Suchergebnisse

A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10(-20)), ER-negative BC (P=1.1 × 10(-13)), BRCA1-associated BC (P=7.7 × 10(-16)) and triple negative BC (P-diff=2 × 10(-5)). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10(-3)) and ABHD8 (P<2 × 10(-3)). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3'-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk. ; We thank all the individuals who took part in these studies and all the researchers, clin- icians, technicians and administrative staff who have enabled this work to be carried out, in particular those involved in the COGS project: Rosalind A. Eeles, Ali Amin Al Olama, Zsofia Kote-Jarai, Sara Benlloch (PRACTICAL), Andrew Lee, and Ed Dicks, Craig Luccarini and the staff of the Centre for Genetic Epidemiology Laboratory, the staff of the CNIO genotyping unit, Daniel C. Tessier, Francois Bacot, Daniel Vincent, Sylvie LaBoissie ` re and Frederic Robidoux and the staff of the McGill University and Ge ́ nome Que ́ bec Innovation Centre, Sune F. Nielsen, Borge G. Nordestgaard, and the staff of the Copenhagen DNA laboratory, and Julie M. Cunningham, Sharon A. Windebank, Christopher A. Hilker, Jeffrey Meyer and the staff of Mayo Clinic Genotyping Core Facility. BCAC (acknowledgements by study) (ABCFS) : Maggie Angelakos, Judi Maskiell, Gillian Dite. (ABCS) C Ellen van der Schoot, Sanquin Amsterdam. (ACP) The ACP study wishes to thank the participants in the Thai Breast Cancer study. Special Thanks also go to the Thai Ministry of Public Health (MOPH), doctors and nurses who helped with the data collection process. Finally, the study would like to thank Dr Prat Boonyawongviroj, the former Permanent Secretary of MOPH and Dr Pornthep Siriwanarungsan, the Department Director-Generalof Disease Control who have supported the study throughout. (BBCS) Eileen Williams, Elaine Ryder-Mills, Kara Sargus (BIGGS) Niall McInerney, Gabrielle Colleran, Andrew Rowan, Angela Jones. (BSUCH) Peter Bugert, Medical Faculty Mannheim (CGPS) Staff and participants of the Copenhagen General Population Study. For the excellent technical assistance: Dorthe Uldall Andersen, Maria Birna Arnadottir, Anne Bank, Dorthe Kjeldgård Hansen (CNIO-BCS) Guillermo Pita, Charo Alonso, Daniel Herrero, Nuria A ́ lvarez, Pilar Zamora, Primitiva Menendez, the Human Genotyping-CEGEN Unit (CNIO)(CTS). The CTS Steering Committee includes Leslie Bernstein, Susan Neuhausen, James Lacey, Sophia Wang, Huiyan Ma, Yani Lu, and Jessica Clague DeHart at the Beckman Research Institute of City of Hope, Dennis Deapen, Rich Pinder, Eunjung Lee, and Fred Schumacher at the University of Southern California, Pam Horn-Ross, Peggy Reynolds, Christina Clarke Dur and David Nelson at the Cancer Prevention Institute of California, and Hoda Anton-Culver, Argyrios Ziogas, and Hannah Park at the University of California Irvine. (ESTHER) Hartwig Ziegler, Sonja Wolf, Volker Hermann. (GC-HBOC) Heide Hellebrand, Stefanie Engert and GC-HBOC (Supported by Deutsche Krebshilfe). (GENICA) The GENICA Network: Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, and University of Tu ̈bingen, Germany [HB, Wing-Yee Lo, Christina Justenhoven], German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ) [HB], Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany [Yon-Dschun Ko, Christian Baisch], Institute of Pathology, University of Bonn, Germany [Hans-Peter Fischer], Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany [UH], Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany [Thomas Bru ̈ning, Beate Pesch, Sylvia Rabstein, Anne Lotz]; and Institute of Occupational Medicine and Maritime Medicine, University Medical Center Hamburg-Eppendorf, Germany [Volker Harth] (HEBCS) Kirsimari Aaltonen, Karl von Smitten, Sofia Khan, Tuomas Heikkinen, Irja Erkkila ̈ . (HMBCS) Natalia Antonenkova, Peter Hillemanns, Hans Christiansen and Johann H. Karstens (KBCP) Eija Myo ̈ ha ̈ nen, Helena Kemila ̈ inen. (kConFab/AOCS) We wish to thank Heather Thorne, Eveline Niedermayr, all the kConFab research nurses and staff, the heads and staff of the Family Cancer Clinics, and the Clinical Follow Up Study (which has received funding from the NHMRC, the National Breast Cancer Foundation, Cancer Australia, and the National Institute of Health (USA)) for their contributions to this resource, and the many families who contribute to kConFab. (LAABC) We thank all the study participants and the entire data collection team, especially Annie Fung and June Yashiki. (LMBC) Gilian Peuteman, Dominiek Smeets, Thomas Van Brussel and Kathleen Corthouts. (MARIE) Petra Seibold, Judith Heinz, Nadia Obi, Alina Vrieling, Sabine Behrens, Ursula Eilber, Muhabbet Celik, Til Olchers and Stefan Nickels. (MCCS) MCCS cohort recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further supported by Australian NHMRC grants 209057, 251553 and 504711 and by infrastructure provided by Cancer Council Victoria. Cases and their vital status were ascertained through the Victorian Cancer Registry (VCR) and the Australian Institute of Health and Welfare (AIHW), including the National Death Index. (MBCSG) Bernard Peissel and Daniela Zaffaroni and Giulietta Scuvera of the Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy; Monica Barile and Irene Feroce of the Istituto Europeo di Oncologia (IEO), Milan, Italy; and the personnel of the Cogentech Cancer Genetic Test Laboratory. (MTLGEBCS) We would like to thank Martine Tranchant (CHU de Que ́ bec Research Center), Marie-France Valois, Annie Turgeon and Lea Heguy (McGill University Health Center, Royal Victoria Hospital; McGill Uni- versity) for DNA extraction, sample management and skilful technical assistance. J.S. is Chairholder of the Canada Research Chair in Oncogenetics. (MYBRCA) Phuah Sze Yee, Peter Kang, Kang In Nee, Kavitta Sivanandan, Shivaani Mariapun, Yoon Sook-Yee, Daphne Lee, Teh Yew Ching and Nur Aishah Mohd Taib for DNA Extraction and patient recruitment. (NBHS) We thank study partcipants and research staff for their contributions and commitment to this study. (OBCS) Meeri Otsukka, Kari Mono- nen(OFBCR) Teresa Selander, Nayana Weerasooriya(ORIGO) We thank E. Krol-War- merdam, and J. Blom for patient accrual, administering questionnaires, and managing clinical information. The LUMC survival data were retrieved from the Leiden hospital- based cancer registry system (ONCDOC) with the help of Dr J. Molenaar. (PBCS) Louise Brinton, Mark Sherman, Neonila Szeszenia-Dabrowska, Beata Peplonska, Witold Zatonski, Pei Chao, Michael Stagner(pKARMA) The Swedish Medical Research Counsel. (RBCS) Petra Bos, Jannet Blom, Ellen Crepin, Elisabeth Huijskens, Annette Heemskerk, the Erasmus MC Family Cancer Clinic. (SASBAC) The Swedish Medical Research Counsel. (SBCGS) We thank study partcipants and research staff for their contributions and commitment to this study. (SBCS) Sue Higham, Helen Cramp, Ian Brock, Malcolm W. R. Reed, Sabapathy Balasubramanian and Dan Connley. (SEARCH) The SEARCH and EPIC teams. (SGBCC) We thank the participants and research coordinator Kimberley Chua. (SKKDKFZS) We thank all study participants, clinicians, family doctors, researchers and technicians for their contributions and commitment to this study. (TNBCC) Robert Pilarski and Charles Shapiro were instrumental in the formation of the OSU Breast Cancer Tissue Bank. We thank the Human Genetics Sample Bank for processing of samples and providing OSU Columbus area control samples. (UKBGS) We thank Breakthrough Breast Cancer and the Institute of Cancer Research for support and funding of the Breakthrough Generations Study, and the study participants, study staff, and the doctors, nurses and other health care providers and health information sources who have contributed to the study. We acknowledge NHS funding to the Royal Marsden/ ICR NIHR Biomedical Research Centre. OCAC (acknowledgements by study) : This study would not have been possible without the contributions of the following: J Dennis, P. Hall (COGS); D. C. Tessier, F. Bacot, D. Vincent, S. LaBoissie ` re and F. Robidoux and the staff of the genotyping unit, (Genome Quebec); D. C. Whiteman, P. M. Webb, A. C. Green, N. K. Hayward, P. G. Parsons, D. M. Purdie, B. M. Smithers, D. Gotley, A. Clouston, I. Brown, S. Moore. K. Harrap, T. Sadkowski, S. O'Brien, E. Minehan, D. Roffe, S. O'Keefe, S. Lipshut, G. Connor . Berry, F. Walker, T. Barnes, J. Thomas, L. Terry, M. Connard, L. Bowes, M-R. Malt, J. White, C. Mosse, N. Tait, C. Bambach, A. Biankan, R. Brancatisano, M. Coleman, M. Cox, S. Deane, G. L. Falk, J. Gallagher, M. Hollands, T. Hugh, D. Hunt, J. Jorgensen, C. Martin, M. Richardson, G. Smith, R. Smith, D. Storey, J. Avramovic, J. Croese, J. D'Arcy, S. Fairley, J. Hansen, J. Masson, L. Nathanson, B. O'Loughlin, L. Rutherford, R. Turner, M. Windsor, J. Bessell, P. Devitt, G. Jamieson, D. Watson, S. Blamey, A. Boussioutas, R. Cade, G. Crosthwaite, I. Faragher, J. Gribbin, G. Hebbard, G. Kiroff, B. Mann, R. Millar, P. O'Brien, R. Thomas, S. Wood, S. Archer, K. Faulkner, J. Hamdorf (ACS); R. Stuart-Harris, F. Kirsten, J. Rutovitz, P. Clingan, A.Glasgow, A. Proietto, S. Braye, G. Otton, J. Shannon, T. Bonaventura, J. Stewart, S. Begbie, M. Friedlander, D. Bell, S. Baron-Hay, G. Gard, D. Nevell, N. Pavlakis, S. Valmadre, B. Young, C Camaris, R. Crouch, L. Edwards, N. Hacker, D. Marsden, G. Robertson, P. Beale, J. Beith, J. Carter, C. Dalrymple, R. Houghton, P. Russell, L. Anderson, M. Links, J. Grygiel, J. Hill, A. Brand, K. Byth, R. Jaworski, P. Harnett, R. Sharma,.G Wain, D. Purdie, D. Whiteman, B. Ward, D. Papadimos, A. Crandon, M. Cummings, K. Horwood. A. Obermair, L. Perrin, D. Wyld, J. Nicklin, M. Davy, M. K. Oehler, C. Hall, T. Dodd, T. Healy, K. Pittman, D. Henderson, J. Miller, J. Pierdes, A. Achan, P. Blomfield, D. Challis, R. McIntosh, A. Parker, B. Brown, R. Rome, D. Allen, P. Grant, S. Hyde, R. Laurie, M. Robbie, D. Healy, T. Jobling, T. Manolitsas, J. McNealage, P Rogers, B. Susil, E. Sumithran, I. Simpson, I. Haviv, K. Phillips, D. Rischin, S. Fox, D. Johnson, S. Lade, P. Waring, M. Loughrey, N.O'Callaghan, B. Murray, L. Mileshkin, P. Allan; V. Billson, J. Pyman, D. Neesham, M. Quinn, A. Hamilton, C. Underhill, R. Bell, L. F Ng, R. Blum, V.Ganju, I. Hammond, C. Stewart, Y. Leung, M. Buck, N. Zeps (ACS); G. Peuteman, T. Van Brussel and D. Smeets (BEL); U. Eilber and T. Koehler (GER); L. Gacucova (HMO); P. Schu ̈rmann, F. Kramer, W. Zheng, T.-W. Park-Simon, K. Beer-Grondke and D. Schmidt (HJO); G.S. Keeney, S. Windebank, C. Hilker and J. Vollenweider (MAY); the state cancer registries of AL, AZ, AR, CA, CO, CT, DE, FL, GA, HI, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA, and WYL (NHS); L. Paddock, M. King, U. Chandran, A. Samoila, and Y. Bensman (NJO); L. Brinton, M. Sherman, A. Hutchinson, N. Szeszenia- Dabrowska, B. Peplonska, W. Zatonski, A. Soni, P. Chao and M. Stagner (POL); ); C. Luccarini, P. Harrington the SEARCH team and ECRIC (SEA); the Scottish Gynaecological Clinical Trails group and SCOTROC1 investigators (SRO); W-H. Chow, Y-T. Gao (SWH); Information about TCGA and the investigators and institutions who constitute the TCGA research network can be found at http://cancergenome.nih.gov/ (TCGA); I. Jacobs, M. Widschwendter, E. Wozniak, N. Balogun, A. Ryan and J. Ford (UKO); Carole Pye (UKR); a full list of the investigators who contributed to the generation of the WTCCC data is available from http://www.wtccc.org.uk/ (WTCCC). CIMBA (acknowledgements by study) : (BCFR-AU) Maggie Angelakos, Judi Maskiell, Gillian Dite, Helen Tsimiklis. (BCFR-NY) We wish to thank members and participants in the New York site of the Breast Cancer Family Registry for their contributions to the study. (BCFR-ON) We wish to thank members and participants in the Ontario Familial Breast Cancer Registry for their contributions to the study. (BFBOCC-LT) We acknowledge Vilius Rudaitis, Laimonas Gris ˇ kevic ˇ ius, Ramu ̄ nas Janavic ˇ ius (if not in the authorship). BFBOCC-LV acknowledge Drs Janis Eglitis, Anna Krilova and Aivars Stengrevics. (BMBSA) We wish to thank the families who contribute to the BMBSA study. (BRICOH) We wish to thank Yuan Chun Ding and Linda Steele for their work in participant enrolment and biospecimen and data management.(CNIO) We thank Alicia Barroso, Rosario Alonso and Guillermo Pita for their assistance. (CONSIT TEAM) Alessandra Viel and Riccardo Dolcetti of the CRO Aviano National Cancer Institute, Aviano (PN), Italy; Laura Ottini of the 'Sapienza' University, Rome, Italy; Liliana Varesco of the IRCCS AOU San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy; Laura Papi and Gabriele Capone of the University of Florence, Florence, Italy; Antonella Savarese and Aline Martayan of the Istituto Nazionale Tumori Regina Elena, Rome, Italy; Stefania Tommasi and Brunella Pilato of the Istituto Nazionale Tumori 'Giovanni Paolo II', Bari, Italy. (CORE) The CIMBA data management and analysis is funded through Cancer Research- UK grant C12292/A11174. ACA is a Senior Cancer Research - UK Research Fellow. (EMBRACE) RE is supported by NIHR support to the Biomedical Research Centre at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust. (FCCC) We thank Ms. JoEllen Weaver and Dr Betsy Bove for their technical support. (GEMO) Genetic Modifiers of Cancer Risk in BRCA1/2 Mutation Carriers (GEMO) study: National Cancer Genetics Network ) UNICANCER Genetic Group * , France. We wish to thank all the GEMO collaborating groups for their contribution to this study. GEMO Collaborating Centres are: Coordinating Centres, Unite ́ Mixte de Ge ́ ne ́ tique Constitutionnelle des Cancers Fre ́ quents, Hospices Civils de Lyon - Centre Le ́ on Be ́ rard, and Equipe ) Ge ́ ne ́ tique du cancer du sein * , Centre de Recherche en Cance ́ rologie de Lyon: Olga Sinilnikova w , Sylvie Mazoyer, Francesca Damiola, Laure Barjhoux, Carole Verny-Pierre, Me ́ lanie Le ́ one, Nadia Boutry-Kryza, Alain Calender, Sophie Giraud; and Service de Ge ́ ne ́ tique Oncologique, Institut Curie, Paris: Dominique Stoppa-Lyonnet, Marion Gauthier-Villars, Bruno Buecher, Claude Houdayer, Etienne Rouleau, Lisa Golmard, Agne ` s Collet, Virginie Moncoutier, Ce ́ drick Lefol, Muriel Belotti, Antoine de Pauw, Camille Elan, Catherine Nogues, Emmanuelle Fourme, Anne-Marie Birot. Institut Gustave Roussy, Villejuif: Brigitte Bressac-de-Pail- lerets, Olivier Caron, Marine Guillaud-Bataille. Centre Jean Perrin, Clermont–Ferrand: Yves-Jean Bignon, Nancy Uhrhammer. Centre Le ́ on Be ́ rard, Lyon: Christine Lasset, Vale ́ rie Bonadona, Sandrine Handallou. Centre Franc ̧ ois Baclesse, Caen: Agne ` s Hardouin, Pascaline Berthet, Dominique Vaur, Laurent Castera. Institut Paoli Calmettes, Marseille: Hagay Sobol, Violaine Bourdon, Tetsuro Noguchi, Audrey Remenieras, Franc ̧ ois Eisinger. CHU Arnaud-de-Villeneuve, Montpellier: Isabelle Coupier, Pascal Pujol. Centre Oscar Lambret, Lille: Jean-Philippe Peyrat, Joe ̈ lle Fournier, Franc ̧ oise Re ́ villion, Philippe Vennin w , Claude Adenis. Centre Paul Strauss, Strasbourg: Danie ` le Muller, Jean-Pierre Fricker. Institut Bergonie ́ , Bordeaux: Emmanuelle Barouk-Simonet, Franc ̧ oise Bonnet, Virginie Bubien, Nicolas Sevenet, Michel Longy. Institut Claudius Regaud, Toulouse: Christine Toulas, Rosine Guimbaud, Laurence Gladieff, Viviane Feillel. CHU Grenoble: Dominique Leroux, He ́ le ` ne Dreyfus, Christine Rebischung, Magalie Peysselon. CHU Dijon: Fanny Coron, Laurence Faivre. CHU St-Etienne: Fabienne Prieur, Marine Lebrun, Caroline Kientz. Ho ˆ tel Dieu Centre Hospitalier, Chambe ́ ry: Sandra Fert Ferrer. Centre Antoine Lacassagne, Nice: Marc Fre ́ nay. CHU Limoges: Laurence Ve ́ nat-Bouvet. CHU Nantes: Capucine Delnatte. CHU Bretonneau, Tours: Isabelle Mortemousque. Groupe Hospitalier Pitie ́ -Salpe ́ trie ` re, Paris: Florence Coulet, Chrystelle Colas, Florent Soubrier, Mathilde Warcoin. CHU Vandoeuvre-les- Nancy: Johanna Sokolowska, Myriam Bronner. CHU Besanc ̧ on: Marie-Agne ` s Collonge- Rame, Alexandre Damette. Creighton University, Omaha, USA: Henry T. Lynch, Carrie L. Snyder. (G-FAST) We wish to thank the technical support of Ilse Coene en Brecht Crombez. (HCSC) We acknowledge Alicia Tosar for her technical assistance(HEBCS) HEBCS would like to thank Dr Kristiina Aittoma ̈ ki, Taru A. Muranen, Drs Carl Blomqvist and Kirsimari Aaltonen and RNs Irja Erkkila ̈ and Virpi Palola for their help with the HEBCS data and samples. (HEBON) The Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON) consists of the following Collaborating Centres: Coordinating center: Netherlands Cancer Institute, Amsterdam, NL: M.A. Rookus, F.B.L. Hogervorst, F.E. van Leeuwen, S. Verhoef, M.K. Schmidt, N.S. Russell, J.L. de Lange, R. Wijnands; Erasmus Medical Center, Rotterdam, NL: J.M. Colle ́ e, A.M.W. van den Ouweland, M.J. Hooning, C. Seynaeve, C.H.M. van Deurzen, I.M. Obdeijn; Leiden University Medical Center, NL: C.J. van Asperen, J.T. Wijnen, R.A.E.M. Tollenaar, P. Devilee, T.C.T.E.F. van Cronenburg; Radboud University Nijmegen Medical Center, NL: C.M. Kets, A.R. Mensenkamp; University Medical Center Utrecht, NL: M.G.E.M. Ausems, R.B. van der Luijt, C.C. van der Pol; Amsterdam Medical Center, NL: C.M. Aalfs, T.A.M. van Os; VU University Medical Center, Amsterdam, NL: J.J.P. Gille, Q. Waisfisz, H.E.J. Meijers-Heijboer; University Hospital Maastricht, NL: E.B. Go ́ mez- Garcia, M.J. Blok; University Medical Center Groningen, NL: J.C. Oosterwijk, A.H. van der Hout, M.J. Mourits, G.H. de Bock; The Netherlands Foundation for the detection of hereditary tumours, Leiden, NL: H.F. Vasen; The Netherlands Comprehensive Cancer Organization (IKNL): S. Siesling, J.Verloop; The Dutch Pathology Registry (PALGA): L.I.H. Overbeek. The HEBON study is supported by the Dutch Cancer Society grants NKI1998-1854, NKI2004-3088, NKI2007-3756, the Netherlands Organization of Scien- tific Research grant NWO 91109024, the Pink Ribbon grants 110005 and 2014- 187.WO76, the BBMRI grant NWO 184.021.007/CP46 and the Transcan grant JTC 2012 Cancer 12-054. HEBON thanks the registration teams of IKNL and PALGA for part of the data collection. (HRBCP) We wish to thank Hong Kong Sanatoriuma and Hospital for their continual support. (HUNBOCS) We wish to thank the Hungarian Breast and Ovarian Cancer Study Group members (Janos Papp, Tibor Vaszko, Aniko Bozsik, Timea Pocza, Judit Franko, Maria Balogh, Gabriella Domokos, Judit Ferenczi, Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary) and the clin- icians and patients for their contributions to this study.(HVH) We wish to thank the Oncogenetics Group (VHIO), and the High Risk and Cancer Prevention Unit of the University Hospital Vall d'Hebron.(ICO) We wish to thank the ICO Hereditary Cancer Program team led by Dr Gabriel Capella. (INHERIT) We would like to thank Dr Martine Dumont, Martine Tranchant for sample management and skilful technical assistance. J.S. is Chairholder of the Canada Research Chair in Oncogenetics. J.S. and P.S. were part of the QC and Genotyping coordinating group of iCOGS (BCAC and CIMBA). (IPOBCS) We wish to thank Drs Ana Peixoto, Catarina Santos, Patrı ́ cia Rocha and Pedro Pinto for their skilful contribution to the study. (KCONFAB) We wish to thank Heather Thorne, Eveline Niedermayr, all the kConFab research nurses and staff, the heads and staff of the Family Cancer Clinics, and the Clinical Follow Up Study (which has received funding from the NHMRC, the National Breast Cancer Foundation, Cancer Australia, and the National Institute of Health (USA)) for their contributions to this resource, and the many families who contribute to kConFab. (MODSQUAD) Modifier Study of Quantitative Effects on Disease (MODSQUAD): we acknowledge ModSQuaD members Csilla Szabo (National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA); Lenka Foretova and Eva Machackova (Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and MF MU, Brno, Czech Republic); and Michal Zikan, Petr Pohlreich and Zdenek Kleibl (Oncogynecologic Center and Department of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University, Prague, Czech Republic). (MSKCC) Anne Lincoln, Lauren Jacobs. (NICCC) We wish to thank the NICCC National Familial Cancer Consultation Service team led by Sara Dishon, the lab team led by Dr Flavio Lejbkowicz, and the research field operations team led by Dr Mila Pinchev. (NRG Oncology) We thank the investigators of the Australia New Zealand NRG Oncology group. (OCGN) We wish to thank members and participants in the Ontario Cancer Genetics Network for their contributions to the study. (OSU CCG) Leigha Senter, Kevin Sweet, Caroline Craven, and Michelle O'Conor were instrumental in accrual of study participants, ascertainment of medical records and database management. Samples were processed by the OSU Human Genetics Sample Bank. (SEABASS) We would like to thank Yip Cheng Har, Nur Aishah Mohd Taib, Phuah Sze Yee, Norhashimah Hassan and all the research nurses, research assistants and doctors involved in the MyBrCa Study for assistance in patient recruitment, data collection and sample preparation. In addition, we thank Philip Iau, Sng Jen-Hwei and Sharifah Nor Akmal for contributing samples from the Singapore Breast Cancer Study nd the HUKM-HKL Study respectively. The Malaysian Breast Cancer Genetic Study is funded by research grants from the Malaysian Ministry of Science, Technology and Innovation, Ministry of Higher Education (UM.C/HIR/MOHE/06) and charitable funding from Cancer Research Initiatives Foundation. (SMC) SMC team wishes to acknowledge the assistance of the Meirav Comprehensice breast cancer center team at the Sheba Medical Center for assistance in this study. (SWE-BRCA) Swedish scientists participating as SWE-BRCA collaborators are: from Lund University and University Hospital: Åke Borg, Håkan Olsson, Helena Jernstro ̈ m, Karin Henriksson, Katja Harbst, Maria Soller, Ulf Kristoffersson; from Gothenburg Sahlgrenska University Hospital: Anna O ̈ fverholm, Margareta Nordling, Per Karlsson, Zakaria Einbeigi; from Stockholm and Karolinska University Hospital: Anna von Wachenfeldt, Annelie Liljegren, Annika Lindblom, Brita Arver, Gisela Barbany Bustinza, Johanna Rantala; from Umeå University Hospital: Beatrice Melin, Christina Edwinsdotter Ardnor, Monica Emanuelsson; from Uppsala University: Hans Ehrencrona, Maritta Hellstro ̈ m Pigg, Richard Rosenquist; from Linko ̈ ping University Hospital: Marie Stenmark-Askmalm, Sigrun Lied- gren(UCHICAGO) We wish to thank Cecilia Zvocec, Qun Niu, physicians, genetic counsellors, research nurses and staff of the Cancer Risk Clinic for their contributions to this resource, and the many families who contribute to our programme. (UCLA) We thank Joyce Seldon MSGC and Lorna Kwan, MPH for assembling the data for this study. (UCSF) We would like to thank Dr Robert Nussbaum and the following genetic coun- sellors for participant recruitment: Beth Crawford, Kate Loranger, Julie Mak, Nicola Stewart, Robin Lee, Amie Blanco and Peggy Conrad. And thanks to Ms. Salina Chan for her data management. (UKFOCR) We thank Carole Pye, Patricia Harrington and Eva Wozniak for their contributions towards the UKFOCR. (VFCTG) Geoffrey Lindeman, Marion Harris, Martin Delatycki of the Victorian Familial Cancer Trials Group. We thank Sarah Sawyer and Rebecca Driessen for assembling this data and Ella Thompson for performing all DNA amplification. Grant Support : The COGS project is funded through a European Commission's Seventh Framework Programme grant (agreement number 223175—HEALTH-F2-2009- 223175). BCAC is funded by Cancer Research UK [C1287/A10118, C1287/A12014] and by the European Community ́ s Seventh Framework Programme under grant agreement number 223175 (grant number HEALTH-F2-2009-223175) (COGS). The CIMBA data management and analytical work is funded by Cancer Research UK (C12292/A11174, C12292/A20861). Funding for the iCOGS infrastructure came from: the European Community's Seventh Framework Programme under grant agreement n ° 223175 (HEALTH-F2-2009-223175) (COGS), Cancer Research UK (C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565), the National Institutes of Health (CA128978) and Post-Cancer GWAS initiative (1U19 CA148537, 1U19 CA148065 and 1U19 CA148112 - the GAME-ON initiative), the Department of Defence (W81XWH-10-1-0341), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund. The Ovarian Cancer Association Consortium is supported by a grant from the Ovarian Cancer Research Fund thanks to donations by the family and friends of Kathryn Sladek Smith (PPD/RPCI.07). The scientific development and funding for this project were in part supported by the US National Cancer Institute GAME-ON Post-GWAS Initiative (U19-CA148112). This study made use of data generated by the Wellcome Trust Case Control consortium. Funding for the project was provided by the Wellcome Trust under award 076113. The results published here are in part based on data generated by The Cancer Genome Atlas Project established by the National Cancer Institute and National Human Genome Research Institute. Personal support: K.L. is supported by a K99/R00 grant from the National Cancer Institute (Grant number 1K99CA184415-01). This project was supported in part by a Program Project Development Grant from the Ovarian Cancer Research Fund (S.A.G and A.M). The in vitro aspects of this project were performed within the Norris Cancer Centre at USC, which is supported in part by award number P30CA014089 from the National Cancer Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute or the National Institutes of Health. D.F.E. is a Principal Research Fellow of Cancer Research UK. A.C.A. is a Cancer Research—UK Senior Cancer Research Fellow. G.C.-T. and P.M.W. are supported by the National Health and Medical Research Council. (WCP) B.Y.K is funded by the American Cancer Society Early Detection Professorship (SIOP- 06-258-01-COUN) and the National Center for Advancing Translational Sciences (NCATS), Grant UL1TR000124. L.E.K. is supported by a Canadian Institutes of Health Research Investigator award (MSH-87734). S.P.K. is supported by a Gates Cambridge Scholarship. J.S. is Chairholder of the Canada Research Chair in Oncogenetics. RB was a Cancer Institute NSW Clinical Research Fellow. M.C.S. is a NHMRC Senior Research Fellow. A.K.G. was funded by 5U01CA113916, R01CA140323, and by the Chancellors Distinguished Chair in Biomedical Sciences Professorship. J.L.H. is a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellow. S.L.E. and J.D.F. are supported by Fellowships from the National Breast Cancer Foundation (NBCF) Australia and NHMRC project grant (1058415). Funding : BCAC: The Australian Breast Cancer Family Study (ABCFS) was supported by grant UM1 CA164920 from the National Cancer Institute (USA). The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centres in the Breast Cancer Family Registry (BCFR), nor does mention of trade names, commercial products, or organizations imply endorsement by the USA Government or the BCFR. The ABCFS was also supported by the National Health and Medical Research Council of Australia, the New South Wales Cancer Council, the Victorian Health Promotion Foundation (Australia) and the Victorian Breast Cancer Research Consortium. The ABCS study was supported by the Dutch Cancer Society [grants NKI 2007-3839; 2009 4363]. The ACP study is funded by the Breast Cancer Research Trust, UK. The BBCS is funded by Cancer Research UK and Breakthrough Breast Cancer and acknowledges NHS funding to the NIHR Biomedical Research Centre, and the National Cancer Research Network (NCRN).ES is supported by NIHR Comprehensive Biomedical Research Centre, Guy's and St. Thomas' NHS Foundation Trust in partnership with King's College London, United Kingdom. IT is supported by the Oxford Biomedical Research Centre.The BSUCH study was supported by the Dietmar-Hopp Foundation, the Helmholtz Society and the German Cancer Research Center (DKFZ). The CGPS was supported by the Chief Physician Johan Boserup and Lise Boserup Fund, the Danish Medical Research Council and Herlev HospitalThe CNIO-BCS was supported by the Instituto de Salud Carlos III, the Red Tema ́ tica de Investigacio ́ n Cooperativa en Ca ́ ncer and grants from the Asociacio ́ n Espan ̃ ola Contra el Ca ́ ncer and the Fondo de Investigacio ́ n Sanitario (PI11/00923 and PI12/00070). The CTS was initially supported by the California Breast Cancer Act of 1993 and the California Breast Cancer Research Fund (contract 97-10500) and is cur- rently funded through the National Institutes of Health (R01 CA77398). Collection of cancer incidence data was supported by the California Department of Public Health as part of the statewide cancer reporting program mandated by California Health and Safety Code Section 103885. HAC receives support from the Lon V Smith Foundation (LVS39420). The ESTHER study was supported by a grant from the Baden Wu ̈rttemberg Ministry of Science, Research and Arts. Additional cases were recruited in the context of the VERDI study, which was supported by a grant from the German Cancer Aid (Deutsche Krebshilfe). The GC-HBOC was supported by Deutsche Krebshilfe (107 352). The GENICA was funded by the Federal Ministry of Education and Research (BMBF) Germany grants 01KW9975/5, 01KW9976/8, 01KW9977/0 and 01KW0114, the Robert Bosch Foundation, Stuttgart, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, the Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, as well as the Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany. The HEBCS was financially supported by the Helsinki University Central Hospital Research Fund, Academy of Finland (266528), the Finnish Cancer Society, The Nordic Cancer Union and the Sigrid Juselius Foundation. The HMBCS was supported by a grant from the Friends of Hannover Medical School and by the Rudolf Bartling Foundation. The KBCP was financially supported by the special Government Funding (EVO) of Kuopio University Hospital grants, Cancer Fund of North Savo, the Finnish Cancer Organizations, and by the strategic funding of the University of Eastern Finland. kConFab is supported by a grant from the National Breast Cancer Foundation, and previously by the National Health and Medical Research Council (NHMRC), the Queensland Cancer Fund, the Cancer Councils of New South Wales, Victoria, Tasmania and South Australia, and the Cancer Foundation of Western Australia. Financial support for the AOCS was provided by the United States Army Medical Research and Materiel Command [DAMD17-01-1-0729], Cancer Council Victoria, Queensland Cancer Fund, Cancer Council New South Wales, Cancer Council South Australia, The Cancer Foundation of Western Australia, Cancer Council Tasmania and the National Health and Medical Research Council of Australia (NHMRC; 400413, 400281, 199600). LAABC is supported by grants (1RB-0287, 3PB-0102, 5PB-0018, 10PB-0098) from the California Breast Cancer Research Program. Incident breast cancer cases were collected by the USC Cancer Surveillance Program (CSP), which is supported under subcontract by the California Department of Health. The CSP is also part of the National Cancer Institute's Division of Cancer Prevention and Control Surveillance, Epidemiology, and End Results Program, under contract number N01CN25403. LMBC is supported by the 'Stichting tegen Kanker' (232-2008 and 196-2010). Diether Lambrechts is supported by the FWO and the KULPFV/10/016-SymBioSysII.The MARIE study was supported by the Deutsche Krebshilfe e.V. [70-2892-BR I, 106332, 108253, 108419], the Hamburg Cancer Society, the German Cancer Research Center (DKFZ) and the Federal Ministry of Education and Research (BMBF) Germany [01KH0402]. (MBCSG) is supported by grants from the Italian Association for Cancer Research (AIRC) and by funds from the Italian citizens who allocated the 5/1000 share of their tax payment in support of the Fondazione IRCCS Istituto Nazionale Tumori, according to Italian laws (INT-Institutional strategic projects '5x1000'). The work of MTLGEBCS was supported by the Quebec Breast Cancer Foundation, the Canadian Institutes of Health Research for the 'CIHR Team in Familial Risks of Breast Cancer' program – grant # CRN-87521 and the Ministry of Economic Development, Innovation and Export Trade – grant # PSR-SIIRI-701.MYBRCA is funded by research grants from the Malaysian Ministry of Science, Technology and Innovation (MOSTI), Malaysian Ministry of Higher Education (UM.C/HlR/MOHE/06) and Cancer Research Initiatives Foundation (CARIF). Additional controls were recruited by the Singapore Eye Research Institute, which was supported by a grant from the Biomedical Research Council (BMRC08/1/35/19/550), Singapore and the National medical Research Council, Singa- pore (NMRC/CG/SERI/2010). The NBHS was supported by NIH grant R01CA100374. Biological sample preparation was conducted the Survey and Biospecimen Shared Resource, which is supported by P30 CA68485. The OBCS was supported by research grants from the Finnish Cancer Foundation, the Academy of Finland (grant number 250083, 122715 and Center of Excellence grant number 251314), the Finnish Cancer Foundation, the Sigrid Juselius Foundation, the University of Oulu, the University of Oulu Support Foundation and the special Governmental EVO funds for Oulu University Hospital-based research activities. The Ontario Familial Breast Cancer Registry (OFBCR) was supported by grant UM1 CA164920 from the National Cancer Institute (USA). The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centres in the Breast Cancer Family Registry (BCFR), nor does mention of trade names, commercial products, or organizations imply endorsement by the USA Government or the BCFR. The ORIGO study was supported by the Dutch Cancer Society (RUL 1997-1505) and the Biobanking and Biomolecular Resources Research Infrastructure (BBMRI-NL CP16). The PBCS was funded by Intramural Research Funds of the National Cancer Institute, Department of Health and Human Services, USA. The pKARMA study was supported by Ma ̈ rit and Hans Rausings Initiative Against Breast CancerThe RBCS was funded by the Dutch Cancer Society (DDHK 2004-3124, DDHK 2009-4318). The SASBAC study was sup- ported by funding from the Agency for Science, Technology and Research of Singapore (A*STAR), the US National Institute of Health (NIH) and the Susan G. Komen Breast Cancer Foundation. The SBCGS was supported primarily by NIH grants R01CA64277, R01CA148667, and R37CA70867. Biological sample preparation was conducted the Survey and Biospecimen Shared Resource, which is supported by P30 CA68485. The scientific development and funding of this project were, in part, supported by the Genetic Associations and Mechanisms in Oncology (GAME-ON) Network U19 CA148065.The SBCS was supported by Yorkshire Cancer Research S295, S299, S305PA and Sheffield Experimental Cancer Medicine Centre.SEARCH is funded by a programme grant from Cancer Research UK [C490/A10124] and supported by the UK National Institute for Health Research Biomedical Research Centre at the University of Cambridge.SGBCC is funded by the NUS start-up Grant, National University Cancer Institute Singapore (NCIS) Centre Grant and the NMRC Clinician Scientist Award. Additional controls were recruited by the Singapore Consortium of Cohort Studies-Multi-ethnic cohort (SCCS-MEC), which was funded by the Biomedical Research Council, grant number: 05/ 1/21/19/425.SKKDKFZS is supported by the DKFZ. The TNBCC was supported by: a Specialized Program of Research Excellence (SPORE) in Breast Cancer (CA116201), a grant from the Breast Cancer Research Foundation, a generous gift from the David F. and Margaret T. Grohne Family Foundation, the Hellenic Cooperative Oncology Group research grant (HR R_BG/04) and the Greek General Secretary for Research and Technology (GSRT) Program, Research Excellence II, the European Union (European Social Fund – ESF), and Greek national funds through the Operational Program 'Education and Lifelong Learning' of the National Strategic Reference Framework (NSRF) - ARISTEIA. The UKBGS is funded by Breakthrough Breast Cancer and the Institute of Cancer Research (ICR), London. ICR acknowledges NHS funding to the NIHR Biomedical Research Centre. Funding : OCAC : Funding of the constituent studies was provided by the American Cancer Society (CRTG-00-196-01-CCE); the California Cancer Research Program (00-01389 V-20170, N01-CN25403, 2II0200); the Canadian Institutes for Health Research (MOP-86727); Cancer Council Victoria; Cancer Council Queensland; Cancer Council New South Wales; Cancer Council South Australia; Cancer Council Tasmania; Cancer Foundation of Western Australia; the Cancer Institute of New Jersey; Cancer Research UK (C490/A6187, C490/A10119, C490/A10124, C536/A13086, C536/A6689); the Celma Mastry Ovarian Cancer Foundation; the Danish Cancer Society (94-222-52); the ELAN Program of the University of Erlangen-Nuremberg; the Eve Appeal; the Helsinki University Central Hospital Research Fund; Helse Vest; Imperial Experimental Cancer Research Centre (C1312/A15589); the Norwegian Cancer Society; the Norwegian Research Council; the Ovarian Cancer Research Fund; Nationaal Kankerplan of Belgium; Grant-in-Aid for the Third Term Comprehensive 10-Year Strategy for Cancer Control from the Ministry of Health Labour and Welfare of Japan; the L and S Milken Foun- dation; the Polish Ministry of Science and Higher Education (4 PO5C 028 14, 2 PO5A 068 27); Malaysian Ministry of Higher Education (UM.C/HlR/MOHE/06) and Cancer Research Initiatives Foundation; the Roswell Park Cancer Institute Alliance Foundation; the US National Cancer Institute (K07-CA095666, K07-CA143047, K22-CA138563, N01-CN55424, N01-PC067010, N01-PC035137, P01-CA017054, P01-CA087696, P30-CA15083, P50-CA105009, P50- CA136393, R01-CA014089, R01-CA016056, R01-CA017054, R01-CA049449, R01-CA050385, R01-CA054419, R01- CA058598, R01-CA058860, R01-CA061107, R01-CA061132, R01-CA063682, R01-CA064277, R01-CA067262, R01- CA071766, R01-CA074850, R01-CA076016, R01-CA080742, R01-CA080978, R01-CA083918, R01-CA087538, R01- CA092044, R01-095023, R01-CA106414, R01-CA122443, R01-CA112523, R01-CA114343, R01-CA126841, R01- CA136924, R01-CA149429, R03-CA113148, R03-CA115195, R37-CA070867, R37-CA70867, U01-CA069417, U01- CA071966, R01-CA063678 and Intramural research funds); the US Army Medical Research and Material Command (DAMD17-98-1- 8659, DAMD17-01-1-0729, DAMD17-02-1-0666, DAMD17-02-1- 0669, W81XWH-10-1-0280); the National Health and Medical Research Council of Australia (199600 and 400281); the German Federal Ministry of Education and Research of Germany Programme of Clinical Biomedical Research (01 GB 9401); the state of Baden-Wu ̈rttemberg through Medical Faculty of the University of Ulm (P.685); the Minnesota Ovarian Cancer Alliance; the Mayo Foundation; the Fred C. and Katherine B. Andersen Foundation; the Lon V. Smith Foundation (LVS-39420); the Oak Foundation; the OHSU Foundation; the Mermaid I project; the Rudolf-Bartling Foundation; the UK National Institute for Health Research Biomedical Research Centres at the University of Cambridge, Imperial College London, University College Hospital 'Womens Health Theme' and the Royal Marsden Hospital; WorkSafeBC. Funding : CIMBA (BCFR—all) : This work was supported by grant UM1 CA164920 from the National Cancer Institute. The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centres in the Breast Cancer Family Registry (BCFR), nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government or the BCFR. (BFBOCC-LT) BFBOCC is partly supported by: Lithuania (BFBOCC-LT): Research Council of Lithuania grant LIG-07/2012; (BIDMC) BIDMC is supported by the Breast Cancer Research Foundation. (BMBSA) BRCA-gene mutations and breast cancer in South African women (BMBSA) was supported by grants from the Cancer Association of South Africa (CANSA) to Elizabeth J. van Rensburg. (BRICOH) SLN was partially supported by the Morris and Horowitz Familes Endowed Professorship. (CBCS) This work was supported by the NEYE Foundation. (CNIO) This work was partially supported by Spanish Association against Cancer (AECC08), RTICC 06/0020/1060, FISPI08/1120, Mutua Madrilen ̃ a Foundation (FMMA) and SAF2010-20493 (COH-CCGCRN) City of Hope Clinical Cancer Genetics Community Network and the Hereditary Cancer Research Registry, supported in part by Award Number RC4CA153828 (PI: J. Weitzel) from the National Cancer Institute and the Office of the Director, National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. (CONSIT TEAM) Funds from Italian citizens who allocated the 5x1000 share of their tax payment in support of the Fondazione IRCCS Istituto Nazionale Tumori, according to Italian laws (INT-Institutional strategic projects '5x1000') to Siranoush Manoukian. (CORE) The CIMBA data management and data analysis were supported by Cancer Research – UK grants C12292/A11174 and C1287/A10118.SH is supported by an NHMRC Program Grant to GCT. ACA is a Cancer Research -UK Senior Cancer Research Fellow. (DEMOKRITOS) This research has been co-financed by the European Union (European Social Fund – ESF) and Greek national funds through the Operational Program 'Education and Lifelong Learning' of the National Strategic Reference Frame- work (NSRF) - Research Funding Program of the General Secretariat for Research and Technology: ARISTEIA. Investing in knowledge society through the European Social Fund.(DKFZ) The DKFZ study was supported by the DKFZ. (EMBRACE) EMBRACE is supported by Cancer Research UK Grants C1287/A10118 and C1287/A11990. D. Gareth Evans and Fiona Lalloo are supported by an NIHR grant to the Biomedical Research Centre, Manchester. The Investigators at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust are supported by an NIHR grant to the Biomedical Research Centre at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust. (FCCC) The authors acknowledge support from The University of Kansas Cancer Center (P30 CA168524) and the Kansas Bioscience Authority Eminent Scholar Program. (GC-HBOC) The German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC) is supported by the German Cancer Aid (grant no 109076, Rita K. Schmutzler) and by the Center for Molecular Medicine Cologne (CMMC). (GEMO) The study was supported by the Ligue Nationale Contre le Cancer; the Association 'Le cancer du sein, parlons-en!' Award; the Canadian Institutes of Health Research for the 'CIHR Team in Familial Risks of Breast Cancer' program and the French National Institute of Cancer (INCa). (GEORGETOWN) CI received support from the Non-Therapeutic Subject Registry Shared Resource at Georgetown University (NIH/NCI grant P30-CA051008), the Fisher Center for Familial Cancer Research, and Swing Fore the Cure. (G-FAST) Kim De Leeneer is supported by GOA grant BOF10/ GOA/019 (Ghent University) and spearhead financing of Ghent University Hospital. (HCSC) HCSC supported by a grant RD12/0036/0006 and 12/00539 from ISCIII (Spain), partially supported by European Regional Development FEDER funds. (HEBCS) The HEBCS was financially supported by the Helsinki University Hospital Research Fund, Academy of Finland (266528), the Finnish Cancer Society and the Sigrid Juselius Foundation. (HEBON) The HEBON study is supported by the Dutch Cancer Society grants NKI1998-1854, NKI2004-3088, NKI2007-3756, the Netherlands Organization of Scientific Research grant NWO 91109024, the Pink Ribbon grant 110005 and the BBMRI grant NWO 184.021.007/CP46. HEBON thanks the registration teams of the Comprehensive Cancer Centre Netherlands and Comprehensive Centre South (together the Netherlands Cancer Registry) and PALGA (Dutch Pathology Registry) for part of the data collection. (HRBCP) HRBCP is supported by The Hong Kong Hereditary Breast Cancer Family Registry and the Dr Ellen Li Charitable Foundation, Hong Kong (HUNBOCS) Hungarian Breast and Ovarian Cancer Study was supported by Hungarian Research Grants KTIA-OTKA CK-80745, OTKA K-112228 and the Norwegian EEA Financial Mechanism Hu0115/NA/2008-3/OP-9. (ICO) Contract grant sponsor: Asociacio ́ n Espan ̃ ola Contra el Ca ́ ncer, Spanish Health Research Fund; Carlos III Health Institute; Catalan Health Institute and Autonomous Government of Catalonia. Contract grant numbers: ISCIIIRETIC RD06/0020/1051, RD12/0036/008, PI10/01422, PI10/ 00748, PI13/00285, PIE13/00022, 2009SGR290 and 2014SGR364. (IHCC) The IHCC was supported by Grant PBZ_KBN_122/P05/2004(ILUH) The ILUH group was supported by the Icelandic Association 'Walking for Breast Cancer Research' and by the Landspitali University Hospital Research Fund. (INHERIT) This work was supported by the Canadian Institutes of Health Research for the 'CIHR Team in Familial Risks of Breast Cancer' program, the Canadian Breast Cancer Research Alliance-grant #019511 and the Ministry of Economic Development, Innovation and Export Trade – grant # PSR-SIIRI- 701. (IOVHBOCS) IOVHBOCS is supported by Ministero della Salute and '5 1,000' Istituto Oncologico Veneto grant. (IPOBCS) This study was in part supported by Liga Portuguesa Contra o Cancro.(KCONFAB) kConFab is supported by a grant from the National Breast Cancer Foundation, and previously by the National Health and Medical Research Council (NHMRC), the Queensland Cancer Fund, the Cancer Councils of New South Wales, Victoria, Tasmania and South Australia, and the Cancer Foundation of Western Australia; (KOHBRA) KOHBRA is supported by a grant from the National R&D Program for Cancer Control, Ministry for Health, Welfare and Family Affairs,Republic of Korea (1020350). (MAYO) MAYO is supported by NIH grants CA116167, CA128978 and CA176785, an NCI Specialized Program of Research Excellence (SPORE) in Breast Cancer (CA116201), a U.S. Department of Defence Ovarian Cancer Idea award (W81XWH-10-1-0341), a grant from the Breast Cancer Research Foundation, a generous gift from the David F. and Margaret T. Grohne Family Foundation and the Ting Tsung and Wei Fong Chao Foundation. (MCGILL) Jewish General Hospital Weekend to End Breast Cancer, Quebec Ministry of Economic Development, Innovation and Export Trade (MODSQUAD) MODSQUAD was supported by MH CZ - DRO (MMCI, 00209805) and by the European Regional Development Fund and the State Budget of the Czech Republic (RECAMO, CZ.1.05/2.1.00/03.0101) to LF, and by Charles University in Prague project UNCE204024 (MZ). (MSKCC) MSKCC is supported by grants from the Breast Cancer Research Foundation, the Robert and Kate Niehaus Clinical Cancer Genetics Initiative, and the Andrew Sabin Research Fund. (NAROD) 1R01 CA149429- 01. (NCI) The research of Drs MH Greene, JT Loud and PL Mai was supported by the Intramural Research Program of the US National Cancer Institute, NIH, and by support services contracts NO2-CP-11019-50 and N02-CP-65504 with Westat, Inc, Rockville, MD. (NICCC) NICCC is supported by Clalit Health Services in Israel. Some of it's activities are supported by the Israel Cancer Association and the Breast Cancer Research Foundation (BCRF), NY. (NNPIO) This work has been supported by the Russian Federation for Basic Research (grants 13-04-92613, 14-04-93959 and 15-04-01744). (NRG Oncology) This study was supported by National Cancer Institute grants to the NRG Oncology Administrative Office and Tissue Bank (CA 27469), the NRG Oncology Statistical and Data Center (CA 37517), and NRG Oncology's Cancer Prevention and Control Committee (CA 101165). (OSU CCG) OSUCCG is supported by the Ohio State University Comprehensive Cancer Center. (PBCS) This work was supported by the ITT (Istituto Toscano Tumori) grants 2011-2013. (SEABASS) Ministry of Science, Technol- ogy and Innovation, Ministry of Higher Education (UM.C/HlR/MOHE/06) and Cancer Research Initiatives Foundation. (SMC) This project was partially funded through a grant by the Isreal cancer association and the funding for the Israeli Inherited breast cancer consortium (SWE-BRCA) SWE-BRCA collaborators are supported by the Swedish Cancer Society. (UCHICAGO) UCHICAGO is supported by NCI Specialized Program of Research Excellence (SPORE) in Breast Cancer (CA125183), R01 CA142996, 1U01CA161032 and by the Ralph and Marion Falk Medical Research Trust, the Entertainment Industry Fund National Women's Cancer Research Alliance and the Breast Cancer research Foundation. OIO is an ACS Clinical Research Professor.(UCLA) Jonsson Comprehensive Cancer Center Foundation; Breast Cancer Research Foundation. (UCSF) UCSF Cancer Risk Program and Helen Diller Family Comprehensive Cancer Center. (UKFOCR) UKFOCR was supported by a project grant from CRUK to Paul Pharoah. (UPENN) National Institutes of Health (NIH) (R01-CA102776 and R01- CA083855; Breast Cancer Research Foundation; Susan G. Komen Foundation for the cure, Basser Research Center for BRCA. (UPITT/MWH) Frieda G. and Saul F. Shapira BRCA-Associated Cancer Research Program;Hackers for Hope Pittsburgh. (VFCTG) Victorian Cancer Agency, Cancer Australia, National Breast Cancer Foundation unding for the iCOGS infrastructure came from: the European Community's Seventh Framework Programme under grant agreement n ° 223175 (HEALTH-F2-2009-223175) (COGS), Cancer Research UK (C1287/A10118, C1287/A 10710, C12292/A11174, C1281/ A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565), the National Institutes of Health (CA128978) and Post-Cancer GWAS initiative (1U19 CA148537, 1U19 CA148065 and 1U19 CA148112 - the GAME-ON initiative), the Department of Defence (W81XWH-10-1-0341), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund and grants R01-CA122443 and P50-CA136393. ; Sí

