovation programme. This project was also supported by the UK government department for Business, Energy and Industrial Strategy through NMS funding (Low Loss Electronics) and the UK national Quantum Technologies programme. A. S. and D. S. thanks EPSRC for their supports through NPIF EPSRC Doctoral studentship (EP/R512400/1) and Centre for Doctoral Training in Advanced Characterisation of Materials (EP/L015277/1) respectively. We would like to thank P. Zubko for fruitful discussions on the X-ray reflectivity measurements as well as T. Dion for general discussion of the manuscript.

The role of badgers in the geographic expansion of the bovine tuberculosis (bTB) epidemic in England is unknown: indeed there have been few published studies of bTB in badgers outside of the Southwest of England where the infection is now endemic in cattle. Cheshire is now on the edge of the expanding area of England in which bTB is considered endemic in cattle. Previous studies, over a decade ago when bovine infection was rare in Cheshire, found no or only few infected badgers in the south eastern area of the county. In this study, carried out in 2014, road-killed badgers were collected through a network of local stakeholders (farmers, veterinarians, wildlife groups, government agencies), and Mycobacterium bovis was isolated from 21% (20/94) badger carcasses. Furthermore, there was strong evidence for co-localisation of M. bovis SB0129 (genotype 25) infection in both badgers and cattle herds at a county scale. While these findings suggest that both badgers and cattle are part of the same geographically expanding epidemic, the direction of any cross-species transmission and the drivers of this expansion cannot be determined. The study also demonstrated the utility of using road-killed badgers collected by stakeholders as a means of wildlife TB surveillance.

Coronary artery disease, CAD, is associated with both narrowing of the epicardial coronary arteries and microvascular disease, thereby limiting coronary flow and myocardial perfusion. CAD accounts for almost 2 million deaths within the European Union on an annual basis. In this paper, we review the physiological and pathophysiological processes underlying clinical decision making in coronary disease as well as the models for interpretation of the underlying physiological mechanisms. Presently, clinical decision making is based on non-invasive magnetic resonance imaging, MRI, of myocardial perfusion and invasive coronary hemodynamic measurements of coronary pressure and Doppler flow velocity signals obtained during catheterization. Within the euHeart project, several innovations have been developed and applied to improve diagnosis-based understanding of the underlying biophysical processes. Specifically, MRI perfusion data interpretation has been advanced by the gradientogram, a novel graphical representation of the spatiotemporal myocardial perfusion gradient. For hemodynamic data, functional indices of coronary stenosis severity that do not depend on maximal vasodilation are proposed and the Valsalva maneuver for indicating the extravascular resistance component of the coronary circulation has been introduced. Complementary to these advances, model innovation has been directed to the porous elastic model coupled to a one-dimensional model of the epicardial arteries. The importance of model development is related to the integration of information from different modalities, which in isolation often result in conflicting treatment recommendations.

Climate-driven redistribution of tuna threatens to disrupt the economies of Pacific Small Island Developing States (SIDS) and sustainable management of the world's largest tuna fishery. Here we show that by 2050, under a high greenhouse gas emissions scenario (RCP 8.5), the total biomass of three tuna species in the waters of ten Pacific SIDS could decline by an average of 13% (range = −5% to −20%) due to a greater proportion of fish occurring in the high seas. The potential implications for Pacific Island economies in 2050 include an average decline in purse-seine catch of 20% (range = −10% to −30%), an average annual loss in regional tuna-fishing access fees of US$90 million (range = −US$40 million to –US$140 million) and reductions in government revenue of up to 13% (range = −8% to −17%) for individual Pacific SIDS. Redistribution of tuna under a lower-emissions scenario (RCP 4.5) is projected to reduce the purse-seine catch from the waters of Pacific SIDS by an average of only 3% (range = −12% to +9%), indicating that even greater reductions in greenhouse gas emissions, in line with the Paris Agreement, would provide a pathway to sustainability for tuna-dependent Pacific Island economies. An additional pathway involves Pacific SIDS negotiating within the regional fisheries management organization to maintain the present-day benefits they receive from tuna, regardless of the effects of climate change on the distribution of the fish.

