Suchergebnisse

Achieving tenure and promotion is an integral process to becoming a member of the academy's community.Tenure provides job security, ensures academic freedom, and protects faculty from institutional threats. Asnewcomers in the academy, women and minorities face challenges not previously encountered by theirwhite male peers. Research indicates that in addition to scholarly, pedagogical, political, and personalissues, the tenure process for women and minorities also includes issues of gender and race. This paperprovides women and minority faculty on the tenure track at research universities with practical strategiesintended to facilitate their tenure and promotion process. The strategies focus on the three areas used intenure and promotion decisions: research, teaching, and service.

Achieving tenure and promotion is an integral process to becoming a member of the academy's community.Tenure provides job security, ensures academic freedom, and protects faculty from institutional threats. Asnewcomers in the academy, women and minorities face challenges not previously encountered by theirwhite male peers. Research indicates that in addition to scholarly, pedagogical, political, and personalissues, the tenure process for women and minorities also includes issues of gender and race. This paperprovides women and minority faculty on the tenure track at research universities with practical strategiesintended to facilitate their tenure and promotion process. The strategies focus on the three areas used intenure and promotion decisions: research, teaching, and service.

This thesis takes as a focal point an important Archbishop of the Greek community in Venice, Meletios Typaldos, who lived in the turbulent era of the late seventeenthearly eighteenth century (1651-1713). An enquiry into the course of his life was deemed worthy of scholarly research: first, because he had not been till now adequately investigated; second, because he is a multi-faceted personage who is highly representative of the ambiguities of that historical period but also clearly and sophisticatedly involved in them. In addition, a study of his life and work reveals a great deal about the religious and cultural beliefs and bias of the flourishing Greek Diaspora of Venice during this historical period. The dissertation investigates initially the political background within which Venice played a crucial role. Moreover, it brings to the fore the religious conflicts of the era as well as the renewal of the theological and philosophical ideas related to scholastic Aristotelism, derived from the teachings at Padua University which spread to the territory of the city-state of Venice. The emphasis in the dissertation is to focus on the impact that these ideas had on the beliefs and views of Typaldos. Principally, the thesis disambiguates the initiatives of Meletios Typaldos who, as head of the Orthodox Church in Venice, planned to convert the Orthodox Greeks to Catholicism without taking into consideration the church body, i.e., the Greek Orthodox clergy and congregation. In contrast to the prevailing view that his ambition to become a cardinal drove him to the acceptance of the Catholic doctrine, this dissertation argues that Typaldos' activities were inspired by his desire to play a crucial role in a Uniate Church under the Pope's auspices, with the ultimate ambition to convert all Greeks to it. Finally, specific attention has been given to the resistance of the Greeks of Venice to Typaldos' plans. After examining the evidence, the thesis concludes that the will of the Greek Confraternity to maintain its social independence -that was guaranteed by the Venetian state - and its passionate desire to maintain unchanged the Confraternity's Greek ethnic and religious identity are the main causes that determined its reactions against Typaldos. The conflict between the Archbishop and leadership of the Greek community ended in Typaldos' excommunication by the Patriarchate of Constantinople and, with the loss of his leadership, the decline of the Greek Community of Venice.

In mitosis, themolecular motor dynein is recruited to kinetochores by the Rod-Zw10-Zwilch complex (RZZ) and Spindly to control spindle assembly checkpoint (SAC) signaling and microtubule attachment. How the ubiquitous dynein co-factors Lis1 and NudE contribute to these functions remains poorly understood. Here, we show that the C. elegans NudE homolog NUD-2 is dispensable for dynein- and LIS-1-dependent mitotic spindle assembly in the zygote. This facilitates functional characterization of kinetochore-localized NUD-2, which is recruited by the CENP-F-like proteins HCP-1 and HCP-2 independently of RZZ- Spindly and dynein-LIS-1. Kinetochore dynein levels are reduced in ¿nud-2 embryos, and, as occurs upon RZZ inhibition, loss of NUD-2 delays the formation of load-bearing kinetochore-microtubule attachments and causes chromatin bridges in anaphase. Survival of ¿nud-2 embryos requires a functional SAC, and kinetochores without NUD-2 recruit an excess of SAC proteins. Consistent with this, SAC signaling in early ¿nud-2 embryos extends mitotic duration and prevents high rates of chromosome mis-segregation. Our results reveal that both NUD-2 and RZZ-Spindly are essential for dynein function at kinetochores, and that the gain in SAC strength during early embryonic development is relevant under conditions that mildly perturb mitosis. ; This project was funded by the European Research Council under the European Union's Seventh Framework Programme (ERC grant agreement no. ERC-2013-StG-338410-DYNEINOME to R.G.), and the European Union's Horizon 2020 Research and Innovation Programme (ERC grant agreement no. ERC-2014-StG-640553-ACTOMYO to A.X.C.). Additional funding was fromthe European Molecular Biology Organization (Installation Grant; R.G.), from the Fundação para a Ciência e a Tecnologia(IF/01015/2013/CP1157/CT0006; R.G.), and from the project 'Norte-01-0145-FEDER-000029, Advancing cancer research: from basic knowledge to application', supported by the Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement through the European Regional Development Fund (FEDER). Deposited in PMC for immediate release.

Off-label drug bills are back on track but could run off the rails

During the archaeological research conducted in 2019 under the project "The Former Headquarters of the Gestapo and the Communist Provincial Office of Public Security in Anstadt Avenue in Łódź. Interdisciplinary Site Research" under the supervision of Dr Olgierd Ławrynowicz, an object filled with products on a paper base and bookbinding materials was found in one of the excavations. This paper attempts to clarify the chronology of paper products and to identify their type (typescripts, prints of monetary value, books, bookbinding materials, arrangement drawings, other paper products) and the material used. The visible content was identified using basic research methods and digital photographic documentation of it was made to preserve it.