The WSU Stewart Library Annual UC-UI Symposium took place from 2001-2007. The collection consists of memorabilia from the symposium including a yearly keepsake, posters, and presentations through panel discussions or individual lectures. ; Audio Recording ; Thomas D. Dee: Founder, Builder, Public Servant a commemorative lecture presented at the 2007 Utah Construction/ Utah International Symposium The Beginning of an Era by Professor John Sillito Thursday, October 18, 2007 1 Well I'd like to thank Gene for that generous introduction. He read it exactly the way I wrote it for him. No thank you, I do appreciate it. Can you hear me okay? I've got more wires on me than the last time I had a test at McKay Dee Hospital let me tell you and if things start going off you'll know I'm in real trouble here today. Let me repeat something I said a little bit earlier, you don't know how pleased I am to be one of this years Utah International Fellows. It's been a marvelous experience for me to be involved in the research on a most interesting individual and I won't do that individual even remotely justice today, but will just touch the surface. As part of that process I have had the pleasure of having two fellows to assist me in research. Stan said earlier that we were both spoiled by this to have someone to actually find things, and keep us on track, and catch an error occasionally. I really appreciate those two fellows. Brett Peterson is one of my fellows. Brett has graduated from Weber and gone on to law school. My other fellow Marci Farr is with us today and Marci stand up. I appreciated everything Marci did to help and again keeping on track and it's been a great experience. My paper today is entitled Thomas D. Dee: Founder, Pioneer and Public Servant. In Ogden Utah on July 12th 1905 grocers and butchers closed their shops, school children lined city streets, public officials turned away from their duties and hundreds of prominent and ordinary citizens gathered at the Ogden Tabernacle. On the diocese were Utah Governor John C. Cutler and LDS Church President Joseph F. Smith who had traveled north to speak at the funeral of a man the Ogden Standard called, " The city's foremost citizen," Thomas 2 Duncombe Dee. As the paper reported that day, no other man in Ogden was identified with so many and diverse enterprises as he. Indeed in a career spanning fifty- five years, Dee lead in business, church, education, political and governmental affairs. During his life time Dee accomplished many things. He was a devoted husband and family man, the father of eight children. He was a friend, business partner and political ally of David Eccles and the two men along with several other created, organized and expanded a wide range of commercial ventures. Simultaneously, Dee pursued a career in politics as an office holder and judge. He chaired the Ogden Board of Education, served in a variety of capacities in his local ward. And as the twentieth century began Dee became the first president of the Utah Construction Company which sprouted from humble root and flowered into international prominence. Today it is my challenge and opportunity to address the many facets in the life of this important Ogden figure. While time will not permit an in depth examination of each aspect, I purpose to survey the breath of his career and hopefully down the line will be able to explore the many strands in detail. To begin let us examine Thomas D. Dee's roots and the series of event that in 1860 brought him to Ogden. Two important facts lead our inquiry. First the history of the Dee family is deeply rooted in the soil of Wales, and second, the family was part of what William Mulder has called " a unique element in the total stream on American migration," the relocation of thousands of Mormon converts to their Zion in western America's Great Basin. Thomas Duncombe Dee was born on November 10, 1844 in Llanelly South Wales, the second son and third 3 child of Thomas Hill and Elizabeth Reese Dee. We know very little of Thomas and Elizabeth's early lives, but they seemed typical of many citizens of nineteenth century Great Britain who faced a hard scrabble existence. We do know that the young couple, both age twenty- five married in 1837. Thomas Hill Dee sought work where ever he could find it practicing the trades of potter, gardener, plate maker and likely others. The couple moved frequently, no doubt in search of economic opportunity and their first two children Annie and James were born in Staffordshire England. At some point prior to young Tom's birth in 1844 the family returned to Wales where the couple's last child, Elizabeth, was born in 1851. Six years later in July 1857 the Dees made a decision which would alter and shape their lives and those of their decedents. When they joined the American based Church of Jesus Christ of Latter- day Saints and became part of that intense conversion period sweeping the British Isles between 1837 and 1870. Not long after their baptism Thomas and Elizabeth decided to come to America. Apparently Tom's parents and siblings were baptized into their new faith earlier than he. As church records indicate he was baptized and confirmed just a few days prior to leaving England. His daughter Maud records that family lore held that " young Tom would stay at home reading and studying while the other attended church services. In the end," Maud added, " he was a better Mormon than any of them, because he understood what he believed." Many English Latter- day Saints during that time drew upon the church's Perpetual Emigrating Fund, the PEF, to provide the necessary financial 4 assistance to make the trip. From 1850 to 1887 that fund brought some 30,000 converts to America in the eighteenth century, including the family of David Eccles. The system allowed them to repay their loan over time through their labor once they had settled here in Utah. While some sources indicate that the Dees came with the help of PEF British mission records housed at the LDS Church Archives do not support this claim. It is possible that they may have received some assistance from some local church members in Wales or that the PEF aided them later in their journey. The Dee family left Liverpool on March 30th 1860 aboard the Underrider. Carrying as many provisions as possible or required by law, and paying the fare of some twenty- four English pounds. The ships manifest lists Thomas Hill Dee as a potter, Elizabeth as his wife, James as a plasterer and Tom as a joiner. Annie just barely twenty is listed as a spinster, tough crowd. A local band serenaded the departing vessel as the 600 passengers from Wales, England and Switzerland left port. The group was under the leadership of James D. Ross who was returning from his second mission to England and his counselors James Taylor, who will marry into the family, and John Croft. The Underrider arrived in New York on May 1st. During the voyage according to the Mormon publication the Millennial Star, " there were four deaths and four marriages and upon their arrival the health of the saints was generally good." Two days later the Dees set out for their destination of Florence, Nebraska not far from Omaha. From there the saints prepared for the final leg of their journey to the Great Basin. The company of 240, including both British and Swiss 5 immigrants as well as some U. S. citizens, left Florence on June 17th 1860, again under the leadership of James D. Ross. According to Church records the Dees were among those traveling on a church wagon train as opposed to a hand cart which the church was discontinuing during that period of time. The Ross Train arrived in the Salt Lake Valley three months later on September 3rd 1860. Unfortunately fifteen year old Tom kept no journal describing his trip across the plains. We do have however the reminiscence of Charles W. Nibley an eleven year old member of the same party. Nibley would immerge as an important church leader and business man and in later years a very close friend and business associate of Tom Dee's. Nibley recalled, quoting from his reminiscences, " The journey across the plains was of the usual ox team kind. There was little of special note that transpired. We traveled about ninety miles a week, which was an average of fifteen miles a day for six days a week. No traveling was done on the Sabbath. Of course there are inconveniences and more or less hardships in that mode of travel but I was a child and do not remember the hardship, on the contrary," he said, " I rather enjoyed the whole trip." In his reminiscences which were complied while Nibley was in his mid- 80' s he still vividly recalled walking barefoot across the plains sighting herds of buffalo and feasting as he says on their sweet meat. He also remembered the circling of the wagons, unrolling and rolling the bed rolls, and the Indians who were plentiful and sometimes he said " a little troublesome although we never had any conflict whatever with them." 6 No doubt Tom Dee shared similar memories of that trip, including the journeys end. The party camped near Parley's Summit and were greeted by Apostles George A. Smith, Wilford Woodruff, Lorenzo Snow and other leading brethren. The next Nibley recalled, " We came out of the canyon and on to the bench near Fort Douglas, and I could very well remember with what joy and pleasure each one of our company looked upon the growing city in the wilderness. We felt that all of our troubles and trial were practically at an end when, as a matter of fact, they had only just begun. The immigrants camped near what is presently the Salt Lake City and County Building then prepared to either stay there in Salt Lake City or move to one of the other outposts along the Mormon corridor. The Nibley family like the Dees headed north past the Great Salt Lake, which he noted " was very low that year." The wagon road from Salt Lake City lay considerably west of any green fields, right out in the alkali lake bottoms, as dry as a bone. While Nibely admitted he had no recollection of Ogden the Dees stopped to make their home. Tom Dee would spend the rest of his life here. Another aspect of the journey westward bears noting. About the time the Ross train made its final preparations for its final trip to Utah, another English convert, John Taylor, arrived at winter quarters with his wife Ann Faulkner Taylor, their two children and John's two daughters nine year old Mary and seven year old Annie, born to his first deceased wife Ann Standard. It is not clear whether Tom Dee and Annie Taylor met at this time. Annie records however that her train discovered a bleached buffalo skull which read, " Captain Ross Train passed here 7 July 15th. All is well." As we will see the paths of these two young people will definitely cross in the future. After getting settled Tom worked as a carpenter at times along with his brother in law James Taylor. He had learned carpentry skills as an apprentice in Wales and as noted he was listed on the Underrider's manifest as a joiner. Over time Dee became a successful building contractor as well, constructing both residential and commercial structures. Hard working and ingenious the young man began to make a mark in his community, but Tom Dees mind was not only on work. Tom had lived in Utah for a decade or so before he seriously considered Annie Taylor as a possible spouse. The two had met from time to time and according to some accounts at one family gathering Tom told the young Annie he was " gonna wait for you to grow up and then I'm gonna marry you." The Dee and Taylor families were close in part because as noted not long after their arrival in Utah Tom's sister Annie Dee had married James Taylor, Annie Taylor's uncle. Now gets a little confusing here, okay. Annie Dee Taylor and Annie Taylor Dee, hang with me here. In any event their courtship evidentially became serious around 1868 or so. In her charming book Memories of a Pioneer, Annie wrote that as a young girl she went to a Washington's Birthday dance in Salt Lake City where the dashing officers from Fort Douglass and their ladies added to the beautiful atmosphere. Tom Dee escorted Annie to this memorable party clad in his territorial militia uniform. Annie also recalled another Salt Lake event in January of 1870 celebrating a branch of the railroad from Ogden Tom and his mother 8 were in attendance. Annie remembered " Thanks to complimentary tickets from the railroad." At the conclusion of the celebration Annie and her sister rode the train to Ogden stayed a few days with the Dees and then returned to their Salt Lake home. The railroad she said, " Made people nearer neighbors." Reading between the lines, perhaps the railroad also facilitated a budding romance for on January 15th Thomas D. Dee wrote Annie's father John Taylor to request Annie's hand in marriage. We have this delightful letter and the reply to it in our Dee family collection here in the library and it's displayed in the back just for today. It goes back into the archives after today, in that cabinet back there. Tom wrote, " It has been known to you that for some time your daughter Annie and myself have been corresponding with each other, and that I have made occasional visits to her; well such things generally lead to something more important, and the object of this letter is to ask your consent for us to get married." Tom said that he didn't need to add more but hoped your favorable consideration. Actually I think it was the uniform. A few days later the perspective bridegroom had his answer when John Taylor replied that he could " find no reason why I should not give my consent to her to becoming your wife." Taylor told his future son in law he wished Annie to have a husband of her own choice, a man she could honor and respect. Therefore he wrote, " You have my permission and are at liberty to make your own arrangements." The marriage was performed on April 10, 1871 in a ceremony in the Endowment House in Salt Lake City when Brigham Young's counselor Neil H. Wells united twenty- six year old Thomas D. Dee and eighteen 9 year old Annie Taylor in marriage. The young couple then traveled to and settled in a two room adobe house on 22nd street, their home for the next decade. Over time as the family grew they need more space and relocated in Annie's word, " Out in the country" in a home near today's 8th street and Washington Boulevard. Even though he was working hard to support his family Tom Dee also took an interest in Ogden's civic affairs. Between 1879 and 1893 he served as assessor, alderman, Justice of the Peace, constable, and city councilman sometimes simultaneously. He became a municipal judge and thus was often referred to as Judge Dee. As his good friend Warren L. Wattis observed, " Dee served as a judged in the early days when the position had perplexities then financial rewards. He first allied with the Mormon controlled People's Party, but when politics was Americanized in the 1890' s Dee became a democrat. His daughter Maud called him, " a good democrat who discussed the Democratic Party as though it were a religion;" long time ago. During his adult life Tom Dee was an active and faithful Latter- day Saint. He spent more then thirty years serving as superintendent of the Sunday school in two different wards, but his efforts were not limited to Sunday alone. In June 1881, for example, Superintendent Dee led the saints of Ogden's third ward on a pleasant excursion to Lake Shore. The Ogden Standard reported that on the breezy shore of the Great Salt Lake ward members quote, " spent a most agreeable day sporting in the saline billows and on the grounds which have been much improved and embellished. Dancing was indulged in with vim, Watkins' band furnishing the musical accompaniment. The sports were diversified; 10 bathing, boat sailing, rifle shooting, swinging, etc," must have had a different meaning then. " And the pleasant party returned home in excellent spirits." In November of 1881 the Dee family relocated to the Mount Fort ward. Where Tom continued his service the Sunday school and later as a councilor to his brother in law Bishop James Taylor. His removal from the third ward was a sad day for ward members as a result they issued an elaborate framed scroll headed conomorea, and it too it to is displayed right here and if you have a chance I encourage you to take a look at it. It's really amazing. Dee was also active as a Weber Stake home missionary and as a high priest. As one considers Dees commitment to the Mormon faith, two questions arise. First it is interesting that he never served as a full time missionary a common occurrence for faithful men of the time. More importantly at a time when Latter- day Saint men were encouraged to take additional wives, some say as a sign of solidarity, Tom remained monogamous. This seems more than happenstance for Annie's father had three wives, including sisters he'd married after his first died. Tom's good friend David Eccles had entered into the principle as did many other local men. But it never seemed to have been on Tom's agenda. In any event Dee's commitment to the faith was never in doubt. Over time this friend David Eccles became a central figure in Tom Dee's professional life. It is not exactly clear when the two men first met. An article in the Deseret News implies that they became business partners as early as 1876, but other sources differ on that date. It is possible that the two men met around 1882 as Tom was leaving Ogden's third ward and David was moving in. Ogden 11 wasn't a huge town in those days, with a population of some 6,000 or so they may have known each other from a number of activities. They clearly known to each other by 1885 however, as both had served as Ogden alderman, Dee representing the fourth ward, Eccles representing the third. Business easily trumps civic service however as the many Dee- Eccles partnerships took shape. As Bertha Eccles later recalled, " Judge Dee occupied the closest association with David Eccles, More so that any other one." Initially their partnership evolved around lumbering, a natural for Dee as a carpenter and contractor. Overtime their business association broadened. A couple of things should be taken into account considering Dee's role in these business activities. First as vice president of Ogden's First National Bank he played a central role in the financing of many of these ventures. Second as I've examined the scope of Dee's business involvements I concur with the observation again from his good friend Warren Wattis, " No detail was too trivial, no task was too large to receive his personal attention." While it would be impossible to even list the many Eccles- Dee partnerships, not to mention others that involved Dee alone or with other partners, let me highlight just a few. One of the most important involved the Utah Canning Company. Organized by Isaac M. Pierce in 1888, the company grew steadily for several years but then went into bankruptcy in the recession of the mid- 1890' s as I think Tom mentioned earlier today was probably the second most severe depression in American history. Lots of people lost everything as a result. Toward the end of the decade in 1897, a group led by Eccles and Dee bring in a capital outlay of 12 $ 12,000 purchased the property and equipment and built a better facility and operated the company under the same name. Dee served as president of the reorganized company until his death eight years later. The company marketed its products under a number of brand names. One of the most prominent was Peirce's with red, blue and gold striped cans containing tomatoes, and catsup, and juice, and vegetables. But Utah Canning was perhaps best known for Peirce's Pork and Beans, sometimes called the daddy of them all. The company was also known for its rolly polly peas and temple brand tomatoes. At the same time Dee and Eccles also consolidated their holding in sugar, along with several other church and business leaders they created the Ogden Sugar Company on December 6th 1897 at a meeting held at the Weber County Courthouse. Upon the motion of H. H. Spencer, Dee was elected to chair this organizing meeting and later became the company's vice president. Additionally these men along with other created Logan Sugar and Lewiston Sugar Companies between 1897 and 1901. In 1902 the various companies were combined into Amalgamated Sugar. At that point the company produced 60,000 100 pound bags annually, while returning attractive dividends to investors. In 1900 Eccles and Dee formed the Ogden Rapid Transit Company, purchasing the Ogden Electric Railway Company which had gone into receivership. Under their control the company pushed ahead with a program of repair and modernization. Over the years this successful company expanded and improved the city street railways and extended service beyond the city itself. 13 For most of us here today however, it is Dee's involvement in Utah Construction that is of particular interest. He was the company's first president, a major shareholder and as the minutes demonstrate actively involved in company affairs. Moreover as Gene Sessions and Sterling Sessions write the immergence of Utah Construction brought Dee and Eccles into direct partnership with the Wattis brothers and marked the beginning of a long and fruitful relationship that would stretch across generations. Company records and other sources also reveal Dee's important relationship with all three brothers that stretch well beyond business to real friendship as well. While pursuing a successful business and political career Dee was also interested in improving the educational climate of his home town. Even though his own formal education was limited ranging from six week to two years depending on which source you consult, his daughter Maud noted that, " he was really an educated man because he was dedicated to self improvement and study. He loved literature, especially the classics and devoured good books." Not surprisingly he took an active role in developing a public library system here in Ogden. More over Tom Dee became the father of public education in this town, serving as a member of Ogden's school boards for thirty- five years. In 1890 Ogden schools were consolidated by the Utah Legislature into one district. Dee became a member of that first board and served as president of the board at the time of his death. It is also clear that Tom Dee was very popular with Ogden residence because of his efforts to further education. In fact as the Ogden Herald noted, " As Dee faced reelection to the board in November 1904 14 though a democrat, he would have gained the endorsement of Ogden republicans if the call from their convention had not distinctly specified that a republican candidate must be nominated." He won. As the Utah State Journal observed, " Dee always took a deep interest in educational matters, giving freely of his time and means to promote the welfare of public schools and his unselfish devotion to this great cause is at the root of the high standard of excellence of Ogden's schools." But Thomas D. Dee's life was not all work. Despite his many business, civic, political, and church responsibilities along with an abiding commitment to family he also really enjoyed life. His daughter Maud often describes him as " often buoyantly happy and a wonderful mixture of down right practical and idealistic. Though he could be a stern disciplinarian he delighted in his children and encouraged them in their pursuits." " He was," Maud admitted, " Not much of a dancer, but he danced just the same. Not much of a singer, but he sang just the same." And Dee played and loved to watch baseball. What more needs to be said? Despite this zest for living, Dee's life was not free of sadness and pain. Both of his parents died reasonably young, and he out lived his three siblings including his Elizabeth who died at the age of fifteen and the loss of his oldest child and his name sake Thomas Reese Dee who died in his early twenty's was devastating. Perhaps these sorrows these personal sorrows not only redoubled his efforts to uplift his family, but to improve Ogden as well. But his commitment to all of these concerns came to an abrupt end in July of 1905. While we do not 15 have any documentation to support it, one suspects that Tom, Annie and the children joined with other residence to observe that years July 4th celebrations according to the Ogden Standard, " the day broke clear and fine with scarcely a cloud in the sky and early parties could be seen working their way toward the canyon or boarding the street cars for a trip to the country," that would be the Dee- Eccles street cars you understand. Perhaps the Dees joined the largely attended celebration of Lester Park, which featured patriotic speeches and songs. If Tom picked up the Standard he would have seen and likely been offended by accounts of a meeting of radical unionist in Chicago, they had drafted a document favoring the general strike as the only means by which the working class could displace the capitalist class. He may have seen an account in the standard reporting the Western Pacific was considering dropping making Salt Lake City the eastern terminus of the railroad they projected building from Oakland to Oroville California and then east across Nevada. Perhaps in favor of Ogden, at least the paper reported the prospect of Ogden securing the road seemed brighter. Ultimately the Feather River route that we've talked about today became a major project that put the Utah Construction Company on the map as builders of western railroads. We do know that on Wednesday July 5th Dee along with H. H. Spencer and Mathew S. Browning took the latter's car to South Fork Canyon near Huntsville to look for additional sources of water for the growing city. As historians F. Ross Peterson and Bob Parson write, " As Ogden grew it suffered numerous epidemics of contagious disease and often people blamed the water 16 supply." In late 1879 the city council located a small reservoir on the bench to collect water from the springs there. A year later they constructed a reservoir on 24th street to collect more spring water. Pipes conveyed these waters to businesses along Washington Boulevard. In 1881 the Ogden Water Company controlled by the city piped water from Ogden Canyon to the city. Ogden's council bought out the water company in 1884 and then bought water rights to the streams coming from Strong and Waterfall Canyons east of the city. The fact that Dee and his colleagues were searching for additional water sources is understandable. For Dee had been interested in the question for many years. As early as 1881 he was nominated by Mayor Lester J. Herrick as a capable person to sit on the board of the Ogden Water Company and the council concurred. In 1900 the Ogden City council again called upon him to serve with a number of prominent citizens to advise them in matter of purchasing or building water works in Ogden City. Ultimately in October of that year, Dee was part of a group headed by David Eccles that purchased the financially strapped Ogden Water Works Company for an amount that would be paid in bonds of a reorganized company and ultimately the water works would be sold by Eccles to the city in 1908. Unfortunately Dee's commitment to Ogden indirectly led to his untimely death. A decade later Warren L. Wattis remembered the circumstances, " while undertaking assignment made for him, by him for the up building of Ogden," he wrote, " Dee slipped into a stream and contracted a sever cold. Initially Dee's condition did not seem grave and in fact his illness was not generally know, by 17 Friday July 7th however, when it became obvious that he was to ill to attend a regularly scheduled meeting of the board of education people were concerned. And in fact Dee's condition became the sole topic of conversation amongst the cities businessmen." In the early morning hours of July 9th surrounded by his wife and children, his physicians Edward M. Conroy, and Dr. Chester E. Coulter and two long time business associates H. H. Rolapt and C. C. Richards, Thomas D. Dee in Warren Wattis' words in the home he had builded with pride passed into the silent shadows of the dreamless sleep." Once the news of Dee's death was made public Ogden's citizens mourned as one. The funeral was held on July12th, using the words of Warren Wattis, " The mourners were of all creeds and conditions. The rich and the poor, the young and the old, the learned and the unlearned, the high and the humble, all united to do him honor." As mentioned, eulogies were given by Utah's Governor Cutler and LDS Church President Joseph F. Smith and others. The pallbearers included several of Dee's business associates, David Eccles, H. H. Spencer, C. W. Nibley, W. H. Wattis, and Neil Flygare. For Eccles Dee's death closed an important era of friendship and business success. In his taciturn way Eccles recorded the death in his day book for July 9th, simply noting, " Judge Dee died 1: 15 a. m." But the depths of his feelings were revealed in a death notice sent out by the First National Bank, " In the death of Mr. Dee this community suffers and almost irreparable loss." Dee's unexpected death also shook the leadership of companies like the Utah Construction Company and Amalgamated Sugar. 18 A special meeting of Utah Construction's board of director was held on August 7th 1905 at request of vice president W. H. Wattis to make an official announcement of Dee's death and to elect a successor. Adam Patterson was unanimously elected a member of the board and David Eccles upon the motion of James Pingree was elect president and he would direct the company until his own sudden death in 1912. At the same meeting W. H. Wattis suggested that a committee be appointed to draw resolution to respect to the memory of the late Judge Dee. Composed of Eccles, Joseph Clark and Warren L. Wattis the committee drafted a resolution to be embodied as part of the meeting and transmitted to the Dee family. It said in part that the company directors deplored the untimely death of their late president and cherishes his worthy of constant emulation. His ideals of personal and business honor, his unswerving loyalty to every trust and business obligation imposed upon him as an officer. And that they recognized the splendid ability and loyalty which he brought to the affairs of Utah Construction Company as important elements in the company's success. The resolution was signed by Warren L. Wattis and W. H. Wattis as secretary and vice president respectively. A month later a sadden board now under the direction of David Eccles met to approve the minutes and resolution of respect and to move on with company business, particularly the construction of that Feather River Route. Similar sentiments are found in the minutes of Amalgamated Sugar. This time Joseph F. Smith announced that, " On the ninth day of July A. D. it pleased providence to remove from our midst the honorable Thomas D. Dee." Smith 19 noted that, " The board had learned to appreciate and respect Judge Dee because of his many attributes and his decisive methods. He was an excellent supervisor of corporate interest because of his clear, just and impartial judgment. He was a distinctive conservative mind, building successfully where others hesitated or failed. He was a desirable associate because of his loveable and cheerful disposition. He was an esteemed citizen because of his broad mindedness and his devotion to his fellows and the interest in developing the country's resources." Smith went on to say that, " Dee's devotion to his wife and children had become proverbial among all who knew him and as a Christian his love for his neighbor was limited only by the universe." A committee consisting of H. H. Rollap, Fred Keisel, Adam Patterson, Joseph Howell and H. H. Spencer was appointed to deliver the resolution to the family. Stockholders Mathew S. Browning and W. H. Wattis were appointed to the board of directors to replace Dee as well as his long time friend Charles W. Nibley, who had resigned his post previously. H. H. Spencer who had moved to elect Dee chair at the company's original organizing meeting that I mentioned and recommended that he be his first vice president was selected to replace Dee himself as vice president. These appointments constituted the only items of business conducted at the meeting. Thomas D. Dee's tragic and untimely death did not forever end his impact on the Ogden community. In the years since his family has expanded on his commitment through a wide range of civic and philanthropic activities. Here in the Stewart Library we are particularly proud of our Thomas Dee reading room which is behind you. The Dee Events center, the site of sports, cultural and civic 20 activities, is prominent and popular. Perhaps the best known however is the hospital that bears the family name. Since its founding in 1911 this hospital has served the health needs of the local community, responded to new medical realities and provided employment to Ogden citizens. While we do not have sufficient time today to examine the many ways the decedents of Thomas D. Dee have acted in this communities best interest, it is abundantly clear that they too have been founders, builder and public servants. Thank you. © 2007 WSU Stewart Library, All rights reserved.