Accurate assessment of anthropogenic carbon dioxide (CO2) emissions and their redistribution among the atmosphere, ocean, and terrestrial biosphere - the "global carbon budget" - is important to better understand the global carbon cycle, support the development of climate policies, and project future climate change. Here we describe data sets and methodology to quantify the five major components of the global carbon budget and their uncertainties. Fossil CO2 emissions (E-FF) are based on energy statistics and cement production data, while emissions from land use change (E-LUC), mainly deforestation, are based on land use and land use change data and bookkeeping models. Atmospheric CO2 concentration is measured directly and its growth rate (G(ATM)) is computed from the annual changes in concentration. The ocean CO2 sink (S-OCEAN) and terrestrial CO2 sink (S-LAND) are estimated with global process models constrained by observations. The resulting carbon budget imbalance (B-IM), the difference between the estimated total emissions and the estimated changes in the atmosphere, ocean, and terrestrial biosphere, is a measure of imperfect data and understanding of the contemporary carbon cycle. All uncertainties are reported as +/- 1 sigma. For the last decade available (2009-2018), E-FF was 9.5 +/- 0.5 GtC yr 1, E-LUC 1.5 +/- 0.7 GtC yr 1, G(ATM) 4.9 +/- 0.02 GtC yr(-1) (2.3 +/- 0.01 ppm yr(-1)), S-OCEAN 2.5 +/- 0.6 GtC yr(-1), and S-LAND 3.2 +/- 0.6 GtC yr(-1), with a budget imbalance B-IM of 0.4 GtC yr(-1) indicating overestimated emissions and/or underestimated sinks. For the year 2018 alone, the growth in E-FF was about 2.1% and fossil emissions increased to 10.0 +/- 0.5 GtC yr 1, reaching 10 GtC yr(-1) for the first time in history, E-LUC was 1.5 +/- 0.7 GtC yr(-1), for total anthropogenic CO2 emissions of 11.5 +/- 0.9 GtC yr(-1) (42.5 +/- 3.3 GtCO(2)). Also for 2018, G(ATM) was 5.1 +/- 0.2 GtC yr(-1) (2.4 +/- 0.1 ppm yr(-1)), S-OCEAN was 2.6 +/- 0.6 GtC yr(-1), and S-LAND was 3.5 +/- 0.7 GtC yr(-1), with a B-IM of 0.3 GtC. The global atmospheric CO2 concentration reached 407.38 +/- 0.1 ppm averaged over 2018. For 2019, preliminary data for the first 6-10 months indicate a reduced growth in E-FF of +0.6% (range of -0.2% to 1.5 %) based on national emissions projections for China, the USA, the EU, and India and projections of gross domestic product corrected for recent changes in the carbon intensity of the economy for the rest of the world. Overall, the mean and trend in the five components of the global carbon budget are consistently estimated over the period 1959-2018, but discrepancies of up to 1 GtC yr(-1) persist for the representation of semi-decadal variability in CO2 fluxes. A detailed comparison among individual estimates and the introduction of a broad range of observations shows (1) no consensus in the mean and trend in land use change emissions over the last decade, (2) a persistent low agreement between the different methods on the magnitude of the land CO2 flux in the northern extra-tropics, and (3) an apparent underestimation of the CO2 variability by ocean models outside the tropics. This living data update documents changes in the methods and data sets used in this new global carbon budget and the progress in understanding of the global carbon cycle compared with previous publications of this data set (Le Quere et al., 2018a, b, 2016, 2015a, b, 2014, 2013).

