Suchergebnisse

7‐11 November 2010, Tenth International Congress on Drug Therapy in HIV Infection, Glasgow, UK

One of the most intensely studied features in the chemistry of nitrosamines is the restricted rotation around the N-N bond and, consequently, the estimation of the energy strain (Estr) determined by the NO group. This is rationalized in terms of the interaction between the electron lone-pairs of the amine nitrogen and the 𝜋 electrons of the –N=O group (nN-πNO* conjugation). Combining the results of DFT calculations on 43 nitrosamines (11 acyclic, 20 mono- and bicyclic and 12 tricyclic) with a multiple linear regression analysis, the paper affords a number of additive increments, which, by appropriate summation, are able to predict with a good accuracy the total energy of the nitroso compound (E) and the energy strain (Estr) values of the –N=O group for any acyclic or cyclic saturated nitrosamines.

© The Author(s) 2014. The aim of this study was to determine optimally efficient cutoff scores on the Posttraumatic Stress Disorder Checklist (PCL) for identifying full posttraumatic stress disorder (PTSD) and partial PTSD (P-PTSD) in active-duty Marines and Sailors. Participants were 1,016 Marines and Sailors who were administered the PCL and Clinician-Administered PTSD Scale (CAPS) 3 months after returning from Operations Iraqi and Enduring Freedom. PCL cutoffs were tested against three CAPS-based classifications: full PTSD, stringent P-PTSD, and lenient P-PTSD. A PCL score of 39 was found to be optimally efficient for identifying full PTSD. Scores of 38 and 33 were found to be optimally efficient for identifying stringent and lenient P-PTSD, respectively. Findings suggest that the PCL cutoff that is optimally efficient for detecting PTSD in active-duty Marines and Sailors is substantially lower than the score of 50 commonly used by researchers. In addition, findings provide scores useful for identifying P-PTSD in returning service members.

Throughout this internship, I, Abhi Pasupula, have worked with my internship mentor, Barry Federici, in order to help him start up a new service. This service is targeted specifically towards veterans and their paths in their lives after they retire from the military. The service is split up into two categories, those being Jobs and Veteran Benefits. Jobs entailed creating and implement a job board into our website for retired veterans to search for. Veteran benefits showcase a list of benefits that veterans are eligible for, divided up by Federal Benefits, State Benefits, Local Benefits, and a page for all available benefits. For the Job Board page on the website, we got into contact with a job board service known as Hiring Opps and spent many days working through the features and seeing which features would serve us the best for the website. In addition, we set up a Sandbox so that we could physically see the service in action. The benefits required more menial work, such as compiling the list of total benefits and categorizing them into states with links that lead to the state Veteran Benefits commission for more information. Once organized, the benefits were organized into 4 sections, each section having its own page on the website. Both of these websites were connected back to the original website, which served as a homepage for all the services. The homepage also had services to meet with my mentor, Mr. Federici. Working on both of these websites and services really opened my eyes to the professional world of Software Development, where there was so much more apart from just programming. Similar to this internship, the real world will require me to be able to voice my thoughts as well as put them down on paper and be able to explain them well to others, something that I believe this internship set me up for very well. ; https://digitalcommons.imsa.edu/intern_reports_2021/1004/thumbnail.jpg

Antimicrobials are included in commercial animal feed rations in many low- and middle-income countries (LMICs). We measured antimicrobial use (AMU) in commercial feed products consumed by 338 small-scale chicken flocks in the Mekong Delta of Vietnam, before a gradual nationwide ban on prophylactic use of antimicrobials (including in commercial feeds) to be introduced in the country over the coming five years. We inspected the labels of commercial feeds and calculated amounts of antimicrobial active ingredients (AAIs) given to flocks. We framed these results in the context of overall AMU in chicken production, and highlighted those products that did not comply with Government regulations. Thirty-five of 99 (35.3%) different antimicrobial-containing feed products included at least one AAI. Eight different AAIs (avilamycin, bacitracin, chlortetracycline, colistin, enramycin, flavomycin, oxytetracycline, virginamycin) belonging to five classes were identified. Brooding feeds contained antimicrobials the most (60.0%), followed by grower (40.9%) and finisher feeds (20.0%). Quantitatively, chlortetracycline was consumed most (42.2 mg/kg SEM ±0.34; 50.0% of total use), followed by enramycin (18.4 mg/kg SEM ±0.03, 21.8%), bacitracin (16.4 mg/kg SEM ±0.20, 19.4%) and colistin (6.40 mg/kg SEM ± 4.21;7.6%). Other antimicrobials consumed were virgianamycin, avilamycin, flavomycin and oxytetracycline (each ≤0.50 mg/kg). Antimicrobials in commercial feeds were more commonly given to flocks in the earlier part of the production cycle. A total of 10 (9.3%) products were not compliant with existing Vietnamese regulation (06/2016/TT-BNNPTNT) either because they included a non-authorised AAI (4), had AAIs over the permitted limits (4), or both (2). A number of commercial feed formulations examined included colistin (polymyxin E), a critically important antimicrobial of highest priority for human medicine. These results illustrate the challenges for effective implementation and enforcement of restrictions of antimicrobials in ...

Retrospective study of transverse type from January to June 2009 in the Tinbuktu area for specific supervision of activities to combat tuberculosis, whose main objective was to make the analysis of the epidemiological situation of tuberculosis in the Tinbuktu area. The ratio was of two men for one woman, this male is observed in all circles except Niafunké where he had parity. The new cases of smear-positive cases represent 85% and the circle of Tinbuktu outwits the greatest number of TB patients in the region either 29.6% unlike Gourma RHAROUS 4.8 percent of the cases. By making the same crossing for therapeutic failure rate, we see that the single Goundam circle holds 50% of cases of failure of the region. Lost to rate is higher in the circle of Tinbuktu 46.7% Unlike Niafounké where this is 5.6%. Cases of tuberculosis in negative microscopy and pulmonary extra represent, respectively, 3.2 and 6.4 percent of cases of tuberculosis in the region of Tinbuktu. We have found a statistically significant relationship (P = 0. 004) between failed and death in the region. The fight against tuberculosis remains a struggle that deserves to require the attention of political power and vigilance of social health. ; Etude rétrospective de type transversal de janvier à juin 2009 dans la région de Tombouctou dans le cadre de la supervision spécifique des activités de lutte contre la tuberculose, dont l'objectif principal était de faire l'analyse de la situation épidémiologique de la tuberculose dans la région de Tombouctou. Le ratio était de 2 hommes pour une femme, cette prédominance masculine s'observait dans tous les cercles sauf à Niafounké où il avait une parité. Les nouveaux cas frottis positifs représentent 85% et le cercle de Tombouctou dépiste le plus grand nombre de tuberculeux de la région soit 29.6 % des cas contrairement à Gourma RHAROUS 4.8% des cas. En faisant le même croisement pour le taux d'échec thérapeutique, nous constatons que le cercle de Goundam seul détient 50% des cas d'échec de la région. Le taux de perdus de vue est plus élevé dans le cercle de Tombouctou soit 46,7% contrairement à Niafounké où ce taux est de 5,6 %. Les cas de Tuberculose à microscopie négative et les extra pulmonaires représentent respectivement 3,2 et 6,4% des cas de tuberculose de la région de Tombouctou. Nous avons retrouvé, une relation statistiquement significative (P=0 ,004) entre Echec et Décès dans toute la région. La lutte contre la tuberculose reste un combat qui mérite de requérir l'attention des pouvoirs politiques et la vigilance du personnel socio sanitaire.