Part two of an interview with Settimio "Babe" Pellechia. Topics include: His children's education. The Italian traditions Babe's family tries to keep. Memories from Lincoln School. How Italians in Leominster were treated while Babe was growing up. Social clubs in the Leominster area. Babe's experience in World War II. His thoughts about September 11th. The Italian Colonial cooperative grocery store. Pride in being Italian. ; 1 SETTIMIO: … did very, very good from the hill. But no, we felt that he lacked the basic knowledge at the very beginning in schooling. The first three years were completely lost. But I think it was no fault of his. He couldn't see, and we didn't know it. We didn't know that he couldn't until one day we had an exam for some reason. He had glasses and he said, "Now I can see the blackboard now." We said, "Why didn't you say that before?" He said, "I thought everybody saw it," you know. So that could have been part of it, too, that he just didn't get it. We believe in education: my daughter had paid for her own education, my daughter went to Smith, and she got a graduate from Harvard. So education is the number one priority. We didn't have it. Isn't that something else? Going through, paying for all that education? LINDA: It is. It's remarkable. So it sounds almost as if it wasn't an option for them to work at the motel or… SETTIMIO: No, no. They had to go to school. They had, definitely. My daughter -- my son-in law -- my daughter always, because she was, she graduated out of Smith with a 3.9, so she just ate up school, and as far as I could -- she just -- I used to help her do her spelling, she insisted. You know, there are three columns of spelling and I'm supposed to bring them down. So what I would do is one night I just went in diagonal and I go back, and she said, "Dad, you missed a word." I said, "Well then, that's enough for me." The only thing that I didn't do with her, which was mean, was on math. She had to struggle for math. And one day she did her homework and she did -- everyone was wrong. 'Cause I always used to help her. So just one night I said, "I'm not going to let her get away with that." So it was all set [unintelligible - 00:02:08]. The next night she comes home crying, she said, "You made me get a zero!" I said, "No, you got the zero yourself. You didn't put anything into it." So then I would help her, but she would check. And if I knew she didn't find [unintelligible - 00:02:22], which was, I think even though that she got a zero, it helped her, I think. 2 LINDA: You were talking about Lincoln Terrace and how people had pigs and chickens and gardens. Did you and your wife do that also? SETTIMIO: My wife? LINDA: You and your wife. Did you keep gardens and chickens? SETTIMIO: With all that we had to do? No. LINDA: I could have guessed. I just wanted to know the different generation. SETTIMIO: Nope. My wife always liked that work that she did out there, and I liked what I did. You know? LINDA: Have you kept many of the traditions alive in your family? The Italian traditions? SETTIMIO: Naturally it kind of falls apart. We do a big Christmas meal. We [unintelligible - 00:03:23] children come over, or if they can't make it, because there are times they couldn't make it, [unintelligible - 00:03:29] Thanksgiving. But [unintelligible - 00:03:32] when my mother-in-law was living, we spent a lot of time with her on weekends and so forth. That was strictly all-Italian, you know. Her mom lived to be 99, and she did all the things like that. She was -- she could crochet a bedspread in one month, she'd do a whole bedspread. [Unintelligible - 00:04:00] doing her own cooking, 99 and doing her own cooking and everything. So that's it, but we've got the tradition with that. We got close to her like that. Actually, my parents were gone. You know, they died long before that. LINDA: Who was your closest friend growing up? SETTIMIO: My closest friend when? LINDA: When you were growing up in Leominster. SETTIMIO: In Lincoln Terrace we were all friends; all the guys were very friendly. We all went together. In fact, being in school, in Lincoln School, when I was in sixth grade, I had all I could do to get Cs in spelling and English and anything like that. You know, I just worked hard and I just gotta get a C. But in math I was always a straight A. So at the end of the year, when the principal would ask who was the smartest one in the class, and by all means, I wasn't the smartest, but all of Lincoln Terrace would vote for me, 3 so she got sort of mad. She said, "Now I know Settimio knows math, but we've got people smarter than him in all subjects. Now, we'll have one more vote. We will not have any election this year," she said. That's how close people were. LINDA: So you were going to school at…? SETTIMIO: Lincoln School. LINDA: So was it mostly Italians there? SETTIMIO: Yeah, that school was. LINDA: Do you remember the teachers? SETTIMIO: Mrs. Blunt was the Principal, Mrs. Taylor was the fifth grade, Mrs. Benz was special. I think the others were the younger ones: Mrs. Heinz and Mrs. Lane was there. I think they had newer ones too. But I have to say I don't think they were fair to the Italian people on different things. I like to see justice and so forth, and I don't think there was any justice in that school for the Italian people. LINDA: Can you give me an example? SETTIMIO: Hmm? LINDA: Can you give me an example? SETTIMIO: Just remarks they'd make and so forth. [Unintelligible - 00:06:25] school system. LINDA: That's right. There's a lot of Italians there. A lot of Italians were in education. So you were giving me an example, or you were about to give me an example of how you thought maybe some of the teachers weren't fair at Lincoln School? SETTIMIO: That's the feeling you'd get. Describing something now would be difficult, but in one case, even my brother, the teacher asked, "What makes a good centerpiece in every Italian home that had a bottle of wine on the table?" And he said that he got expelled for a week. They asked the question, and that was his honest answer. So that the -- that was one case that really stuck out when they did that. 4 LINDA: So it sounds as though the teachers really didn't know anything about the culture or the tradition. SETTIMIO: I don't think they cared either. LINDA: They didn't need to care until one became a principal. SETTIMIO: Like I said, I went there six years, and I'm not talking -- mostly the higher up, two old ladies were what they were by then. So old that you could just see it, remarks, much like my remarks and so forth that they… LINDA: Well, speaking about ethnic differences, did you notice anything in Leominster growing up? SETTIMIO: I noticed while we were growing up that people of Italian descent had a rough deal as far as city hall, the banks, especially. They never got a fair shake. Never during that whole time. The difference today is that almost all of our politicians are Polish or Italian, like when you see almost any principal, all but one is Italian. So that's the biggest difference that I can see that's happened. I had a banker tell me when I was billing up and the president of the bank said to me -- I wanted to get some money, to borrow some money, and he says, "You know, you can spoil a baby by giving him too much candy." I said, "I really didn't come here to get candy. I came here to get money." He said, "Well, you've done well. You should just stay where you are," and let it go like that. That's the banker telling me, so I says, "Well, I didn't come here for your opinion either." I said, "I'm still looking for money." So with that, he said, "Well you've got money in this bank." So while I'm sitting at the time, I just saw the door of the bank had gold leaf at that time, Capital, and so forth, Reserve. So I said, "Could you explain to me why the bank would need a reserve?" He said, "Well, you've got to draw," he says, you know, "on the money," he says we've gotta -- I said, "You're asking me to do something you yourself believe in? You want me to take my reserve of my savings and go with other reserves?" With that, he finally gave me the money. 5 But that's funny with banks, with banks I always find it funny you've got to have an answer for everything because they just try to talk you out of things. That's what they do. When I built the motel, that was the time when -- this is the other bank, Savings Bank -- they said, "We'd like to loan you the money. We feel you can do it, but we don't know about your wife. What would she be able to do?" I said, "My wife is able to -- I can prove to you -- my wife was all upset thinking I'd get the loan." He said, "Well, yeah." But I says I've got so much insurance policy, and the whole loan would be paid up with insurance policy. "Is that good enough, sir?" Security, and I got the money. So you had to play with them at that time, and I still think it was because of who we were. LINDA: When did you see that start to change? SETTIMIO: Hmm? LINDA: When did you see that start to change? SETTIMIO: They started dying off and the Italian population kept increasing. They all knew that group for what it is there. We've got to look at [unintelligible - 00:11:31]. I'm sorry I keep… LINDA: That's okay. SETTIMIO: In 25, 30 years we'll probably learn the same thing with the Spanish people. If they fill out the note they're going to be allowed to do what we did, and I hope they do as well as we did. LINDA: Did you see your children go through any of the hardship that you went through? SETTIMIO: No. No. They don't know what hardship is. LINDA: But they're successful anyway? SETTIMIO: Hmm? LINDA: But they are successful anyway? SETTIMIO: Yeah, yeah. They are, yeah. LINDA: Why do you think that is? SETTIMIO: Well, of course they knew they would always have whatever they need from us, and then we always ingrained in them to go out and do better and 6 keep doing things, like -- my daughter didn't take that much, she absorbs education. She was very, very good at that. My son, we had to kind of push him a little bit, but he's glad now that we did that because he notices a difference. LINDA: So did you feel it was equally important for your daughter to have an education? Did she go to Worcester Academy too? SETTIMIO: No. She didn't need it. She graduated with all these kids [unintelligible - 00:12:56] while we lived in Sterling. So, National Honors Society. She got it all as far as marks. LINDA: Would you like to tell me a little bit about the clubs that you had joined? SETTIMIO: The one was -- we mentioned the Italian Society on there. I'm somewhat disappointed it wasn't what it was supposed to be. I really thought what I wanted was a culture society, where we have -- where they teach Italian, where they have Italian plays and Italian speakers, and it didn't turn out that way. They spent a lot of money and made a big place out of it. It's almost -- which they hardly use it, but you need somebody coming in to pay for the bills. So I just call it a glorified ballroom now. So that wasn't -- I didn't like that too much. LINDA: I didn't take the information. Were there any clubs that you had joined in your younger years, or ones that your father and mother had belonged to? SETTIMIO: No, because they faded out. My father belonged to a couple of clubs but they pretty much starting fading out by the time we would be ready for that. I was really active in a lot of other things, charitable things. I've been Director of the Red Cross. I spent 22 years in a hospital as a cooperator trustee and on the executive board. I was President of the [unintelligible - 00:14:46] Club, which is a men's Rotary Club in Sterling. And then I did my bit as far as charity work and so forth. I felt someone's been very, very good to me, and that's why I got into the charitable end of it, to help out.7 LINDA: You see that continuing with this next generation? Do you see that volunteer, that commitment to give back to the community in the next generation? SETTIMIO: I really don't know. I hope they do. I know I really felt -- and I used to say I like that the hospital I fought for was doing something for the benefit of the people. I would always say so, you know. They were going to do certain things, and I said, "This would be better and cheaper." And that's all I could contribute until it started getting away -- I finally left when we got an administrator that just liked to spend money. So after 22 years I said, "You don't need to spend money. Anybody could spend money." So I resigned at that time. The Historical Society, I've been a Director there for years. I'm still on there right now. LINDA: How did -- has faith played an important part of your life? An important role in your life? SETTIMIO: What was that? LINDA: Faith? SETTIMIO: Absolutely. Absolutely. You've got to have faith, you have to be charitable, gotta be fair to one another. That's all really, really important, I feel. LINDA: Think that's an Italian cultural …? SETTIMIO: I've always thought of it that way, yep. See, but oftentimes you take some of the older people, I say that they probably could have done even better, but because they had to work to get to where they were, they just didn't have time for some of those things. So I think they would have been a lot better off, a lot better. I know that. Yeah. LINDA: Another question: getting back to the banks and maybe how they weren't fair enough, did the Leominster Credit Union play a big part in our helping, let's say, Italians in Leominster? SETTIMIO: Italians in Leominster? They were sympathetic to the Italian calling I'd say, but whether they helped or not I don't know that part. Credit-wise, I know they didn't help us in the building. Nobody had the opportunity to 8 sell them anything. And I said this to [Seth] at the time. He was [unintelligible - 00:17:46] he called me up, said, "Some people want to see you. You've got to make money." So the last time I said, "Do you even realize, Seth, that the only way that people will give you money is they've got to earn it?" He had taken me to this bank in New Haven. Not once did they even entertain taking in a bid from me. I said, "You won't be able to get money anymore." The Credit Union did this. I was a little bitter. But they had the opportunity, which I didn't like. I didn't think that was fair; that was -- probably that's one of the things that bothers me most about as long as you belong to when all our lives you got the big jobs. You work hard to get it. I know that my father, it never bothered him how much time he spent figuring jobs as long as he had the opportunity to bid on it. But when they didn't even give you that opportunity, and if you're high you just say "We can get it done cheaper," and that's the end of it. But don't just ignore them. Or even at the hospital, one time we got some bids for some work and a friend of mine asked, he wanted to bid the job. I said, okay, so I talked to the board, I said, "This, also, would like to bid the job." I says, "He's a low bidder. You'll want to give a job." He became the lone bidder and they didn't give him a job. You know, that night, I told them at the meeting, I said, "I don't think this -- I've done this all my life and I don't believe in it. You shouldn't have had him bid if you didn't want to give him the job, because it takes time and money to do that bid. It just isn't fair." LINDA: Just two more things: what was your hardest experience in your life? SETTIMIO: Three years in World War II. That was quite difficult. LINDA: Would you like to explain a little bit? SETTIMIO: Huh? LINDA: Would you like to explain a little bit or share a story? SETTIMIO: No, we're always a family in our own home, and to be away like that. And then under the conditions that you had to live in that you would think you 9 did. But you said the worst thing, that's doing that, although it turned out, I came back, no problems. But even then I worked -- I had to fight to get -- to the top. Now, I was in heavy artillery and, my job was handling 96-pound shells, and of course I just felt that there were better things in life than handling 96-pound shells. There was no future in it. So I hung out with the boys in the survey section, there were eight of them. They did the computing, running the transits, computing for these -- because we had this survey, anything you did on it. And I learned anything that there was to learn on it, and when OCS came, that's officer's training, they get anybody to go that likes to go, and of course the survey is supposedly the brains of the battalion, there's six of them that left for OCS. So I asked permission from -- through the first sergeant and my captain that I'd like to get on survey. And he was nice to me, real nice. He took me a bunch of papers like this here, and they had all these on all circled around, and then they put parts between them. And he said, "I'm going to shake this, and all the cards that fall out, if your name's in there, you can get on survey." My name didn't fall out. And he said, "Now let's see why." Ninth grade -- you have to be a minimum of a high school graduate to get on it, because it required trigonometry and you don't get trigonometry in the ninth grade. You get algebra but you don't get trig. So I said, "But I can do it." He said, "I can't promise you nothing." He said, "You stay with your shells." I still kept there, I started doing it, and I became the -- I became the chief computer -- the [unintelligible - 00:22:24] operator, which wasn't all too good with all the shell people in back now that I'm on the front-line. If we can see the enemy, they can see us. So the payoff. LINDA: I just want you to end with asking you about how you feel about September 11th, what's happening in the country now. SETTIMIO: Terrible, the whole thing is real, real uncalled for. I don't know why you'd have to do something like that. You know, it's murder -- it just gets 10 me that they, that they [unintelligible - 00:23:05] for the world and shelling them and killing civilians. What did they do? Kill 10 people, there's a big [unintelligible - 00:23:16] about it. They killed almost 6,000, let alone the damage. The damage can always be fixed, but lives -- life is gone, you know. Once it's gone, it's gone. So I don't know what the -- what's going to happen. We got to do something to -- somewhere along the line though we've changed. We used to -- every year, immigrants had to register at the post office. Why did they discontinue that in this country? I don't know if you remember that, do you? Every year you had to go to the post office if you were an immigrant, your address, what you're doing and so forth. So they actually were [unintelligible - 00:23:59] they knew where all -- if they still had that, they would know that these guys, number one, that their visas had gone past and so forth. LINDA: I often wonder what the veterans of let's say World War II feel about the men going to fight now, because at least you knew who the enemy was. SETTIMIO: You don't know who the enemy is in this. This is what they -- you have to fight their game, which isn't -- there again, it's not fair. [Unintelligible - 00:24:37] we fought the Germans. We knew what they did. They were in front of us, we were on one side, you knew what you were doing. But to have somebody you can -- somebody in your home and you got terrorists and just get information, the next day you could be gone. LINDA: Anything else you'd like to share? SETTIMIO: Huh? LINDA: Is there anything else you'd like to share with us? SETTIMIO: One of the other things I thought is -- you see that package right there? That little one right there? You organize this; you're at the grocery store. He closed his grocery store so the Italian Colonial could start. LINDA: What was the Italian Colonial? SETTIMIO: Huh?11 LINDA: I don't -- what was the Italian Colonial? SETTIMIO: A grocery store. LINDA: A grocery store? SETTIMIO: [Unintelligible - 00:25:28] be one up there and they became a cooperative. They all bought shares, and he moved his grocery store right next to the other one with all the stuff that we had, you know. We wanted to leave once they start that. LINDA: Well… SPEAKER 3: They were all Italians that got together and formed this cooperative, Colonial -- SETTIMIO: [Unintelligible - 00:25:54]. SPEAKER 3: And when they finally disbanded, they all formed their own little corner stores [unintelligible - 00:26:03]. LINDA: So what was they -- where did they get -- would they be growing their own produce and bring it in, and… SPEAKER 3: Some of them did that. SETTIMIO: Oh no, they bought it. They bought everything, like a legitimate store [unintelligible - 00:26:20] -- I keep moving this don't I? LINDA: That's okay though, that's not important. SETTIMIO: Yes it is, or you wouldn't have it. LINDA: Or I wouldn't touch it. You're right. SETTIMIO: No, but the -- he was very instrumental in helping on getting this Italian Colonial, because he -- number one, if he can close his store, [unintelligible - 00:26:40] but… and then the other thing was bringing the Italian Colonial, you know, the Lincoln Hall in Leominster, which is now Saint Anne's Church, they started the Lincoln Hall, I believe, when -- in 1926, I believe it was. And it was -- the main purpose of it was to naturalize as many Italians as they could. They wanted to move their building because at that time all the different Italians that come from different parts -- Italy was not unified at that time. 12 It wasn't unified until I think in 1961, '56 or something like that, but all these people -- if one club was running the hall, the other clubs wouldn't go. One of those things that they -- that's why the Lincoln Hall failed, contrary to what their remarks they made in the book in the office at Saint Anne's. They said they foreclosed on them -- they foreclosed because none of them would join it. They shouldn't have lost that, you know. LINDA: So why is it they wouldn't join? SPEAKER 3: Parts of Italy, [Forgia, Saladini, Graphinio] had their own [unintelligible - 00:28:05]. SETTIMIO: You could almost [unintelligible - 00:28:08] Boston and then New York and then somebody in Chicago. If the guy in Chicago is on the organization we don't want nothing to do with it, and New York we don't if we're doing it, they don't want to, and that's what happened to that Lincoln Hall, which we can't -- that was one of the bad things the Italian Colonial let go. We don't -- otherwise we wouldn't have Saint Anne's now. So everything turned out pretty well. LINDA: Like who was Lincoln Hall -- who was affiliated with Lincoln Hall, which group? SETTIMIO: All the Italians. LINDA: Oh, so it was a mixture. SPEAKER 3: The functions they would hold there, if one little group was holding a dance or a social event, the other groups stayed away. SETTIMIO: [Unintelligible - 00:28:51]. This is a letter that was written in 1929, as much of it is in Italian, I don't know if you can understand it. But what it is that unless the people joined and paid their dues, they're going to lose the hall. They didn't do it, so… SPEAKER 3: Sounds like your brother, your brother. SETTIMIO: [Unintelligible - 00:29:24]. LINDA: So you said they were trying to naturalize as many Italians as they could. So Italians from any region? SETTIMIO: [Unintelligible - 00:29:34].13 LINDA: In Leominster or any region? SPEAKER 3: Yes. Danny [Cato]? SETTIMIO: Huh? SPEAKER 3: Danny Cato was on this Italian American [unintelligible - 00:29:45]. SETTIMIO: This is the bleeding Italian Americans in Massachusetts. LINDA: Oh, that's an honor. That's your father, right? SPEAKER 3: Mm-hmm. LINDA: So Ann, do you have anything to add? Can you think of anything? SPEAKER 3: Oh, you were speaking about that cooperative grocery store. Is that where some of the people, when they sold out, they would open up their own store like Chet's Grocery, [unintelligible - 00:30:24], all those little stores? SETTIMIO: Nemo had a little store too. SPEAKER 3: Who did? SETTIMIO: Nemo also. SPEAKER 3: Nemo? SETTIMIO: Yeah, it was very lucrative. You hear [unintelligible - 00:30:35]. I'll just tell you a little story about that. My father wanted to get it going good and at the time [unintelligible - 00:30:43] made cash registers, and he had six-drawer cash registers, so each clerk would have to punch their own if they bought it. So my father suggested that the salesmen should go there and sell it, and maybe it would keep them honest, you know, they'd have their own cash box. So at the last minute, my father told the salesman the night of the meeting, he says, "Now don't get alarmed, I'm going to vote against it." He says, "You called me, and now you're going to vote against it?" He said, "If I vote for it, they won't buy it." They bought it, they never used it. LINDA: So the coop -- did different people sell different things? SETTIMIO: Oh no, it was all -- it was a regular store but it was just owned by a cooperative. SPEAKER 3: It was owned by all of them.14 SETTIMIO: This is interesting too, nothing to do with Leominster, but [unintelligible - 00:31:33] they had in Boston in 1492 when Columbus -- it was unbelievable what they did [unintelligible - 00:31:43] try and list it on that. But you see where they -- just the parade and all -- look the way they decorated their buildings. LINDA: Wow, this is to celebrate Columbus Day? SETTIMIO: Yeah, it's unbelievable. It's all parades and all that. There's a state house. It's so unusual. There were no Italians -- I went through this. I couldn't find an Italian name, but it was a big deal for Columbus. Now, in 1992, nothing was done. LINDA: Wow. I know with my children in school, nowadays there's a big discussion whether or not you should even celebrate Columbus Day. SETTIMIO: [Unintelligible - 00:32:28], mm-hmm. SPEAKER 3: But October is the Italian Heritage Month and they have functions going on almost every day, either here or in Boston or some other place where there are Italians. LINDA: That brings up something interesting though. Did you -- when growing up, did you feel proud of Christopher Columbus and that he was an Italian? Do you remember? SETTIMIO: We felt proud of anyone that was Italian. [Unintelligible - 00:33:00] proud of any American that's done unusual things. I don't feel too proud when they name a building for some politician that got paid all his life and had to -- 15, 20, 30 years they name a building after him. What did he contribute actually as far as for the benefit of the people? But we still keep doing that, you know. SPEAKER 3: There are a lot of things -- there are a lot of Italians that have contributed to the world as we see it today, as we know it today, in the arts and the music, and… SETTIMIO: Did you read the one that I had -- the Italian [unintelligible - 00:33:45]? Did you ever see that one? Yeah? LINDA: No, no… where did this come from? From an Italian American?15 SPEAKER 3: I think I saw this on the board at the Italian Center in Leominster. LINDA: Do your children consider themselves Italian American? SPEAKER 3: Oh yeah. SETTIMIO: I hope so. I know my daughter; she spent more time in Italy than she does here now. Sabbaticals and so forth. In fact she's going there for -- she just got a grant to go there with the grade eight students, give a lecture over there. [Unintelligible - 00:34:30] also, you know, different parts of Rome and Florence and [unintelligible - 00:34:36]. SPEAKER 3: She has a doctorate in Italian. She has a doctorate in Italian History. SETTIMIO: She can read even the old script Italian. She's really -- she spent a lot of time there. She spent six years in Florence, so she can really -- in fact my daughter's very thin and so forth. We went up to visit her one day and went to the grocery store, and I saw my daughter do something that she never did. She literally, with her little frame, pushed a big Italian lady in the line. I said, "Linda, where did you learn that?" She said, "Dad, I'll be at the end of the line all day if I didn't do that." That's what they do. So she learned she's got to get in there. SPEAKER 3: Make her way. LINDA: Where does she teach? SETTIMIO: University of Delaware. LINDA: Oh. SETTIMIO: Yeah. LINDA: Have you -- you ever gone back to Italy? SETTIMIO: Oh yeah. I've been there three times. My wife keeps going, but she goes a little more than I do, because women like to travel more than men. My wife likes to travel. She's been to Jerusalem three times. She's been to Kenya; we both went to South America. LINDA: Did you ever go back to the village of your father? SETTIMIO: Went back up to where my mother was born and where my father was, and also where she was born. You know that. LINDA: Well, thank you.16 SETTIMIO: That's all? We're done? LINDA: It was a long time, two hours. Aren't you tired? It's tiring. SETTIMIO: I just tried to accept what I'm going to do every year what my father did from 19-, from when he came here up until he passed away. I want to make it complete. [Unintelligible - 00:36:47] yeah. That's one project I got to do. The other project I got to do is I got a lot of movie pictures that I took, and I want to put those on VHS and break them down. I got the floods of '38, and I got parades and all that sort of stuff, and I got also Saint Anne's -- the opening of Saint Anne's dedication. SPEAKER 3: Very good history. SETTIMIO: I have a library, and I'm a collector [unintelligible - 00:37:23] stuff. I'm proud of a lot of it too. I got all the directories going back -- that's why it was so easy to do this. I have all these downstairs, these books. I also have it on Fitchburg, I go back Fitchburg 1880, and I keep buying local history, whatever I can get, or anything that originally was made in Leominster, so forth. [Unintelligible - 00:37:51] LINDA: It's interesting. SETTIMIO: The only thing is time is running out. LINDA: Oh, it seems like you come from a long line. It seems like people live a long time in your family. SETTIMIO: Well, they try to do it. Whether they make it or not, I don't know. Time will tell. LINDA: Well, don't give up. SPEAKER 3: Don't give up. SETTIMIO: Oh, no. SPEAKER 3: You have a lot of good work here. SETTIMIO: Huh? SPEAKER 3: You have a lot of good things here. LINDA: Did you mention to me that you had your mother's -- maybe your grandmother's wedding dress? SETTIMIO: Yes, I have it.17 SPEAKER 3: Your mother's or your grandmother's? SETTIMIO: My mother's. SPEAKER 3: Your mother's wedding dress. LINDA: Wow. SPEAKER 3: That was 19 -- what? What year? SETTIMIO: They got married what would be the year 1902, I think, or something like that. LINDA: Wow. SETTIMIO: Would you like to see it? LINDA: I'd like to. SETTIMIO: I think it's in the closet. LINDA: Okay, hold on. This is the end of the interview. /AT/pa/rjh/es

En mi formación de posgrado a finales de los años ochenta, teníamos cerca de treinta camas hospitalarias en un pabellón llamado "sépticas" (1). En Colombia, donde el aborto estaba totalmente penalizado, allí estaban mayoritariamente mujeres con abortos inseguros complicados. El enfoque que recibíamos era técnico: manejo de cuidados intensivos; realizar histerectomías, colostomías, resecciones intestinales, etc. En esa época algunas enfermeras eran monjas, y se limitaban a interrogar a las pacientes para que "confesaran" qué se habían hecho para abortar. Siempre me inquietó que las mujeres que salían vivas se iban sin ninguna asesoría, ni con un método anticonceptivo. Al preguntar alguna vez a uno de mis docentes me contestó con desdén: "este es un hospital de tercer nivel, esas cosas las hacen las enfermeras en primer nivel". Al ver tanto dolor y muerte, decidí hablar con las pacientes del servicio y empecé a entender sus decisiones. Recuerdo aún con tristeza tantas muertes, pero un caso en particular aún me duele: era una mujer cercana a los cincuenta años que llegó con una perforación uterina en estado de sepsis avanzada. A pesar de la cirugía y los cuidados intensivos, falleció. Alcancé a hablar con ella y me contó que era viuda, tenía dos hijos mayores y había abortado por "vergüenza con ellos", pues se iban a dar cuenta de que tenía vida sexual activa. A los pocos días de su fallecimiento, me llamó el profesor de patología, extrañado, para decirme que el útero que habíamos enviado para examen patológico no tenía embarazo. Era una mujer en estado perimenopáusico con una prueba de embarazo falsamente positiva, debido a los altos niveles de FSH/LH típicos de su edad. ¡¡¡NO ESTABA EMBARAZADA!!! No tenía menstruación porque estaba en premenopausia y una prueba falsamente positiva la llevó a un aborto inseguro. Claro, las lesiones causadas en las maniobras abortivas la llevaron al desenlace fatal, pero la real causa subyacente fue el tabú social respecto a la sexualidad. Tuve que ver muchas adolescentes y mujeres jóvenes salir del hospital vivas, pero sin útero, a veces sin ovarios y con colostomías, para ser despreciadas por una sociedad que les recriminaba el haber decidido no ser madres. Tuve que ver situaciones de mujeres que llegaban con sus intestinos protruyendo a través de sus vaginas por abortos inseguros. Vi mujeres que en su desespero se autoinfligieron lesiones tratando de abortar con elementos como palos, ramas, gajos de cebolla, barras de alumbre, ganchos, entre otros. Eran tantas las muertes que era difícil no tener por lo menos una mujer diariamente en la morgue a consecuencia de un aborto inseguro. En esa época no se abordaba la salud desde lo biopsicosocial sino solamente desde lo técnico (2); sin embargo, en las evaluaciones académicas que nos hacían, ante la pregunta de definición de salud, había que recitar el texto de la Organización Mundial de la Salud que involucraba estos tres aspectos, ¡qué contrasentido! Para dar respuesta a las necesidades de salud de las mujeres y garantizar sus derechos, cuando ya era docente, inicié el servicio de anticoncepción posevento obstétrico en ese hospital de tercer nivel. Hubo resistencia de las directivas, pero afortunadamente logré donaciones internacionales para la institución y esto facilitó su aceptación. Decidí concursar para carrera docente con el ánimo de poder sensibilizar a profesionales de la salud hacia un enfoque integral de la salud y la enfermedad. Cuando en 1994 se realizó la Conferencia Internacional de Población y Desarrollo (CIPD) en El Cairo ya llevaba varios años en la docencia, y cuando leí su Programa de Acción, encontré nombre para lo que estaba trabajando: derechos sexuales y derechos reproductivos. Empecé a incorporar en mi vida profesional y docente las herramientas que este documento me daba. Pude sensibilizar personas del Ministerio de Salud de mi país y trabajamos en conjunto recorriéndolo con un abordaje de derechos humanos en materia de salud sexual y reproductiva (SSR). Esta nueva mirada buscaba además de ser integral, dar respuesta a viejos problemas como la mortalidad materna, el embarazo en la adolescencia, la baja prevalencia anticonceptiva, el embarazo no planeado o no deseado o la violencia contra la mujer. Con otras personas sensibilizadas empezamos a permear con estos temas de SSR la Sociedad Colombiana de Obstetricia y Ginecología, algunas universidades y hospitales universitarios. Todavía seguimos dando la lucha en un país que a pesar de tantas dificultades ha mejorado muchos indicadores de SSR. Con la experiencia de haber trajinado en todas las esferas con estos temas, logramos con un puñado de colegas y amigas de la Universidad El Bosque crear la Maestría en Salud Sexual y Reproductiva, abierta a todas las profesiones, en la que rompimos varios paradigmas. Se inició un programa en el que la investigación cualitativa y cuantitativa tenían el mismo peso y algunos de los egresados del programa están ahora en posiciones de liderazgo en los entes gubernamentales e internacionales replicando modelos integrales. En la Federación Latinoamericana de Obstetricia y Ginecología (FLASOG) y en la Federación Internacional de Obstetricia y Ginecología (FIGO), pude por varios años aportar mi experiencia en los comités de SSR de esas asociaciones para beneficio de las mujeres y las niñas en los ámbitos regional y global. Cuando pienso en quienes me han inspirado en esta lucha, debo resaltar las grandes feministas que me han enseñado y acompañado en tantas batallas. No puedo mencionarlas a todas, pero he admirado la historia de vida de Margaret Sanger con su persistencia y mirada visionaria. Ella luchó durante toda su vida para ayudar a las mujeres del siglo XX para que obtuvieran el derecho a decidir si querían o no tener hijos o hijas y cuándo (3). De las feministas actuales he tenido el privilegio de compartir experiencias con Carmen Barroso, Giselle Carino, Debora Diniz y Alejandra Meglioli, lideresas de la Federación Internacional de Planificación de la Familia, Región del Hemisferio Occidental (IPPF-RHO, por su nombre en inglés). De mi país quiero resaltar a mi compatriota Florence Thomas, psicóloga, columnista, escritora y activista feminista colombo-francesa. Es una de las voces más influyentes e importantes del movimiento por los derechos de la mujer en Colombia y en la región. Arribó procedente de Francia en la década de 1960, en los años de la contracultura, los Beatles, los hippies, Simone de Beauvoir y Jean-Paul Sartre, época en la que se empezó a criticar el capitalismo y la cultura del consumo (4). Fue entonces cuando se comenzó a hablar del cuerpo femenino, la sexualidad femenina y cuando llegó la píldora anticonceptiva como una revolución total para las mujeres. A su llegada en 1967, ella experimentó un choque porque acababa de asistir a toda una revolución y solo encontró un país de madres, no de mujeres (5). Ese era el único destino de una mujer, ser callada y sumisa. Entonces se dio cuenta de que no se podía seguir así, hablando de "vanguardias revolucionarias" en un ambiente tan patriarcal. En 1986 con las olas del feminismo norteamericano y europeo, y con su equipo académico crearon el grupo Mujer y Sociedad de la Universidad Nacional de Colombia, semillero de grandes iniciativas y logros para el país (6). Ella ha liderado grandes cambios con su valentía, la fuerza de sus argumentos, y un discurso apasionado y agradable a la vez. Dentro de sus múltiples libros resalto Conversaciones con Violeta (7), motivado por el desdén hacia el feminismo de algunas mujeres jóvenes. Lo escribe a manera de diálogo con una hija imaginaria en el que, de una manera íntima, reconstruye la historia de las mujeres a través de los siglos y da nuevas luces sobre el papel fundamental del feminismo en la vida de la mujer moderna. Otro libro muestra de su valentía es Había que decirlo (8), en el que narra la experiencia de su propio aborto a sus 22 años en la Francia de los años sesenta. Mi experiencia de trabajo en la IPPF-RHO me ha permitido conocer líderes y lideresas de todas las edades en diversos países de la región, quienes con gran mística y dedicación, de manera voluntaria, trabajan por lograr una sociedad más equitativa y justa. Particularmente me ha impresionado la apropiación del concepto de derechos sexuales y reproductivos por parte de las personas más jóvenes, y esto me ha dado gran esperanza en el futuro del planeta. Seguimos con una agenda incompleta del Plan de acción de la CIPD de El Cairo, pero ver cómo la juventud enfrenta con valentía los retos, me motiva a seguir adelante y aportar mis años de experiencia en un trabajo intergeneracional. La IPPF-RHO evidencia un gran compromiso por los derechos y la SSR de adolescentes en sus políticas y programas, que son consistentes con lo que la Organización promueve; por ejemplo, el 20% de los puestos de toma de decisión están en manos de jóvenes. Las organizaciones miembros, que basan su labor en el voluntariado, son verdaderas incubadoras de jóvenes que harán ese recambio generacional inexpugnable y necesario. A diferencia de lo que nos tocó a muchos de nosotros, trabajar en esta complicada agenda de salud sexual y reproductiva sin bases teóricas, hoy vemos personas comprometidas y con una sólida formación para reemplazarnos. En la Facultad de Medicina de la Universidad Nacional de Colombia y en la Facultad de Enfermería de la Universidad El Bosque, las nuevas generaciones están más motivadas y empoderadas, con grandes deseos de cambiar las rígidas estructuras subyacentes. Nuestra gran preocupación son los embates de ultraderecha que soportan grupos antiderechos, muchas veces mejor organizados que nosotros, que sí apoyamos los derechos y somos verdaderos provida (9). Ante este escenario, debemos organizarnos mejor y seguir dando batallas para garantizar los derechos de las mujeres en el ámbito local, regional y global, aunando esfuerzos de todas las organizaciones proderechos. Estamos ahora comprometidos con los Objetivos de Desarrollo Sostenible (10), entendidos como aquellos que satisfacen las necesidades de la generación presente sin comprometer la capacidad de las generaciones futuras para satisfacer sus propias necesidades. Esta nueva agenda se basa en: - El trabajo no finalizado de los Objetivos de Desarrollo del Milenio - Los compromisos pendientes (convenciones ambientales internacionales) - Los temas emergentes en las tres dimensiones del desarrollo sostenible: social, económica y ambiental. Tenemos ahora 17 Objetivos de Desarrollo Sostenible y 169 metas (11). Entre estos objetivos se menciona en varias ocasiones el "acceso universal a la salud reproductiva". En el Objetivo 3 de esa lista se incluye garantizar, de aquí al año 2030, "el acceso universal a los servicios de salud sexual y reproductiva, incluidos los de planificación familiar, información y educación". De igual manera, el Objetivo 5, "Lograr la igualdad de género y empoderar a todas las mujeres y las niñas", establece que se deberá "asegurar el acceso universal a la salud sexual y reproductiva y los derechos reproductivos según lo acordado de conformidad con el Programa de Acción de la Conferencia Internacional sobre la Población y el Desarrollo, la Plataforma de Acción de Beijing". No se puede olvidar que el término acceso universal a la salud sexual y reproductiva incluye el acceso universal al aborto y la anticoncepción. Actualmente 830 mujeres mueren cada día por causas maternas prevenibles; de estos decesos, el 99% ocurre en países en desarrollo, más de la mitad en entornos frágiles y en contextos humanitarios (12). 216 millones de mujeres no pueden acceder a métodos de anticoncepción moderna y la mayoría vive en los nueve países más pobres del mundo y en un ambiente cultural propio de la década de los sesenta (13). Este número solo incluye las mujeres de 15 a 49 años en cualquier tipo de unión, es decir el número total es mucho mayor. Cumplir con los objetivos marcados supondría prevenir 67 millones de embarazos no deseados y reducir a un tercio las muertes maternas. Actualmente tenemos una alta demanda insatisfecha de anticoncepción moderna, con un bajísimo uso de los métodos de larga duración reversible (dispositivos intrauterinos e implantes subdérmicos) que son los más efectivos y de mayor adherencia (14). No hay uno solo de los 17 Objetivos de Desarrollo Sostenible donde la anticoncepción no tenga un papel preponderante: desde el primero que se refiere al fin de la pobreza, pasando por el quinto de igualdad de género, el décimo de reducción de la desigualdad, entre los países y en el mismo país, hasta el decimosexto relacionado con paz y justicia. Si queremos cambiar el mundo, debemos procurar acceso universal a la anticoncepción sin mitos ni barreras. Tenemos la obligación moral de lograr la erradicación de la pobreza extrema y avanzar en la construcción de sociedades más igualitarias, justas y felices. En anticoncepción de urgencia (AU), estamos muy lejos de alcanzar lo que esperamos. Si en métodos de larga duración reversible tenemos una baja prevalencia, en la AU la situación empeora. No en todas las facultades de medicina de la región se aborda este tema, y donde sí se hace, no hay homogeneidad de contenidos, ni siquiera dentro del mismo país. Hay aún mitos sobre su verdadero mecanismo de acción. Hay países como Honduras donde está prohibida y no hay un medicamento dedicado, como tampoco lo hay en Haití. Donde está disponible el acceso es ínfimo, particularmente entre las niñas, adolescentes, jóvenes, migrantes, afrodescendientes e indígenas. Hay que derrumbar las múltiples barreras para el uso eficaz de la anticoncepción de emergencia, y para eso necesitamos trabajar en romper mitos y percepciones erróneas, tabúes y normas culturales; lograr cambios en las leyes y normas restrictivas de los países; lograr acceso sin barreras a la AU; trabajar intersectorialmente; capacitar al personal de salud y la comunidad. Es necesario transformar la actitud del personal de salud en una de servicio por encima de sus propias opiniones. Reflexionando acerca de lo que ha pasado después de la CIPD realizada en El Cairo, su Programa de Acción cambió cómo miramos las dinámicas de población de un énfasis en la demografía a un enfoque en los derechos humanos y las personas. Los gobiernos acordaron que, en este nuevo enfoque, el éxito era el empoderamiento de las mujeres y la posibilidad de elegir a través de expandir el acceso a la educación, la salud, los servicios y el empleo, entre otros. Sin embargo, ha habido avances desiguales y persiste la inequidad en nuestra región, no se cumplieron todas las metas, los derechos sexuales y reproductivos continúan fuera del alcance de muchas mujeres (15). Aún queda un largo camino para recorrer, hasta que mujeres y niñas del mundo puedan reclamar sus derechos y la libertad de decidir. Globalmente la mortalidad materna se ha reducido, hay mayor asistencia calificada del parto, mayor prevalencia anticonceptiva, la educación integral en sexualidad y el acceso a servicios de SSR para adolescentes ya son derechos reconocidos y con grandes avances, además ha habido ganancias concretas en materia de marcos legales más favorables en particular en nuestra región; sin embargo, si bien las condiciones de acceso han mejorado, las legislaciones restrictivas de la región exponen a las mujeres más vulnerables a abortos inseguros. Hay aún grandes desafíos para que los gobiernos reconozcan la SSR y los DSR como parte integral de los sistemas de salud, existe una amplia agenda contra las mujeres. En ese sentido, el acceso a SSR está bajo amenaza y opresión, se requiere movilización intersectorial y litigios estratégicos, investigación y apoyo a los derechos de las mujeres como agenda intersectorial. Hacia adelante hay que esforzarnos más en el trabajo con jóvenes, para avanzar no solo en el Programa de Acción de la CIPD, sino en todos los movimientos sociales. Son uno de los grupos más vulnerables, y de los mayores catalizadores para el cambio. La población joven aún enfrentan muchos desafíos, especialmente las mujeres y niñas; las jóvenes están especialmente en alto riesgo debido a la falta de servicios y salud sexual y reproductiva amigables y confidenciales, la presencia de violencia basada en género y la falta de acceso a los servicios. Además hay que mejorar el acceso al aborto; es responsabilidad de los estados garantizar la calidad y seguridad en el acceso. Aún en nuestra región existen países con marcos totalmente restrictivos. Las nuevas tecnologías facilitan el autocuidado (16), lo que permitirá ampliar el acceso universal, pero los gobiernos no pueden desvincularse de su responsabilidad. El autocuidado se está expandiendo en el mundo y puede ser estratégico para llegar a las poblaciones más vulnerables. Hay nuevos desafíos para los mismos problemas, que requieren una reinterpretación de las medidas necesarias para garantizar los DSR de todas las personas, en particular mujeres, niñas y en general las poblaciones marginadas y vulnerables. Es necesario tener en cuenta aspectos como las migraciones, el cambio climático, el impacto de medios digitales, el resurgimiento de discursos de odio, la opresión, la violencia, la xenofobia, la homo/transfobia y otros problemas emergentes, pues la SSR debe verse en un marco de justicia, y no aislado. Debemos exigir rendición de cuentas a los 179 gobiernos que participaron en la CIPD hace 25 años y a los 193 países que firmaron los Objetivos de Desarrollo Sostenible. Deben reafirmarse en sus compromisos y expandir la agenda a los temas no considerados en ese momento. Nuestra región ha dado ejemplo al mundo con el Consenso de Montevideo, que se convierte en una hoja de ruta para el cumplimiento del plan de acción de la CIPD y no debe permitirnos retroceder. Este Consenso pone en el centro a las personas, en especial a las mujeres, e incluye el tema de aborto invitando a los estados a que consideren la posibilidad de legalizarlo, lo que abre la puerta para que los gobiernos de todo el mundo reconozcan que las mujeres tienen el derecho a decidir sobre la maternidad. Este Consenso es mucho más inclusivo: Considerando que las brechas en salud continúan sobresalientes en la región y las estadísticas promedio suelen ocultar los altos niveles de mortalidad materna, de infecciones de transmisión sexual, de infección por VIH/SIDA y de demanda insatisfecha de anticoncepción entre la población que vive en la pobreza y en áreas rurales, entre los pueblos indígenas y las personas afrodescendientes y grupos en condición de vulnerabilidad como mujeres, adolescentes y jóvenes y personas con discapacidad, acuerdan: 33-Promover, proteger y garantizar la salud y los derechos sexuales y los derechos reproductivos para contribuir a la plena realización de las personas y a la justicia social en una sociedad libre de toda forma de discriminación y violencia. 37-Garantizar el acceso universal a servicios de salud sexual y salud reproductiva de calidad, tomando en consideración las necesidades específicas de hombres y mujeres, adolescentes y jóvenes, personas LGBT, personas mayores y personas con discapacidad, prestando particular atención a personas en condición de vulnerabilidad y personas que viven en zonas rurales y remotas y promoviendo la participación ciudadana en el seguimiento de los compromisos. 42-Asegurar, en los casos en que el aborto es legal o está despenalizado en la legislación nacional, la existencia de servicios de aborto seguros y de calidad para las mujeres que cursan embarazos no deseados y no aceptados e instar a los demás Estados a considerar la posibilidad de modificar las leyes, normativas, estrategias y políticas públicas sobre la interrupción voluntaria del embarazo para salvaguardar la vida y la salud de mujeres adolescentes, mejorando su calidad de vida y disminuyendo el número de abortos (17). ; In my postgraduate formation during the last years of the 80's, we had close to thirty hospital beds in a pavilion called "sépticas" (1). In Colombia, where abortion was completely penalized, the pavilion was mostly filled with women with insecure, complicated abortions. The focus we received was technical: management of intensive care; performance of hysterectomies, colostomies, bowel resection, etc. In those times, some nurses were nuns and limited themselves to interrogating the patients to get them to "confess" what they had done to themselves in order to abort. It always disturbed me that the women who left alive, left without any advice or contraceptive method. Having asked a professor of mine, he responded with disdain: "This is a third level hospital, those things are done by nurses of the first level". Seeing so much pain and death, I decided to talk to patients, and I began to understand their decision. I still remember so many deaths with sadness, but one case in particular pains me: it was a woman close to being fifty who arrived with a uterine perforation in a state of advanced sepsis. Despite the surgery and the intensive care, she passed away. I had talked to her, and she told me she was a widow, had two adult kids and had aborted because of "embarrassment towards them" because they were going to find out that she had an active sexual life. A few days after her passing, the pathology professor called me, surprised, to tell me that the uterus we had sent for pathological examination showed no pregnancy. She was a woman in a perimenopausal state with a pregnancy exam that gave a false positive due to the high levels of FSH/LH typical of her age. SHE WAS NOT PREGNANT!!! She didn't have menstruation because she was premenopausal and a false positive led her to an unsafe abortion. Of course, the injuries caused in the attempted abortion caused the fatal conclusion, but the real underlying cause was the social taboo in respect to sexuality. I had to watch many adolescents and young women leave the hospital alive, but without a uterus, sometime without ovaries and with colostomies, to be looked down on by a society that blamed them for deciding to not be mothers. I had to see situation of women that arrived with their intestines protruding from their vaginas because of unsafe abortions. I saw women, who in their despair, self-inflicted injuries attempting to abort with elements such as stick, branches, onion wedges, alum bars and clothing hooks among others. Among so many deaths, it was hard not having at least one woman per day in the morgue due to an unsafe abortion. During those time, healthcare was not handled from the biopsychosocial, but only from the technical (2); nonetheless, in the academic evaluations that were performed, when asked about the definition of health, we had to recite the text from the International Organization of Health that included these three aspects. How contradictory! To give response to the health need of women and guarantee their right when I was already a professor, I began an obstetric contraceptive service in that third level hospital. There was resistance from the directors, but fortunately I was able to acquire international donations for the institution, which facilitated its acceptance. I decided to undertake a teaching career with the hope of being able to sensitize health professionals towards an integral focus of health and illness. When the International Conference of Population and Development (ICPD) was held in Cairo in 1994, I had already spent various years in teaching, and when I read their Action Program, I found a name for what I was working on: Sexual and Reproductive Rights. I began to incorporate the tools given by this document into my professional and teaching life. I was able to sensitize people at my countries Health Ministry, and we worked together moving it to an approach of human rights in areas of sexual and reproductive health (SRH). This new viewpoint, in addition to being integral, sought to give answers to old problems like maternal mortality, adolescent pregnancy, low contraceptive prevalence, unplanned or unwanted pregnancy or violence against women. With other sensitized people, we began with these SRH issues to permeate the Colombian Society of Obstetrics and Gynecology, some universities, and university hospitals. We are still fighting in a country that despite many difficulties has improved its indicators of SRH. With the experience of having labored in all sphere of these topics, we manage to create, with a handful of colleagues and friend at the Universidad El Bosque, a Master's Program in Sexual and Reproductive Health, open to all professions, in which we broke several paradigms. A program was initiated in which the qualitative and quantitative investigation had the same weight, and some alumni of the program are now in positions of leadership in governmental and international institutions, replicating integral models. In the Latin American Federation of Obstetrics and Gynecology (FLASOG, English acronym) and in the International Federation of Obstetrics and Gynecology (FIGO), I was able to apply my experience for many years in the SRH committees of these association to benefit women and girls in the regional and global environments. When I think of who has inspired me in these fights, I should highlight the great feminist who have taught me and been with me in so many fights. I cannot mention them all, but I have admired the story of the life of Margaret Sanger with her persistence and visionary outlook. She fought throughout her whole life to help the women of the 20th century to be able to obtain the right to decide when and whether or not they wanted to have children (3). Of current feminist, I have had the privilege of sharing experiences with Carmen Barroso, Giselle Carino, Debora Diniz and Alejandra Meglioli, leaders of the International Planned Parenthood Federation – Western Hemisphere Region (IPPF-RHO). From my country, I want to mention my countrywoman Florence Thomas, psychologist, columnist, writer and Colombo-French feminist. She is one of the most influential and important voices in the movement for women rights in Colombia and the region. She arrived from France in the 1960's, in the years of counterculture, the Beatles, hippies, Simone de Beauvoir, and Jean-Paul Sartre, a time in which capitalism and consumer culture began to be criticized (4). It was then when they began to talk about the female body, female sexuality and when the contraceptive pill arrived like a total revolution for women. Upon its arrival in 1967, she experimented a shock because she had just assisted in a revolution and only found a country of mothers, not women (5). That was the only destiny for a woman, to be quiet and submissive. Then she realized that this could not continue, speaking of "revolutionary vanguards" in such a patriarchal environment. In 1986 with the North American and European feminism waves and with her academic team, they created the group "Mujer y Sociedad de la Universidad Nacional de Colombia", incubator of great initiatives and achievements for the country (6). She has led great changes with her courage, the strength of her arguments, and a simultaneously passionate and agreeable discourse. Among her multiple books, I highlight "Conversaciones con Violeta" (7), motivated by the disdain towards feminism of some young women. She writes it as a dialogue with an imaginary daughter in which, in an intimate manner, she reconstructs the history of women throughout the centuries and gives new light of the fundamental role of feminism in the life of modern women. Another book that shows her bravery is "Había que decirlo" (8), in which she narrates the experience of her own abortion at age twenty-two in sixty's France. My work experience in the IPPF-RHO has allowed me to meet leaders of all ages in diverse countries of the region, who with great mysticism and dedication, voluntarily, work to achieve a more equal and just society. I have been particularly impressed by the appropriation of the concept of sexual and reproductive rights by young people, and this has given me great hope for the future of the planet. We continue to have an incomplete agenda of the action plan of the ICPD of Cairo but seeing how the youth bravely confront the challenges motivates me to continue ahead and give my years of experience in an intergenerational work. In their policies and programs, the IPPF-RHO evidences great commitment for the rights and the SRH of adolescent, that are consistent with what the organization promotes, for example, 20% of the places for decision making are in hands of the young. Member organizations, that base their labor on volunteers, are true incubators of youth that will make that unassailable and necessary change of generations. In contrast to what many of us experienced, working in this complicated agenda of sexual and reproductive health without theoretical bases, today we see committed people with a solid formation to replace us. In the college of medicine at the Universidad Nacional de Colombia and the College of Nursing at the Universidad El Bosque, the new generations are more motivated and empowered, with great desire to change the strict underlying structures. Our great worry is the onslaught of the ultra-right, a lot of times better organized than us who do support rights, that supports anti-rights group and are truly pro-life (9). Faced with this scenario, we should organize ourselves better, giving battle to guarantee the rights of women in the local, regional, and global level, aggregating the efforts of all pro-right organizations. We are now committed to the Objectives of Sustainable Development (10), understood as those that satisfy the necessities of the current generation without jeopardizing the capacity of future generations to satisfy their own necessities. This new agenda is based on: - The unfinished work of the Millennium Development Goals - Pending commitments (international environmental conventions) - The emergent topics of the three dimensions of sustainable development: social, economic, and environmental. We now have 17 objectives of sustainable development and 169 goals (11). These goals mention "universal access to reproductive health" many times. In objective 3 of this list is included guaranteeing, before the year 2030, "universal access to sexual and reproductive health services, including those of family planning, information, and education." Likewise, objective 5, "obtain gender equality and empower all women and girls", establishes the goal of "assuring the universal access to sexual and reproductive health and reproductive rights in conformity with the action program of the International Conference on Population and Development, the Action Platform of Beijing". It cannot be forgotten that the term universal access to sexual and reproductive health includes universal access to abortion and contraception. Currently, 830 women die every day through preventable maternal causes; of these deaths, 99% occur in developing countries, more than half in fragile environments and in humanitarian contexts (12). 216 million women cannot access modern contraception methods and the majority live in the nine poorest countries in the world and in a cultural environment proper to the decades of the seventies (13). This number only includes women from 15 to 49 years in any marital state, that is to say, the number that takes all women into account is much greater. Achieving the proposed objectives would entail preventing 67 million unwanted pregnancies and reducing maternal deaths by two thirds. We currently have a high, unsatisfied demand for modern contraceptives, with extremely low use of reversible, long term methods (intrauterine devices and subdermal implants) which are the most effect ones with best adherence (14). There is not a single objective among the 17 Objectives of Sustainable Development where contraception does not have a prominent role: from the first one that refers to ending poverty, going through the fifth one about gender equality, the tenth of inequality reduction among countries and within the same country, until the sixteenth related with peace and justice. If we want to change the world, we should procure universal access to contraception without myths or barriers. We have the moral obligation of achieving the irradiation of extreme poverty and advancing the construction of more equal, just, and happy societies. In emergency contraception (EC), we are very far from reaching expectations. If in reversible, long-term methods we have low prevalence, in EC the situation gets worse. Not all faculties in the region look at this topic, and where it is looked at, there is no homogeneity in content, not even within the same country. There are still myths about their real action mechanisms. There are countries, like Honduras, where it is prohibited and there is no specific medicine, the same case as in Haiti. Where it is available, access is dismal, particularly among girls, adolescents, youth, migrants, afro-descendent, and indigenous. The multiple barriers for the effective use of emergency contraceptives must be knocked down, and to work toward that we have to destroy myths and erroneous perceptions, taboos and cultural norms; achieve changes in laws and restrictive rules within countries, achieve access without barriers to the EC; work in union with other sectors; train health personnel and the community. It is necessary to transform the attitude of health personal to a service above personal opinion. Reflecting on what has occurred after the ICPD in Cairo, their Action Program changed how we look at the dynamics of population from an emphasis on demographics to a focus on the people and human rights. The governments agreed that, in this new focus, success was the empowerment of women and the possibility of choice through expanded access to education, health, services, and employment among others. Nonetheless, there have been unequal advances and inequality persists in our region, all the goals were not met, the sexual and reproductive goals continue beyond the reach of many women (15). There is a long road ahead until women and girls of the world can claim their rights and liberty of deciding. Globally, maternal deaths have been reduced, there is more qualified assistance of births, more contraception prevalence, integral sexuality education, and access to SRH services for adolescents are now recognized rights with great advances, and additionally there have been concrete gains in terms of more favorable legal frameworks, particularly in our region; nonetheless, although it's true that the access condition have improved, the restrictive laws of the region expose the most vulnerable women to insecure abortions. There are great challenges for governments to recognize SRH and the DSR as integral parts of health systems, there is an ample agenda against women. In that sense, access to SRH is threatened and oppressed, it requires multi-sector mobilization and litigation strategies, investigation and support for the support of women's rights as a multi-sector agenda. Looking forward, we must make an effort to work more with youth to advance not only the Action Program of the ICPD, but also all social movements. They are one of the most vulnerable groups, and the biggest catalyzers for change. The young population still faces many challenges, especially women and girls; young girls are in particularly high risk due to lack of friendly and confidential services related with sexual and reproductive health, gender violence, and lack of access to services. In addition, access to abortion must be improved; it is the responsibility of states to guarantee the quality and security of this access. In our region there still exist countries with completely restrictive frameworks. New technologies facilitate self-care (16), which will allow expansion of universal access, but governments cannot detach themselves from their responsibility. Self-care is expanding in the world and can be strategic for reaching the most vulnerable populations. There are new challenges for the same problems, that require a re-interpretation of the measures necessary to guaranty the DSR of all people, in particular women, girls, and in general, marginalized and vulnerable populations. It is necessary to take into account migrations, climate change, the impact of digital media, the resurgence of hate discourse, oppression, violence, xenophobia, homo/transphobia, and other emergent problems, as SRH should be seen within a framework of justice, not isolated. We should demand accountability of the 179 governments that participate in the ICPD 25 years ago and the 193 countries that signed the Sustainable Development Objectives. They should reaffirm their commitments and expand their agenda to topics not considered at that time. Our region has given the world an example with the Agreement of Montevideo, that becomes a blueprint for achieving the action plan of the CIPD and we should not allow retreat. This agreement puts people at the center, especially women, and includes the topic of abortion, inviting the state to consider the possibility of legalizing it, which opens the doors for all governments of the world to recognize that women have the right to choose on maternity. This agreement is much more inclusive: Considering that the gaps in health continue to abound in the region and the average statistics hide the high levels of maternal mortality, of sexually transmitted diseases, of infection by HIV/AIDS, and the unsatisfied demand for contraception in the population that lives in poverty and rural areas, among indigenous communities, and afro-descendants and groups in conditions of vulnerability like women, adolescents and incapacitated people, it is agreed: 33- To promote, protect, and guarantee the health and the sexual and reproductive rights that contribute to the complete fulfillment of people and social justice in a society free of any form of discrimination and violence. 37- Guarantee universal access to quality sexual and reproductive health services, taking into consideration the specific needs of men and women, adolescents and young, LGBT people, older people and people with incapacity, paying particular attention to people in a condition of vulnerability and people who live in rural and remote zone, promoting citizen participation in the completing of these commitments. 42- To guarantee, in cases in which abortion is legal or decriminalized in the national legislation, the existence of safe and quality abortion for non-desired or non-accepted pregnancies and instigate the other States to consider the possibility of modifying public laws, norms, strategies, and public policy on the voluntary interruption of pregnancy to save the life and health of pregnant adolescent women, improving their quality of life and decreasing the number of abortions (17).