U.S. Department of Energy ; U.S. National Science Foundation ; Ministry of Science and Education of Spain ; Science and Technology Facilities Council of the United Kingdom ; Higher Education Funding Council for England ; National Center for Supercomputing Applications at the University of Illinois at Urbana-Champaign ; Kavli Institute of Cosmological Physics at the University of Chicago ; Center for Cosmology and Astro-Particle Physics at the Ohio State University ; Mitchell Institute for Fundamental Physics and Astronomy at Texas AM University ; Financiadora de Estudos e Projetos ; Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) ; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) ; Ministerio da Ciencia, Tecnologia e Inovacao ; Deutsche Forschungsgemeinschaft ; Argonne National Laboratory ; University of California at Santa Cruz ; University of Cambridge ; Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas-Madrid ; University of Chicago ; University College London ; DES-Brazil Consortium ; University of Edinburgh ; Eidgenossische Technische Hochschule (ETH) Zurich ; Fermi National Accelerator Laboratory ; University of Illinois at Urbana-Champaign ; Institut de Ciencies de l'Espai (IEEC/CSIC) ; Institut de Fisica d'Altes Energies ; Lawrence Berkeley National Laboratory ; Ludwig-Maximilians Universitat Munchen ; associated Excellence Cluster Universe ; University of Michigan ; National Optical Astronomy Observatory ; University of Nottingham ; Ohio State University ; University of Pennsylvania ; University of Portsmouth ; SLAC National Accelerator Laboratory ; Stanford University ; University of Sussex ; Texas AM University ; National Science Foundation ; MINECO ; Centro de Excelencia Severo Ochoa ; European Research Council under the European Union, ERC ; NSF ; Alfred P. Sloan Foundation ; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; ICREA ; National Science Foundation: AST-1138766 ; MINECO: AYA2012-39559 ; MINECO: ESP2013-48274 ; MINECO: FPA2013-47986 ; Centro de Excelencia Severo Ochoa: SEV-2012-0234 ; European Research Council under the European Union, ERC: 240672 ; European Research Council under the European Union, ERC: 291329 ; European Research Council under the European Union, ERC: 306478 ; NSF: AST-1518052 ; Processo FAPESP: 2015/12338-1 ; The collapse of a stellar core is expected to produce gravitational waves (GWs), neutrinos, and in most cases a luminous supernova. Sometimes, however, the optical event could be significantly less luminous than a supernova and a direct collapse to a black hole, where the star just disappears, is possible. The GW event GW150914 was detected by the LIGO Virgo Collaboration via a burst analysis that gave localization contours enclosing the Large Magellanic Cloud (LMC). Shortly thereafter, we used DECam to observe 102 deg(2) of the localization area, including 38 deg(2) on the LMC for a missing supergiant search. We construct a complete catalog of LMC luminous red supergiants, the best candidates to undergo invisible core collapse, and collected catalogs of other candidates: less luminous red supergiants, yellow supergiants, blue supergiants, luminous blue variable stars, and Wolf-Rayet stars. Of the objects in the imaging region, all are recovered in the images. The timescale for stellar disappearance is set by the free-fall time, which is a function of the stellar radius. Our observations at 4 and 13 days after the event result in a search sensitive to objects of up to about 200 solar radii. We conclude that it is unlikely that GW150914 was caused by the core collapse of a relatively compact supergiant in the LMC, consistent with the LIGO Collaboration analyses of the gravitational waveform as best interpreted as a high mass binary black hole merger. We discuss how to generalize this search for future very nearby core-collapse candidates.