The College Metcuty. VOL. IV. GETTYSBURG, PA., JULY, 1896. No. 5. THE COLLEGE MEfiCUftr, Published each month during the college year by the Students of Pennsylvania (Gettysburg) College. STAFF. Editor: ROB3IN B. WOLF, '97. Associate Editors : LEWIS C. MANGES, '97. ED. W. MEISENHELDER, '98. SAMUEL J. MILLER '97. CHARLES T. JOHN W. OTT, '97. CHARLES H. E. L. KOLLER, '98. LARK TILP, Alumni Association Editor: REV. D. FRANK GARLAND, A. M., Baltimore, Md. Business Manager: HARRY R, SMITH, '97. Assistant Business Manager: JOHN E. MEISENHELDER, '97. -n.-.iru ("One volume (ten months). U'UMS-\Slngle copies Finable is advance. $1,110 .15 AH Students are requested to hand us matter tor publication. The Alumni and ex-members or the College will favor us by sending information concerning their whereabouts or any items they may think would be interesting for publication. All subscriptions and business matters should be addressed to the business manager. , Matter intended for publication should be addressed to the Editor Address, THE COLLEGE MEKCUHY, Gettysburg, Pa! CONTENTS. ABSTRACT or BACCALAUREATE SERMON, - 66 THE PLACE or THE Y. M. C. A. IN THE \ ,R SOCIOLOGY OF THE COLLEGE, | CLASS-DAY EXERCISES, . - --- 71 CLASS-DAY POEM, - 71 JUNIOR ORATORICAL CONTEST, - 71 HOME, SWEET HOME. - 71 ROLL OF HONOR, - - -.- - - - - - -74 COLLEGE COMMENCEMENT PROGRAM. --- 74 DEGREES. -74 SPECIAL ANNOUNCEMENT, - - 75 ALUMNI NOTES, 75 SrF.ciAL ANNOUNCEMENT, - - - 77 COLLEGE LOCALS, -' --- . 77 ATHLETICS, 79 HOTEL LOOKOUT, --81 ABSTRACT OF BACCALAUREATE SERMON. BY II. W. MCKNIGHT, D D., IX. D. li'h- 8: 5. "See, saith He, that thou make all things according to the pattern showed to thee in the Mount." These words relate to the building of the tabernacle in the wilderness. It was to sub-serve such great purposes in the camp of the chosen people that God himself had revealed the pattern of it to Moses on Mount Sinai, in-dicating and fixing both its general plan and its minutest details, and saying to him : "See that thou make all things according- to the pattern showed to thee.'' Moses was, first, to grasp clearly the plan, the ideal. He was to go to his work, not aimlessly, but knowing what he was to do and how he was to do it. Definiteness of plan, distinctness of ideal, and fidelity to it were to him the esseutialconditions of success. The lessons thus taught are easily discerned. They are applicable now and here. You, my young friends, are about to go down from a veritable mount of privilege and preparatory training to engagements and a mission that have been fixed for you in the divine plan. Your intended work is to be constructive. You are to be builders in a very high and real sense—builders of character, organizers and constructors of a lifework as solemn in its im-port as destiny and as enduring as the endless cycles of eternity. Nor are you left to guess what you are to do and how you are to do it. God, who has built the universe and formed its myriad and minutest parts together in a comprehensive and harmonious plan, whose purpose shines in every star, blooms in every flower, is enfolded in every seed and finds ex-pression in every voice of nature, has his plan, also, for your life and work. He has embod-ied it for your guidance in the precepts and principles of His word. He has revealed it 67 THE COLLEGE MERCURY. most clearly and impressively in the spotless example of His Son. He has brought you up to that other mount of latest and sweetest reve-lation, the mount of the cross, that you might with open-face behold and with grateful hearts love the heavenly pattern of living and work-ing. Fidelity to this divine ideal is central and all inclusive in your preparation for life. To ignore it is the madness of turning from light to darkness. To practically neglect it will be to repeat the fatal mistake of the foolish builder who "built his house upon the sand," and whose plans and efforts and hopes came to naught in the ruin wrought by the tempest's and torrent's fury. Speaking to you, therefore, in the name of your instructors and delivering to you the final and affectionate charge of the institution, whose training you have received, permit me to set before you the pattern of a true life, to urge you to embody it in the ideal, and plans you form for your work, and to re-peat to you the solemn injunction : "See that you make all things according to it.'' He then presented and discussed the ideal of a true life as ist. The subordination of the material to the spiritual. 2nd. The embodiment of beneficence. 3rd. Having as its radiant centre—its Holy of Holies, God, his will, grace and glory. After discussing these points he addressed the class as follows : "My young friends of the class of'96: In sending you forth now, the Institution is concerned, not only for what you will do, but also for the spirit in which you will do it. It would have you adopt as the stand-ard by which you will measure your achieve-ments a high and worthy ideal and aim. What you will do, the spheres you will fill, will be determined largely by your endowments and opportunities, by circumstances not always within your control. You may not be per-mitted to choose what you will do, but you can determine the spirit in which you will do it. This, more than anything else, will settle the question of your worthiness and real suc-cess. Ideals and aims, whether right or wrong, true or false, lofty or low, though but neutral facts, mere abstractions, become a vitalized force to those who make them their own—a power to be measured only by the comprehen-siveness and reach of the principles involved. Whether in the form of proverbs, mottoes or doctrine, they have masterful force. Men bow before them as the ripened corn before the au-tumn winds. How the recent re-statement of the Monroe doctrine, our nation's ideal for this continent, and its interposition against the ag-gression of England roused the people with readiness to subordinate to it all other interests and to defend it at any cost : "Freedom for the American slave," too, was once only an abstraction, and those who cherished it were decried as wild enthusiasts, but it asserted its sway and, through the proclamation of Presi-dent Lincoln and the victories of the Union arms, became a sublime reality in the disen-thrallment of swarthy millions. Of the Puri-tans, whose unswerving devotion to truth and the principles of liberty once made them seem so visionary, whose name has become familiar as any household word in the homes of free-dom, and whose imperishable memorial is the civil and religious liberty of England and America. Macaulay, tracing the power that swayed them to its source, has well said: "They derived their character from the daily contemplation of superior beings and eternal interests." All history attests the fact that all men who have done the best and largest work first wrought out in thought the pattern of their work. They anticipated the end from the beginning and set their aims toward it as the pilot holds the prow of his ship towards the harbor beyond the sea. Greatness and steadiness of aim impelled Paul and Luther to heroic deeds and made them a world-wide force. The loftiness of their ideals drew them up with increasing strength into spheres of sub-limest achievement. Nor can you come into excellence of char-acter and work in any other way. "Purpose," it has been wisely said, "is what gives life a meaning." It rouses and directs the energies, THE COLLEGE MERCURY. 68 and prevents drifting. Bind your life to that which is great and good, and greatness and goodness will be your enduring portion. A worthy ideal will give its ennobling impress to vour character and work, in any sphere, even as the beauty of the blossom is determined by the colors laid at the root of the tree. In the very sense of incompleteness, of "having not yet attained" which it begets and perpetuates vou will find a prime condition of progress, and an urgency to such sustained effort as in-sures increasing effectiveness and power. "Mrs. Sarah Larman Smith," it is said, "learned to talk of Christ to the Arab women in a few months, and Schwartz to the Hindoos in three weeks." Why? A great purpose— to preach the gospel to the benighted and per-ishing, quickened their faculties and enabled them to do in a few weeks or months what to minds, lacking such inspiration, would have been the work of years. So let it be with you. While you dwell among things which seem temporal and have to do with them, look above and beyond them at the things which are un-seen and eternal. Let your ideal of living and working be a pattern showed to you in the Mount of God, a celestial power and iuspira: tion in the doing of earthly things. Grasp its full significance "in the perfect man" in whom the ideal became the real, and pattern was changed with person. Let His love constrain you ; His arms control you ; His example in-spire and mould you ; let it be Christ for you to live, and the end will be, must be, eternal gain. "See that you make all things accord-ing to the pattern showed to you in the Mount.'' THE PLACE OF THE Y. M. C. A. IN THE SOCIOLOGY OF THE COLLEGE. BY DR. ENOCH PERRINE. A change international in extent has revo-lutionized the college world. Barriers between the different classes and between professors and students have been broken down. An-tagonism between different professors and bit-ter contention between colleges has largely disappeared. Colleges are bound even in an international fellowship. All departments contribute to this movement, the Y. M. C. A. most of all, suggesting a sociology of the col-lege. The young man coming to college thinks first of his social status, the attitude of other students, and whether he shall make war or peace. Formerly he had to conquer a place and having established his reputation as a dangerous man, he visited the newer comer with the same horrors to which he had been subjected. Now the Y. M. C. A. meets him at the beginning and does numberless acts of kindness, exhibiting the characteristics of Christ, "the first true gentleman that ever breathed." It thus binds the college world fast by social ties. This must be done in the college before we can expect, it to obtain out-side, since in the college are peculiar incen-tives for the work. The young man next adjusts himself to his intellectual environment. He begins to be shut in by the material success about him and may be tempted to leave behind his "trailing clouds of glory." Then the Y. M. C. A. can direct aright his thought, insisting that God ought to be traced everywhere, thus binding all his intellectual efforts around the cross of Christ, "by whom all things consist." The importance and office of the intellect in the pursuit of truth will be plain to him. Darwin suffered an atrophy ou his poetic and spiritual side and the Y. M. C. A. may prevent such a fate from overtaking their fellows, thus pre-venting the head from freezing the heart and working a great benefit in the Intellectual life of the college. As he proceeds in the acquisition of knowl-edge, the young student will begin to think that in ideas alone there is a defense against moral degredation and a nepenthe for all dis-appointments. Culture will keep corruption from his hands—will be a shelter in the time of storm. Orators and poets shall be his all in all. Then the Y. M. C. A. may give him 69 THK COLLEGE MERCURY. right conceptions as to the Moral life, assert-ing that it is pitiful when the soul mounts higher but comes not closer to God and prov-ing that he only is truly moral who bases his life upon God. All parts of the social life are to be harmonized under one supreme principle. This is to be found at the foot of the cross and any other proposal is but a scheme of decep-tion leaving the mighty turmoil to seethe and boil underneath in undiminished horror. As the Y. M. C. A. insists upon this no man of culture will wail with Mathew Arnold that "most men die unfreed, having seen nothing, still unblest." But all these results may be successfully ac-complished and yet the student may miss the crowning glory. He may play the gentleman in the highest outward sense, may go willingly to the point where his logical faculties assure him that'there is a God, may develop his aesthetic sense so that the moral thing shall seem to be a beautiful thing, and yet blending by all this glory he may not know that he is really in Chimerian darkness. Then the Y. M. C. A. can declare that only he truly loves who loves a personality, that no one ever got beyond a cold respect for an abstraction, though that abstraction be a s.ream of tend-ency that makes for righteousness, and that one must see the king in his beauty before he will get that larger outlook without which life is flat, stale and unprofitable. The Y. M. C. A. can bring about this very desirable change of view better than any other agency about the college since the ordinary student out of Christ, now that he is no longer in the acad-emy, will resent the efforts of his professors to a greater degree than he will those of his fel-lows. Hence in the Social, Intellectual, Moral and Spiritual life of the college, the Y. M. C. A. can make its influence felt at every point, con-tributing that great and final binding force which will make the students in colleges in all lauds a more nearly compact body, and hence furnishing the material for an enduring sociol-ogy inside the college that shall spread out-ward in power and bring the world into a fed-erated parliament that-shall be the longest known to history'. FINE ART'S LIFE. BY L. P. EISENHART. Delightfully care-free seems the Fine Art's career to most of us. Light-hearted and blith-some, it is like the Arcadian life of poetic lore. But beneath its ruddy surface are the marks of many a suffering, the traces of many a heartache. The working of these hidden cares gives to genius its wonted lustre. Sons of art whatever be its realm are all of one brotherhood. The story of the one is the re-told tale of the other. The history of Italy is one great romance. It is the story of sailors, painters and poets. But its fulcrum chapter is the tale of that life-tossed son of Florence. Dante. Born into the throes of civil war, banished from office, de-serted by his friends, he was turned out of his beloved Florence, a heart-broken exile. Sor-row- stricken, death-doomed, he became a wan-derer with no home on earth. An American poet told his life-story in the epithet "world-worn." But his thoughts kept tending toward the eternal world. There his tender pitying soul found a calm repose. This hidden pain of a wrecked and thwarted usefulness showed itself seared and smarting in the Divine Comedy. Had he been spared these suffer-ings, the world would have lost its greatest epic, "the voice often silent centuries" would have been unheard. Insanity made an exile of another Italian bard. Vexed in spirit and failing in body, it was during the same moments of his prison lite that he poured forth his sweetest strains. In another clime those ballads which inspired a nation's people with the love of country are the life thoughts of a poverty-cursed poet. England's master poet in the trouble time of life wrote his best tragedies. A German poet touched the key-note of Fine Art's life when he said of a fellow-craftsman, "The Muse of THE COEEEGE MERCURY. 70 Comedy kissed him on the lips, but the Muse of Tragedy on the heart." Many a versed line lightly passed by has in it the throb and heart-break of tragic every day. The picture of Scott's departure from life-bought Abbottsford is painted in cold, gray colors. We who read his tales of Scotland life scarce realize the pathos and romance of their writer's ill-fated career. Of it his own words were: "But death would have them from me, if misfortunes had spared them." Pride-stricken, broken in body and crushed in spirit he toiled until his fingers could no longer grasp that noted pen. Scott, the minstrel of Highlandlays, the story-teller of border life appeared in the tragic fifth act of his life as Scott the great-hearted man. The life of Robert Louis Stevenson was one long struggle for health. It was this that led him into the pleasant scenes of Scotland, brought him to America, and finally carried him to the island of Samoa. Yet in these blighted years came his creative mood, came too his working day. *'I count life just a stuff To try the soul's strength on, educe the man." Delightful Jean Paul Richter gave this word-ing to our theme—thought. "Fate does with poets, as'we-do with birds—it darkens the warbler's cage until he has caught the oft-played air that he is to sing." Workers at canvas and easel have painted with real meaning in dark, sombre hues. Michel Angelo working for years on those Florentine frescoes, a victim of civil strife and hated by his fellow-painters is a picture not to be forgotten. Many a time did faithless patrons and flights for liberty stay his brush. The sweet-faced Madonnas of an earlier art age are their master's souls in color. Had they life, theirs would be a touching tale of dingy garrets, sleepless nights, days of untold hunger. Pressing poverty and a father's violence made intense the storm and stress period of Beethoven's life. Few were the moments not embittered by trouble at home, ingratitude of friends and the sting of unjust criticism. But life itself seemed lost when the dearest of all senses to him was gradually passing away. His own sonatas could no longer make sound-harmony. It was at this time that he poured forth his great symphonies, those tales of human woe. That was poetic music, the music of the soul. Not one of Schubert's greater operas was placed upon the stage ; nor was he ever to hear his own symphonies ; to him starvation was an uncanny darkness, ever near by. The Fine Art's life of our master musicians is a song in minors. The saddening notes of their soul-touching sonatas are the echoes of many sufferings. Behind the richly-colored scenes of the glit-tering theatre have been acted life's sternest realities. Queens of the stage and kings among actors have not only acted tragedies but have also lived them. While yet a mere boy, Edwin Booth, snow-bound amid the' wastes of Nevada, heard the news of his father's death, the loss of his only hope. The woman of his first love, the companion in his art, died in his absence. Then came the rash act of a lunatic brother, which cast a shadow over the whole world and for a moment his reputation and honored name seemed lost. But a nation's sympathy and the sense of duty to his great art called him back from his gloomy retire-ment. Returning, "he saw his fortune of more than a million dollars, together with the toil of some of the best years of his life frittered away." "A crowning hurt was the gradual passing away of his style of dramatic art. Booth was a dreamer, made sublime by suffer-ing. It was his cares and sorrows that made him dreamy and mysterious in Hamlet, tender and majestic in Richelieu, frenzied and at the same time affectionate in King Eear. May we not say, then, that often has it been the storm and stress of things that has cried to the Fine Art's soul, "Awake !" The Kalendar is the name of an interesting exchange that comes to our table from the Woman's College, of Baltimore. 71 THE COLLEGE MERCURY. CLASS-DAY EXERCISES. TUESDAY EVENING, JUNE 16, 1896. Master of Ceremonies, - - - - L. P. EISENHART. Music—Orchestra. CLASS EXERCISES. Class Roll, ARTHUR C. CARTY. Class History, IRA O. MOSER. Class Poem, EDNA M. LOOMIS. Music—Orchestra. Presentation Oration, - - WILLIAM R. REITZEL. Class Prophecy, FRED. J. BAUM. Peace Cup Oration, WILLIAMG. BRUBAKER. Mantle Presentation, - - - - WILLIAM MENGES. Junior Response, HENRY W. BIKI.E. Final Parade around the buildings, headed by the Band. CLASS-DAY POEM. From our Freshman year to Senior, College life meant toil and pain ; Now, lessons all are learned, and never Need we con them o'er again. Oh, the joy this thought brings with it; Joy wo feel but cannot speak. No more trials with mathematics, Logic, chemistry, or Greek. Yet, amid these thoughts of pleasure, I am in a dreadful fix; For the class must have a poem, And what will rhyme with '96? All the words by Webster given, All of those in Worcester found, One by one I've looked them over, But they give no classic sound. Days and nights I've toiled in anguish, 'Till my brain is in a mix; But not a word of sound poetic, Will make a rhyme with '96. All the class has done and conquered, All its record pnre and bright, Merit words of beauty, surely, Yet with prosy pen I write. I would say, the class are noble, Yet I only call them "bricks;" It is slang, I know, but truly, Noble will not rhyme with six. When I say of this or that one, He does well, he never sticks, Do not criticise my language, It's all the fault of '96. I would say they all are students, Aud I say, "They burn their wicks ;" Midnight oil would sound much better, But that won't rhyme with '96. Sometimes, classes passed thro' college, Trusting in a horse that kicks; Some have wasted time, but never, Was this done by '96. Some, the Faculty have worried, With their wild and foolish tricks. Neither this, nor any such thing, Has been done by '96. Thus, our record's full of honor; Not a conscience here that pricks! Every heart is brave and loyal, In the class of'96. But our college days are over, And we turn in sadness round; Noting now, with tender memories, Each familiar sight and sound. Hall, and "dorm" and "lab" and chapel, And the solemn clock that ticks, Mid our jokes and smiles the warrant For the death of'96. Now, the time has come for parting; Hall and Campus, loved of yore, Loved forever, we must leave you, We may dwell with you no more. Gettysburg, our Alma Mater, Mournful is the latch that clicks, As we pass beyond thy portal, A long farewell to '96. JUNIOR ORATORICAL CONTEST. WEDNESDAY, The Magnetism of Mystery, Our Debt to our Forefathers, National Character, - The Model American, - Home, Sweet Home, r International Arbitration, The Mission of the Jew, - Shoals of Success. - fPhrenakosmian. ♦Philomathsan. JUNE 17, 1896. GEORGE W. ENGLAR:* P. T. E- STOCKSLAGER.f - HORACE E- CLUTE.* ROBBIN B. WOLF.t - A. GERTRUDE SIEBER.* JOHN \V. OTT.f - GEORGE F. ABEL.* HENRY W. BIKLE.I HOME, SWEET HOME. BY ANNA G. SIEBER-The home is a divine institution, founded when God created our first parents in his own image and placed them in that home of prim-eval innocence to form the nucleus of the race. Even since the fallj which "brought death into the world and all our woe," the home bears the marks of divine fingers. Here love's first and finest feelings find expression and the wholesome restraints of government begin their peaceful sway. The Father of us all set the solitary in families and bound them together with ties of mutual sympathy, mutual depend-ence and mutual helpfulness. From the begin- THE COLLEGE MERCURY. 72 ning its divine sanction as well as its divine wisdom was recognized. Among the chosen people it developed into the patriarchal gov-ernment ; among the Greeks and Romans, in their highest civilization, the home was a sacred spot and the family the cradle of social and political power and the school of patriotism and religion. With the neglect of the home and a disregard for the family, came the decay of morals, the loss of power and the fall of the empire. The home must ever be the founda-tion of government, and if the foundations be destroyed, how can the individual, social and political building stand ? If the home be pro-tected and the graces of virtue, education, in-dustry and religion be carefully fostered and cultivated, the nation must live and fulfil her high destiny. The coming campaign will doubtless again fill the air with eloquent argu-ment in protection of the national sheep and the American hen and skillfully fail to mention the imperiled boy in the citadel of the Ameri-can home. Whether our great leaders recog-nize the home in their ambition for position or not, the fact remains the same, that here lies the secret of national power or weakness. There are several insidious tendencies which threaten the national life by destroying the home. There is the mad rush to the large cities early in life to secure financial advant-age. Leaving the pure mountain air, the ten-der ministries of home and nature, the asso-ciations of religion in the country or village church, the simple demands of society, the modern young man is tossed like a toy upon the jostling mass of humanity to "break every tender tie" of home, to live in the city board-ing house or hotel and to measure his untried strength with the powers of the world, the flesh and the devil. His future success in building character that will ornament society, strengthen the church, and protect the nation from potitical peril will depend largely upon the principles brought from the obscure home among the hills and valleys of his youth. The permanence of his financial and social standing must depend finally, not so much upon the tricks of trade, nor the chance of fortune, but upon the fidelity to truth, the per-sistent industry and the self-sacrificing econ-omy, laid stone upon stone, in the tedious for-mation of character about the humble home of childhood. Even wealth or position without these would be a calamity. The mountain stream, bursting from the rock, leaping with youthful glee over many a sunlit cascade, goes hurrying to the broad plain below, to turn the weels of industry, to quench the thirst ol a multitude, to join hands with kindred streams and bear upon her jew-eled decked bosom the commerce of a world. But there are a few simple laws laid down by Mother Nature, from which she must never depart. vSo, from the home must go the forces that will drive the machinery of a nation, strike hands with their kindred beyond the seas, and lift an exiled world back to God. Our success will depend upon a few simple laws which God and our Christian mothers will teach us. One of these principles is that gold must not become the individual's nor the nation's god. There are things finer than gold, more pre-cious than much fine gold. Those invisible hands that bind the gold-thirsty young man to his mother, those imperishable chords that in-crease their tension with distant separation and will not relax through the pleadings of time. Those divine threads that are woven into the web of our lives, in such a variety of color, through so many years of tender ministries, which neither the sunshine nor the rain will cause to fade. That mysterious attraction that tears the busy merchant from his surroundings to hasten to the old home, to feast the eyes upon scenes that will not perish, to quicken the affections that cannot die, to grasp the parental hand that warms with age, and to look upon the face of the only one whose feat-ures beautify with years. What strange calculations are these ! By some irresistible logic, as he stands by the grave of the departed mother, he reasons thus: 73 THE COU-EGE MERCURY. Take these stocks and bonds, these railroad and real estate interests, seize these large man-ufacturing and commercial. enterprises, take this palace of marble and bury them all, rather than let the cruel clay hide from me the treas-ured influence that crowned that life, finer than gold. Wealth must not become our ideal nor our idol. Only as it builds more homes and builds them more beautiful, adorns them with culture and religion, sweetens them as fountains of purity for the healing of the nation, strength-ens them as fortresses for her protection, will it bless our civilization. Another tendency that threatens the home is the social condition which seeks to separate the family. There is a kind of centrifugal force which tends to scatter the members of the household and destroy that bond which should bind them together with a kind of social grav-itation, which afterwards becomes the power of the community and of the state. There is danger of the boys and girls being thrown from the home nest before the fledgelings can use their wings or have wisdom to select their food. There are many temptations to lure them from the tender influences and sympa-thies of those who reared them. Even the recognized helps may prove hindrances ;. the schools that place these young lives in the hands of strangers over half their time from six years of age, the social, innocent pleasures that rob the parents of over half the remainder of their heaven-given opportunities, to say nothing of those attractions which cause many to spend the remainder of their time not spent in eating and sleeping outside of the home. How narrow the margin becomes for the home to do its work. To pi ess the plastic ma-terial into shape, to lay the artful chisel to the stone and hew with loving stroke the perfect form. How jealous the parent should be of these first and best opportunities! How guarded the sensitive plate of the mind and heart, that the first light to shine upon its deli-cate surface should reflect a perfect image ! Is the father anxious to spend the leisure hours in the home rather than in the lodge or club house, or is he too busy with his profes-sion, too closely confined to his business to im-press true character upon his own boy, who shall succeed him in business and become heir of his hard-earned estate ? Has the wife and mother been more anxious to keep flies out of the house than to keep her boy in ; has she be-stowed more thought upon velvet or brussels than upon the delicately woven character of an immortal ; has she studied to make an impres-sion upon fashionable society rather than to impress a future citizen of the State ? The law of nature will not be reversed to make amends for parental indifference or careless-ness. The colors we mix will appear on the canvas, the materials we use in the mortar will show themselves in the building. Is the home the centre of attraction and interest? Then it has its rightful place and becomes the sun of the system around which all things re-volve, from which they get their light and heat and are held in their proper orbits. De-stroy this relation, and confusion and anarchy follow. The home is a miniature government, in which the parents rule. Here begins re-spect for authority and obedience to law, the two great essentials in the security of the State; and if not learned here, may be learned too late to avert crime. Here are developed those finer affections toward brothers and sisters which, when en-larged, produce true patriotism and make "the whole world kin." Here under the form of possessions acquired and protected, the true right of ownership becomes early established, that true love of country may become the en-larged law of self-protection ; thus combining the law of chivalry to defend the innocent and the heroism of the soldier to protect the nation. The social and national life are found in min-iature in the empire of the home which, when properly controlled, becomes the ideal of the national government. The King rules his subjects with a father's tenderness. The sub-jects obey the laws, prompted by filial grati-tude for the general good. An injustice against THE COLLEGE MERCURY. 74 one member is an offense against the whole body politic. Suffering in part enlists the sympathy of the whole. A cry of distress startles the nation and all the nerves of sensa-tion carry the news and the alarm brings re-pair and relief trains over every highway of approach. The homes of the nation must ever be the fountains for the public school, the supply for the church, the protection of our liberties against internal and external foes. These must be the watch towers, and the sons and daughters the real standing army to protect our civil and religious liberties. The thousands of men who live on wheels, without a sure place to set their feet, must have a starting-point and a returning point for their souls, a tension to hold them in place more binding than the rules of the business firm, a restraint to stay their feet on the verge of temptation mightier than law, an unseen angel to stand between them and sin, to guard them from its blighting touch This starting-point is the Christian home, this tension, the mystic chord that binds them to the altar, this angel, the messenger that sits in the temple of the memory and holds the wife, the mother, the innocent children before the soul. The home is a type of Heaven, the perfec-tion of future blessedness. God, the Father of us all, Christ, the Brother of us all, we, the children. From the imperfect to the perfect, from the trial to the triumph. We are but children away from home. Earth is but the play-ground. We stretch onr tiny hands toward the stars glimmering in the dark-ness that surrounds us. We tire of these earthly toys. We cry, in our distress, to grasp the eternal. The father hears his lost childrens' piteous wail and calls us home ; sweet, sweet, home. ROLL OF HONOR. FIRST HONOR. LUTHER P. EISENHART, York. D. EDGAR RICE, Chainbersburg. GRAYSON Z. STOP, Frederick, Md. EDNA M LOOMIS, Troy. GRIFF PRIZE, FOR BEST ESSAY ON HOLMES AS THE POET OF COLLEGIANS." LUTHER P. EISENHAET, York. HASSLER GOLD MEDAL, JUNIOR LATIN PRIZE. ELKANAH M. DUCK, Spring Mills. WITH HONORABLE MENTION OF GEORGE F. ABEL, Philadelphia. BAUM SOPHOMORE MATHEMATICAL PRIZE. JAMES A. MCALLISTER, Gettysburg EFPIE ELIZABETH HESS, - - - - Taneytown, Md! WITH HONORABLE MENTION OF EDMUND W. MEISENHELDER, York. EDMUND L. ROLLER, Hanover. CHARLES T. LARK, - - - - - - Millersburg. WILLIAM H. SPRENKLE, - - - Jack's Mountain. ALBERTUS G. FUSS, . Williamsport, Md. MUHLENBERG FRESHMAN PRIZE. FOR BEST GENERAL SCHOLARSHIP. HENRY ALBERS, JR., Jersey City, N. J. WITH HONORABLE MENTION OF ARTHUR STC. 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In my postgraduate formation during the last years of the 80's, we had close to thirty hospital beds in a pavilion called "sépticas" (1). In Colombia, where abortion was completely penalized, the pavilion was mostly filled with women with insecure, complicated abortions. The focus we received was technical: management of intensive care; performance of hysterectomies, colostomies, bowel resection, etc. In those times, some nurses were nuns and limited themselves to interrogating the patients to get them to "confess" what they had done to themselves in order to abort. It always disturbed me that the women who left alive, left without any advice or contraceptive method. Having asked a professor of mine, he responded with disdain: "This is a third level hospital, those things are done by nurses of the first level". Seeing so much pain and death, I decided to talk to patients, and I began to understand their decision. I still remember so many deaths with sadness, but one case in particular pains me: it was a woman close to being fifty who arrived with a uterine perforation in a state of advanced sepsis. Despite the surgery and the intensive care, she passed away. I had talked to her, and she told me she was a widow, had two adult kids and had aborted because of "embarrassment towards them" because they were going to find out that she had an active sexual life. A few days after her passing, the pathology professor called me, surprised, to tell me that the uterus we had sent for pathological examination showed no pregnancy. She was a woman in a perimenopausal state with a pregnancy exam that gave a false positive due to the high levels of FSH/LH typical of her age. SHE WAS NOT PREGNANT!!! She didn't have menstruation because she was premenopausal and a false positive led her to an unsafe abortion. Of course, the injuries caused in the attempted abortion caused the fatal conclusion, but the real underlying cause was the social taboo in respect to sexuality. I had to watch many adolescents and young women leave the hospital alive, but without a uterus, sometime without ovaries and with colostomies, to be looked down on by a society that blamed them for deciding to not be mothers. I had to see situation of women that arrived with their intestines protruding from their vaginas because of unsafe abortions. I saw women, who in their despair, self-inflicted injuries attempting to abort with elements such as stick, branches, onion wedges, alum bars and clothing hooks among others. Among so many deaths, it was hard not having at least one woman per day in the morgue due to an unsafe abortion. During those time, healthcare was not handled from the biopsychosocial, but only from the technical (2); nonetheless, in the academic evaluations that were performed, when asked about the definition of health, we had to recite the text from the International Organization of Health that included these three aspects. How contradictory! To give response to the health need of women and guarantee their right when I was already a professor, I began an obstetric contraceptive service in that third level hospital. There was resistance from the directors, but fortunately I was able to acquire international donations for the institution, which facilitated its acceptance. I decided to undertake a teaching career with the hope of being able to sensitize health professionals towards an integral focus of health and illness. When the International Conference of Population and Development (ICPD) was held in Cairo in 1994, I had already spent various years in teaching, and when I read their Action Program, I found a name for what I was working on: Sexual and Reproductive Rights. I began to incorporate the tools given by this document into my professional and teaching life. I was able to sensitize people at my countries Health Ministry, and we worked together moving it to an approach of human rights in areas of sexual and reproductive health (SRH). This new viewpoint, in addition to being integral, sought to give answers to old problems like maternal mortality, adolescent pregnancy, low contraceptive prevalence, unplanned or unwanted pregnancy or violence against women. With other sensitized people, we began with these SRH issues to permeate the Colombian Society of Obstetrics and Gynecology, some universities, and university hospitals. We are still fighting in a country that despite many difficulties has improved its indicators of SRH. With the experience of having labored in all sphere of these topics, we manage to create, with a handful of colleagues and friend at the Universidad El Bosque, a Master's Program in Sexual and Reproductive Health, open to all professions, in which we broke several paradigms. A program was initiated in which the qualitative and quantitative investigation had the same weight, and some alumni of the program are now in positions of leadership in governmental and international institutions, replicating integral models. In the Latin American Federation of Obstetrics and Gynecology (FLASOG, English acronym) and in the International Federation of Obstetrics and Gynecology (FIGO), I was able to apply my experience for many years in the SRH committees of these association to benefit women and girls in the regional and global environments. When I think of who has inspired me in these fights, I should highlight the great feminist who have taught me and been with me in so many fights. I cannot mention them all, but I have admired the story of the life of Margaret Sanger with her persistence and visionary outlook. She fought throughout her whole life to help the women of the 20th century to be able to obtain the right to decide when and whether or not they wanted to have children (3). Of current feminist, I have had the privilege of sharing experiences with Carmen Barroso, Giselle Carino, Debora Diniz and Alejandra Meglioli, leaders of the International Planned Parenthood Federation – Western Hemisphere Region (IPPF-RHO). From my country, I want to mention my countrywoman Florence Thomas, psychologist, columnist, writer and Colombo-French feminist. She is one of the most influential and important voices in the movement for women rights in Colombia and the region. She arrived from France in the 1960's, in the years of counterculture, the Beatles, hippies, Simone de Beauvoir, and Jean-Paul Sartre, a time in which capitalism and consumer culture began to be criticized (4). It was then when they began to talk about the female body, female sexuality and when the contraceptive pill arrived like a total revolution for women. Upon its arrival in 1967, she experimented a shock because she had just assisted in a revolution and only found a country of mothers, not women (5). That was the only destiny for a woman, to be quiet and submissive. Then she realized that this could not continue, speaking of "revolutionary vanguards" in such a patriarchal environment. In 1986 with the North American and European feminism waves and with her academic team, they created the group "Mujer y Sociedad de la Universidad Nacional de Colombia", incubator of great initiatives and achievements for the country (6). She has led great changes with her courage, the strength of her arguments, and a simultaneously passionate and agreeable discourse. Among her multiple books, I highlight "Conversaciones con Violeta" (7), motivated by the disdain towards feminism of some young women. She writes it as a dialogue with an imaginary daughter in which, in an intimate manner, she reconstructs the history of women throughout the centuries and gives new light of the fundamental role of feminism in the life of modern women. Another book that shows her bravery is "Había que decirlo" (8), in which she narrates the experience of her own abortion at age twenty-two in sixty's France. My work experience in the IPPF-RHO has allowed me to meet leaders of all ages in diverse countries of the region, who with great mysticism and dedication, voluntarily, work to achieve a more equal and just society. I have been particularly impressed by the appropriation of the concept of sexual and reproductive rights by young people, and this has given me great hope for the future of the planet. We continue to have an incomplete agenda of the action plan of the ICPD of Cairo but seeing how the youth bravely confront the challenges motivates me to continue ahead and give my years of experience in an intergenerational work. In their policies and programs, the IPPF-RHO evidences great commitment for the rights and the SRH of adolescent, that are consistent with what the organization promotes, for example, 20% of the places for decision making are in hands of the young. Member organizations, that base their labor on volunteers, are true incubators of youth that will make that unassailable and necessary change of generations. In contrast to what many of us experienced, working in this complicated agenda of sexual and reproductive health without theoretical bases, today we see committed people with a solid formation to replace us. In the college of medicine at the Universidad Nacional de Colombia and the College of Nursing at the Universidad El Bosque, the new generations are more motivated and empowered, with great desire to change the strict underlying structures. Our great worry is the onslaught of the ultra-right, a lot of times better organized than us who do support rights, that supports anti-rights group and are truly pro-life (9). Faced with this scenario, we should organize ourselves better, giving battle to guarantee the rights of women in the local, regional, and global level, aggregating the efforts of all pro-right organizations. We are now committed to the Objectives of Sustainable Development (10), understood as those that satisfy the necessities of the current generation without jeopardizing the capacity of future generations to satisfy their own necessities. This new agenda is based on: - The unfinished work of the Millennium Development Goals - Pending commitments (international environmental conventions) - The emergent topics of the three dimensions of sustainable development: social, economic, and environmental. We now have 17 objectives of sustainable development and 169 goals (11). These goals mention "universal access to reproductive health" many times. In objective 3 of this list is included guaranteeing, before the year 2030, "universal access to sexual and reproductive health services, including those of family planning, information, and education." Likewise, objective 5, "obtain gender equality and empower all women and girls", establishes the goal of "assuring the universal access to sexual and reproductive health and reproductive rights in conformity with the action program of the International Conference on Population and Development, the Action Platform of Beijing". It cannot be forgotten that the term universal access to sexual and reproductive health includes universal access to abortion and contraception. Currently, 830 women die every day through preventable maternal causes; of these deaths, 99% occur in developing countries, more than half in fragile environments and in humanitarian contexts (12). 216 million women cannot access modern contraception methods and the majority live in the nine poorest countries in the world and in a cultural environment proper to the decades of the seventies (13). This number only includes women from 15 to 49 years in any marital state, that is to say, the number that takes all women into account is much greater. Achieving the proposed objectives would entail preventing 67 million unwanted pregnancies and reducing maternal deaths by two thirds. We currently have a high, unsatisfied demand for modern contraceptives, with extremely low use of reversible, long term methods (intrauterine devices and subdermal implants) which are the most effect ones with best adherence (14). There is not a single objective among the 17 Objectives of Sustainable Development where contraception does not have a prominent role: from the first one that refers to ending poverty, going through the fifth one about gender equality, the tenth of inequality reduction among countries and within the same country, until the sixteenth related with peace and justice. If we want to change the world, we should procure universal access to contraception without myths or barriers. We have the moral obligation of achieving the irradiation of extreme poverty and advancing the construction of more equal, just, and happy societies. In emergency contraception (EC), we are very far from reaching expectations. If in reversible, long-term methods we have low prevalence, in EC the situation gets worse. Not all faculties in the region look at this topic, and where it is looked at, there is no homogeneity in content, not even within the same country. There are still myths about their real action mechanisms. There are countries, like Honduras, where it is prohibited and there is no specific medicine, the same case as in Haiti. Where it is available, access is dismal, particularly among girls, adolescents, youth, migrants, afro-descendent, and indigenous. The multiple barriers for the effective use of emergency contraceptives must be knocked down, and to work toward that we have to destroy myths and erroneous perceptions, taboos and cultural norms; achieve changes in laws and restrictive rules within countries, achieve access without barriers to the EC; work in union with other sectors; train health personnel and the community. It is necessary to transform the attitude of health personal to a service above personal opinion. Reflecting on what has occurred after the ICPD in Cairo, their Action Program changed how we look at the dynamics of population from an emphasis on demographics to a focus on the people and human rights. The governments agreed that, in this new focus, success was the empowerment of women and the possibility of choice through expanded access to education, health, services, and employment among others. Nonetheless, there have been unequal advances and inequality persists in our region, all the goals were not met, the sexual and reproductive goals continue beyond the reach of many women (15). There is a long road ahead until women and girls of the world can claim their rights and liberty of deciding. Globally, maternal deaths have been reduced, there is more qualified assistance of births, more contraception prevalence, integral sexuality education, and access to SRH services for adolescents are now recognized rights with great advances, and additionally there have been concrete gains in terms of more favorable legal frameworks, particularly in our region; nonetheless, although it's true that the access condition have improved, the restrictive laws of the region expose the most vulnerable women to insecure abortions. There are great challenges for governments to recognize SRH and the DSR as integral parts of health systems, there is an ample agenda against women. In that sense, access to SRH is threatened and oppressed, it requires multi-sector mobilization and litigation strategies, investigation and support for the support of women's rights as a multi-sector agenda. Looking forward, we must make an effort to work more with youth to advance not only the Action Program of the ICPD, but also all social movements. They are one of the most vulnerable groups, and the biggest catalyzers for change. The young population still faces many challenges, especially women and girls; young girls are in particularly high risk due to lack of friendly and confidential services related with sexual and reproductive health, gender violence, and lack of access to services. In addition, access to abortion must be improved; it is the responsibility of states to guarantee the quality and security of this access. In our region there still exist countries with completely restrictive frameworks. New technologies facilitate self-care (16), which will allow expansion of universal access, but governments cannot detach themselves from their responsibility. Self-care is expanding in the world and can be strategic for reaching the most vulnerable populations. There are new challenges for the same problems, that require a re-interpretation of the measures necessary to guaranty the DSR of all people, in particular women, girls, and in general, marginalized and vulnerable populations. It is necessary to take into account migrations, climate change, the impact of digital media, the resurgence of hate discourse, oppression, violence, xenophobia, homo/transphobia, and other emergent problems, as SRH should be seen within a framework of justice, not isolated. We should demand accountability of the 179 governments that participate in the ICPD 25 years ago and the 193 countries that signed the Sustainable Development Objectives. They should reaffirm their commitments and expand their agenda to topics not considered at that time. Our region has given the world an example with the Agreement of Montevideo, that becomes a blueprint for achieving the action plan of the CIPD and we should not allow retreat. This agreement puts people at the center, especially women, and includes the topic of abortion, inviting the state to consider the possibility of legalizing it, which opens the doors for all governments of the world to recognize that women have the right to choose on maternity. This agreement is much more inclusive: Considering that the gaps in health continue to abound in the region and the average statistics hide the high levels of maternal mortality, of sexually transmitted diseases, of infection by HIV/AIDS, and the unsatisfied demand for contraception in the population that lives in poverty and rural areas, among indigenous communities, and afro-descendants and groups in conditions of vulnerability like women, adolescents and incapacitated people, it is agreed: 33- To promote, protect, and guarantee the health and the sexual and reproductive rights that contribute to the complete fulfillment of people and social justice in a society free of any form of discrimination and violence. 37- Guarantee universal access to quality sexual and reproductive health services, taking into consideration the specific needs of men and women, adolescents and young, LGBT people, older people and people with incapacity, paying particular attention to people in a condition of vulnerability and people who live in rural and remote zone, promoting citizen participation in the completing of these commitments. 42- To guarantee, in cases in which abortion is legal or decriminalized in the national legislation, the existence of safe and quality abortion for non-desired or non-accepted pregnancies and instigate the other States to consider the possibility of modifying public laws, norms, strategies, and public policy on the voluntary interruption of pregnancy to save the life and health of pregnant adolescent women, improving their quality of life and decreasing the number of abortions (17).

PUBLISHED ; BACKGROUND: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls. PRINCIPAL FINDINGS: In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p?=?1.4?10-6) and 14 (IGHV1-67 p?=?7.9?10-8) which indexed novel susceptibility loci. SIGNIFICANCE: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease. ; The i-Select chips was funded by the French National Foundation on Alzheimer?s disease and related disorders. The French National Fondation on Alzheimer?s disease and related disorders supported several I-GAP meetings and communications. Data management involved the Centre National de Ge ? notypage,and was supported by the Institut Pasteur de Lille, Inserm, FRC (fondation pour la recherche sur le cerveau) and Rotary. This work has been developed and supported by the LABEX (laboratory of excellence program investment for the future) DISTALZ grant (Development of Innovative Strateg ies for a Transdisciplinary approach to ALZheimer?s disease) and by the LABEX GENMED grant (Medical Genomics). The French National Foundation on Alzheimer? s disease and related disorders and the Alzheimer?s Association (Chicago, Illinois) grant supported IGAP in-person meetings, communication and the Alzheim er?s Association (Chicago, Illinois) grant provided some funds to each consortium for analyses. EADI The authors thank Dr. Anne Boland (CNG) for her techn ical help in preparing the DNA samples for analyses. This work was supported by the National Foundation for Alzheimer?s disease and related disorders, the Instit ut Pasteur de Lille and the Centre National de Ge ? notypage. The Three-City Study was performed as part of a collaboration between the Institut National de la Sante ? et de la Recherche Me ? dicale (Inserm), the Victor Segalen Bordeaux II University and Sanofi-Synthe ? labo. The Fondation pour la Recherche Me ? dicale funded the preparation and initiation of the study. The 3C Study was also funded by the Caisse Nationale Maladie des Travailleurs Salarie ? s, Direction Ge ? ne ? rale de la Sante ? , MGEN, Institut de la Longe ? vite ? , Agence Franc ?aise de Se ? curite ? Sanitaire des Produits de Sante ? , the Aquitaine and Bourgogne Regional Councils, Agence Nationale de la Recherche, ANR supported the COGINUT and COVADIS projects. Fondation de France and the joint French Ministry of Research/INSERM ?Cohortes et collec tions de donne ? es biologiques? programme. Lille Ge ? nopo ? le received an unconditional grant from Eisai. The Three-city biological bank was developed and maintained by the laboratory for genomic analysis LAG-BRC - Institut Pasteur de Lille. Belgium sample collection: The patients were clinically and pathologica l characterized by the neurologists Sebastiaan Engelborghs, Rik Vandenberghe and Peter P. De Deyn, and in part genetically by Caroline Van Cauwenberghe, Karolien Be ttens and Kristel Sleegers. Research at the Antwerp site is funded in part by the Belgian Science Policy Office Interuniversity Attraction Poles program, t he Foundation Alzheimer Research (SAO-FRA), the Flemish Government initiated Methusalem Excellence Program, the Research Foundation Flanders (FWO) and the Uni versity of Antwerp Research Fund, Belgium. Karolien Bettens is a postdoctoral fellow of the FWO. The Antwerp site authors thank the personnel of the VIB Genetic S ervice Facility, the Biobank of the Institute Born-Bunge and the Departments of Neurology and Memory Clinics at the Hospital Network Antwerp and the Univers ity Hospitals Leuven. Finish sample collection: Financial support for this project was provided by the Health Research Council of the Academy of Finland , EVO grant 5772708 of Kuopio University Hospital, and the Nordic Centre of Excellence in Neurodegeneration. Italian sample collections: the Bologna site (FL) obtained funds from the Italian Ministry of research and University as well as Carimonte Foundation. The Florence site was supported by grant RF-2010-2319722, gran t from the the Cassa di Risparmio di Pistoia e Pescia (Grant 2012) and the Cassa di Risparmio di Firenze (Grant 2010 ?fondazione Monzino?. The authors thank the expert contribution of Mr. Carmelo Romano. The Roma site received financial support from Italian Minist ry of Health, Grant RF07-08 and RC08-09-10-11-12. The Pisa site is grateful to Dr. Annalisa LoGerfo for her technical assistance in the DNA purification st udies. Spanish sample collection: the Madrid site (MB) was supported by grants of the Ministerio de Educacio ? n y Ciencia and the Ministerio de Sanidad y Consumo (Instituto de Salud Carlos III), and an institutional grant of the Fundacio ? n Ramo ? n Areces to the CBMSO. The authors thank I. Sastre and Dr. A. Mart? ? nez-Garc? ? afor the preparation and control of the DNA collection, and Drs. P. Gil and P. Coria for their cooperation in the cases/controls recruitment. The authors ar e grateful to the Asociacio ? n de Familiares de Alzheimer de Madrid (AFAL) for continuous encouragement and help. Swedish sample collection: Financially supported in part by the Swedish Brain Power network, the Marianne and Marcus Wallenberg Foundation, the Swedish Research Council (521-2010-3134), the King Gust af V and Queen Victoria?s Foundation of Freemasons, the Regional Agreement on Medical Training and Clinical Research (ALF) between Stockholm County Cou ncil and the Karolinska Institutet, the Swedish Brain Foundation and the Swedish Alzheimer Foundation. CHARGE AGES: The AGES-Reykjavik Study is funded b y National Institutes of Health (NIH) contract N01-AG-12100 (National Institute on Aging (NIA) with contributions from the National Eye Institute, N ational Institute on Deafness and Other Communication Disorders and National Heart, Lung, and Blood Institute (NHLBI)), the NIA Intramural Research Progra m, Hjartavernd (the Icelandic Heart Association), and the Althingi (the Icelandic Parliament). ASPS/PRODEM: The Austrian Stroke Prevention Study an d The Prospective Dementia Register of the Austrian Alzheimer Society was supported by The Austrian Science Fond (FWF) grant number P20545-P05 (H. Schmid t) and P13180; The Austrian Alzheimer Society; The Medical University of Graz. Cardiovascular Health Study (CHS): This CHS research was supported by NH LBI contracts HHSN268201200036C, HHSN268200800007C, N01HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086, and HHSN268200960009C; and NHLBI grants HL080295, HL087652, HL105756 with additional contribution from the National Institute of Neurological Disor ders and Stroke (NINDS). Additional support was provided through AG023629, AG15928, AG20098, AG027058 and AG033193 (Seshadri) from the NIA. A full list of CH S investigators and institutions can be found at http://www.chs-nhlbi.org/pi. The provision of genotyping data was supported in part by the National Center for Advancing Translational Sciences, CTSI grant UL1TR000124, and the National Institute of Diabetes and Digestive and Kidney Disease Diabetes Resear ch Center (DRC) grant DK063491 to the Southern California Diabetes Endocrinology Research Center. Framingham Heart Study (FHS): This work was supported by th e National Heart, Lung and Blood Institute?s Framingham Heart Study (Contract No. N01-HC-25195) and its contract with A_ymetrix, Inc for genotyping s ervices (Contract No. N02-HL-6-4278). A portion of this research utilized the Linux Cluster for Genetic Analysis (LinGA-II) funded by the Robert Dawson Evan s Endowment of the Department of Medicine at Boston University School of Medicine and Boston Medical Center. This study as also supported by grants from the National Institute on Aging: AG08122 and AG033193 (Seshadri). Drs. Seshadri and DeStefano were also supported by additional grants from the Nati onal Institute on Aging: (R01 AG16495; AG031287, AG033040), the National Institute of Neurological Disorders and Stroke (R01 NS17950), and the National Heart, Lung and Blood Institute (U01 HL096917, HL093029 and K24HL038444, RC2-HL102419 and UC2 HL103010. Fundacio ? ACE would like to thank patients and controls who participated in this project. This work has been funded by the Fundacio ? n Alzheimur (Murcia), the Ministerio de Educacio ? n y Ciencia (PCT-010000- 2007-18), (DEX-580000-2008-4), (Gobierno de Espan ? a), Corporacio ? n Tecnolo ? gica de Andaluc? ? a (08/211) and Agencia IDEA (841318) (Consejer? ? a de Innovacio ? n, Junta de Andaluc? ? a). The authors thank to Ms. Trinitat Port-Carbo ? and her family for their generous support of Fundacio ? ACE research programs. The Rotterdam Study: The Rotterdam Study was funded by Erasmus Medical Center and Erasmus University, Rotterdam; the Netherlands Organization for Health Researc h and Development; the Research Institute for Diseases in the Elderly; the Ministry of Education, Culture and Science; the Ministry for Health, Welfare an d Sports; the European Commission;and the Municipality of Rotterdam; by grants from the Research Institute for Diseases in the Elderly (014-93-015; RIDE2), Inte rnationale Stichting Alzheimer Onderzoek, Hersenstichting Nederland, the Netherlands Genomics Initiative?Netherlands Organization for Scientific Resea rch (Center for Medical Systems Biology and the Netherlands Consortium for Healthy Aging), the Seventh Framework Program (FP7/2007-2013), the ENGAGE project (gra nt agreement HEALTH-F4-2007-201413), MRACE-grant from the Erasmus Medical Center, the Netherlands Organization for Health Research and Developmen t (ZonMW Veni-grant no. 916.13.054). ARIC: The Atherosclerosis Risk in Communities Study (ARIC) is carried out as a collaborative study supported by N ational Heart, Lung, and Blood Institute contracts N01-HC-55015, N01-HC-55016, N01-HC-55018, N01- HC-55019, N01-HC-55020, N01-HC-55021, N01-HC-55022 and grants R01-HL087641, RC2-HL102419 (Boerwinkle, CHARGE-S), UC2 HL103010, U01-HL096917 (Mosley) and R01-HL093029; NHGRI contract U01- HG004402; and NIH contract HHSN268200625226C and NIA: R01 AG033193 (Seshadri). Infrastructure was partly supported by Grant Number UL1RR025005, a component of the National Institutes of Health and NIH Roadmap for Medical Research. GERAD Cardiff University was supported by the Wellcome Trust, Medical Resear ch Council (MRC), Alzheimer?s Research United Kingdom (ARUK) and the Welsh Government. ARUK supported sample collections at the Kings College London, the South West Dementia Bank, Universities of Cambridge, Nottingham, Manchester and Belfast. The Belfast group acknowledges support from the Alzheime r?s Society, Ulster Garden Villages, N. Ireland R & D Office and the Royal College of Physicians/Dunhill Medical Trust. The MRC and Mercer?s Institute for Research on Ageing supported the Trinity College group. DCR is a Wellcome Trust Principal Research fellow. The South West Dementia Brain Bank acknowledges suppo rt from Bristol Research into Alzheimer?s and Care of the Elderly. The Charles Wolfson Charitable Trust supported the OPTIMA group. Washington Univers ity was funded by NIH grants, Barnes Jewish Foundation and the Charles and Joanne Knight Alzheimer?s Research Initiative. Patient recruitment for the MRC Pr ion Unit/ UCL Department of Neurodegenerative Disease collection was supported by the UCLH/UCL Biomedical Centre and their work was supported by the NIHR Queen Square Dementia BRU. LASER-AD was funded by Lundbeck SA. The Bonn group would like to thank Dr. Heike Koelsch for her scientific support. The Bonn group was funded by the German Federal Ministry of Education and Research (BMBF): Competence Network Dementia (CND) grant number 01GI0102, 01GI0711, 01GI0420. The AgeCoDe study group was supported by the German Federal Ministry for Education and Research grants 01 GI 0710, 01 GI 0712, 01 GI 0713, 01 GI 0714, 01 GI 0715, 01 GI 0716, 01 GI 0717. The Homburg group was funded by the German Federal Ministry of Education and Research (BMBF): German National Genome Research Network (NGFN); Alzheimer?s disease Integrated Genome Research Network; AD-IG: 01GS0465. Genotyping of the Bonn case-control sample was funded by the German centre for Neurodegenerative Diseases (DZNE), Germany. The GERAD Consortium also used samples ascertained by the NIMH AD Genetics Initiative. Harald Hampel was supported by a grant of the Katharina-Hardt-Foundation, Bad Homburg vor der Ho ? he, Germany. The KORA F4 studies were financed by Helmholtz Zentrum Mu ? nchen; German Research Center for Environmental Health; BMBF; German National Genome Research Network and the Munich Center of Health Sciences. The Heinz Nixdorf Recall cohort was funded by the Heinz Nixdorf Foundation (Dr. Jur. G.Schmidt, Chairman) and BMBF. Coriell Cell Repositories is supported by NINDS and the Intramural Research Program of the National Institute on Agin g. The authors acknowledge use of genotype data from the 1958 Birth Cohort collection, funded by the MRC and the Wellcome Trust which was genotyped by the Wellcome Trust Case Control Consortium and the Type-1 Diabetes Genetics Consortium, sponsored by the National Institute of Diabetes and Digestive a nd Kidney Diseases, National Institute of Allergy and Infectious Diseases, National Human Genome Research Institute, National Institute of Child Hea lth and Human Development and Juvenile Diabetes Research Foundation International. The Nottingham Group (KM) are supported by the Big Lottery. MRC CFAS is part of the consortium and data will be included in future analyses. ADGC The National Institutes of Health, National Institute on Aging (NIH-NIA) supported thi s work through the following grants: ADGC, U01 AG032984, RC2 AG036528; NACC, U01 AG016976; NCRAD, U24 AG021886; NIA LOAD, U24 AG026395, R01 AG041797; MIRAGE R01 AG025259; Banner Sun Health Research Institute P30 AG019610; Boston University, P30 AG013846, U01 AG10483, R01 CA129769, R01 MH080295, R01 AG017173, R01AG33193; Columbia University, P50 AG008702, R37 AG015473; Duke University, P30 AG028377, AG05128; Emory University, AG025688; Group Health Research Institute, UO1 AG06781, UO1 HG004610; Indiana University, P30 AG10133; Johns Hopkins University, P50 AG005146, R01 AG020688 ; Massachusetts General Hospital, P50 AG005134; Mayo Clinic, P50 AG016574; Mount Sinai School of Medicine, P50 AG005138, P01 AG002219; New York University, P30 AG08051, MO1RR00096, and UL1 RR029893; Northwestern University, P30 AG013854; Oregon Health & Science University, P30 AG008017, R 01 AG026916; Rush University, P30 AG010161, R01 AG019085, R01 AG15819, R01 AG17917, R01 AG30146; TGen, R01 NS059873; University of Alabama at Birmingham, P50 AG016582, UL1RR02777; University of Arizona, R01 AG031581; University of California, Davis, P30 AG010129; University of Californ ia, Irvine, P50 AG016573, P50, P50 AG016575, P50 AG016576, P50 AG016577; University of California, Los Angeles, P50 AG016570; University of California, San Die go, P50 AG005131; University of California, San Francisco, P50 AG023501, P01 AG019724; University of Kentucky, P30 AG028383; University of Michigan, P50 A G008671; University of Pennsylvania, P30 AG010124; University of Pittsburgh, P50 AG005133, AG030653, AG041718; University of Southern California, P50 AG0 05142; University of Texas Southwestern, P30 AG012300; University of Miami, R01 AG027944, AG010491, AG027944, AG021547, AG019757; University of Washing ton, P50 AG005136; Vanderbilt University, R01 AG019085; and Washington University, P50 AG005681, P01 AG03991. The Kathleen Price Bryan Brain Bank at Duk e University Medical Center is funded by NINDS grant # NS39764, NIMH MH60451 and by Glaxo Smith Kline. Genotyping of the TGEN2 cohort was supported by Kronos Science. The TGen series was also funded by NIA grant AG034504 to AJM, The Banner Alzheimer?s Foundation, The Johnnie B. Byrd Sr. Alzheimer?s Institute, the Medical Research Council, and the state of Arizona and also includes samples from the following sites: Newcastle Brain Tissue Resourc e (funding via the Medical Research Council, local NHS trusts and Newcastle University), MRC London Brain Bank for Neurodegenerative Diseases (funding via the Medical Research Council), South West Dementia Brain Bank (funding via numerous sources including the Higher Education Funding Council for England (HEFCE) , Alzheimer?s Research Trust (ART), BRACE as well as North Bristol NHS Trust Research and Innovation Department and DeNDRoN), The Netherlands Brain Bank (funding via numerous sources including Stichting MS Research, Brain Net Europe, Hersenstichting Nederland Breinbrekend Werk, International Par kinson Fonds, Internationale Stiching Alzheimer Onderzoek), Institut de Neuropatologia, Servei Anatomia Patologica, Universitat de Barcelona. Marcel le Morrison- Bogorad, PhD., Tony Phelps, PhD and Walter Kukull PhD are thanked for helping to co-ordinate this collection. ADNI Funding for ADNI is through the Nort hern California Institute for Research and Education by grants from Abbott, AstraZeneca AB, Bayer Schering Pharma AG, Bristol-Myers Squibb, Eisai Globa l Clinical Development, Elan Corporation, Genentech, GE Healthcare, Glaxo-SmithKline, Innogenetics, Johnson and Johnson, Eli Lilly and Co., Medpace, Inc., Merck and Co., Inc., Novartis AG, Pfizer Inc, F. Hoffman-La Roche, Schering-Plough, Synarc, Inc., Alzheimer?s Association, Alzheimer?s Drug Discovery Foun dation, the Dana Foundation, and by the National Institute of Biomedical Imaging and Bioengineering and NIA grants U01 AG024904, RC2 AG036535, K01 AG030514. Data collection and sharing for this project was funded by the ADNI (National Institutes of Health Grant U01 AG024904). ADNI is funded by the National Insti tute on Aging, the National Institute of Biomedical Imaging and Bioengineering, and through generous contributions from the following: Alzheimer?s Assoc iation; Alzheimer?s Drug Discovery Foundation; BioClinica, Inc.; Biogen Idec Inc.; Bristol-Myers Squibb Company; Eisai Inc.; Elan Pharmaceuticals, Inc. ; Eli Lilly and Company; F. Hoffmann-La Roche Ltd and its affiliated company Genentech, Inc.; GE Healthcare; Innogenetics, N.V.; IXICO Ltd.; Janssen Alzheimer Immunotherapy Research & Development, LLC.; Johnson & Johnson Pharmaceutical Research & Development LLC.; Medpace, Inc.; Merck & Co., Inc.; Meso Sc ale Diagnostics, LLC.; NeuroRx Research; Novartis Pharmaceuticals Corporation; Pfizer Inc.; Piramal Imaging; Servier; Synarc Inc.; and Takeda Pharm aceutical Company. The Canadian Institutes of Health Research is providing funds to support ADNI clinical sites in Canada. Private sector contributions are fa cilitated by the Foundation for the National Institutes of Health (www.fnih.org). The grantee organization is the Northern California Institute for Research an d Education, and the study is coordinated by the Alzheimer?s Disease Cooperative Study at the University of California, San Diego. ADNI data are disseminated by th e Laboratory for Neuro Imaging at the University of California, Los Angeles. This research was also supported by NIH grants P30 AG010129 and K01 AG03051 4. The authors thank Drs. D. Stephen Snyder and Marilyn Miller from NIA who are ex-o_cio ADGC members. Support was also from the Alzheimer?s Association (LAF, IIRG-08-89720; MP-V, IIRG-05-14147) and the United States Department of Veterans Affairs Administration, Office of Research and Developmen t, Biomedical Laboratory Research Program. Peter St George-Hyslop is supported by Wellcome Trust, Howard Hughes Medical Institute, and the Canadian Institute of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Diese Studie ist nicht mehr aktuell. Bitte nutzen Sie die aktualisierte Nachfolgestudie ZA7503: EVS Trend File 1981-2017.
Der neue Datensatz wird aufgrund der vorgenommenen Änderungen und Datenrevisionen auch als verbessertes Update für Analysen empfohlen.


Moralische, religiöse, gesellschaftliche, politische, ökonomische und soziale Wertvorstellungen der Europäer.

Der Online Variable Overview ermöglicht den Vergleich von Trend Variablen über die vier EVS Wellen 1981, 1990, 1999 und 2008 sowie einen Vergleich von originalsprachlichen Fragen aus den Wellen 1999 und 2008.

Themen: Einige Fragen wurden nicht in allen Ländern und zu allen Befragungszeiträumen gestellt.

Freizeit: Wichtigkeit der Lebensbereiche Familie, Freunde, Freizeit, Politik, Arbeit, Religion (nur in Schweden: Einsatz für andere); Glücksgefühl; subjektiver Gesundheitszustand; Gefühle von: Aufregung oder Interesse, Rastlosigkeit, Stolz aufgrund von Komplimenten, Einsamkeit, Freude über Vollendung einer Sache, Langeweile, Wohlfühlen, depressiv oder unglücklich, alles gelingt mir, Traurigkeit aufgrund von Kritik; Gefühlslage des Befragten zu Hause: Entspannung, Angst, Zufriedenheit, Aggression oder Sicherheit.

Respekt und Liebe für die Eltern; Verantwortlichkeit der Eltern für ihre Kinder; wichtige Erziehungsziele bei Kindern: gute Manieren, Höflichkeit, Unabhängigkeit, Arbeitsorientierung, Ehrlichkeit, Verantwortungsgefühl, Geduld, Vorstellungskraft, Toleranz und Respekt für andere, Führungsrolle, Selbstkontrolle, Sparsamkeit, Beharrlichkeit, religiöser Glaube, Bescheidenheit, Gehorsam und Loyalität; Rechtfertigung von Abtreibung bei: gesundheitlichem Risiko für die Mutter, Behinderung des Kindes, nicht verheirateter Mutter, fehlendem Kinderwunsch.

Freizeitgestaltung: allein, mit der Familie, mit Freunden, an belebten Orten; Verkehrskreise in der Freizeit; Diskussionshäufigkeit politischer Themen im Freundeskreis; politische Meinungsführerschaft; Mitgliedschaften und ehrenamtliche Tätigkeiten in Vereinen, Parteien, Organisationen, Bürgerinitiativen und Berufsorganisationen; Motive für ehrenamtliche Tätigkeiten; Abneigung gegenüber Leuten mit anderer Einstellung; Einsamkeitsgefühl; Einschätzung der allgemeinen Hilfsbereitschaft in der heutigen Zeit.

Toleranz gegenüber Minderheiten: Straffällige, andere Rasse, Alkoholiker, Muslime, HIV-Infizierte, Drogenabhängige, Homosexuelle, Juden, Zigeuner, Christen, Linke, Rechte, Großfamilien, Hindus, Ausländern; Nachbarschaft von Studenten, unverheirateten Müttern, Andersgläuben und Sektenmitgliedern; zwischenmenschliches Vertrauen; gegenseitiges Vertrauen jüngerer Menschen zu Älteren; derzeitige Lebenszufriedenheit und vor fünf Jahren; erwartete Lebenszufriedenheit in fünf Jahren; empfundene Freiheit und Selbstbestimmung; Bereitschaft zum Einkommensverzicht bzw. zu Steuererhöhungen (Wohlstandsverzicht) zugunsten der Umwelt; Reduzierung der Umweltverschmutzung als Aufgabe der Regierung; Verunsicherung der Menschen durch Gerede über Umweltverschmutzung; Bekämpfung der Arbeitslosigkeit wichtiger als Umweltprobleme; Stellenwert von Umweltschutz und Luftreinhaltung niedriger als suggeriert; nur in Schweden: Umweltschutz versus Wirtschaftswachstum, Mensch und Natur; bei Arbeitsplatzmangel: Einstellung zur Bevorzugung von Männern, Menschen der eigenen Nationalität, Einheimischen, Behinderten sowie zum erzwungenen Ruhestand für Ältere; Zufriedenheit mit der finanziellen Situation des Haushalts; erwartete finanzielle Situation in einem Jahr.