U.S. Department of Energy ; U.S. National Science Foundation ; Ministry of Science and Education of Spain ; Science and Technology Facilities Council of the United Kingdom ; Higher Education Funding Council for England ; National Center for Supercomputing Applications at the University of Illinois at Urbana-Champaign ; Kavli Institute of Cosmological Physics at the University of Chicago ; Center for Cosmology and Astro-Particle Physics at the Ohio State University ; Mitchell Institute for Fundamental Physics and Astronomy at Texas AM University ; Financiadora de Estudos e Projetos ; Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) ; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) ; Ministerio da Ciencia, Tecnologia e Inovacao ; Deutsche Forschungsgemeinschaft ; Argonne National Laboratory ; University of California at Santa Cruz ; University of Cambridge ; Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas-Madrid ; University of Chicago ; University College London ; DES-Brazil Consortium ; University of Edinburgh ; Eidgenossische Technische Hochschule (ETH) Zurich ; Fermi National Accelerator Laboratory ; University of Illinois at Urbana-Champaign ; Institut de Ciencies de l'Espai (IEEC/CSIC) ; Institut de Fisica d'Altes Energies ; Lawrence Berkeley National Laboratory ; Ludwig-Maximilians Universitat Munchen ; associated Excellence Cluster universe ; University of Michigan ; National Optical Astronomy Observatory ; University of Nottingham ; Ohio State University ; University of Pennsylvania ; University of Portsmouth ; SLAC National Accelerator Laboratory ; Stanford University ; University of Sussex ; Texas AM University ; National Science Foundation ; MINECO ; Centro de Excelencia Severo Ochoa ; European Research Council under the European Union, ERC ; ICREA ; National Science Foundation: AST-1138766 ; MINECO: AYA2012-39559 ; MINECO: ESP2013-48274 ; MINECO: FPA2013-47986 ; Centro de Excelencia Severo Ochoa: SEV-2012-0234 ; European Research Council under the European Union, ERC: 240672 ; European Research Council under the European Union, ERC: 291329 ; European Research Council under the European Union, ERC: 306478 ; We report the results of a deep search for an optical counterpart to the gravitational wave (GW) event GW150914, the first trigger from the Advanced LIGO GW detectors. We used the Dark Energy Camera (DECam) to image a 102 deg(2) area, corresponding to 38% of the initial trigger high-probability sky region and to 11% of the revised high-probability region. We observed in the i and z bands at 4-5, 7, and 24 days after the trigger. The median 5 sigma point-source limiting magnitudes of our search images are i = 22.5 and z = 21.8 mag. We processed the images through a difference-imaging pipeline using templates from pre-existing Dark Energy Survey data and publicly available DECam data. Due to missing template observations and other losses, our effective search area subtends 40 deg(2), corresponding to a 12% total probability in the initial map and 3% in the final map. In this area, we search for objects that decline significantly between days 4-5 and day 7, and are undetectable by day 24, finding none to typical magnitude limits of i = 21.5, 21.1, 20.1 for object colors (i - z) = 1, 0, - 1, respectively. Our search demonstrates the feasibility of a dedicated search program with DECam and bodes well for future research in this emerging field.

Importance Juvenile amyotrophic lateral sclerosis (ALS) is a rare form of ALS characterized by age of symptom onset less than 25 years and a variable presentation. Objective To identify the genetic variants associated with juvenile ALS. Design, Setting, and Participants In this multicenter family-based genetic study, trio whole-exome sequencing was performed to identify the disease-associated gene in a case series of unrelated patients diagnosed with juvenile ALS and severe growth retardation. The patients and their family members were enrolled at academic hospitals and a government research facility between March 1, 2016, and March 13, 2020, and were observed until October 1, 2020. Whole-exome sequencing was also performed in a series of patients with juvenile ALS. A total of 66 patients with juvenile ALS and 6258 adult patients with ALS participated in the study. Patients were selected for the study based on their diagnosis, and all eligible participants were enrolled in the study. None of the participants had a family history of neurological disorders, suggesting de novo variants as the underlying genetic mechanism. Main Outcomes and Measures De novo variants present only in the index case and not in unaffected family members. Results Trio whole-exome sequencing was performed in 3 patients diagnosed with juvenile ALS and their parents. An additional 63 patients with juvenile ALS and 6258 adult patients with ALS were subsequently screened for variants in the SPTLC1 gene. De novo variants in SPTLC1 (p.Ala20Ser in 2 patients and p.Ser331Tyr in 1 patient) were identified in 3 unrelated patients diagnosed with juvenile ALS and failure to thrive. A fourth variant (p.Leu39del) was identified in a patient with juvenile ALS where parental DNA was unavailable. Variants in this gene have been previously shown to be associated with autosomal-dominant hereditary sensory autonomic neuropathy, type 1A, by disrupting an essential enzyme complex in the sphingolipid synthesis pathway. Conclusions and Relevance These data broaden the phenotype associated with SPTLC1 and suggest that patients presenting with juvenile ALS should be screened for variants in this gene.