Arbeitswelt: Arbeitsorientierung und Aspekte von Arbeitszufriedenheit; Wichtigkeit ausgewählter Merkmale beruflicher Arbeit: gute Bezahlung, wenig Druck, Arbeitsplatzsicherheit, angesehene Tätigkeit, flexible Arbeitszeit, Möglichkeit zur Eigeninitiative, viel Urlaub, Erfüllung von Zielen, Verantwortung, interessante Tätigkeit, Entsprechung der eigenen Fähigkeiten, nette Arbeitskollegen, gute Aufstiegschancen, der Gesellschaft dienlich, Kontakt zu Menschen, gute körperliche Arbeitsbedingungen sowie Wochenendfreizeit; eigene Erwerbstätigkeit; Vorfreude auf die Arbeit nach dem Wochenende; Stolz auf geleistete Arbeit; empfundene Ausnutzung am Arbeitsplatz; allgemeine Arbeitszufriedenheit (Skalometer); Entscheidungsfreiheit bei der Arbeit; Zufriedenheit mit der Arbeitsplatzsicherheit und Selbstbestimmung in der Arbeit (Skalometer); Arbeitsethos (Skala); Nutzung von bezahlten freien Tagen: Suche nach zusätzlicher entlohnter Arbeit, Fortbildung, Treffen mit Freunden und Familie, zusätzliche Arbeit gegen die Langeweile, ehrenamtliche Tätigkeit, Hobbys, Leitung eines eigenen Geschäfts, Entspannung; Einstellung zu einer leistungsorientierten Bezahlung und zum kritiklosen Befolgen von Arbeitsanweisungen; Präferenz für Mitbestimmung oder staatliche Steuerung von Unternehmen.

Vertrauen in die Familie; Zufriedenheit mit dem Privatleben; Übereinstimmung der Ansichten des Partners sowie der Eltern mit dem Befragten im Hinblick auf: Religion, moralische Standards, soziale Einstellungen, politische Ansichten und sexuelle Vorstellungen; ideale Kinderzahl; Einstellung zum Aufwachsen von Kindern mit beiden Eltern, zur Erfüllung von Frau bzw. Mann durch Kinder, zu sexueller Selbstbestimmung, zur Ehe als überholte Institution, zu allein erziehenden Müttern, zum Ausleben sexueller Freiheit sowie zur Notwendigkeit ausdauernder Beziehungen zum Glücklichsein; wichtigste Kriterien für eine erfolgreiche Ehe (Skala: Treue, gutes Einkommen, gleicher sozialer Hintergrund, Respekt und Anerkennung, religiöser Hintergrund, gute Unterkunft, politisches Einvernehmen, Verstehen und Toleranz, Abstand von Angeheirateten, gute sexuelle Beziehung, Arbeitsteilung im Haushalt, Kinder, Diskussion von Problemen, gemeinsam verbrachte Zeit, Gespräche, gleicher Geschmack und gemeinsame Interessen, Übereinstimmung der ethnischen Herkunft; akzeptierte Gründe für eine Scheidung: finanzieller Bankrott, Krankheit, Alkoholabhängigkeit, Gewalttätigkeit oder Untreue seitens des Partners, sexuelle Unzufriedenheit, nachlassende Liebe, Nicht-Verstehen mit Verwandten, Kinderlosigkeit, unterschiedliche Persönlichkeiten.

Einstellung zur Ehe und zur traditionellen Familienstruktur: Rollenverständnis von Mann und Frau in Beruf und Familie (Skala); Postmaterialismus (Skala); wichtigste Staatsziele des eigenen Landes; Hauptziel von Gefängnisstrafen; Bereitschaft für sein Land zu kämpfen; Einschätzung der Kriegswahrscheinlichkeit im eigenen Land in den nächsten fünf Jahren; erwartete Veränderungen von Werten wie: materielle Güter, Arbeit, Technologie, Individuum, Autoritätsgläubigkeit, Familie, einfachem Lebensstil; Einstellung zum wissenschaftlichen Fortschritt.

Politikinteresse; politische Partizipation: Unterzeichnung einer Petition, Teilnahme an Boykotts, Teilnahme an genehmigten Demonstrationen bzw. an wilden Streiks, Hausbesetzung, Gewalt gegen Personen bzw. Sachen; Präferenz für Freiheit oder Gleichheit; Selbsteinschätzung auf einem Links-Rechts-Kontinuum; gesellschaftliche Grundeinstellungen; Einstellung zum Wirtschaftssystem, zu Einkommensgleichheit, zu Staatsunternehmen, zu Wettbewerb, Leistungsorientierung und zur Akkumulation von Wohlstand bei wenigen Personen; wirtschaftlicher Liberalismus; Einstellung zum Wohlfahrtsstaat; Konservatismus und Notwendigkeit zur Veränderung des Wirtschaftssystems (Skala); persönliche Charaktereigenschaften; Institutionsvertrauen (Kirche, Armee, Bildungssystem, Presse, Gewerkschaften, Polizei, Parlament, öffentlicher Dienst, Sozialsysteme, große Unternehmen, Gesundheitswesen, Justizwesen, Europäische Union, NATO, Vereinte Nationen); Einstellung zu ausgewählten Bewegungen: Umweltschutz, Anti-Atomkraft, Friedensbewegung, Menschenrechte, Frauen und Anti-Apartheid; Demokratiezufriedenheit; Einstellung zum derzeitigen politischen System des Landes und Beurteilung des politischen System des Landes vor zehn Jahren (Skalometer); Präferenz für ein demokratisches politisches System oder für starke Führungspersönlichkeiten (Skala); Einstellung zur Demokratie; Einschätzung der Beachtung der individuellen Menschenrechte im Land.

Nur in Schweden: Zufriedenheit mit öffentlichen Bediensteten; Wirtschaftshilfe für arme Länder; präferierter Entscheidungsträger hinsichtlich Friedenssicherung, Umweltschutz, Hilfe für Entwicklungsländer, Flüchtlinge und Menschenrechte.

Beurteilung der Lösbarkeit von Umweltproblemen, Kriminalität und Arbeitslosigkeit auf nationaler oder internationaler Ebene; präferierte Einwanderungspolitik; Einstellung zur Assimilation und Integration von Immigranten; Wichtigkeit der Angleichung von Einkommen, von Bildungschancen, der Sicherung der Grundbedürfnisse sowie Anerkennung anderer aufgrund ihrer Leistung; Interesse an politischen Nachrichten in den Medien; Individualismus und Gemeinschaftsdenken; Nähe zur Familie, zur Nachbarschaft, den Menschen in der Region, zu den Landsleuten, den Europäern und der Menschheit; Nähe zu älteren Menschen, zu Arbeitslosen, Ausländern, Kranken und Behinderten; Bereitschaft sich für die Familie, Menschen in der Nachbarschaft, Alte, Ausländer, Kranke und Behinderte einzusetzen; persönliche Gründe für Hilfeleistungen bei älteren Menschen sowie bei Ausländern; Parteineigung; Parteipräferenz und Parteiidentifikation; regelmäßige Lektüre einer Tageszeitung; Fernsehkonsum; (nur in Schweden: Fernsehen wichtigste Unterhaltung); vermutete Gründe individueller oder gesellschaftlicher Ursachen für die wirtschaftliche Notlage Einzelner; Einstellung zu Terrorismus, gedankliche Beschäftigung mit dem Sinn des Lebens; Gefühl von Sinnlosigkeit des Lebens; Gedanken über den Tod.

Gottgläubigkeit oder Nihilismus (Skala); Meinung zu Gut und Böse in jedem Menschen; Reue empfinden; Dinge, für die es sich lohnt sein Leben zu riskieren: Land, Leben eines anderen, Gerechtigkeit, Freiheit, Frieden sowie Religion; Einstellung zu Gut und Böse sowie Religion und Wahrheit; derzeitige und gegebenenfalls frühere Konfession; derzeitige Kirchgangshäufigkeit und im Alter von 12 Jahren; Wichtigkeit religiöser Feiern bei Geburt, Hochzeit und Beerdigung; Selbsteinschätzung der Religiosität; Kompetenz der Religionsgemeinschaft in moralischen Fragen, bei Problemen im Familienleben, bei geistigen Bedürfnissen und aktuellen sozialen Problemen des Landes; Einschätzung der Bedeutung von Religion für die Zukunft; Einstellung zur Rolle der Kirche in politischen Streitfragen (Skala); Glaube an: Gott, ein Leben nach dem Tod, Seele, Hölle, Himmel, Sünde, Telepathie, Reinkarnation, Engel, Teufel, Wiederauferstehung von den Toten; Festhalten an der eigenen Religion versus Erkunden verschiedener Religionen; wichtigstes dieser Glaubensgrundsätze; Bedeutung Gottes im eigenen Leben (Skalometer); Kraft und Trost durch Religion; Bedürfnis nach Gebet und Meditation; Beten außerhalb von Gottesdiensten; Zustimmung oder Ablehnung der einzelnen 10 Gebote durch den Befragten und die meisten Menschen; übersinnliche Erlebnisse: Gefühl der Verbundenheit mit jemand weit entfernten, Wahrnehmung weit entfernter Ereignisse, mit einem Toten in Kontakt treten, Nähe zu einer mächtigen Lebenskraft; Veränderung der Sichtweise auf das Leben durch ein übersinnliches Erlebnis; Beziehung zwischen den Eltern in der Jugendzeit des Befragten; Verbundenheit des Befragten zu beiden Elternteilen; strenge Erziehung durch die Eltern; Glaube an übernatürliche Kräfte; Besitz und Glaube an Glücksbringer oder Talisman (Skalometer); Lesen und Berücksichtigen von Horoskopen; Einstellung zur Trennung von Kirche (Religion) und Staat (Skala).

Moral und Sexualität: Moralische Einstellungen (Skala: ungerechtfertigte Inanspruchnahme staatlicher Sozialleistungen, Schwarzfahren, Steuerhinterziehung, Akzeptanz von Schmiergeld, Euthanasie, Suizid, unbefugte Ingebrauchnahme eines Fahrzeugs (Diebstahl), Drogengebrauch, Lügen, Einbruch, Umweltverschmutzung, Alkohol am Steuer, Korruption, Rauchen in öffentlichen Gebäuden, Geschwindigkeitsüberschreitung in Ortschaften, politisches Attentat bzw. Mord, Embryonenforschung, Genmanipulation von Lebensmitteln, Hehlerei, Behalten von gefundenem Geld, Gewalt gegen die Polizei, Fahrerflucht bei Schaden an einem geparkten Fahrzeug, Drohungen gegen Streikbrecher, Töten aus Notwehr); moralische Einstellungen zu Partnerschaft und Sexualität (Homosexualität, Prostitution, Abtreibung, Scheidung, Ehebruch, Promiskuität, Pädophilie); vermutete Verbreitung der oben aufgeführten unmoralischen Verhaltensweisen in der Bevölkerung des Landes (Skala); Häufigkeit des eigenen Alkoholkonsums; Menge des eigenen Alkoholkonsums im Vergleich zu anderen; Einschätzung des Gefahrenpotentials durch den Konsum illegaler Drogen und Alkoholismus; Einstellung zu einer Bestrafung in Abhängigkeit von der Situation des Täters bzw. des Geschädigten (Skala); Einordnung in eine geographische Gruppe; Nationalstolz; Vertrauen in die Landsleute; Einstellung zur Europäischen Union.

Demographie: Geschlecht; Alter (Geburtsjahr); Familienstand; frühere Ehe und Scheidung; Zusammenleben mit einem Partner; Kinderzahl; Haushaltsgröße und Alter der Kinder im Haushalt; Haushaltszusammensetzung; abgeschlossene Berufsausbildung; Alter bei Beendigung der Schulausbildung; Zusammenleben mit den Eltern; Befragter ist Haushaltsvorstand; Charakteristika des Haushaltsvorstands; Wohnstatus; Erwerbsstatus; Vorgesetztenfunktion und Kontrollspanne; Betriebsgröße; Beruf (ISCO88) und berufliche Stellung; Arbeitslosigkeitsdauer; Gewerkschaftsmitgliedschaft des Befragten oder seines Ehepartners; (Schweden: Familienersparnisse während des letzten Jahres); Selbsteinschätzung der Schichtzugehörigkeit; sozioökonomischer Status des Befragten; Einkommen; Ortsgröße; Art der Wohnung; ethnische Zugehörigkeit.

Zusätzlich verkodet wurde: Region, Land; Interviewdatum, Interviewdauer (Schweden: Interviewende); Interviewsprache, Erhebungsjahr; Erhebungswelle; Beginn und Ende des Erhebungszeitraums (Jahr und Monat); Postmaterialismus-Index.

Interviewerrating: Kooperationsbereitschaft des Befragten; Vertrauenswürdigkeit und Gesamteindruck des Befragten.

Diese Studie ist nicht mehr aktuell. Bitte nutzen Sie die aktualisierte Nachfolgestudie ZA7504: EVS Trend File 1981-2017 - Sensitive Dataset.
Der neue Datensatz wird aufgrund der vorgenommenen Änderungen und Datenrevisionen auch als verbessertes Update für Analysen empfohlen.


Moralische, religiöse, gesellschaftliche, politische, ökonomische und soziale Wertvorstellungen der Europäer.

Der Online Variable Overview ermöglicht den Vergleich von Trend Variablen über die vier EVS Wellen 1981, 1990, 1999 und 2008 sowie einen Vergleich von originalsprachlichen Fragen aus den Wellen 1999 und 2008.

Themen: Einige Fragen wurden nicht in allen Ländern und zu allen Befragungszeiträumen gestellt.

Freizeit: Wichtigkeit der Lebensbereiche Familie, Freunde, Freizeit, Politik, Arbeit, Religion (nur in Schweden: Einsatz für andere); Glücksgefühl; subjektiver Gesundheitszustand; Gefühle von: Aufregung oder Interesse, Rastlosigkeit, Stolz aufgrund von Komplimenten, Einsamkeit, Freude über Vollendung einer Sache, Langeweile, Wohlfühlen, depressiv oder unglücklich, alles gelingt mir, Traurigkeit aufgrund von Kritik; Gefühlslage des Befragten zu Hause: Entspannung, Angst, Zufriedenheit, Aggression oder Sicherheit.

Respekt und Liebe für die Eltern; Verantwortlichkeit der Eltern für ihre Kinder; wichtige Erziehungsziele bei Kindern: gute Manieren, Höflichkeit, Unabhängigkeit, Arbeitsorientierung, Ehrlichkeit, Verantwortungsgefühl, Geduld, Vorstellungskraft, Toleranz und Respekt für andere, Führungsrolle, Selbstkontrolle, Sparsamkeit, Beharrlichkeit, religiöser Glaube, Bescheidenheit, Gehorsam und Loyalität; Rechtfertigung von Abtreibung bei: gesundheitlichem Risiko für die Mutter, Behinderung des Kindes, nicht verheirateter Mutter, fehlendem Kinderwunsch.

Freizeitgestaltung: allein, mit der Familie, mit Freunden, an belebten Orten; Verkehrskreise in der Freizeit; Diskussionshäufigkeit politischer Themen im Freundeskreis; politische Meinungsführerschaft; Mitgliedschaften und ehrenamtliche Tätigkeiten in Vereinen, Parteien, Organisationen, Bürgerinitiativen und Berufsorganisationen; Motive für ehrenamtliche Tätigkeiten; Abneigung gegenüber Leuten mit anderer Einstellung; Einsamkeitsgefühl; Einschätzung der allgemeinen Hilfsbereitschaft in der heutigen Zeit.

Toleranz gegenüber Minderheiten: Straffällige, andere Rasse, Alkoholiker, Muslime, HIV-Infizierte, Drogenabhängige, Homosexuelle, Juden, Zigeuner, Christen, Linke, Rechte, Großfamilien, Hindus, Ausländern; Nachbarschaft von Studenten, unverheirateten Müttern, Andersgläuben und Sektenmitgliedern; zwischenmenschliches Vertrauen; gegenseitiges Vertrauen jüngerer Menschen zu Älteren; derzeitige Lebenszufriedenheit und vor fünf Jahren; erwartete Lebenszufriedenheit in fünf Jahren; empfundene Freiheit und Selbstbestimmung; Bereitschaft zum Einkommensverzicht bzw. zu Steuererhöhungen (Wohlstandsverzicht) zugunsten der Umwelt; Reduzierung der Umweltverschmutzung als Aufgabe der Regierung; Verunsicherung der Menschen durch Gerede über Umweltverschmutzung; Bekämpfung der Arbeitslosigkeit wichtiger als Umweltprobleme; Stellenwert von Umweltschutz und Luftreinhaltung niedriger als suggeriert; nur in Schweden: Umweltschutz versus Wirtschaftswachstum, Mensch und Natur; bei Arbeitsplatzmangel: Einstellung zur Bevorzugung von Männern, Menschen der eigenen Nationalität, Einheimischen, Behinderten sowie zum erzwungenen Ruhestand für Ältere; Zufriedenheit mit der finanziellen Situation des Haushalts; erwartete finanzielle Situation in einem Jahr.

Arbeitswelt: Arbeitsorientierung und Aspekte von Arbeitszufriedenheit; Wichtigkeit ausgewählter Merkmale beruflicher Arbeit: gute Bezahlung, wenig Druck, Arbeitsplatzsicherheit, angesehene Tätigkeit, flexible Arbeitszeit, Möglichkeit zur Eigeninitiative, viel Urlaub, Erfüllung von Zielen, Verantwortung, interessante Tätigkeit, Entsprechung der eigenen Fähigkeiten, nette Arbeitskollegen, gute Aufstiegschancen, der Gesellschaft dienlich, Kontakt zu Menschen, gute körperliche Arbeitsbedingungen sowie Wochenendfreizeit; eigene Erwerbstätigkeit; Vorfreude auf die Arbeit nach dem Wochenende; Stolz auf geleistete Arbeit; empfundene Ausnutzung am Arbeitsplatz; allgemeine Arbeitszufriedenheit (Skalometer); Entscheidungsfreiheit bei der Arbeit; Zufriedenheit mit der Arbeitsplatzsicherheit und Selbstbestimmung in der Arbeit (Skalometer); Arbeitsethos (Skala); Nutzung von bezahlten freien Tagen: Suche nach zusätzlicher entlohnter Arbeit, Fortbildung, Treffen mit Freunden und Familie, zusätzliche Arbeit gegen die Langeweile, ehrenamtliche Tätigkeit, Hobbys, Leitung eines eigenen Geschäfts, Entspannung; Einstellung zu einer leistungsorientierten Bezahlung und zum kritiklosen Befolgen von Arbeitsanweisungen; Präferenz für Mitbestimmung oder staatliche Steuerung von Unternehmen.

Vertrauen in die Familie; Zufriedenheit mit dem Privatleben; Übereinstimmung der Ansichten des Partners sowie der Eltern mit dem Befragten im Hinblick auf: Religion, moralische Standards, soziale Einstellungen, politische Ansichten und sexuelle Vorstellungen; ideale Kinderzahl; Einstellung zum Aufwachsen von Kindern mit beiden Eltern, zur Erfüllung von Frau bzw. Mann durch Kinder, zu sexueller Selbstbestimmung, zur Ehe als überholte Institution, zu allein erziehenden Müttern, zum Ausleben sexueller Freiheit sowie zur Notwendigkeit ausdauernder Beziehungen zum Glücklichsein; wichtigste Kriterien für eine erfolgreiche Ehe (Skala: Treue, gutes Einkommen, gleicher sozialer Hintergrund, Respekt und Anerkennung, religiöser Hintergrund, gute Unterkunft, politisches Einvernehmen, Verstehen und Toleranz, Abstand von Angeheirateten, gute sexuelle Beziehung, Arbeitsteilung im Haushalt, Kinder, Diskussion von Problemen, gemeinsam verbrachte Zeit, Gespräche, gleicher Geschmack und gemeinsame Interessen, Übereinstimmung der ethnischen Herkunft; akzeptierte Gründe für eine Scheidung: finanzieller Bankrott, Krankheit, Alkoholabhängigkeit, Gewalttätigkeit oder Untreue seitens des Partners, sexuelle Unzufriedenheit, nachlassende Liebe, Nicht-Verstehen mit Verwandten, Kinderlosigkeit, unterschiedliche Persönlichkeiten.

Einstellung zur Ehe und zur traditionellen Familienstruktur: Rollenverständnis von Mann und Frau in Beruf und Familie (Skala); Postmaterialismus (Skala); wichtigste Staatsziele des eigenen Landes; Hauptziel von Gefängnisstrafen; Bereitschaft für sein Land zu kämpfen; Einschätzung der Kriegswahrscheinlichkeit im eigenen Land in den nächsten fünf Jahren; erwartete Veränderungen von Werten wie: materielle Güter, Arbeit, Technologie, Individuum, Autoritätsgläubigkeit, Familie, einfachem Lebensstil; Einstellung zum wissenschaftlichen Fortschritt.

Politikinteresse; politische Partizipation: Unterzeichnung einer Petition, Teilnahme an Boykotts, Teilnahme an genehmigten Demonstrationen bzw. an wilden Streiks, Hausbesetzung, Gewalt gegen Personen bzw. Sachen; Präferenz für Freiheit oder Gleichheit; Selbsteinschätzung auf einem Links-Rechts-Kontinuum; gesellschaftliche Grundeinstellungen; Einstellung zum Wirtschaftssystem, zu Einkommensgleichheit, zu Staatsunternehmen, zu Wettbewerb, Leistungsorientierung und zur Akkumulation von Wohlstand bei wenigen Personen; wirtschaftlicher Liberalismus; Einstellung zum Wohlfahrtsstaat; Konservatismus und Notwendigkeit zur Veränderung des Wirtschaftssystems (Skala); persönliche Charaktereigenschaften; Institutionsvertrauen (Kirche, Armee, Bildungssystem, Presse, Gewerkschaften, Polizei, Parlament, öffentlicher Dienst, Sozialsysteme, große Unternehmen, Gesundheitswesen, Justizwesen, Europäische Union, NATO, Vereinte Nationen); Einstellung zu ausgewählten Bewegungen: Umweltschutz, Anti-Atomkraft, Friedensbewegung, Menschenrechte, Frauen und Anti-Apartheid; Demokratiezufriedenheit; Einstellung zum derzeitigen politischen System des Landes und Beurteilung des politischen System des Landes vor zehn Jahren (Skalometer); Präferenz für ein demokratisches politisches System oder für starke Führungspersönlichkeiten (Skala); Einstellung zur Demokratie; Einschätzung der Beachtung der individuellen Menschenrechte im Land.

Nur in Schweden: Zufriedenheit mit öffentlichen Bediensteten; Wirtschaftshilfe für arme Länder; präferierter Entscheidungsträger hinsichtlich Friedenssicherung, Umweltschutz, Hilfe für Entwicklungsländer, Flüchtlinge und Menschenrechte.

Beurteilung der Lösbarkeit von Umweltproblemen, Kriminalität und Arbeitslosigkeit auf nationaler oder internationaler Ebene; präferierte Einwanderungspolitik; Einstellung zur Assimilation und Integration von Immigranten; Wichtigkeit der Angleichung von Einkommen, von Bildungschancen, der Sicherung der Grundbedürfnisse sowie Anerkennung anderer aufgrund ihrer Leistung; Interesse an politischen Nachrichten in den Medien; Individualismus und Gemeinschaftsdenken; Nähe zur Familie, zur Nachbarschaft, den Menschen in der Region, zu den Landsleuten, den Europäern und der Menschheit; Nähe zu älteren Menschen, zu Arbeitslosen, Ausländern, Kranken und Behinderten; Bereitschaft sich für die Familie, Menschen in der Nachbarschaft, Alte, Ausländer, Kranke und Behinderte einzusetzen; persönliche Gründe für Hilfeleistungen bei älteren Menschen sowie bei Ausländern; Parteineigung; Parteipräferenz und Parteiidentifikation; regelmäßige Lektüre einer Tageszeitung; Fernsehkonsum; (nur in Schweden: Fernsehen wichtigste Unterhaltung); vermutete Gründe individueller oder gesellschaftlicher Ursachen für die wirtschaftliche Notlage Einzelner; Einstellung zu Terrorismus, gedankliche Beschäftigung mit dem Sinn des Lebens; Gefühl von Sinnlosigkeit des Lebens; Gedanken über den Tod.

Gottgläubigkeit oder Nihilismus (Skala); Meinung zu Gut und Böse in jedem Menschen; Reue empfinden; Dinge, für die es sich lohnt sein Leben zu riskieren: Land, Leben eines anderen, Gerechtigkeit, Freiheit, Frieden sowie Religion; Einstellung zu Gut und Böse sowie Religion und Wahrheit; derzeitige und gegebenenfalls frühere Konfession; derzeitige Kirchgangshäufigkeit und im Alter von 12 Jahren; Wichtigkeit religiöser Feiern bei Geburt, Hochzeit und Beerdigung; Selbsteinschätzung der Religiosität; Kompetenz der Religionsgemeinschaft in moralischen Fragen, bei Problemen im Familienleben, bei geistigen Bedürfnissen und aktuellen sozialen Problemen des Landes; Einschätzung der Bedeutung von Religion für die Zukunft; Einstellung zur Rolle der Kirche in politischen Streitfragen (Skala); Glaube an: Gott, ein Leben nach dem Tod, Seele, Hölle, Himmel, Sünde, Telepathie, Reinkarnation, Engel, Teufel, Wiederauferstehung von den Toten; Festhalten an der eigenen Religion versus Erkunden verschiedener Religionen; wichtigstes dieser Glaubensgrundsätze; Bedeutung Gottes im eigenen Leben (Skalometer); Kraft und Trost durch Religion; Bedürfnis nach Gebet und Meditation; Beten außerhalb von Gottesdiensten; Zustimmung oder Ablehnung der einzelnen 10 Gebote durch den Befragten und die meisten Menschen; übersinnliche Erlebnisse: Gefühl der Verbundenheit mit jemand weit entfernten, Wahrnehmung weit entfernter Ereignisse, mit einem Toten in Kontakt treten, Nähe zu einer mächtigen Lebenskraft; Veränderung der Sichtweise auf das Leben durch ein übersinnliches Erlebnis; Beziehung zwischen den Eltern in der Jugendzeit des Befragten; Verbundenheit des Befragten zu beiden Elternteilen; strenge Erziehung durch die Eltern; Glaube an übernatürliche Kräfte; Besitz und Glaube an Glücksbringer oder Talisman (Skalometer); Lesen und Berücksichtigen von Horoskopen; Einstellung zur Trennung von Kirche (Religion) und Staat (Skala).

Moral und Sexualität: Moralische Einstellungen (Skala: ungerechtfertigte Inanspruchnahme staatlicher Sozialleistungen, Schwarzfahren, Steuerhinterziehung, Akzeptanz von Schmiergeld, Euthanasie, Suizid, unbefugte Ingebrauchnahme eines Fahrzeugs (Diebstahl), Drogengebrauch, Lügen, Einbruch, Umweltverschmutzung, Alkohol am Steuer, Korruption, Rauchen in öffentlichen Gebäuden, Geschwindigkeitsüberschreitung in Ortschaften, politisches Attentat bzw. Mord, Embryonenforschung, Genmanipulation von Lebensmitteln, Hehlerei, Behalten von gefundenem Geld, Gewalt gegen die Polizei, Fahrerflucht bei Schaden an einem geparkten Fahrzeug, Drohungen gegen Streikbrecher, Töten aus Notwehr); moralische Einstellungen zu Partnerschaft und Sexualität (Homosexualität, Prostitution, Abtreibung, Scheidung, Ehebruch, Promiskuität, Pädophilie); vermutete Verbreitung der oben aufgeführten unmoralischen Verhaltensweisen in der Bevölkerung des Landes (Skala); Häufigkeit des eigenen Alkoholkonsums; Menge des eigenen Alkoholkonsums im Vergleich zu anderen; Einschätzung des Gefahrenpotentials durch den Konsum illegaler Drogen und Alkoholismus; Einstellung zu einer Bestrafung in Abhängigkeit von der Situation des Täters bzw. des Geschädigten (Skala); Einordnung in eine geographische Gruppe; Nationalstolz; Vertrauen in die Landsleute; Einstellung zur Europäischen Union.

Demographie: Geschlecht; Alter (Geburtsjahr); Familienstand; frühere Ehe und Scheidung; Zusammenleben mit einem Partner; Kinderzahl; Haushaltsgröße und Alter der Kinder im Haushalt; Haushaltszusammensetzung; abgeschlossene Berufsausbildung; Alter bei Beendigung der Schulausbildung; Zusammenleben mit den Eltern; Befragter ist Haushaltsvorstand; Charakteristika des Haushaltsvorstands; Wohnstatus; Erwerbsstatus; Vorgesetztenfunktion und Kontrollspanne; Betriebsgröße; Beruf (ISCO88) und berufliche Stellung; Arbeitslosigkeitsdauer; Gewerkschaftsmitgliedschaft des Befragten oder seines Ehepartners; (Schweden: Familienersparnisse während des letzten Jahres); Selbsteinschätzung der Schichtzugehörigkeit; sozioökonomischer Status des Befragten; Einkommen; Ortsgröße; Art der Wohnung; ethnische Zugehörigkeit.

Zusätzlich verkodet wurde: Region, Land; Interviewdatum, Interviewdauer (Schweden: Interviewende); Interviewsprache, Erhebungsjahr; Erhebungswelle; Beginn und Ende des Erhebungszeitraums (Jahr und Monat); Postmaterialismus-Index.

Interviewerrating: Kooperationsbereitschaft des Befragten; Vertrauenswürdigkeit und Gesamteindruck des Befragten.

Domestic Violence in Danielle Steel's Journey (A Liberal Feminism Approach) Aryani Fitri Hira Kartika English Department, Faculty of Languages and Arts, Surabaya State University Aryanifitri11@gmail.com Fabiola Dharmawati Kurnia English Department, Faculty of Languages and Arts, Surabaya State University fabkurnia@gmail.com Abstrak Permasalahan kekerasan dalam rumah tangga selalu menjadi ancaman bagi wanita. Hak asasi manusia mereka ditiadakan oleh suami.Tujuan penelitian ini adalah menganalisis bagaimana kekerasan dalam rumah tangga dan bagaimana wanita melawan kekerasan yang tergambarkan pada Journey karya Danielle Steel. Penelitian ini menggunakan metode data deskriptif-qualitatif dengan pendekatan konsep kekerasan menurut Paula and Margie untuk menunjukkan bentuk kekerasan dalam rumah tangga dan liberal feminisme menurut Naomi Wolf dan John Stuart Mill untuk menunjukkan usaha wanita untuk melawan kekerasan dan bangkit dari permasalahannya. Hasil penelitian ini mengungkapkan (1) bentuk kekerasan yang dialami Mddy, tokoh utama dalam Journey yang ditinjau dari pendekatan liberal feminisme adalah kekerasan emosional; penghinaan, ancaman, menganggap rendah, dan pengisolasian sosial, sementara kekerasan seksual;pemaksaan seks, pemaksaan sterilisasi, penyiksaan secara seksual, dan menganggap wanita sebagai objek seks. (2) Bagaimana Maddy melawan kekerasan melalui berani berbicara ketika Ia ingin diberi kesempatan untuk memberi ide-idenya dalam area pekerjaan, membuat keputusan dalam hidupnya, bersosialisasi dengan teman-temannya, melalui tindakan ketika Ia menentang perintah suaminya untuk menjauhi anak istrinya, keinginan Maddy tetap pada merawat anaknya, dan yang terakhir melalui personal autonomi ketika Ia mengambil sikap untuk berpisah dari suaminya demi terbebas dari kekerasan suaminya. Berpisah dari suaminya, Ia bisa hidup mandiri tanpa bayang-bayang suaminya. Keywords : Kekerasan, Wanita, Perlawanan, Liberal Feminisme Abstract Violence always becomes threat for women. Their human rights are denied by their husband.The purpose of this study is analyzing how domestic violence to woman and how woman resists against violence as reflected in Danielle Steel's JOURNEY. This research of method used to analyze the data is a descriptive-qualitative with an approach of domestic violence by Paula and Margie to show the forms of domestic violence and liberal feminism by Naomi Wolf and John Stuart Mill to show her efforts to resist against violence and revival from her problems. The result of this research exposes that (1) violence experienced by Maddy as the main female character are emotional abuse; humiliation, threats, belittling, and social isolation, meanwhile sexual abuse; rape, enforced sterilization, torturing sexually, and looking woman as sexual object. (2) How Maddy resists against violence through speak out as she wants to be given opportunity in giving her ideas in her working place, making her own decisions in her life, socializing with her friends, and, through doing action as Maddy tries to oppose every her husband's commands, one of them is her decision for taking care her children and through being personal autonomy when she decides to divorce with her husband and lived independent with working without the shadows of her husband. She has had power to be personal hood in determining self, mind, body, and feeling that divorce is the best way for sake of happiness and pleasure (freedom of emotional and sexual abuses) perpetuated by her husband. Keywords : Violence, Women, Resistance, Liberal Feminism INTRODUCTION: God creates a man to the earth for living in love with others but in reality lately the acts of violence has always been part of the human experience. Acts of violence can happen in everywhere, be experienced by anyone, and be perpetrated by anyone (Dustin, 2009:87). However, survey from UNICEF Research Centre in 2000 states that violence is regular part of women's experience in domestic violence. They are unable to make their own decisions, voice their own opinions or protect themselves and their children for fear of further repercussions. Their human rights are denied and their lives are stolen from the abuser by regularly getting threats of violence (Khan, 2000:2). Many factors make women experience violence, one of them is gender bias, unequal power relations between men and women in which women is forced into a subordination position compared women than men that leads women as the victim of men dominance and discrimination and to prevention of the full advancement of women (Khan, 2000:2). Violence in domestic life always happens toward wife as a party who is regarded weaker than her husband. Joda et al, 2009:2 states that husband often do not feel guilty with what he does even he feels no breaking the law when he commits violence to his wife. Some women activists believes that violence in domestic sphere is rooted in belief of patriarchal system that still applied by husband in system of his household. According to Dobash, patriarchy contributes toward wife abuse. The system had defined the differences of gender between men and women. Husband was supposed to be strong, dominant, authoritarian, aggressive, and rational provider while women had devalued as secondary and inferior who had been assigned to be irrational, dependent, passive, submissive, soft, nurturing (in Margie, 2002:34). Patriarchal society regarded women as men's property and gave authority toward husband to control and decide decision for wife. Araji and Carlson (2001) argued that patriarchal societies may foster domestic violence because the dominant male is perceived to be appropriately disciplining and controlling the behaviour of the subordinate wife in the family (in Florence, 2008:592). The forms of women abuse can be classified into three forms, those are physical abuse, emotional abuse, and sexual abuse. Physical abuse is like grabbing, hitting, and kicking, sexual abuse is like demanding sex when one's partner is unwilling, enforced to sterilization, regarding women as a sex object, and emotional abuse is like humiliation, threatening, belittling, and social abuse (Paula, 2006:5 &16 and Margie, 2000: 3-6). Bhasin states that patriarchy as a concept to refer social system of masculine domination over women. Patriarchal society places men in superior or masculine position meanwhile women is put in subordinate position (2000:10). Murniati states that patriarchy is a system of socio-culture that marginalizes women's position in all aspects including in economic, social, education, politic sphere as if the system legitimizes some a various inequality, deprivation, and oppression over women (2004:227-229). In patriarchal situation, women had only little influences in society where they did not have rights on common areas in society such as in family, social, government, education. So, women's economic social, political, psychological condition depended on men. Domestic violence always becomes the hidden issue. Almost all of the victims are unwilling to report the police because wife still depends on financial on husband, wife still loves her husband, and many reason else. Summer states that many the victim is always silent toward violence perpetrated by her husband, never resists the abuser and never tells anyone (Summers, 2002:170). Moreover, according to Joyce, victims of violence over time experiences more serious consequences than of one-time incidents. Domestic violence against women where husband as the perpetrator can lead psychological consequences for the victim (2009:134-135). Gender bias that causes women are always marginalized, subordinated, and oppressed in the family at the place of work, and in society emmerges feminism. Feminism is an awareness of women oppression at the place of work within the family and an awareness of patriarchal control (Bhasin, 2000:31). Meanwhile Carter states that feminism is a movement for women that attempts to resist the dominance of a patriarchal society have a long history (2006:910). One of feminism movement that defend equality rights between men and women is liberal feminism. Liberal feminism is a movement that is reflected in every struggle done by women to demand the right of freedom (Humm, 2002:250). Liberal feminism emphasizes the importance of individualism, freedom, especially freedom of choice. The feminist movement is that women gain control. Both of the body itself as well as the social world. They reject the gender symbols attached to each sex and gender socialization to children that had been done. Women experience discrimination because of gender inequality but women should have same opportunity like men in all of aspects, including private field, or public field, or public field (Ritzer, 1992:450). John Stuart Mill states that women must be personal autonomy as women are rational beings and have the same capacity as men. Problems faced by women more often caused by women if legal reform has happened to make equality between men and women (Tong, 2009:29). Women who success financially comfortable, succesful does not guarantee them will freedom from discrimination and violation. As women regard themselves as the victim of discrimination and violation, Wolf states that women have the power to control what happens to them so stop thinking of themselves as victim and to capitalize on the power inherent in their majority status. Society does not oppress them. It is time for women to do self defeating (speak out) against violation and discrimination. Proclaiming themselves as victimhood does not project strength (Wood, 2009:84). Journey is a novel that will be analyzed. This research chooses the novel as the main female character, experiences violence emotionally and sexually during her marriage life however Maddy is a representation of woman's movement who is brave to speak out against violence perpetruated by her husband but she never tries to hate marriage institution. Maddy as a woman who is not afraid to out of comfort zone and false happiness created by her husband after getting supports from her friends, a support group for battered women, daughter. She escapes from the shackle of oppression to be an independent, free women with her daughter and her friends who support her not like many wives commonly are afraid to escape from violence or say divorce cause they still depend on their husband. Based on the explanation above, the writer is interested to analyze how domestic violence is reflected using the concept of domestic violence from sociological approach by Paula and Margie and how woman resists against violence and revival from her problems by using liberal feminism by Naomi Wolf and John Stuart Mill. Theoritical Framework In producing a good understanding of the conflicts in domestic life which woman experiences and how woman resists against violence in Danielle Steel's Journey, this study applies extrinsic approach in analyzing the problems. The theory of domestic violence by Paula and Margi is chosen as the tool to find out domestic violence to woman is reflected in Danielle Steel's Journey. Theory of domestic violence is a theory which is used to analyze how the forms of abuses which is experienced by the victim. The types of domestic violence according to Paula and Margie consist of physical abuse, emotional abuse, and sexual abuse. (1) Physical abuse is the action of physically assaults, causing injury, pinching, or squeezing, (2) emotional or psychological abuse is consistently doing or saying things verbally that results in fear, loss of confidence, loss of the ability to act, a sense of helplessness and or severe psychological suffering on a person, and (3) sexual abuse is including sadism and forcing a person to have sex when he or she does not want to, forcing a person to engage in sexual act that he or she does not like or finds unpleasant, frightening, or violent, touches the victim sexually in uncomfortable ways, and regards women as a sexual object. Liberal feminism is chosen as the tool to analyze how woman resist against violence. Its feminism emphasizes that violence toward women is based on unequal power relations between women and men. Its theory emphasizes equal individual rights and liberties for women and downplaying sexual differences. Liberal feminist propose a series of strategies for eliminating gender inequality; supporting individual in challenging sexism wherever it is enccountered in daily life without hating the marriage institution. As women experience inequality, the soulution is on women themselves (Ritzer, 1992:452-53). In challenging discrimination and violation toward women, Wolf demands woman to do self defeating (speak out). Its concept is used by Wolf to give powerness for women resist against discrimination and violation (Wood, 84). Wolf states that women are not needed to ask for permission toward anyone for achieving social equality (1999:79). Meanwhile John Stuart Mill gives powerness on women for being personal autonomy. Personal autonomy is a autonomous decision making. John Stuart Mill states that women have powerness as personhood over their self, their thinking, their feeling, their body in determining a choice in their living for sake of happiness and pleasure but not obstruct another people's right in the process (Tong, 2009:16) Based on the background of the study above, the questions below will be answered. (1). How is domestic violence to woman reflected in the Danielle Steel's Journey? (2). How does woman in Danielle Steel's Journey resist against violence? Research Design and Method: To analyze Danielle Steel's Journey, this study uses descriptive qualitative. Thomas (2003) defines qualitative methods as method that involves research by describing kinds of characteristics people and events without comparing the events in term of amounts. The main data is the novel entitled Journey by Danielle Steel, published in 2000 by Dell Publishing, New York. Meanwhile the additional data are taken from many sources such as journal, book, and internet sources. Besides that, quotations in the novel is taken also related how domestic violence to woman is reflected and how woman resists against woman as represented by the main female character of Maddy. There were some steps taken in conducting this study. First, reading was the first step to do to gain the idea the novel intends to deliver. After the writer has finished reading the novel, the next step which was hold was close reading. This step was applied to find quotations related to the topic and problems going to analyze. Close reading was done three times. The first close reading was to find the quotations which are related how domestic violence to woman, then the second close reading was to find how woman resists against woman as represented in Danielle Steel's Journey. The data observed from the novel were then analyzed to the statement of the problems. It was then synchronized with the similar concept of domestic violence by Paula and Margie, concept of victimization by Joyce, and the concept of liberal feminism by Naomi Wolf and John Stuart Mill taken from journals, books, and critical essays. The synchronized data were useful to take final conclusions. Therefore, the significance of the study can be achieved well. Data analysis For the first question this study take theory from the theoritical framework which concerns with forms of abuse toward woman. The concept of domestic violence by Paula and Margie will be explained in this research to find out how domestic violence to woman is reflected in Danielle Steel's Journey. In this research, the writer only found two forms of abuses to women, they are emotional abuses, and sexual abuses. For the second question this study take theory from the theoritical framework which concerns with women's efforts to resist against violence. The concept of liberal feminism by Naomi Wolf and John Stuart Mill which are used to reveal how woman in Danielle Steel's Journey resists against violence. RESULT (1). As the explanation of the domestic violence, this study finds out domestic violence to woman into two forms of abuse, they are emotional abuse and sexual abuse. Emotional Abuse consists of humiliation, threatening, belittling, social isolation. Meanwhile sexual abuse consist of rape, enforced sterilization, torturing sexually, and looking woman as a sexual object. (2). As the explanation of liberal feminism by Naomi Wolf and John Stuart Mill, this study reveal how woman resists against violence. The strategy of Maddy's resistance to get out of domestic violence in Danielle Steel's Journey through speak out, doing action, and being personal autonomy. 1.1 Emotional Abuse 1.1.1 Humiliation "I don't give a damn what you think. I don't pay you to think. I pay you to look good and read the news of a TelePrompTer. That's all I want from you. And with that, he walked into his bathroom, and slammed the door behind him, as she burst into tears in their bedroom. (Steel, p. 34) The quotation above show the form of humiliation by men toward women. In this Journey, Jack always puts his wife into subordinate position. Jack never regards his wife having capability in thinking. Jack just cares how Maddy could look beautiful in front of audiences without giving opportunity for her in giving her arguments or ideas as she is delivering the news. Jack will getting angry as Maddy tries to oppose his commands. One of his commands is prohibitting his wife to hold the program of editorial however Maddy still holds it for the sake of helping her new friend who committed suicide due to abused by her husband, Jack's friend also. 1.1.2 Threatening "I heard you, she said numbly. And I hate you for it. I don't give a damn what you think or feel about this. I only care about what you do, and it goddamn better be the right thing this time, or you're finished. With me and the network. Is that clear, Mad? She looked at him for a long moment and then turned on her heel and walked swiftly down the stairs, back to her own floor. She was pale and shaking." (Steel, p.63) The quotation above shows that Jack always tries threats for Maddy, his wife. Besides she will loss her jobs, Jack will divorce Maddy as his threat for his wife as she does not obey what Jack says to her. Maddy loves so much her husband and also depend financially with her husband. That's Maddy has no other alternatives to leave her husband. In her marriage, Maddy has no power over her husband. Jack always regards her as his property that could be ordered by Jack. Jack feels Maddy as his wife and his employee so he deserves to control his wife as she tries to show her potential in giving comments which acrosses with Jack's principles. 1.1.3 Belittling "That's insulting! It's the truth. As I recall, Mad, you never went to college. In fact, I'm not even sure if you finished high school. It was the ultimate put-down, insinuating that she was too stupid and uneducated to think (Steel, p. 90) The quotation above shows that Maddy tries to oppose all of belittling which is perpetruated by Jack to her however Jack gives awareness to Maddy that the reason of belittling is because Jack doubts whether Maddy ever finished her school or not. The unequal power relation in educational things lead discrimination over Maddy by Jack. Jack belittles Maddy as a stupid wife so Maddy should put down with her husband's commands. 1.1.4 Social Isolation "She didn't have that many friends in Washington, she'd never had time to make them and those she had made, Jack never liked, and eventually pressured her not to see them. She never objected because Jack always had some objection to them, regarding her friends were fat, ugly, inappropriate, or indiscreet. He kept Madeleine carefully guarded, and inadvertently isolated. She knew he meant well in protecting her, and she didn't mind, but it meant that the person she was closest to was Jack, and in recent years, Greg Morris." (Steel, p. 25) From the quotation above, social isolation is as form of discrimination. Men have full power over women as well as limits women to socialize with their friends. In Journey, Jack as the head of family, he determines which is a friend should be and should not be met by Maddy. Meanwhile Jack is freedom to choose which a friend he wants to meet. Besides his bussiness relation, he can also meet with woman. The quotation can be seen below: "He had been so quick to explain the photograph of the woman he's been with at Annabel's in london (Steel, p.159) 1.2 Sexual Abuse 1.2.1 Rape "He was smiling at her, and he reached out a hand and gently touched her breast, and then before she could stop him, he had grabbed her so hard, it made her gasp, and she begged him to stop "Why, baby? Tell me why? Don't you love me? I love you, but you're hurting me. There were tears in her eyes as she said it. I don't want to make love tonight, she tried to say, but he didn't listen, he grabbed a handful of her hair and sharply pulled her head back. What she sensed most in his love for her was danger. (Steel, p.87) From the quotation above shows that Jack regards Maddy as his own property which could be used by Jack anytime Jack wants. Jack always controls Maddy's sexuality. It can be shown from the quotation above as Jack always forces Maddy to have a sex with him although Maddy does not want to have a sex with Jack or finds unpleasant, frightening, violent when having a sex. Jack does not care with his wife's refusal, instead Jack grabs a handful of her hair and sharply pulled her head back to make his sexual impulse satisfied. 1.1.5 Enforced Sterilization "Jack convinced Maddy that children will obstacle her career. Jack had made it very clear to her right from the beginning that he didn't want children. And after a brief period of mourning for the babies she would never have, at Jack's insistence, Maddy had had her tubes tied. It seemed easier to give in to Jack's wishes and not take any chances. He had given her so much, and wanted such great things for her. She could see his point that children would only be an obstacle she'd have to overcome, and a burden on her career. But there were still times when she regretted the irreversibility of her decision. (Steel, p. 15). From the quotation above shows forcing woman to tie the rope uterus shows the violations of human rights because it is band for woman's reproduction where woman will never have children again. The factors that leads this abuse still attached to the dominant assumption has the right to control the weak and the wife playing the role of a person who is required to comply, in terms of the economic dependence of women makes women cannot do anything other than comply with applicable rules. Jack Maddy action to force the rope cut the uterus with the aim that Maddy is not hampered career is a form of self control female reproduction by males while liberal feminism oppose the restrictions on reproduction for having offspring is the right of every individual, and no one was allowed to prohibit or restrict. 1.1.6 Torturing sexually "Are you going to be a good girl now?" he asked, taunting her, torturing her with pleasure. "Do you promise?" "I promise," she said breathlessly. "Promise again, Mad." He was a master at what he was doing, it had taken long years of practice. "Promise me again"I promise I promise I promise I'll be good, I swear." All she wanted now was to please him, and from the distance, she knew she hated herself for it. She had sold out to him again, given herself to him again, but he was too powerful a force to resist (Steel, p. 70) From the quotation above can be stated that Jack as a husband who tries to pressure toward his wife in order to always being submissive and does not break commands which have applied by her husband. Jack reminds his wife with torturing her sexually slow by slow when having sex, in order to his wife realizes that the acts which have been done by Maddy is wrong. As Maddy's position is in inferior status and depends financially toward her husband, Jack regards her as his own property that can be treated anything. 1.1.7 Looking woman as a sexual abuse "They often lay there for a while before they went to sleep, talking about what had happened that day, the places they'd been, the people they'd met with, the parties they'd been to. As they did now, and Maddy tried to guess what the President was up to. I told you, I'll tell you when I can, stop guessing. Secrets drive me crazy, she giggled. You drive me crazy, he said, turning her gently toward him, and feeling the satin of her flesh beneath the silky nightgown (Steel, p. 15). The quotation above shows that woman still is put in inferior position. Because of her position in inferior, man always regards woman's existence as a sexual object not as a friend in helping her husband in solving the problems. From the quotation above, Maddy feels curious what is talking with her husband with the president, she tries to ask well but her husband instead say crazy to Maddy. Jack only focuses on her body which is reflected in he stops her husband's conversation which tries to ask what happens between her husband and president, Jack instead turns Maddy gently toward him, and feeling the satin of her flesh beneath the silky nightgown. 2. The Strategy woman's resistance against violence 2.1 Speak out "Have you ripped Jack's head off yet about our editorials? He grinned at her. No, but I will later, when I see him. As Jack and Maddy sped together toward Georgetown, she said to Jack "What the hell happened to our editorials? "Bullshit, Jack, they love them. Whydidn't you say something to me about it this morning?" She still looked annoyed. You never even asked me. It would have been nice to know. I think you really made the wrong decision on that one. (Steel, chapt 3: 27) The quotation above shows that Maddy tries to do refusal against Jack's treatment that suddenly stopped the editorial program which is hosted by Maddy. For Maddy, the act of Jack that has stopped the editorial program which is hosted by her is as form of individual rights violation as Jack who always created his own decisions without giving freedom his wife to speak or deliver her ideas or just giving refusal with Jack's concepts which must be runned by his wife. In working place, Jack is as a concept maker meanwhile Maddy is just a puppet that only run the duties of work from Jack without being given the opportunity to give her ideas. Maddy dare to challenge Jack the event that a decision to dismiss an editorial decision is the kind of action one dared speak against the arbitrary actions of Jack who always underestimate the ability of Maddy in guiding news event. "I'm so proud of you, Madeleine," said a soft voice Phyllis Armstrong , wife of the president. "That was a very brave thing you did, and the editorial is very necessary. It was a wonderful broadcast, Maddy." "Thank you, Mrs. Armstrong, said Maddy." (Steel, chapt 3: 32) The quotation above shows that Maddy has strengtheness against Jack's commands which acrosses with Maddy's principle. She does not want to regard herself as victim of victimhood. Although Jack has stopped the program however Maddy is not afraid to air the program without unbeknownst by Jack. Without helping from Jack's concepts, Maddy actually has power in delivering news well. It can be shown as many audiences and the president's wife commend her broadcast is very amazing. For Maddy, the struggle which has done by her toward Janet is a form of struggle as woman to help other women and also her efforts to show her existence. In the sphere of work, Maddy does not want to regulated by Jack, she wanted to be given the opportunity to organize the editorial program which is ever hosted by her. 2.2 Doing action Liberal feminism supports that every women have equal rights and freedom same as men, including freedom in making choice for reproduction. As Maddy decides to marry with Jack, she thinks that her life will brings happiness. Jack always brings luxurious gifts for Maddy, she never got abuses physically like her marriage life with Bobby Joe and her childhood life that her father always beats her and his mother. However, Jack never gives rights as individual and social beings. One of human right violation which is perpetrated by Jack to Maddy is prohibitting Maddy to have a baby that Maddy must allow her tube of uterus tied in the name of love her for Jack. "Why didn't you tell me that you'd had a visit from my daughter?" Her eyes never lefthis as she asked the question, and she saw something cold and hard come into his, a burning ember that was rapidly being kindled by anger. "Why didn't you tell me you had a daughter?" he asked just as bluntly. "What I want to know from you is why you didn't tell me that you saw her. What were you saving it for?" (Steel, 111) The quotation above shows that as a woman, Maddy wants to her existence can be regarded, a form of recognition of the existence of women by men with giving woman to create reproduction choice. From the quotation above is explained that Maddy shows her anger to Jack as he has intended Maddy to meet her daughter who has ever regarded lost. The action of Jack to Maddy can be categorized with human rights violation to have descent. Understanding that Jack never accept Lizzy's presence, Maddy does not care how Jack will respond the situation. In Maddy's mind is only Lizzy. She deserves to have a right for having a child after Jack ever loss Maddy's opportunity. As stated by Naomi Wolf that social equality is not things that are entreated from others. Women must be ready to have a place that has become their rights. Maddy realizes that she has a right to be mother without asking for permission from Jack, she still maintain her rights to regard Maddy to be her children and meets with her. The quotation can be seen below: "Where were you? Try telling me the truth this time.I was with Lizzie. Who is that?" My daughter. Oh, for God's sake," he said." (Steel, p.129). 2.3 Being Personal Autonomy "You owe me everything. And I hope you realize you'll be out of a job if you leave me." His eyes glittered like steel."Possibly. I'll let my lawyers handle that, Jack. I have a contract with the network.You can't just throw me out without notice or compensation." She had gotten braver and smarter while fighting for her life in the rubble. (185) Based on the above text can be proved that maddy had dared to oppose, and to threaten Jack behind. The quotation above explains that the woman has power to determine self, body, and mind. Maddy has shows how she is able to stand alone. For sake of happiness and pleasure, she does not let his wife to hurt her heart agains. She deseves to find her autonomous choices witthout being afraid with threats from her husband as stated by John Stuart Mill above. After she decides to leave living which is borrowed by Jack, Maddy get offers to become a broadcaster of three big television station still she thinks that it is time for her taking care her daughter and her son first. She wants to feel how being a mother thrutfully as John Stuart Mill states that women have power to determine her self, her body, and her mind. In this case Maddy wants to determine her self as a mother first, "I don't know yet. I want to go back to work, but I want to enjoy you and Andy for a while. This is my first chance, and my last, to be a full-time mother. Her lawyer was organizing a major lawsuit against Jack and his network. He owed her a huge severance for kicking her out of her job, and there was the issue of slander, malicious intent, (Steel, p. 201). She also wants to determine her body as Madelaine Beaumont. Determining self, body, and mind according his or her own wishes without getting a force from other, it means that he or she has been personal autonomy. The quotation can be seen below: "She didn't want anything more to do with Jack Hunter. Even if she went on another show again, she had decided to do so as Madeleine Beaumont." (Steel, p. 199) The quotation on 199-201 above can be explained that Maddy as an individual that has found her true identity as a woman, who ever had been despoiled by Jack, her husband. With the emergence of self confidence on Maddy cultivates an attitude of optimism in her mind that without abundant wealth from, happiness could be achieved by Maddy with is accompanied by her children. Maddy could choose to leave her husband, changes her name with using her own name and decides to work again without any coercion from others, she has personal autonomy, a autonomous decision making. Besides she has been personal autonomy, she also becomes a flourishing person that she still decides to work and she is not afraid to sue her husband and her husband networking as he had done violation toward Maddy's name. CONCLUSION The first problem is domestic violence to woman reflected. Based on the result of data analysis and discussions which have been explained on previous chapter, it is revealed that in Journey happens oppression which is perpetrated by Jack to Maddy in their marriage life in some aspects, including emotional, sexual abuses then discrimination in sphere of work. Emotional abuse is reflected in Journey including humiliation, threatening, belittling, social isolation which is committed all by the main male character to the main female character. Meanwhile sexual abuse is reflected in Journey including prohibition to have a baby by the main male character, Jack to the main female character, Maddy, forces in having sex, use torturing sexually when having sex as a punishment so that the main female character is submissive with the main male character. Discrimination in working spheres also reflected in Journey including subordination toward integrity of woman, for instance woman is considered incapable of doing anything without the concept of men's, women in this novel is described only as a performer who does things her own unsubstantiated opinion, and woman is only regarded as an benefit asset in increasing television program which is guided by the main female character. Woman in Journey need only look beautiful in a career without having to use her mind and her ability as an independent individual. In Journey, the female character, Maddy is always prosecuted for looking beautiful, elegant and not much demand to her husband. Woman does not have important role in all of spheres such as in her private life at home and in her public life at working place. The second problem is how woman resists against violence. The forms of woman's resistance which are reflected in Journey, including speak out action, act of courage to speak to her husband when finding things that are not in accordance with her conscience in addition to speak out, the main female character in Journey resists violence through doing action, against the rules which across with the principle of the main female character mind as the image of woman in Journey is reflected very dare to oppose rules which limit ability of woman in expression. As her husband still does not show change in attitude, finally the main female decides to become personal autonomy, dare to take a firm stance with which she considers leaving her husband and had trampled her dignity as a woman. In the field work, Maddy in an attempt to show her integrity dare express her opinions, and show the concept of the work which should become her responsibility. Besides she is brave to speak out, the main female character in attempt to get happiness she is brave to oppose all imposed restrictions by the main male character, Jack. Form of opposition is reflected in Journey is she keeps on airing the program of editorial, which has been banned by Jack. The main female character presents the editorial in an effort to gain public attention over the fate of other women, still socialization with her friends, and meets with her daughter although she gets refusal from her husband. Besides doing action, the female character chooses to be personal autonomy with leaving home in order to getting happiness in her life. She has successed in determining her self, her body, her thinking that she will be happy without her husband. The resistance of female character to her husband for leaving her husband is having arisen awareness in women that she can be independent in the material, social, and can decide for the direction and purpose of her life with the ability, intelligence, skills she has with supporting her friends, and her daughters. She wants to reach her dreams to achieve happiness without getting abuses, and being a mother for her daughter who is ever entrusted in baby house and a new baby whom she gets from her friend, find another men who can love her so much and understand her weakness or her excess. SUGGESTION From some of the conclusion above, the writer can propse following suggestions: a) Gender injustice can happen anytime and anywhere and overwrite both men and women in all aspects and levels of life. Therefore, there needs to be an effort to address gender inequality. b) There needs to be provision of an understanding of gender and gender inequality early on in the community both within the family, the education in school, and so forth. c) The result of this study is served as a material to conduct in-depth analysis of gender approach, especially gender inequalities that afflict women. REFERENCES Bhasin, Kamala (2000). Understanding Gender. New Delhi : Kali for Women Carter, David (2006). Literary Theory Pocket Essential. United States of America : Harpenden Denmark, Florence (2008). Psychology of Women. United States of America : Greenwood Publishing Group, Inc. Dustin, Ells Howes (2009). Toward a Credible Pacifism Violence and the Possibilitties of Politics. Albany : State University of New York Press. Humm, Maggie (1986). Feminist Criticism. Women as Contemporarary Critics. United States of America : The Harverster Press. Joda A, Zubairu H, Abdulwaheed S, Giwa A, Abass R, Adidu V, Okagbue I, Balogun O (2007). Against Violence Against Women. Baobab Legal Literacy Leaflet No.1 Khan, Mehr (2000). Domestic Violence Against Women And Girl : UNICEF Innocenti Digest Lundberg, Paula K and Shelly Marmion (2006). Intimate'' Violence against Women : When Spouses, Partners, o Lovers Attack. United States of America: Greenwood Publishing Group, Inc. Margi, McCue Laird (2002). Domestic Violence : A Reference Handbook Contemporary World Issues. United States of America: ABC-CLIO. Tong, Rosemarie (2009). Feminist Thought. United States of America: Westview Press. Wolf, Naomi (1994). Fire With Fire, The New Female Power and How it Hill Chane the 21st Century. United States of America : Vintage. Wood, Julia T (2009). Gendered Lives Communication. Canada : Nelson Education, Ltd.

Part nine of an interview with Gloria Mulcahy and Marion Madonia. Topics include: People who were important to their father's campaign. Their father as a religious man and how Father Duran was a personal friend of the family. Time they spent at Whalom Park. Dating. Carrying on Italian traditions. How their father lost his election for a fourth term as mayor. Their father became a state representative. Their father's retirement. ; 1 SPEAKER 1: Well, let's see. When he put on our thinking caps. Well, a lot of Italians helped him, too, I think. SPEAKER 3: Yeah. SPEAKER 1: You know, like a lot of the businessmen. I would say, I think… did Bill Gerone help him? SPEAKER 3: I'm sure he did. SPEAKER 1: [Unintelligible – 00:00:16]? SPEAKER 3: Sure. SPEAKER 1: Yeah, he was really active. And Mike Bernanti. SPEAKER 3: Mike Bernanti, too. SPEAKER 1: He helped a lot. SPEAKER 3: But they're both… they're gone now. SPEAKER 1: Everybody is… SPEAKER 3: They're dead. SPEAKER 1: Did Joe die too? SPEAKER 3: Didn't he? Yeah, I think he did. SPEAKER 1: Of course, every -- yeah. So that's it. You know, look, the women are… we're past the age that they were. SPEAKER 2: That's why it's important that we're trying to capture this history before it goes. SPEAKER 1: Okay. It goes. Because that's it. We try to explain it to the children, our children. And they wish that they were around when this happened, you know. But they were -- they enjoyed the times at the house with my mother and father every Sunday. They enjoyed being with their grandparents on holidays, you know. That was a lot of fun. Our family, we did have a lot of fun together. SPEAKER 3: Oh yeah, yeah. SPEAKER 1: That was one thing that we -- the closeness. And in what they did to us is five… there are five sisters. And we're still close. SPEAKER 3; We're still close.2 SPEAKER 1: We talk every day. We talk to all our sisters. SPEAKER 3: We have to call and talk to them. SPEAKER 1: Usually sisters don't get together. We just had a get-together Sunday. SPEAKER 3: We had two christenings. SPEAKER 1: Yeah. So, I mean, our closeness as a family stayed, and we want to have that with our children, too, and their children, you know. But times have changed a little bit because of problems, which… SPEAKER 3: Right. SPEAKER 1: But, I mean, every Sunday we were at dad's house and mom's, you know. And the kids just loved it. They'd put on shows for us. Remember? SPEAKER 3: Yeah, yes. SPEAKER 1: And dad. Oh, and then when my mother got sick, you know, we had this priest friend, Father Duran. He would come and say Mass… SPEAKER 3: At the house. SPEAKER 1: At the house. Every Christmas, especially. Every Christmas, and we would all be there, the whole family. SPEAKER 3: Yeah. SPEAKER 1: Of course. And he would -- even on Sundays, he would say Mass because my mother was very religious, of course, you know. And my father was, too. But my father -- but at the end, he would be -- because he was getting so elderly that he'd be saying the Mass with Father Duran. Remember? SPEAKER 3: Yeah. SPEAKER 1: He'd be saying the words, I mean, because he was, you know. The last 15 years that he stayed in. He went out, but he was in most of the time, you know, because he was getting, he was sickly. SPEAKER 2: Now Father Duran, was he from Fitchburg? SPEAKER 1: Well, he came from -- or he lived in…3 SPEAKER 3: Oxford. SPEAKER 1: Oxford, yeah. But then he came to Fitchburg when he was in his thirties, and he was a close friend of mine, and he married all our children just about. SPEAKER 3: Yeah. He's a minister now. He changed… SPEAKER 1: Yeah, he's a minister now. Father Duran. Personal friend of the family. SPEAKER 3: Yeah. SPEAKER 1: Once you know him, he just knows you. I mean, he'll call you by your first name. And he helped us get through the time of our sicknesses that we had with my mother and father. And coming to say the Mass was great because we could -- and, remember, our kids, remember, would -- one of them, one time actually -- once in a while would say the readings in church—not in church, in the living room—because they had a big living room, so that was nice too. But we were always used to entertaining, because we always had people. I'm trying to think who we had. Did Margetti have -- well, I remember now going when we were kids with Daddy and Ma. Now, even though he was busy in politics. And Bernie Monahan used to come. SPEAKER 3: Oh, yes. SPEAKER 1: We'd always go to Weiland Park. You know, Weiland Park was a big thing in Fitchburg. SPEAKER 3: Right. SPEAKER 1: In Nuremberg and Leominster. SPEAKER 3: Yeah. SPEAKER 1: And we used to go to Weiland Park on Sundays and go on all the rides. And I remember Dad being with us. I mean, even though he was so busy being in politics and all these organizations that he belonged to. SPEAKER 3: He took time.4 SPEAKER 1: He always took time, yeah. And we always had fun. And then another thing, one more thing I'd like to think of. And I just carry it on to my family. When my father -- when we got to be 16, say, or 17, whenever we could get our license, our driver's license, he'd let us have the car for the whole day. So imagine, five daughters taking the car for the whole day, you know. You know, when it was each by our years, you know. So then I remember when I had my children, I was alone. I went through a divorce. And when they were 16, that was our only car in the house, and I let them take it for the whole day. I thought it was so nice that he, you know, trusted us to drive alone. And we always got in accidents almost. SPEAKER 3: Almost, but we didn't. SPEAKER 1: Yeah, I remember I would always be with you. And there were always like tagalongs because we were always sisters, you know, with the boyfriends and the girlfriends. SPEAKER 3: Right. SPEAKER 1: I thought that was a nice thing to do. I mean, because nowadays, I hear a lot of parents say, you know, "Oh, my son can't take the car," or my daughter. SPEAKER 3: We always took his car. He was good in that way. SPEAKER 1: Yeah, he was very -- he was an easy father. He was -- the only thing he was strict about was the boys. SPEAKER 3: Yeah. SPEAKER 1: Because girls weren't supposed to date until we were like 17. SPEAKER 3: And come home a certain time. SPEAKER 1: Yeah. He was strict about that. SPEAKER 2: Was it important for him that you married Italian? SPEAKER 1: No. SPEAKER 3: No. SPEAKER 1: No, because…5 SPEAKER 3: He never pushed us. SPEAKER 1: Yeah, he didn't want to… as long as we were happy, he was happy. But like two of us married Italians, Evie and I. Oh, and Paula did. I forgot. He is half Italian. SPEAKER 3: Oh, okay. Ray. SPEAKER 1: That's right, Ray. I forgot, gosh. Yeah. SPEAKER 2: Was it important to marry the same religion? SPEAKER 1: Yes, it was. But if you met… SPEAKER 3: And marry. SPEAKER 1: Tell her about it. SPEAKER 3: Mike, he was what, part Irish and English? He wasn't Catholic, but he didn't object to it, no. SPEAKER 1: As long as they were going to be happy. SPEAKER 3: Right. And they are. They're still married. SPEAKER 1: They're still married. SPEAKER 3: 51 years married, yeah. SPEAKER 1: And Evie is still -- Evie was the first one to marry an Italian. She was the third in line, okay. We all got married in line. Isn't that funny? SPEAKER 2: Wow. SPEAKER 1: It's just, you know, by age. SPEAKER 3: By age. SPEAKER 1: Yeah. And we still do things that way. Like when we decide things, we go by our age and we go down, and we try -- we all talk about it and say these things. But Evie, she's still married to George, and he's Italian. Then I was the next one. SPEAKER 3: But he never said… SPEAKER 1: He never said no. SPEAKER 3: --he had to be Catholic or Italian. SPEAKER 1: Yeah. In the beginning, they thought -- because in those days -- that was the thing, you know, to get married in a Catholic church.6 SPEAKER 3: Right. SPEAKER 1: It had to be proper. But then it changed. When Mary got married to Mike, the first one, well, they were going to get married in the rectory, and then they changed the laws just then that they could get married behind the altar. SPEAKER 3: In church. SPEAKER 1: We called it kneeling… you know, you couldn't go on the altar because in those days -- now you go on the altar, but in those days you just knelt on the kneeler, and then -- so that was the first marriage, I think. I mean the first in our family anyway. SPEAKER 2: What was the first family? SPEAKER 1: Well, I mean that he was non-Catholic, you know. SPEAKER 2: Yeah. SPEAKER 1: Yeah. And he wasn't Italian. But, no, he didn't insist. No. Because I think they might have… you know. You know how parents think, you know. Well, let's face it. We all think, like myself. Like I just want my kids now to be happy because nowadays, you know, how they marry all different ethnic groups in college and stuff, so you just want them to be happy. SPEAKER 3: Right. SPEAKER 1: When I say that. SPEAKER 2: [Unintelligible – 00:07:54]. SPEAKER 1: You don't -- I know, yeah. But they were good parents when it came to… Yeah, they just wanted to see us happy and healthy. But they wanted us to carry on. That's why we want to carry on the Italian tradition because we are Italian. The daughters are anyway, you know. SPEAKER 2: So in which ways do you carry it on? SPEAKER 1: Holidays. SPEAKER 3: Yeah, holidays. SPEAKER 1: The oldies.7 SPEAKER 3: We get together. Mum taught us how to make the meatballs. SPEAKER 1: Yeah, right. Yeah. SPEAKER 3: Different recipes. SPEAKER 1: And we'd say a few words in Italian. Not much. Slang words [laughter]. No. And… by listening and by having Italian music, you know, listening to the Italian music. And I belong, like I said, I do things at Italian club. I don't know what else. What else? We really don't talk Italian. SPEAKER 3: In church. SPEAKER 1: In our church, Italian church. And we have a lot of Italian friends. SPEAKER 3: Right. SPEAKER 2: How do you celebrate Christmas Eve? SPEAKER 1: Now, we just do it by our own family. SPEAKER 3: Yeah. We used to years ago go to mom and dad's, and then we always opened gifts on Christmas Eve. And now we have Christmas. So, I have Christmas Eve. Now my children come to my house here, and we do it separate on Christmas Eve with our own families. SPEAKER 1: Yeah, with our own families. Yeah. Right. SPEAKER 3: Christmas this year, we got together. SPEAKER 1: Yeah. SPEAKER 3: When mom was around and dad, both days. SPEAKER 1: Yeah. Like your tradition now is to get with your own. SPEAKER 3: With my own. SPEAKER 1: With your own family. You know, that's what we do now. SPEAKER 3: And the children, we get together. SPEAKER 2: What kind of -- do you keep the same food that your mother used to cook for around Christmas Eve? SPEAKER 1: Not always. SPEAKER 3: No. Mom didn't bake fish. SPEAKER 1: No.8 SPEAKER 2: No? SPEAKER 1: No. Yeah, Dad -- see, my father didn't like fish. So we didn't have a tradition of… SPEAKER 3: No, like a lot of Italians on Christmas Day would have their ravioli and all that. And Christmas Eve, we would have sausages. SPEAKER 1: We'd eat meat and sausages. SPEAKER 2: Sausage was the big thing then. SPEAKER 1: Yeah, because our father wouldn't eat fish. SPEAKER 3: No. SPEAKER 1: Not in those days, he didn't eat fish. When he got older, I know [unintelligible – 00:10:17]. If I made it, he'd eat it. SPEAKER 3: Then he would. Yeah. SPEAKER 1: He stopped it. So my mother's tradition and our tradition when we were kids, 'cause we -- our tradition in those days when we were little kids, you know, Santa Claus was coming, we'd go to bed early. You know what I mean? It's like nowadays, it's so different. SPEAKER 3: They want to stay up, right. SPEAKER 1: Yeah, because it's like you stay up on Christmas Eve and go to midnight Mass. Like, I know when I was 15 or so -- no, 16, when I started dating Dick. SPEAKER 3: Yeah. SPEAKER 1: Remember, we -- 'cause my mother had Paula. That's right, when Paula was born, things changed because Paula had to go to bed early. You know what I mean? On Christmas Eve, before we used to -- we could stay up and we'd go to the Medonia's. SPEAKER 3: Yeah. SPEAKER 1: I'm trying to remember what we did Christmas Eve, because it was just Ma and Dad and the five of us, four of us, because Paula came along when I was 11. So Christmas Eve, we'd go to bed. We'd probably just have our supper and then go to bed, because we'd 9 wait for Santa Claus to come. In those days, you didn't celebrate, did we? SPEAKER 3: Right. Well, we used to go… SPEAKER 1: Did we? SPEAKER 3: Mother, Jack and I would go Christmas Eve. SPEAKER 1: Yeah, but when we were real little. I'm talking about before you got married when we were kids. SPEAKER 3: No, it was Christmas Day when… SPEAKER 1: Yeah. Christmas Eve, in those days, you went to bed early. SPEAKER 3: Yeah. We didn't have a celebration then. SPEAKER 1: Yeah, you didn't really in those days. SPEAKER 3: Yeah, not until later on, right. SPEAKER 1: Yeah. And then we didn't have the fish. We had sausages or whatever. I can't even remember what we had, but we didn't have -- I know it's like -- I have another friend, Florence, and her tradition, her mother, they cooked all kinds of fish, and they still do. SPEAKER 3: Yeah. But, see, we never did that. Mother never did, so we don't. SPEAKER 1: Yeah. But now you make Italian foods even Christmas Eve because your kids… SPEAKER 3: Yeah, I do. They like it. SPEAKER 1: Yeah. SPEAKER 2: So you know, getting back to your dad and the Sicilian -- you mentioned something about a pizzeria? SPEAKER 1: Yeah. SPEAKER 2: Were there a group of Sicilians that hung around at that club? SPEAKER 1: Yeah. [Pepezia] or something they used to call it. I can hear it. Yeah, the pizza was the best, so thick. You know, it's Sicilian pizza. I used to love it there. SPEAKER 2: And what would they do down there?10 SPEAKER 1: They had a club. It was a [unintelligible – 00:12:35] club. But that isn't listed there, no. SPEAKER 2: [Unintelligible – 00:12:40]. SPEAKER 1: It doesn't say anything about the pizzeria. SPEAKER 2: No. SPEAKER 1: That was more, I think, just… SPEAKER 3: It's a group of… SPEAKER 1: Group of Sicilians, yeah. SPEAKER 3: Yeah. They sat around. SPEAKER 1: Sicilians, I think, yeah. I don't remember. But I can remember the Pepe Club, yeah, because we used to go down and get pizza and hang around. I don't know. SPEAKER 2: What does it mean to be Italian to both of you? SPEAKER 3: We're proud of it. SPEAKER 1: Oh, very proud of it, yeah. SPEAKER 2: But why? Where does that proudness come from? SPEAKER 1: I like being Italian, to tell you the truth. Isn't that awful? SPEAKER 2: No. SPEAKER 3: We should be proud, right? SPEAKER 1: Yeah, like you're saying about how groups, how people -- how we split up, like, like I always say -- and I still do it now. SPEAKER 3: What? SPEAKER 1: I have -- all my friends, I have my Italian friends. And then when I went to work at city hall, I got my Irish friends from there. SPEAKER 3: Sure. They're proud to be Irish like we're proud to be Italian. SPEAKER 1: Yeah, yeah. SPEAKER 3: We were in line. SPEAKER 1: The schools separate you, yeah. So to be proud of being Italian, I like the ethnic background that Italians have. I think they have the looks, especially. I just can't help it. I'm still into Italians: the eyes. My first thing that I always loved. And, I mean, Italian men, 11 I still am drawn to them. I guess I married an Italian man, and yeah, I'm kind of drawn to -- I just don't know what it is. SPEAKER 2: That's fine. How did your father's career end? Did he decide not to run for mayor for a fourth term and then became… SPEAKER 1: No, he was beaten. SPEAKER 2: He was beaten? SPEAKER 3: Yeah. And that was… SPEAKER 1: By a farmer. That was a little hurt. That was very sad. It was… SPEAKER 3: Yeah. SPEAKER 1: He lost by only a few votes see. So… we had to have a recount and everything. It was only like 60 votes. SPEAKER 2: Wow. SPEAKER 1: It was by. So there were some 60 people there that -- or 65 people that either didn't go vote, or… I always said jealousy, but you know, from that same nationality, could be jealous too, you know. But I doubt that should be said, so erase that because actually, I don't need to say that. SPEAKER 2: You think so? SPEAKER 1: I don't know. SPEAKER 3: Everywhere. SPEAKER 1: It happens everywhere. SPEAKER 3: Every nationality, people are jealous. SPEAKER 1: But we just felt bad because who beat him was -- he used to go up and go and give -- he had a farm, and he'd give those free vegetables to everybody, and we figured that's why they voted for him. You know, we couldn't give anything free. We couldn't give away anything. My father couldn't afford it. And, you know, he was married. He didn't have the money. That's why he almost lost his business, because he was dedicated to the people of Fitchburg and to his city, our city. And I can understand why he was, because it's a beautiful city. With Fitchburg State College, I 12 mean, now it's even beautiful. I mean, it really is. So I just think of… but yeah, so he lost. And we were sick, all of us. SPEAKER 3: Yeah. But someone has to win and someone has to lose in politics. SPEAKER 1: Right. And then it gave him a better opportunity to run for state representative and so then, and so he did that. From losing being mayor, then he went to state rep. And then he held that office, and then he retired. SPEAKER 3: Right. SPEAKER 1: Yeah, he had to retire. SPEAKER 2: Did he run almost immediately? SPEAKER 1: Yeah, yeah. Wasn't it '57? He lost in '56, the next year. SPEAKER 3: I think around that time. SPEAKER 1: Yeah, the next year, in '57. He ran that next fall in '57. SPEAKER 3: Right. SPEAKER 1: Then he started in '58, January of '58. SPEAKER 2: So how did his life change after he became state rep? SPEAKER 1: Yes. He went to Boston five days a week. But it didn't… he felt that that would be easier than being mayor because people weren't calling you every day, every minute, you know. SPEAKER 3: Yeah, and there weren't as many meetings like he had. SPEAKER 1; Yes, and then you vote at the house, you know. You vote and you talk to the people that call him. Like the voter friend, I tell them what to vote for, and he was always voting for what the people wanted, you know. He used to -- I mean, he enjoyed that. SPEAKER 3: Yeah. He enjoyed that. SPEAKER 1: Yeah, it was a piece of cake. Yeah, it was good. And then he was on a couple of state committees, so he had some meetings. Was it aeronautics and cities? He was in the… yeah, they told us that he was… And I thought he was on Ways and Means, but it wasn't in that book. But I remember him once saying. But, you know, they 13 got on committees, different representatives. Very interesting. I don't know how long he was there, but he enjoyed that. SPEAKER 3: He did. SPEAKER 2: And then he retired? SPEAKER 1: Then he retired, yeah. SPEAKER 3: Yes. SPEAKER 1: Because, let's see, he was… It was '61 that he retired, or '62. SPEAKER 2: Okay. So he was about 60 then. SPEAKER 1: Okay, yeah. Oh my. Yeah, and then they moved. Then Ma and Dad went to Florida. No, I know it was '61 or '62, because I remember going -- right when Chip had surgery, and Joe, my son, was at my mom's. I was sleeping at my mother's house when my ex had major surgery on his back, spinal fusion. And I remember. So then we'd be driving to Boston. I'd drive with dad, and then I'd come home with him at night. And Chip was in the hospital in '61. Joe was born October '61. This was '62. So I think he was in office for '58, '59, '60, '61. Anyways, yeah, he retired because he got sickly… '62. SPEAKER 3: I don't know the date or year. I don't remember. SPEAKER 1: I know. We should have gotten them. All right, so he -- yeah, he didn't, I don't think -- he wasn't defeated. He retired. SPEAKER 2: He retired. SPEAKER 1: He retired from that state house. No, no one ran against him and beat him, because he retired. SPEAKER 2: Did he run as a Democrat? SPEAKER 1: Oh, yes. SPEAKER 3: Yeah. SPEAKER 1: Oh, yeah, democrat always. SPEAKER 3: Right. SPEAKER 2: But when he first won mayor, it was because of a coalition of Republicans and Democrats?14 SPEAKER 1: Right. SPEAKER 3: He was still a Democrat, but they… SPEAKER 1: But he was a… See, and George was a Republican. George Stanton was a Republican. Or was he a Democrat? I don't know. It doesn't matter. It was at state. SPEAKER 3: [Unintelligible – 00:19:50] SPEAKER 1: Yeah because he needed backing to win. But, yeah, for state rep, he just… /AT/pa/ke/es

This book contains the abstracts of the papers/posters presented at the Tanzania Health Summit 2020 (THS-2020) Organized by the Ministry of Health Community Development, Gender, Elderly and Children (MoHCDGEC); President Office Regional Administration and Local Government (PORALG); Ministry of Health, Social Welfare, Elderly, Gender, and Children Zanzibar; Association of Private Health Facilities in Tanzania (APHFTA); National Muslim Council of Tanzania (BAKWATA); Christian Social Services Commission (CSSC); & Tindwa Medical and Health Services (TMHS) held on 25–26 November 2020. The Tanzania Health Summit is the annual largest healthcare platform in Tanzania that attracts more than 1000 participants, national and international experts, from policymakers, health researchers, public health professionals, health insurers, medical doctors, nurses, pharmacists, private health investors, supply chain experts, and the civil society. During the three-day summit, stakeholders and decision-makers from every field in healthcare work together to find solutions to the country's and regional health challenges and set the agenda for a healthier future. Summit Title: Tanzania Health SummitSummit Acronym: THS-2020Summit Date: 25–26 November 2020Summit Location: St. Gasper Hotel and Conference Centre in Dodoma, TanzaniaSummit Organizers: Ministry of Health Community Development, Gender, Elderly and Children (MoHCDGEC); President Office Regional Administration and Local Government (PORALG); Ministry of Health, Social Welfare, Elderly, Gender and Children Zanzibar; Association of Private Health Facilities in Tanzania (APHFTA); National Muslim Council of Tanzania (BAKWATA); Christian Social Services Commission (CSSC); & Tindwa Medical and Health Services (TMHS).

COVID-STORM Clinicians Giuseppe Foti1, Giacomo Bellani 1, Giuseppe Citerio1, Ernesto Contro1, Alberto Pesci2, Maria Grazia Valsecchi3, Marina Cazzaniga4 1Department of Emergency, Anesthesia and Intensive Care, School of Medicine and Surgery, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy. 2Department of Pneumology, School of Medicine and Surgery, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy. 3Center of Bioinformatics and Biostatistics, School of Medicine and Surgery, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy. 4Phase I Research Center, School of Medicine and Surgery, University of Milano-Bicocca, San Gerardo Hospital, Monza IT ; COVID Clinicians Jorge Abad1, Sergio Aguilera-Albesa2, Ozge Metin Akcan3, Ilad Alavi Darazam4, Juan C. Aldave5, Miquel Alfonso Ramos6, Seyed Alireza Nadji7, Gulsum Alkan8, Jerome Allardet-Servent9, Luis M. Allende10, Laia Alsina11, Marie-Alexandra Alyanakian12, Blanca Amador-Borrero13, Zahir Amoura14, Arnau Antolí15, Sevket Arslan16, Sophie Assant17, Terese Auguet18, Axelle Azot19, Fanny Bajolle20, Aurélie Baldolli21, Maite Ballester22, Hagit Baris Feldman23, Benoit Barrou24, Alexandra Beurton25, Agurtzane Bilbao26, Geraldine Blanchard-Rohner27, Ignacio Blanco1, Adeline Blandinières28, Daniel Blazquez-Gamero29, Marketa Bloomfield30, Mireia Bolivar-Prados31, Raphael Borie32, Cédric Bosteels33, Ahmed A. Bousfiha34, Claire Bouvattier35, Oksana Boyarchuk36, Maria Rita P. Bueno37, Jacinta Bustamante20, Juan José Cáceres Agra38, Semra Calimli39, Ruggero Capra40, Maria Carrabba41, Carlos Casasnovas42, Marion Caseris43, Martin Castelle44, Francesco Castelli45, Martín Castillo de Vera46, Mateus V. Castro37, Emilie Catherinot47, Martin Chalumeau48, Bruno Charbit49, Matthew P. Cheng50, Père Clavé31, Bonaventura Clotet51, Anna Codina52, Fatih Colkesen53, Fatma Çölkesen54, Roger Colobran55, Cloé Comarmond56, David Dalmau57, David Ross Darley58, Nicolas Dauby59, Stéphane Dauger60, Loic de Pontual61, Amin Dehban62, Geoffroy Delplancq63, Alexandre Demoule64, Jean-Luc Diehl65, Stephanie Dobbelaere66, Sophie Durand67, Waleed Eldars68, Mohamed Elgamal69, Marwa H. Elnagdy70, Melike Emiroglu71, Emine Hafize Erdeniz72, Selma Erol Aytekin73, Romain Euvrard74, Recep Evcen75, Giovanna Fabio41, Laurence Faivre76, Antonin Falck43, Muriel Fartoukh77, Morgane Faure78, Miguel Fernandez Arquero79, Carlos Flores80, Bruno Francois81, Victoria Fumadó82, Francesca Fusco83, Blanca Garcia Solis84, Pascale Gaussem85, Juana Gil-Herrera86, Laurent Gilardin87, Monica Girona Alarcon88, Mònica Girona-Alarcón88, Jean-Christophe Goffard89, Funda Gok90, Rafaela González-Montelongo91, Antoine Guerder92, Yahya Gul93, Sukru Nail Guner93, Marta Gut94, Jérôme Hadjadj95, Filomeen Haerynck96, Rabih Halwani97, Lennart Hammarström98, Nevin Hatipoglu99, Elisa Hernandez-Brito100, Cathérine Heijmans101, María Soledad Holanda-Peña102, Juan Pablo Horcajada103, Levi Hoste104, Eric Hoste105, Sami Hraiech106, Linda Humbert107, Alejandro D. Iglesias108, Antonio Íñigo-Campos91, Matthieu Jamme109, María Jesús Arranz110, Iolanda Jordan111, Philippe Jorens112, Fikret Kanat113, Hasan Kapakli114, Iskender Kara115, Adem Karbuz116, Kadriye Kart Yasar117, Sevgi Keles118, Yasemin Kendir Demirkol119, Adam Klocperk120, Zbigniew J. Król121, Paul Kuentz122, Yat Wah M. Kwan123, Jean-Christophe Lagier124, Bart N. Lambrecht33, Yu-Lung Lau125, Fleur Le Bourgeois60, Yee-Sin Leo126, Rafael Leon Lopez127, Daniel Leung125, Michael Levin128, Michael Levy60, Romain Lévy20, Zhi Li49, Agnes Linglart129, Bart Loeys130, José M. Lorenzo-Salazar91, Céline Louapre131, Catherine Lubetzki131, Charles-Edouard Luyt132, David C. Lye133, Davood Mansouri134, Majid Marjani135, Jesus Marquez Pereira136, Andrea Martin137, David Martínez Pueyo138, Javier Martinez-Picado139, Iciar Marzana140, Alexis Mathian14, Larissa R. B. Matos37, Gail V. Matthews141, Julien Mayaux142, Jean-Louis Mège143, Isabelle Melki144, Jean-François Meritet145, Ozge Metin146, Isabelle Meyts147, Mehdi Mezidi148, Isabelle Migeotte149, Maude Millereux150, Tristan Mirault151, Clotilde Mircher67, Mehdi Mirsaeidi152, Abián Montesdeoca Melián153, Antonio Morales Martinez154, Pierre Morange155, Clémence Mordacq107, Guillaume Morelle156, Stéphane Mouly13, Adrián Muñoz-Barrera91, Leslie Naesens157, Cyril Nafati158, João Farela Neves159, Lisa FP. Ng160, Yeray Novoa Medina161, Esmeralda Nuñez Cuadros162, J. Gonzalo Ocejo-Vinyals163, Zerrin Orbak164, Mehdi Oualha20, Tayfun Özçelik165, Qiang Pan-Hammarström166, Christophe Parizot142, Tiffany Pascreau167, Estela Paz-Artal168, Sandra Pellegrini49, Rebeca Pérez de Diego84, Aurélien Philippe169, Quentin Philippot77, Laura Planas-Serra170, Dominique Ploin171, Julien Poissy172, Géraldine Poncelet43, Marie Pouletty173, Paul Quentric142, Didier Raoult143, Anne-Sophie Rebillat67, Ismail Reisli174, Pilar Ricart175, Jean-Christophe Richard176, Nadia Rivet28, Jacques G. Rivière177, Gemma Rocamora Blanch15, Carlos Rodrigo1, Carlos Rodriguez-Gallego178, Agustí Rodríguez-Palmero179, Carolina Soledad Romero180, Anya Rothenbuhler181, Flore Rozenberg182, Maria Yolanda Ruiz del Prado183, Joan Sabater Riera15, Oliver Sanchez184, Silvia Sánchez-Ramón185, Agatha Schluter170, Matthieu Schmidt186, Cyril E. Schweitzer187, Francesco Scolari188, Anna Sediva189, Luis M. Seijo190, Damien Sene13, Sevtap Senoglu117, Mikko R. J. Seppänen191, Alex Serra Ilovich192, Mohammad Shahrooei62, Hans Slabbynck193, David M. Smadja194, Ali Sobh195, Xavier Solanich Moreno15, Jordi Solé-Violán196, Catherine Soler197, Pere Soler-Palacín137, Yuri Stepanovskiy198, Annabelle Stoclin199, Fabio Taccone149, Yacine Tandjaoui-Lambiotte200, Jean-Luc Taupin201, Simon J. Tavernier202, Benjamin Terrier203, Caroline Thumerelle107, Gabriele Tomasoni204, Julie Toubiana48, Josep Trenado Alvarez205, Sophie Trouillet-Assant206, Jesús Troya207, Alessandra Tucci208, Matilde Valeria Ursini‬83, Yurdagul Uzunhan209, Pierre Vabres210, Juan Valencia-Ramos211, Eva Van Braeckel33, Stijn Van de Velde212, Ana Maria Van Den Rym84, Jens Van Praet213, Isabelle Vandernoot214, Hulya Vatansev215, Valentina Vélez-Santamaria42, Sébastien Viel171, Cédric Vilain216, Marie E. Vilaire67, Audrey Vincent35, Guillaume Voiriot217, Fanny Vuotto107, Alper Yosunkaya90, Barnaby E. Young126, Fatih Yucel218, Faiez Zannad219, Mayana Zatz37, Alexandre Belot220* ; Imagine COVID Group Christine Bole-Feysot, Stanislas Lyonnet*, Cécile Masson, Patrick Nitschke, Aurore Pouliet, Yoann Schmitt, Frederic Tores, Mohammed Zarhrate Imagine Institute, Université de Paris, INSERM UMR 1163, Paris, France. *Leader of the Imagine COVID Group. ; French COVID Cohort Study Group Laurent Abel1, Claire Andrejak2, François Angoulvant3, Delphine Bachelet4, Romain Basmaci5, Sylvie Behillil6, Marine Beluze7, Dehbia Benkerrou8, Krishna Bhavsar4, François Bompart9, Lila Bouadma4, Maude Bouscambert10, Mireille Caralp11, Minerva Cervantes-Gonzalez12, Anissa Chair4, Alexandra Coelho13, Camille Couffignal4, Sandrine Couffin-Cadiergues14, Eric D'Ortenzio12, Charlene Da Silveira4, Marie-Pierre Debray4, Dominique Deplanque15, Diane Descamps16, Mathilde Desvallées17, Alpha Diallo18, Alphonsine Diouf13, Céline Dorival8, François Dubos19, Xavier Duval4, Philippine Eloy4, Vincent VE Enouf20, Hélène Esperou21, Marina Esposito-Farese4, Manuel Etienne22, Nadia Ettalhaoui4, Nathalie Gault4, Alexandre Gaymard10, Jade Ghosn4, Tristan Gigante23, Isabelle Gorenne4, Jérémie Guedj24, Alexandre Hoctin13, Isabelle Hoffmann4, Salma Jaafoura21, Ouifiya Kafif4, Florentia Kaguelidou25, Sabina Kali4, Antoine Khalil4, Coralie Khan17, Cédric Laouénan4, Samira Laribi4, Minh Le4, Quentin Le Hingrat4, Soizic Le Mestre18, Hervé Le Nagard24, François-Xavier Lescure4, Yves Lévy26, Claire Levy-Marchal27, Bruno Lina10, Guillaume Lingas24, Jean Christophe Lucet4, Denis Malvy28, Marina Mambert13, France Mentré4, Noémie Mercier18, Amina Meziane8, Hugo Mouquet20, Jimmy Mullaert4, Nadège Neant24, Marion Noret29, Justine Pages30, Aurélie Papadopoulos21, Christelle Paul18, Nathan Peiffer-Smadja4, Ventzislava Petrov-Sanchez18, Gilles Peytavin4, Olivier Picone31, Oriane Puéchal12, Manuel Rosa-Calatrava10, Bénédicte Rossignol23, Patrick Rossignol32, Carine Roy4, Marion Schneider4, Caroline Semaille12, Nassima Si Mohammed4, Lysa Tagherset4, Coralie Tardivon4, Marie-Capucine Tellier4, François Téoulé8, Olivier Terrier10, Jean-François Timsit4, Théo Trioux4, Christelle Tual33, Sarah Tubiana4, Sylvie van der Werf34, Noémie Vanel35, Aurélie Veislinger33, Benoit Visseaux16, Aurélie Wiedemann26, Yazdan Yazdanpanah36 1Inserm UMR 1163, Paris, France. 2CHU Amiens, France. 3Hôpital Necker, Paris, France. 4Hôpital Bichat, Paris, France. 5Hôpital Louis Mourrier, Colombes, France. 6Institut Pasteur, Paris, France. 7F-CRIN Partners Platform, AP-HP, Université de Paris, Paris, France. 8Inserm UMR 1136, Paris, France. 9Drugs for Neglected Diseases Initiative, Geneva, Switzerland. 10Inserm UMR 1111, Lyon, France. 11Inserm Transfert, Paris, France. 12REACTing, Paris, France. 13Inserm UMR 1018, Paris, France. 14Inserm, Pôle Recherche Clinique, Paris, France. 15CIC 1403 Inserm-CHU Lille, Paris, France. 16Université de Paris, IAME, INSERM UMR 1137, AP-HP, University Hospital Bichat Claude Bernard, Virology, Paris, France. 17Inserm UMR 1219, Bordeaux, France. 18ANRS, Paris, France. 19CHU Lille, Lille, France. 20Pasteur Institute, Paris, France. 21Inserm sponsor, Paris, France. 22CHU Rouen–SMIT, Rouen, France. 23FCRIN INI-CRCT, Nancy, France. 24Inserm UMR 1137, Paris, France. 25Centre d'Investigation Clinique, Inserm CIC1426, Hôpital Robert Debré, Paris, France. 26Inserm UMR 955, Créteil, France; Vaccine Research Instiute (VRI), Paris, France. 27F-CRIN INI-CRCT, Paris, France. 28CHU de Bordeaux–SMIT, Bordeaux, France. 29RENARCI, Annecy, France. 30Hôpital Robert Debré, Paris, France. 31Hôpital Louis Mourier–Gynécologie, Colombes, France. 32University of Lorraine, Plurithematic Clinical Investigation Centre Inserm CIC-P; 1433, Inserm U1116, CHRU Nancy Hopitaux de Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France. 33Inserm CIC-1414, Rennes, France. 34Institut Pasteur, UMR 3569 CNRS, Université de Paris, Paris, France. 35Hôpital la Timone, Marseille, France. 36Bichat–SMIT, Paris, France. ; CoV-Contact Cohort Loubna Alavoine1, Karine K. A. Amat2, Sylvie Behillil3, Julia Bielicki4, Patricia Bruijning5, Charles Burdet6, Eric Caumes7, Charlotte Charpentier8, Bruno Coignard9, Yolande Costa1, Sandrine Couffin-Cadiergues10, Florence Damond8, Aline Dechanet11, Christelle Delmas10, Diane Descamps8, Xavier Duval1, Jean-Luc Ecobichon1, Vincent Enouf3, Hélène Espérou10, Wahiba Frezouls1, Nadhira Houhou11, Emila Ilic-Habensus1, Ouifiya Kafif11, John Kikoine11, Quentin Le Hingrat8, David Lebeaux12, Anne Leclercq1, Jonathan Lehacaut1, Sophie Letrou1, Bruno Lina13, Jean-Christophe Lucet14, Denis Malvy15, Pauline Manchon11, Milica Mandic1, Mohamed Meghadecha16, Justina Motiejunaite17, Mariama Nouroudine1, Valentine Piquard11, Andreea Postolache11, Caroline Quintin1, Jade Rexach1, Layidé Roufai10, Zaven Terzian11, Michael Thy18, Sarah Tubiana1, Sylvie van der Werf3, Valérie Vignali1, Benoit Visseaux8, Yazdan Yazdanpanah14 1Centre d'Investigation Clinique, Inserm CIC 1425, Hôpital Bichat Claude Bernard, APHP, Paris, France. 2IMEA Fondation Léon M'Ba, Paris, France. 3Institut Pasteur, UMR 3569 CNRS, Université de Paris, Paris, France. 4University of Basel Children's Hospital. 5Julius Center for Health Sciences and Primary Care, Utrecht, Netherlands. 6Université de Paris, IAME, Inserm UMR 1137, F-75018, Paris, France, Hôpital Bichat Claude Bernard, APHP, Paris, France. 7Hôpital Pitiè Salpétriere, APHP, Paris. 8Université de Paris, IAME, INSERM UMR 1137, AP-HP, University Hospital Bichat Claude Bernard, Virology, Paris, France. 9Santé Publique France, Saint Maurice, France. 10Pole Recherche Clinique, Inserm, Paris, France. 11Hôpital Bichat Claude Bernard, APHP, Paris, France. 12APHP, Paris, France. 13Virpath Laboratory, International Center of Research in Infectiology, Lyon University, INSERM U1111, CNRS UMR 5308, ENS, UCBL, Lyon, France. 14IAME Inserm UMR 1138, Hôpital Bichat Claude Bernard, APHP, Paris, France. 15Service des Maladies Infectieuses et Tropicales; Groupe Pellegrin-Place Amélie-Raba-Léon, Bordeaux, France. 16Hôpital Hotel Dieu, APHP, Paris, France. 17Service des Explorations Fonctionnelles, Hôpital Bichat–Claude Bernard, APHP, Paris, France. 18Center for Clinical Investigation, Assistance Publique-Hôpitaux de Paris, Bichat-Claude Bernard University Hospital, Paris, France. ; Amsterdam UMC Covid-19 Biobank Michiel van Agtmael1, Anna Geke Algera2, Frank van Baarle2, Diane Bax3, Martijn Beudel4, Harm Jan Bogaard5, Marije Bomers1, Lieuwe Bos2, Michela Botta2, Justin de Brabander6, Godelieve de Bree6, Matthijs C. Brouwer4, Sanne de Bruin2, Marianna Bugiani7, Esther Bulle2, Osoul Chouchane1, Alex Cloherty3, Paul Elbers2, Lucas Fleuren2, Suzanne Geerlings1, Bart Geerts8, Theo Geijtenbeek9, Armand Girbes2, Bram Goorhuis1, Martin P. Grobusch1, Florianne Hafkamp9, Laura Hagens2, Jorg Hamann10, Vanessa Harris1, Robert Hemke11, Sabine M. Hermans1, Leo Heunks2, Markus W. Hollmann8, Janneke Horn2, Joppe W. Hovius1, Menno D. de Jong12, Rutger Koning4, Niels van Mourik2, Jeaninne Nellen1, Frederique Paulus2, Edgar Peters1, Tom van der Poll1, Benedikt Preckel8, Jan M. Prins1, Jorinde Raasveld2, Tom Reijnders1, Michiel Schinkel1, Marcus J. Schultz2, Alex Schuurman13, Kim Sigaloff1, Marry Smit2, Cornelis S. Stijnis1, Willemke Stilma2, Charlotte Teunissen14, Patrick Thoral2, Anissa Tsonas2, Marc van der Valk1, Denise Veelo8, Alexander P.J. Vlaar15, Heder de Vries2, Michèle van Vugt1, W. Joost Wiersinga1, Dorien Wouters16, A. H. (Koos) Zwinderman17, Diederik van de Beek4* 1Department of Infectious Diseases, Amsterdam UMC, Amsterdam, Netherlands. 2Department of Intensive Care, Amsterdam UMC, Amsterdam, Netherlands. 3Experimental Immunology, Amsterdam UMC, Amsterdam, Netherlands. 4Department of Neurology, Amsterdam UMC, Amsterdam Neuroscience, Amsterdam, Netherlands. 5Department of Pulmonology, Amsterdam UMC, Amsterdam, Netherlands. 6Department of Infectious Diseases, Amsterdam UMC, Amsterdam, Netherlands. 7Department of Pathology, Amsterdam UMC, Amsterdam, Netherlands. 8Department of Anesthesiology, Amsterdam UMC, Amsterdam, Netherlands. 9Department of Experimental Immunology, Amsterdam UMC, Amsterdam, Netherlands. 10Amsterdam UMC Biobank Core Facility, Amsterdam UMC, Amsterdam, Netherlands. 11Department of Radiology, Amsterdam UMC, Amsterdam, Netherlands. 12Department of Medical Microbiology, Amsterdam UMC, Amsterdam, Netherlands. 13Department of Internal Medicine, Amsterdam UMC, Amsterdam, Netherlands. 14Neurochemical Laboratory, Amsterdam UMC, Amsterdam, Netherlands. 15Department of Intensive Care, Amsterdam UMC, Amsterdam, Netherlands. 16Department of Clinical Chemistry, Amsterdam UMC, Amsterdam, Netherlands. 17Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, Amsterdam, Netherlands. 18Department of Neurology, Amsterdam UMC, Amsterdam, Netherlands. *Leader of the AMC Consortium. ; COVID Human Genetic Effort Laurent Abel1, Alessandro Aiuti2, Saleh Al Muhsen3, Fahd Al-Mulla4, Mark S. Anderson5, Andrés Augusto Arias6, Hagit Baris Feldman7, Dusan Bogunovic8, Alexandre Bolze9, Anastasiia Bondarenko10, Ahmed A. Bousfiha11, Petter Brodin12, Yenan Bryceson12, Carlos D. Bustamante13, Manish Butte14, Giorgio Casari15, Samya Chakravorty16, John Christodoulou17, Elizabeth Cirulli9, Antonio Condino-Neto18, Megan A. Cooper19, Clifton L. Dalgard20, Alessia David21, Joseph L. DeRisi22, Murkesh Desai23, Beth A. Drolet24, Sara Espinosa25, Jacques Fellay26, Carlos Flores27, Jose Luis Franco28, Peter K. Gregersen29, Filomeen Haerynck30, David Hagin31, Rabih Halwani32, Jim Heath33, Sarah E. Henrickson34, Elena Hsieh35, Kohsuke Imai36, Yuval Itan8, Timokratis Karamitros37, Kai Kisand38, Cheng-Lung Ku39, Yu-Lung Lau40, Yun Ling41, Carrie L. Lucas42, Tom Maniatis43, Davoud Mansouri44, Laszlo Marodi45, Isabelle Meyts46, Joshua Milner47, Kristina Mironska48, Trine Mogensen49, Tomohiro Morio50, Lisa FP. Ng51, Luigi D. Notarangelo52, Antonio Novelli53, Giuseppe Novelli54, Cliona O'Farrelly55, Satoshi Okada56, Tayfun Ozcelik57, Rebeca Perez de Diego58, Anna M. Planas59, Carolina Prando60, Aurora Pujol61, Lluis Quintana-Murci62, Laurent Renia63, Alessandra Renieri64, Carlos Rodríguez-Gallego65, Vanessa Sancho-Shimizu66, Vijay Sankaran67, Kelly Schiabor Barrett9, Mohammed Shahrooei68, Andrew Snow69, Pere Soler-Palacín70, András N. Spaan71, Stuart Tangye72, Stuart Turvey73, Furkan Uddin74, Mohammed J. Uddin75, Diederik van de Beek76, Sara E. Vazquez77, Donald C. Vinh78, Horst von Bernuth79, Nicole Washington9, Pawel Zawadzki80, Helen C. Su52, Jean-Laurent Casanova81 1INSERM U1163, University of Paris, Imagine Institute, Paris, France. 2San Raffaele Telethon Institute for Gene Therapy, IRCCS Ospedale San Raffaele, Milan, Italy. 3King Saud University, Riyadh, Saudi Arabia. 4Kuwait University, Kuwait City, Kuwait. 5University of California, San Francisco, San Francisco, CA, USA. 6Universidad de Antioquia, Group of Primary Immunodeficiencies, Antioquia, Colombia. 7The Genetics Institute, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 8Icahn School of Medicine at Mount Sinai, New York, NY, USA. 9Helix, San Mateo, CA, USA. 10Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine. 11Clinical Immunology Unit, Pediatric Infectious Disease Departement, Faculty of Medicine and Pharmacy, Averroes University Hospital; LICIA Laboratoire d'Immunologie Clinique, d'Inflammation et d'Allergie, Hassann Ii University, Casablanca, Morocco. 12Karolinska Institute, Stockholm, Sweden. 13Stanford University, Stanford, CA, USA. 14University of California, Los Angeles, CA, USA. 15Medical Genetics, IRCCS Ospedale San Raffaele, Milan, Italy. 16Emory University Department of Pediatrics and Children's Healthcare of Atlanta, Atlanta, GA, USA. 17Murdoch Children's Research Institute, Victoria, Australia. 18University of São Paulo, São Paulo, Brazil. 19Washington University School of Medicine, St. Louis, MO, USA. 20The American Genome Center; Uniformed Services University of the Health Sciences, Bethesda, MD, USA. 21Centre for Bioinformatics and System Biology, Department of Life Sciences, Imperial College London, South Kensington Campus, London, UK. 22University of California, San Francisco, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA. 23Bai Jerbai Wadia Hospital for Children, Mumbai, India. 24School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA. 25Instituto Nacional de Pediatria (National Institute of Pediatrics), Mexico City, Mexico. 26Swiss Federal Institute of Technology Lausanne, Lausanne, Switzerland. 27Research Unit, Hospital Universitario Nuestra Señora de Candelaria, Canarian Health System, Santa Cruz de Tenerife, Spain. 28University of Antioquia, Medellín, Colombia. 29Feinstein Institute for Medical Research, Northwell Health USA, Manhasset, NY, USA. 30Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID Research Lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Edegem, Belgium. 31The Genetics Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. 32Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, UAE. 33Institute for Systems Biology, Seattle, WA, USA. 34Children's Hospital of Philadelphia, Philadelphia, PA, USA. 35Anschutz Medical Campus, Aurora, CO, USA. 36Riken, Tokyo, Japan. 37Hellenic Pasteur Institute, Athens, Greece. 38University of Tartu, Tartu, Estonia. 39Chang Gung University, Taoyuan County, Taiwan. 40The University of Hong Kong, Hong Kong, China. 41Shanghai Public Health Clinical Center, Fudan University, Shanghai, China. 42Yale School of Medicine, New Haven, CT, USA. 43New York Genome Center, New York, NY, USA. 44Shahid Beheshti University of Medical Sciences, Tehran, Iran. 45Semmelweis University Budapest, Budapest, Hungary. 46KU Leuven, Department of Immunology, Microbiology and Transplantation, Leuven, Belgium. 47Columbia University Medical Center, New York, NY, USA. 48University Clinic for Children's Diseases, Skopje, North Macedonia. 49Aarhus University, Aarhus, Denmark. 50Tokyo Medical & Dental University Hospital, Tokyo, Japan. 51Singapore Immunology Network, Singapore. 52National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. 53Bambino Gesù Children's Hospital, Rome, Italy. 54Department of Biomedicine and Prevention, University of Rome "Tor Vergata," Rome, Italy. 55Trinity College, Dublin, Ireland. 56Hiroshima University, Hiroshima, Japan. 57Bilkent University, Ankara, Turkey. 58Laboratory of Immunogenetics of Human Diseases, Innate Immunity Group, IdiPAZ Institute for Health Research, La Paz Hospital, Madrid, Spain. 59IIBB-CSIC, IDIBAPS, Barcelona, Spain. 60Faculdades Pequeno Príncipe e Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba, Brazil. 61Neurometabolic Diseases Laboratory, IDIBELL–Hospital Duran I Reynals; Catalan Institution for Research and Advanced Studies (ICREA); CIBERER U759, ISCiii Madrid Spain, Barcelona, Spain. 62Institut Pasteur (CNRS UMR2000) and Collège de France, Paris, France. 63Infectious Diseases Horizontal Technology Center and Singapore Immunology Network, Agency for Science Technology (A*STAR), Singapore. 64Medical Genetics, University of Siena, Siena, Italy; Genetica Medica, Azienda Ospedaliero-Universitaria Senese, Italy; GEN-COVID Multicenter Study. 65Hospital Universitario de Gran Canaria Dr. Negrín, Canarian Health System, Canary Islands, Spain. 66Imperial College London, London, UK. 67Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. 68Saeed Pathobiology and Genetic Lab, Tehran, Iran. 69Uniformed Services University of the Health Sciences, Bethesda, MD, USA. 70Hospital Universitari Vall d'Hebron, Barcelona, Spain. 71University Medical Center Utrecht, Amsterdam, The Netherlands. 72Garvan Institute of Medical Research, Sydney, Australia. 73The University of British Columbia, Vancouver, Canada. 74Holy Family Red Crescent Medical College; Centre for Precision Therapeutics, NeuroGen Children's Healthcare; Genetics and Genomic Medicine Centre, NeuroGen Children's Healthcare, Dhaka, Bangladesh. 75Mohammed Bin Rashid University of Medicine and Health Sciences, College of Medicine, Dubai, UAE; The Centre for Applied Genomics, Department of Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada. 76Amsterdam UMC, University of Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam, The Netherlands. 77University of California, San Francisco, CA, USA. 78McGill University Health Centre, Montreal, Canada. 79Charité–Berlin University Hospital Center, Berlin, Germany. 80Molecular Biophysics Division, Faculty of Physics, A. Mickiewicz University, Uniwersytetu Poznanskiego 2, Poznań, Poland. 81Rockefeller University, Howard Hughes Medical Institute, Necker Hospital, New York, NY, USA. *Leaders of the COVID Human Genetic Effort. ; NIAID-USUHS/TAGC COVID Immunity Group Huie Jing1,2, Wesley Tung1,2, Christopher R. Luthers3, Bradly M. Bauman3, Samantha Shafer2,4, Lixin Zheng2,4, Zinan Zhang2,4, Satoshi Kubo2,4, Samuel D. Chauvin2,4, Kazuyuki Meguro1,2, Elana Shaw1,2, Michael Lenardo2,4, Justin Lack5, Eric Karlins6, Daniel M. Hupalo7, John Rosenberger7, Gauthaman Sukumar7, Matthew D. Wilkerson7, Xijun Zhang7 1Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. 2NIAID Clinical Genomics Program, National Institutes of Health, Bethesda, MD, USA. 3Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. 4Laboratory of Immune System Biology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. 5NIAID Collaborative Bioinformatics Resource, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, USA. 6Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. 7The American Genome Center, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. ; Clinical outcome upon infection with SARS-CoV-2 ranges from silent infection to lethal COVID-19. We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern TLR3- and IRF7-dependent type I interferon (IFN) immunity to influenza virus, in 659 patients with life-threatening COVID-19 pneumonia, relative to 534 subjects with asymptomatic or benign infection. By testing these and other rare variants at these 13 loci, we experimentally define LOF variants in 23 patients (3.5%), aged 17 to 77 years, underlying autosomal recessive or dominant deficiencies. We show that human fibroblasts with mutations affecting this pathway are vulnerable to SARS-CoV-2. Inborn errors of TLR3- and IRF7-dependent type I IFN immunity can underlie life-threatening COVID-19 pneumonia in patients with no prior severe infection. ; We thank the generous donation from Fisher Center for Alzheimer's Research Foundation for our research. The Laboratory of Human Genetics of Infectious Diseases is supported by the Howard Hughes Medical Institute, the Rockefeller University, the St. Giles Foundation, the National Institutes of Health (NIH) (R01AI088364), the National Center for Advancing Translational Sciences (NCATS), NIH Clinical and Translational Science Award (CTSA) program (UL1 TR001866), a Fast Grant from Emergent Ventures, Mercatus Center at George Mason University, the Yale Center for Mendelian Genomics and the GSP Coordinating Center funded by the National Human Genome Research Institute (NHGRI) (UM1HG006504 and U24HG008956), the French National Research Agency (ANR) under the "Investments for the Future" program (ANR-10-IAHU-01), the Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence (ANR-10-LABX-62-IBEID), the French Foundation for Medical Research (FRM) (EQU201903007798), the FRM and ANR GENCOVID project, ANRS-COV05, the Square Foundation, Grandir - Fonds de solidarité pour l'enfance, the SCOR Corporate Foundation for Science, Institut National de la Santé et de la Recherche Médicale (INSERM), the University of Paris. The French COVID Cohort study group was sponsored by Inserm and supported by the REACTing consortium and by a grant from the French Ministry of Health (PHRC 20-0424). Regione Lombardia, Italy (project "Risposta immune in pazienti con COVID-19 e co-morbidità"), and the Intramural Research Program of the NIAID, NIH. The laboratory of Genomes & Cell Biology of Disease is supported by "Integrative Biology of Emerging Infectious Diseases" (grant no. ANR-10-LABX-62-IBEID), the "Fondation pour la Recherche Medicale" (grant FRM - EQU202003010193), the "Agence Nationale de la Recherche" (ANR FLASH COVID project IDISCOVR cofounded by the "Fondation pour la Recherche Médicale"), University of Paris ("Plan de Soutien Covid-19": RACPL20FIR01-COVID-SOUL). IM is a senior clinical investigator with the FWO Vlaanderen; IM and LM are supported by FWO G0C8517N – GOB5120N. The VS team was supported by "Agence Nationale de la Recherche" (ANR-17-CE15-0003, ANR-17-CE15-0003-01), and by Université de Paris "PLAN D'URGENCE COVID19". LK was supported by a fellowship from the French Ministry of Research. VS-S is supported by a UKRI Future Leaders Fellowship (MR/S032304/1). SZA-M is supported by the Elite Journals Program at King Saud University through grant number PEJP-16-107. JM lab is supported by Columbia University COVID biobank and grant: UL1TR001873. Work in the Laboratory of Virology and Infectious Disease was supported by NIH grants P01AI138398-S1, 2U19AI111825, and R01AI091707-10S1, a George Mason University Fast Grant, and the G. Harold and Leila Y. Mathers Charitable Foundation. JLP is supported by a European Molecular Biology Organization Long-Term Fellowship (ALTF 380-2018). Work at the Neurometabolic Diseases Laboratory received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No 824110 (EasiGenomics grant COVID-19/ PID12342) to A.P., and Roche and Illumina Covid Match Funds to M.G. C.R.G and colleagues are supported by cInstituto de Salud Carlos III (COV20_01333 and COV20_01334), Spanish Ministry of Science and Innovation, with the funding of European Regional Development Fund-European Social Fund -FEDER-FSE; (RTC-2017-6471-1; AEI/FEDER, UE), and Cabildo Insular de Tenerife (CGIEU0000219140 and "Apuestas científicas del ITER para colaborar en la lucha contra la COVID-19"). D.C.V. is supported by the Fonds de la recherche en santé du Québec clinician-scientist scholar program. Helen Su is adjunct faculty at the University of Pennsylvania. A-L.N. was supported by the Foundation Bettencourt Schueller. The Amsterdam UMC Covid-19 Biobank was funded by the Netherlands Organization for Health Research and Development (ZonMw, NWO-vici 91819627), The Corona Research Fund (Amsterdam UMC), Dr. J. C. Vaillantfonds, and Amsterdam UMC. Work on COVID-19 at the AG-S lab is partly supported by NIH supplements to grants U19AI135972, U19AI142733 and R35 HL135834, and to contract HHSN272201800048C, by a DoD supplement to grant W81XWH-20-1-0270, by DARPA project HR0011-19-2-0020, by CRIP (Center for Research on Influenza Pathogenesis), a NIAID funded Center of Excellence for Influenza Research and Surveillance (CEIRS, contract HHSN272201400008C), by an NIAID funded Collaborative Influenza Vaccine Innovation Center (SEM-CIVIC, contract 75N93019C00051) and by the generous support of the JPB Foundation, the Open Philanthropy Project (research grant 2020-215611(5384)) and anonymous donors. The Virscan analysis presented in fig. S11 was performed with financial support from Sidra Medicine ; Peer reviewed

Die European Values Study ist ein groß angelegtes, länderübergreifendes und längsschnittliches Umfrageforschungsprogramm darüber, wie die Europäer über Familie, Arbeit, Religion, Politik und Gesellschaft denken. Die Umfrage wird alle neun Jahre in einer wachsenden Anzahl von Ländern wiederholt und gibt Einblicke in die Ideen, Überzeugungen, Präferenzen, Einstellungen, Werte und Meinungen der Bürger in ganz Europa.

Das EVS Trend File 1981-2017 wird aus den fünf EVS-Wellen erstellt und deckt fast 40 Jahre ab. In insgesamt 160 Umfragen wurden mehr als 224.000 Befragte aus 48 Ländern/Regionen befragt. Es basiert auf den aktualisierten Daten des EVS Longitudinal Data File 1981-2008 (v.3.1.0) und dem aktuellen EVS 2017 Integrated Dataset (v.5.0.0).

Für das EVS Trend File ist neben dem (faktisch anonymisierten) Scientific-Use File (ZA7503) auch ein Restricted-Use File (ZA7504) verfügbar. Das EVS Trend File - Sensitive Dataset (ZA7504) wird als Zusatzdatei angeboten. Zusätzlich zu einem kleinen Satz von Verwaltungs- und Protokollvariablen, die für die Zusammenführung mit den SUF-Daten benötigt werden, enthält der Sensitive Datensatz folgende Variablen, die aufgrund ihrer sensiblen Natur nicht in die Scientific-Use-File aufgenommen werden konnten:

W005_3 Job profession/industry (3-digit ISCO88) - spouse/partner EVS 2008
W005_3_01 Job profession/industry (3-digit ISCO08) - spouse/partner EVS 2017
W005_4 Job profession/industry (4-digit ISCO88) - spouse/partner EVS 2008
X035_3 Job profession/industry (3-digit ISCO88) – respondent EVS 1999, EVS 2008
X035_3_01 Job profession/industry (3-digit ISCO08) - respondent EVS 2017
X035_4 Job profession/industry (4-digit ISCO88) – respondent EVS 1999, EVS 2008
x048c_n3 Region where the interview was conducted (NUTS-3): NUTS version 2006 EVS 2008
X048J_N3 Region where the interview was conducted (NUTS-3): NUTS version 2016 EVS 2017
X049 Size of town (8 categories) EVS 2008, EVS 2017

Detailierte information über den Anonymisierungsprozedere im EVS Trend File ist im Variablen Report enthalten.

Die European Values Study ist ein groß angelegtes, länderübergreifendes und längsschnittliches Umfrageforschungsprogramm darüber, wie die Europäer über Familie, Arbeit, Religion, Politik und Gesellschaft denken. Die Umfrage wird alle neun Jahre in einer wachsenden Anzahl von Ländern wiederholt und gibt Einblicke in die Ideen, Überzeugungen, Präferenzen, Einstellungen, Werte und Meinungen der Bürger in ganz Europa.

Das EVS Trend File 1981-2017 wird aus den fünf EVS-Wellen erstellt und deckt fast 40 Jahre ab. In insgesamt 160 Umfragen wurden mehr als 224.000 Befragte aus 48 Ländern/Regionen befragt. Es basiert auf den aktualisierten Daten des EVS Longitudinal Data File 1981-2008 (v.3.1.0) und dem aktuellen EVS 2017 Integrated Dataset (v.5.0.0).

Sie folgt einem neuen Ansatz, der mit der WVS vereinbart wurde, um die früheren großen EVS- und WVS-Längsschnitt-Trenddateien in schlankere und einfacher zu verwendende Dateien umzuwandeln. Sowohl die EVS- als auch die WVS-Trenddateien basieren auf dem aktualisierten Common EVS/WVS Dictionary (v.2021). Es enthält nur die Variablen/Fragen, die seit den frühen 1980er Jahren von EVS und/oder WVS repliziert wurden. Der EVS Trend File und der World Values Survey Trend File (1981-2022) können so leicht zusammengeführt werden. Die daraus resultierende Integrated Values Surveys 1981-2022 Datendatei enthält die fünf Wellen der EVS und die sieben Wellen der WVS.